The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.
Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease
Open accessAbstract
The responses of central nervous system (CNS) cells such as neurons and glia in neurodegenerative diseases (NDs) suggest that regulation of neuronal and glial functions could be a strategy for ND prevention and/or treatment. However, attempts to develop such therapeutics for NDs have been hindered by the challenge of blood-brain barrier (BBB) permeability and continued constitutive neuronal loss. These limitations indicate the need for additional perspectives for the prevention/treatment of NDs. In particular, the disruption of the blood-brain barrier (BBB) that accompanies NDs allows brain infiltration by peripheral factors, which may stimulate innate immune responses involved in the progression of neurodegeneration. The accumulation of blood factors like thrombin, fibrinogen, c-reactive protein (CRP) and complement components in the brain has been observed in NDs and may activate the innate immune system in the CNS. Thus, strengthening the integrity of the BBB may enhance its protective role to attenuate ND progression and functional loss. In this review, we describe the innate immune system in the CNS and the contribution of blood factors to the role of the CNS immune system in neurodegeneration and neuroprotection.
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“CRP usually does not freely cross BBB [33]”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [33]
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Metadata
- Authors
- Jeon, M.-T., Kim, K.-S., Kim, E. S., Lee, S., Kim, J., Hoe, H.-S., & Kim, D.-G.
- Affiliations
- Korea Brain Research Institute (KR)
- Daegu Gyeongbuk Institute of Science and Technology (KR)
- King's College London (GB)
- Corresponding author
- Hoe, Hyang-Sook
- Kim, Do-Geun
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 68
- Pages
- 101333
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W3138731251
- Cited by
- 76
- References
- 210
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 15 · 2023: 14 · 2022: 16 · 2021: 4
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Ageing Research Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- blood-brain barrier disruption, neurodegenerative diseases, innate immunity, thrombin, fibrinogen, C-reactive protein, complement system, neuroinflammation, neuroprotection, glial cells, blood-brain barrier integrity
- MeSH terms
- Blood-Brain Barrier, Brain, Central Nervous System, Humans, Neuroglia, Neurodegenerative Diseases
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