The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
Exercise benefits on Alzheimer’s disease: State-of-the-science
Abstract
Although there is no unanimity, growing evidence supports the value of regular physical exercise to prevent Alzheimer's disease as well as cognitive decline in affected patients. Together with an introductory summary on epidemiological evidence, the aim of this review is to summarize the current knowledge on the potential biological mechanisms underlying exercise benefits in this condition. Regular physical exercise has proven to be beneficial for traditional cardiovascular risk factors (e.g., reduced vascular flow, diabetes) involved in the pathogenesis of Alzheimer's disease. Exercise also promotes neurogenesis via increases in exercise-induced metabolic factors (e.g., ketone bodies, lactate) and muscle-derived myokines (cathepsin-B, irisin), which in turn stimulate the production of neurotrophins such as brain-derived neurotrophic factor. Finally, regular exercise exerts anti-inflammatory effects and improves the brain redox status, thereby ameliorating the pathophysiological hallmarks of Alzheimer's disease (e.g., amyloid-β deposition). In summary, physical exercise might provide numerous benefits through different pathways that might, in turn, help prevent risk and progression of Alzheimer's disease. More evidence is needed, however, based on human studies.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These beneficial changes underscore the importance of exercise in preventing and slowing the progression of ageing as well as neurodegenerative diseases.504–508”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [506]
In the citing paper
“Moreover, accumulating evidence suggests that physical activity, as shown in preclinical, observational and interventional studies in humans, can prevent or delay the onset of neurodegenerative conditions138.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [138]
Citations
Cites
Items 201–215 of 215
Zhou, B., Yao, H., Wang, P., Zhang, Z., Zhan, Y., Ma, J., Xu, K., Wang, L., An, N., Liu, Y., et al. (2015) · BioMed Research International · doi:10.1155/2015/495375 · Cited by 38
Exercise, Fitness and the Aging Brain: A Review of Functional Connectivity in Aging
Stillman, C. M., Donofry, S. D., & Erickson, K. I. (2019) · Archives of Psychology · doi:10.31296/aop.v3i4.98 · Cited by 37
Carotid Stiffness is Associated with Brain Amyloid-β Burden in Amnestic Mild Cognitive Impairment
Pasha, E. P., Rutjes, E., Tomoto, T., Tarumi, T., Stowe, A. M., Claassen, J. A. H. R., Cullum, C. M., Zhu, D. C., & Zhang, R. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191073 · Cited by 32
Kim, J., Choi, K., Cho, S., Kang, S., Yoo, S. W., Kwon, S., Min, J., Bom, H., & Song, H. (2019) · Scientific Reports · doi:10.1038/s41598-018-37244-9 · Cited by 29
Coll‐Padrós, N., León, M., Valech, N., Ros, E., Vidal, J., Estruch, R., Fitó, M., Salas‐Salvadó, J., Corella, D., Molinuevo, J. L., et al. (2019) · European Review of Aging and Physical Activity · doi:10.1186/s11556-019-0229-y · Cited by 28
on behalf of the SFGG study group, Boully, C., Vidal, J., et al. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1215-y · Cited by 26
Proteomics and Systems Biology in Exercise and Sport Sciences Research
Hittel, D. S., Hathout, Y., & Hoffman, E. P. (2007) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31802d744a · Cited by 25
A highly predictive signature of cognition and brain atrophy for progression to Alzheimer's dementia
Tam, A., Dansereau, C. L., Iturria‐Medina, Y., Urchs, S. G. W., Orban, P., Sharmarke, H., Breitner, J. C. S., Bellec, P., & Initiative, A. D. N. (2019) · GigaScience · doi:10.1093/gigascience/giz055 · Cited by 22
Feature Learning Based Random Walk for Liver Segmentation
Zheng, Y., Ai, D.-N., Zhang, P., Gao, Y., Xia, L., Du, S., Sang, X., & Yang, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164098 · Cited by 20
Exercise conditioned plasma dampens inflammation via clusterin and boosts memoryPreprint
Miguel, Z. D., Betley, M. J., Willoughby, D., Lehallier, B., Olsson, N., Bonanno, L. N., Fairchild, J. K., Contrepois, K., Elias, J. E., Rando, T. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/775288 · Cited by 8
Nascimento, C. M. C., Cominetti, M. R., Pereira, J. R., de Andrade, L. P., Garuffi, M., Kerr, D. S., Forlenza, O. V., & Stella, F. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.07.465 · Cited by 4
Maliszewska‐Cyna, E., Oore, J., Xhima, K., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.762 · Cited by 4
Dougherty, R. J., Boots, E. A., Rowley, H. A., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.06.2388 · Cited by 4
Kwak, K. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.06.1607 · Cited by 3
Teixeira, C. V. L., de Rezende, T. J. R., Magalhães, T. N. C., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.06.362 · Cited by 3
Flagged first, then by citations
Cited by
Sorted by citations
Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927
Self-citationBrain-Derived Neurotrophic Factor in Alzheimer’s Disease and Its Pharmaceutical Potential
Gao, L., Zhang, Y., Sterling, K., & Song, W. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00279-0 · Cited by 606
Dominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433
Exercise sustains the hallmarks of health
Qiu, Y., Fernández-García, B., Lehmann, H. I., Li, G., Kroemer, G., López-Otín, C., & Xiao, J. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.10.003 · Cited by 270
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165
Metadata
- Authors
- Valenzuela, P. L., Castillo-García, A., Morales, J. S., de la Villa, P., Hampel, H., Emanuele, E., Lista, S., & Lucia, A.
- Affiliations
- Universidad de Alcalá (ES)
- Universidad Europea de Madrid (ES)
- Sorbonne Université (FR)
- Centre National de la Recherche Scientifique (FR)
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 62
- Pages
- 101108
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W3036541872
- Cited by
- 337
- References
- 215
- Citations by year
- 2026: 41 · 2025: 64 · 2024: 67 · 2023: 68 · 2022: 51 · 2021: 37 · 2020: 9
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion)
- Funders
- Ministerio de Educación, Cultura y Deporte (FPU14/03435)
- Fondation pour la Recherche sur Alzheimer
- Ministerio de Economía y Competitividad
- Association Sorbonne Université
- Eisai
- Universidad de Alcalá (FPI2016)
- European Regional Development Fund (PI18/00139)
- AXA Research Fund
- Sorbonne Université
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- Alzheimer's disease, physical activity, cognitive decline, neurogenesis, myokines, irisin, cathepsin B, brain-derived neurotrophic factor, neuroinflammation, oxidative stress, amyloid-beta, ketone bodies, lactate, cardiovascular risk factors, diabetes mellitus
- MeSH terms
- Alzheimer Disease, Brain, Exercise Therapy, Humans, Exercise, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
