Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30371-x · Cited by 2,609

The gut microbiota influences blood-brain barrier permeability in mice

Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530

Blood-brain barrier breakdown in the aging human hippocampus

Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.032 · Cited by 2,102

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

Nation, D. A., Sweeney, M. D., Montagne, A., Sagare, A. P., D’Orazio, L. M., Pachicano, M., Sepehrband, F., Nelson, A. R., Buennagel, D. P., Harrington, M. G., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0297-y · Cited by 1,728

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

Constantinescu, C. S., Farooqi, N., O'Brien, K., & Gran, B. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01302.x · Cited by 1,523

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

Bell, R. D., Winkler, E. A., Sagare, A. P., Singh, I., LaRue, B., Deane, R., & Zlokovic, B. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.043 · Cited by 1,448

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

Montagne, A., Nation, D. A., Sagare, A. P., Barisano, G., Sweeney, M. D., Chakhoyan, A., Pachicano, M., Joe, E., Nelson, A. R., D’Orazio, L. M., et al. (2020) · Nature · doi:10.1038/s41586-020-2247-3 · Cited by 1,281

Recognition of lipopolysaccharide pattern by TLR4 complexes

Park, B. S., & Lee, J. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.97 · Cited by 1,276

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

Olson, J. K., & Miller, S. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3916 · Cited by 1,215

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

Gelderblom, M., Leypoldt, F., Steinbach, K., Behrens, D., Choe, C.-U., Siler, D. A., Arumugam, T. V., Orthey, E., Gerloff, C., Tolosa, E., et al. (2009) · Stroke · doi:10.1161/strokeaha.108.534503 · Cited by 1,066

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat

Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060

Microglial Activation and Chronic Neurodegeneration

Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · cited 1×

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Rajamäki, K., Lappalainen, J., Öörni, K., Välimäki, E., Matikainen, S., Kovanen, P. T., & Eklund, K. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011765 · Cited by 1,039

Fibrinogen as a key regulator of inflammation in disease

Davalos, D., & Akassoglou, K. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0290-8 · Cited by 943

Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

Riewald, M., Petrovan, R. J., Donner, A. J., Mueller, B. M., & Ruf, W. (2002) · Science · doi:10.1126/science.1071699 · Cited by 832

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.010 · Cited by 799

Promoting tissue regeneration by modulating the immune system

Julier, Z., Park, A. J., Briquez, P. S., & Martino, M. M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.056 · Cited by 766

Minocycline selectively inhibits M1 polarization of microglia

Kobayashi, K., Imagama, S., Ohgomori, T., Hirano, K., Uchimura, K., Sakamoto, K., Hirakawa, A., Takeuchi, H., Suzumura, A., Ishiguro, N., et al. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.54 · Cited by 742

Clinical trials of new drugs for Alzheimer disease

Huang, L.-K., Chao, S.-P., & Hu, C.-J. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-019-0609-7 · Cited by 702

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

Winkler, E. A., Nishida, Y., Sagare, A. P., Rege, S. V., Bell, R. D., Perlmutter, D., Sengillo, J. D., Hillman, S., Kong, P., Nelson, A. R., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3966 · Cited by 689

Phagocytosis of Microglia in the Central Nervous System Diseases

Fu, R., Shen, Q., Xu, P., Luo, J. J., & Tang, Y. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8620-6 · Cited by 687

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

Montagne, A., Zhao, Z., & Zlokovic, B. V. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171406 · Cited by 672

Neuroinflammation pathways: a general review

Shabab, T., Khanabdali, R., Moghadamtousi, S. Z., Kadir, H. A., & Mohan, G. (2016) · International Journal of Neuroscience · doi:10.1080/00207454.2016.1212854 · Cited by 657

Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

Claesson, L., Dejana, E., & McDonald, D. M. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.11.006 · Cited by 657

Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease

Kim, Y. S., & Joh, T. H. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.40 · Cited by 655

Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection

Abdullahi, W., Tripathi, D. K., & Ronaldson, P. T. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00095.2018 · Cited by 623

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

Deane, R., Singh, I., Sagare, A. P., Bell, R. D., Ross, N. T., LaRue, B., Love, R., Perry, S., Paquette, N., Deane, R. J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58642 · Cited by 619

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

Lian, H., Litvinchuk, A., Chiang, A. C.-A., Aithmitti, N., Jankowsky, J. L., & Zheng, H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2117-15.2016 · Cited by 597

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor–related protein

Yepes, M., Sandkvist, M., Moore, E., Bugge, T. H., Strickland, D. K., & Lawrence, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19212 · Cited by 588

The impact of microglial activation on blood-brain barrier in brain diseases

da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

Cheng, T., Liu, D., Griffin, J. H., Fernández, J. A., Castellino, F., Rosen, E. D., Fukudome, K., & Zloković, B. V. (2003) · Nature Medicine · doi:10.1038/nm826 · Cited by 572

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Davalos, D., Kyu Ryu, J., Merlini, M., Baeten, K. M., Le Moan, N., Petersen, M. A., Deerinck, T. J., Smirnoff, D. S., Bedard, C., Hakozaki, H., et al. (2012) · Nature Communications · doi:10.1038/ncomms2230 · Cited by 568

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

Chen, A., Fang, Z. H., Chen, X.-L., Yang, S., Zhou, Y., Mao, L., Xia, Y., Jin, H., Li, Y., You, M., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1716-9 · Cited by 559

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

Petersen, M. A., Ryu, J. K., & Akassoglou, K. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.13 · Cited by 527

Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

Saint-Pol, J., Gosselet, F., Duban-Deweer, S., Pottiez, G., & Karamanos, Y. (2020) · Cells · doi:10.3390/cells9040851 · Cited by 503

Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE.

Rollins, B. J., Yoshimura, T., Leonard, E. J., & Pober, J. S. (1990) · Europe PMC (PubMed Central) · Cited by 492

Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease

Simpson, I. A., Chundu, K. R., Davies‐Hill, T., Honer, W. G., & Davies, P. (1994) · Annals of Neurology · doi:10.1002/ana.410350507 · Cited by 490

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor–related protein

Yepes, M. A., Sandkvist, M., MOORE, E. G., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319212 · Cited by 456

Microglial Phagocytosis of Fibrillar β-Amyloid through a β1Integrin-Dependent Mechanism

Koenigsknecht-Talboo, J., & Landreth, G. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2557-04.2004 · Cited by 455

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

Wyss-Coray, T., Yan, F., Lin, A. H.-T., Lambris, J. D., Alexander, J. J., Quigg, R. J., & Masliah, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162350199 · Cited by 446

Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

Bacskai, B. J., Kajdasz, S. T., Christie, R. H., Carter, C., Games, D., Seubert, P. A., Schenk, D., & Hyman, B. T. (2001) · Nature Medicine · doi:10.1038/85525 · Cited by 445

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood–Brain Barrier Damage in Early Ischemic Stroke Stage

Liu, J., Jin, X., Liu, K. J., & Liu, W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6409-11.2012 · Cited by 434

Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an Alzheimer's disease model

Merlini, M., Rafalski, V. A., Rios Coronado, P. E., Gill, T. M., Ellisman, M., Muthukumar, G., Subramanian, K. S., Ryu, J. K., Syme, C. A., Davalos, D., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.014 · Cited by 431

Drug candidates in clinical trials for Alzheimer’s disease

Hung, S.-Y., & Fu, W.-M. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0355-7 · Cited by 420

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

Gray, M. T., & Woulfe, J. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.32 · Cited by 409

A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

Ryu, J. K., & McLarnon, J. G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00434.x · Cited by 406

TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability

Aveleira, C. A., Lin, C.-M., Abcouwer, S. F., Ambrósio, A. F., & Antonetti, D. A. (2010) · Diabetes · doi:10.2337/db09-1606 · Cited by 403

Stroke research at a crossroad: asking the brain for directions

Iadecola, C., & Anrather, J. (2011) · Nature Neuroscience · doi:10.1038/nn.2953 · Cited by 398

The Biochemical, Biological, and Pathological Kaleidoscope of Cell Surface Substrates Processed by Matrix Metalloproteinases

Cauwe, B., den Steen, P. E. V., & Opdenakker, G. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701340019 · Cited by 389

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

Nikolakopoulou, A. M., Montagne, A., Kisler, K., Dai, Z., Wang, Y., Huuskonen, M. T., Sagare, A. P., Lazić, D., Sweeney, M. D., Kong, P., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0434-z · Cited by 386

GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier

Seidner, G. A., Alvarez, M. B. G., Yeh, J., O’Driscoll, K. R., Klepper, J., Stump, T., Wang, D., Spinner, N. B., Birnbaum, M. J., & Vivo, D. C. D. (1998) · Nature Genetics · doi:10.1038/ng0298-188 · Cited by 383

Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration

Kempuraj, D., Thangavel, R., Selvakumar, G. P., Zaheer, S. A., Ahmed, M. E., Raikwar, S. P., Zahoor, H., Saeed, D., Natteru, P., Iyer, S. S., et al. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00216 · Cited by 382

Clearance of amyloid-β by circulating lipoprotein receptors

Sagare, A., Deane, R., Bell, R. D., Johnson, B., Hamm, K., Pendu, R., Marky, A., Lenting, P. J., Wu, Z., Zarcone, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1635 · Cited by 373

A possible role for humoral immunity in the pathogenesis of Parkinson's disease

Orr, C., Rowe, D. B., Mizuno, Y., Mori, H., & Halliday, G. M. (2005) · Brain · doi:10.1093/brain/awh625 · Cited by 367

Role of the Blood-Brain Barrier in the Pathogenesis of Alzheimers Disease

Deane, R., & Zloković, B. V. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362245 · Cited by 365

Blood—Brain Barrier Permeability Precedes Senile Plaque Formation in an Alzheimer Disease Model

UJIIE, M., DICKSTEIN, D. L., CARLOW, D. A., & JEFFERIES, W. A. (2003) · Microcirculation · doi:10.1038/sj.mn.7800212 · Cited by 351

Neuroinflammation and blood–brain barrier disruption following traumatic brain injury: Pathophysiology and potential therapeutic targets

Sulhan, S., Lyon, K. A., Shapiro, L. A., & Huang, J. H. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24331 · Cited by 351

Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease

Fonseca, M. I., Zhou, J., Botto, M., & Tenner, A. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0901-04.2004 · Cited by 345

Complement C3 Deficiency Leads to Accelerated Amyloid Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

Maier, M., Peng, Y., Jiang, L., Seabrook, T. J., Carroll, M. C., & Lemere, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0829-08.2008 · Cited by 323

C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

Asgari, E., Friec, G. L., Yamamoto, H., Perucha, E., Sacks, S. H., Köhl, J., Cook, H. T., & Kemper, C. (2013) · Blood · doi:10.1182/blood-2013-05-502229 · Cited by 321

Thrombin Induces Apoptosis in Cultured Neurons and Astrocytes via a Pathway Requiring Tyrosine Kinase and RhoA Activities

Donovan, F. M., Pike, C. J., Cotman, C. W., & Cunningham, D. D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-14-05316.1997 · Cited by 304

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer’s disease

Matsuoka, Y., Picciano, M., Malester, B., LaFrancois, J., Zehr, C., Daeschner, J. M., Olschowka, J. A., Fonseca, M. I., O’Banion, M. K., Tenner, A. J., et al. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64085-0 · Cited by 303

Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization

Bohlson, S. S., Oâ€TMConner, S. D., Hulsebus, H. J., Ho, M.-M., & Fraser, D. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00402 · Cited by 299

Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke

Ren, X. S., Akiyoshi, K., Dziennis, S., Vandenbark, A. A., Herson, P. S., Hurn, P. D., & Offner, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1623-11.2011 · Cited by 298

Role of Microglia TLRs in Neurodegeneration

Fiebich, B. L., Batista, C. R. A., Saliba, S. W., Yousif, N. M., & de Oliveira, A. C. P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00329 · Cited by 291

Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

Wang, Y., Jin, S., Sonobe, Y., Cheng, Y., Horiuchi, H., Parajuli, B., Kawanokuchi, J., Mizuno, T., Takeuchi, H., & Suzumura, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110024 · Cited by 286

A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling

Kook, S.-H., Hong, H. S., Moon, M., Ha, C. M., Chang, S., & Mook‐Jung, I. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6102-11.2012 · Cited by 279

Therapeutics of Neurotransmitters in Alzheimer’s Disease

Kandimalla, R. J. L., & Reddy, P. H. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161118 · Cited by 274

Brain Injury After Intracerebral Hemorrhage: The Role of Thrombin and Iron

Hua, Y., Keep, R. F., Hoff, J. T., & Xi, G. (2007) · Stroke · doi:10.1161/01.str.0000247868.97078.10 · Cited by 273

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Ryu, J. K., Petersen, M. A., Murray, S. G., Baeten, K. M., Meyer-Franke, A., Chan, J. P., Vagena, E., Bedard, C., Machado, M. R., Coronado, P. E. R., et al. (2015) · Nature Communications · doi:10.1038/ncomms9164 · Cited by 271 · cited 1×

Activated protein C: biased for translation

Griffin, J. H., Zlokovic, B. V., & Mosnier, L. O. (2015) · Blood · doi:10.1182/blood-2015-02-355974 · Cited by 257

The Role of Astrocytes in Neuroprotection after Brain Stroke: Potential in Cell Therapy

Becerra-Calixto, A., & Cardona‐Gómez, G. P. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00088 · Cited by 239

Passive induction of experimental allergic encephalomyelitis

Stromnes, I. M., & Goverman, J. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.284 · Cited by 238

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer’s Disease

Shal, B., Ding, W., Ali, H., Kim, Y. S., & Khan, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00548 · Cited by 234

Phenotypic Spectrum of Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

Pearson, T. S., Akman, Ç. I., Hinton, V. J., Engelstad, K., & Vivo, D. C. D. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0342-7 · Cited by 226

Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease

Farkas, E., de Jong, G. I., de Vos, R. A. I., Steur, E. N. H. J., & Luiten, P. G. M. (2000) · Acta Neuropathologica · doi:10.1007/s004010000195 · Cited by 222

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

Gao, H., Zhou, H., & Hong, J. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.008 · Cited by 219

Alzheimer’s disease as an inflammatory disease

Bolós, M., Perea, J. R., & Avila, J. (2017) · BioMolecular Concepts · doi:10.1515/bmc-2016-0029 · Cited by 216

HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

Festoff, B. W., Sajja, R. K., van Dreden, P., & Cucullo, L. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0670-z · Cited by 214

Chemotaxis by a CNS macrophage, the microglia

Yao, J., Harvath, L., Gilbert, D. L., & Colton, C. A. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490270106 · Cited by 212

Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system

Leszek, J., E. Barreto, G., G|siorowski, K., Koutsouraki, E., Ávila-Rodrigues, M., & Aliev, G. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160202125914 · Cited by 206 · cited 1×

Macrophages: A double-edged sword in experimental autoimmune encephalomyelitis

Jiang, Z., Jiang, J., & Zhang, G. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.03.006 · Cited by 205

Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

Vazana, U., Veksler, R., Pell, G. S., Prager, O., Fassler, M., Chassidim, Y., Roth, Y., Shahar, H., Zangen, A., Raccah, R., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0587-16.2016 · Cited by 205

Neurodegenerative Diseases: Multifactorial Conformational Diseases and Their Therapeutic Interventions

Sheikh, S., Safia, Haque, E., & Mir, S. S. (2012) · Journal of Neurodegenerative Diseases · doi:10.1155/2013/563481 · Cited by 199

Fibrin Inhibits Peripheral Nerve Remyelination by Regulating Schwann Cell Differentiation

Akassoglou, K., Yu, W.-M., Akpınar, P., & Strickland, S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00617-7 · Cited by 196

Complement in the pathogenesis of Alzheimer’s disease

Morgan, B. P. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-017-0662-9 · Cited by 194

C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation

Hsuchou, H., Kastin, A. J., Mishra, P. K., & Pan, W. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000343302 · Cited by 192

Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson’s Disease?

Janda, E., Boi, L., & Carta, A. R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00144 · Cited by 190

The Role of Toll-Like Receptor in Inflammation and Tumor Immunity

Cen, X., Liu, S., & Cheng, K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00878 · Cited by 190

Thrombin and Prothrombin Are Expressed by Neurons and Glial Cells and Accumulate in Neurofibrillary Tangles in Alzheimer Disease Brain

Arai, T., Judith Miklossy, A., Klegeris, A., Guo, J., & McGeer, P. L. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000196133.74087.cb · Cited by 189

Effects of Microglia on Neurogenesis

Sato, K. (2015) · Glia · doi:10.1002/glia.22858 · Cited by 187

Neurological Enhancement Effects of Melatonin against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via AMPK/CREB Signaling

Rehman, S. U., Ikram, M. A., Ullah, N., Alam, S. I., Park, H. Y., Badshah, H., Choe, K., & Kim, M. O. (2019) · Cells · doi:10.3390/cells8070760 · Cited by 187

Increased Osteopontin Expression in Dendritic Cells Amplifies IL-17 Production by CD4+ T Cells in Experimental Autoimmune Encephalomyelitis and in Multiple Sclerosis

Murugaiyan, G., Mittal, A., & Weiner, H. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.11.7480 · Cited by 186

Agrin and microvascular damage in Alzheimer’s disease

Berzin, T. M., Zipser, B. D., Rafii, M. S., Kuo-LeBlanc, V., Yancopoulos, G. D., Glass, D. J., Fallon, J. R., & Stopa, E. G. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00121-4 · Cited by 182

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes

Bliederhaeuser, C., Grozdanov, V., Speidel, A., Zondler, L., Ruf, W. P., Bayer, H., Kiechle, M., Feiler, M. S., Freischmidt, A., Brenner, D., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1504-2 · Cited by 181

Tissue-type plasminogen activator–mediated shedding of astrocytic low-density lipoprotein receptor–related protein increases the permeability of the neurovascular unit

Polavarapu, R., Góngora, M. C., Yi, H. L., Ranganthan, S., Lawrence, D. A., Strickland, D. K., & Yepes, M. (2006) · Blood · doi:10.1182/blood-2006-08-043125 · Cited by 174

Recent developments in the treatment of Parkinson's Disease

Stoker, T. B., & Barker, R. A. (2020) · F1000Research · doi:10.12688/f1000research.25634.1 · Cited by 174

C1q Differentially Modulates Phagocytosis and Cytokine Responses during Ingestion of Apoptotic Cells by Human Monocytes, Macrophages, and Dendritic Cells

Fraser, D. A., Laust, A. K., Nelson, E. L., & Tenner, A. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902232 · Cited by 172

Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections

Wager, C. M. L., & Wormley, F. L. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.65 · Cited by 171

Thrombin accumulation in brains of patients with Alzheimer's disease

Akiyama, H., Ikeda, K., Kondo, H., & McGeer, P. L. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90065-f · Cited by 170

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system

Hyvärinen, T., Hagman, S., Ristola, M., Sukki, L., Veijula, K., Kreutzer, J., Kallio, P., & Narkilahti, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-53414-9 · Cited by 168

Thrombin-Induced Microglial Activation Produces Degeneration of Nigral Dopaminergic NeuronsIn Vivo

Choi, S.-H., Joe, E. H., Kim, S. U., & Jin, B. K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05877.2003 · Cited by 165

Thrombin Induces NO Release from Cultured Rat Microglia via Protein Kinase C, Mitogen-activated Protein Kinase, and NF-κB

Ryu, J., Pyo, H., Jou, I., & Joe, E.-H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001220200 · Cited by 158

C-Reactive Protein Polarizes Human Macrophages to an M1 Phenotype and Inhibits Transformation to the M2 Phenotype

Devaraj, S., & Jialal, I. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.225508 · Cited by 158

Matrix metalloproteinase-9 is associated with blood-brain barrier opening and brain edema formation after cortical contusion in rats

Shigemori, Y., Katayama, Y., Mori, T., Maeda, T., & Kawamata, T. (2006) · Springer eBooks · doi:10.1007/3-211-30714-1_29 · Cited by 158

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Balic, J. J., Albargy, H. A., Luu, K., Kirby, F. J., Jayasekara, W. S. N., Mansell, F., Garama, D. J., Nardo, D. D., Baschuk, N., Louis, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17669-5 · Cited by 156

Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: Localization, expression and participation in neurodegenerative diseases

Sokolova, E., & Reiser, G. (2008) · Thrombosis and Haemostasis · doi:10.1160/th08-03-0131 · Cited by 153

Fibrinogen Signal Transduction as a Mediator and Therapeutic Target in Inflammation:Lessons from Multiple Sclerosis

Adams, R., Schachtrup, C., Davalos, D., Tsigelny, I. F., & Akassoglou, K. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707782360015 · Cited by 150

The vascular factor in Alzheimer's disease: A study in Golgi technique and electron microscopy

Baloyannis, S. J., & Baloyannis, I. S. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.07.010 · Cited by 150

Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer’s Disease

Franco-Bocanegra, D. K., McAuley, C., Nicoll, J. A. R., & Boche, D. (2019) · Cells · doi:10.3390/cells8060639 · Cited by 147

The contribution of neutrophils to CNS autoimmunity

Pierson, E. R., Wagner, C. A., & Goverman, J. M. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.06.017 · Cited by 146

Negative regulatory approaches to the attenuation of Toll-like receptor signaling

Anwar, M. A., Basith, S., & Choi, S. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.28 · Cited by 143

Target- and Mechanism-Based Therapeutics for Neurodegenerative Diseases: Strength in Numbers

Trippier, P. C., Labby, K. J., Hawker, D. D., Mataka, J., & Silverman, R. B. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm3015926 · Cited by 141

Photothrombotic Stroke as a Model of Ischemic Stroke

Uzdensky, A. B. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0593-8 · Cited by 141

Mechanisms of C-Reactive Protein-Induced Blood–Brain Barrier Disruption

Kuhlmann, C. R. W., Librizzi, L., Closhen, D., Pflanzner, T., Lessmann, V., Pietrzik, C. U., de Curtis, M., & Luhmann, H. J. (2009) · Stroke · doi:10.1161/strokeaha.108.535930 · Cited by 138

Gene therapy for neurodegenerative diseases

O’Connor, D. M., & Boulis, N. M. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.06.001 · Cited by 135

Fibrin mechanisms and functions in nervous system pathology.

Adams, R. A., Passino, M. A., Sachs, B. D., Nuriel, T., & Akassoglou, K. (2004) · PubMed · doi:10.1124/mi.4.3.6 · Cited by 135

Protease-activated receptor signalling by coagulation proteases in endothelial cells

Rezaie, A. R. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-02-0167 · Cited by 133

Activated protein C, protease activated receptor 1, and neuroprotection

Griffin, J. H., Zloković, B. V., & Mosnier, L. O. (2018) · Blood · doi:10.1182/blood-2018-02-769026 · Cited by 129

Cytoprotective protein C pathways and implications for stroke and neurological disorders

Zlokovic, B. V., & Griffin, J. H. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.01.005 · Cited by 128

Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition

Alluri, H., Wilson, R. L., Shaji, C. A., Wiggins-Dohlvik, K. C., Patel, S. V., Liu, Y., Peng, X., Beeram, M., Davis, M. L., Huang, J. H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154427 · Cited by 128

Sepsis-Associated Encephalopathy: The Blood–Brain Barrier and the Sphingolipid Rheostat

Kuperberg, S. J., & Wadgaonkar, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00597 · Cited by 124

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

Cui, J., Chen, S., Zhang, C., Meng, F., Wu, W., Hu, R., Hadass, O., Lehmidi, T. E., Blair, G. J., Lee, M., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-21 · Cited by 123

Phagocytic Clearance in Neurodegeneration

Sokolowski, J. D., & Mandell, J. W. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.12.051 · Cited by 120

Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein

Tang, M., Gao, G., Rueda, C. B., Yu, H., Thibodeaux, D. N., Awano, T., Engelstad, K., Sanchez‐Quintero, M. J., Yang, H., Li, F., et al. (2017) · Nature Communications · doi:10.1038/ncomms14152 · Cited by 120

The Contribution of Immune and Glial Cell Types in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Duffy, S. S., Lees, J. G., & Moalem‐Taylor, G. (2014) · Multiple Sclerosis International · doi:10.1155/2014/285245 · Cited by 118

Monomeric C-reactive protein-a key molecule driving development of Alzheimer’s disease associated with brain ischaemia?

Slevin, M., Matou, S., Zeinolabediny, Y., Corpas, R., Weston, R., Liu, D., Boras, E., Di Napoli, M., Petcu, E., Sarroca, S., et al. (2015) · Scientific Reports · doi:10.1038/srep13281 · Cited by 115

Cytokines regulate matrix metalloproteinases and migration in cardiac fibroblasts

Brown, R. D., Jones, G. M., Laird, R. E., Hudson, P., & Long, C. S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.003 · Cited by 113

Upregulation of Protease-Activated Receptor-1 in Astrocytes in Parkinson Disease: Astrocyte-Mediated Neuroprotection Through Increased Levels of Glutathione Peroxidase

Ishida, Y., Nagai, A., Kobayashi, S., & Kim, S. U. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000195941.48033.eb · Cited by 109

Interleukin-1β induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood–brain barrier model

Labus, J., Häckel, S., Lucka, L., & Danker, K. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.002 · Cited by 104

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

Sinha, R. K., Wang, Y., Zhao, Z., Xu, X. G., Burnier, L., Gupta, N., Fernández, J. A., Martin, G., Kupriyanov, S., Mosnier, L. O., et al. (2018) · Blood · doi:10.1182/blood-2017-10-810895 · Cited by 102

Fibrinogen induces endothelial cell permeability

Tyagi, N., Roberts, A. M., Dean, W. L., Tyagi, S. C., & Lominadze, D. G. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9579-2 · Cited by 101

C-Reactive Protein and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis

Qiu, X., Xiao, Y., Wu, J., Gan, L., Huang, Y., & Wang, J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00384 · Cited by 101

Role of Atypical Chemokine Receptors in Microglial Activation and Polarization

Salvi, V., Sozio, F., Sozzani, S., & Prete, A. D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00148 · Cited by 99

Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease

Horwood, N., & Davies, D. C. (1994) · Virchows Archiv · doi:10.1007/bf00193951 · Cited by 97

C-Reactive Protein Predicts Hematoma Growth in Intracerebral Hemorrhage

Napoli, M. D., Parry‐Jones, A., Smith, C. J., Hopkins, S. J., SLEVIN, M. A., Masotti, L., Campi, V., Singh, P., Papa, F., Popa‐Wagner, A., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.001721 · Cited by 94

Monomeric C-Reactive Protein and Cerebral Hemorrhage: From Bench to Bedside

Napoli, M. D., SLEVIN, M. A., Popa‐Wagner, A., Singh, P., Lattanzi, S., & Divani, A. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01921 · Cited by 92

Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice

Bodhankar, S., Chen, Y., Vandenbark, A. A., Murphy, S. J., & Offner, H. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9474-3 · Cited by 90

Phagocytic Roles of Glial Cells in Healthy and Diseased Brains

Jung, Y.-J., & Chung, W.-S. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.133 · Cited by 89

Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis

Brilha, S., Ong, C. W. M., Weksler, B. B., Romero, N., Couraud, P., & Friedland, J. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-16250-3 · Cited by 86

Immune Cell Infiltration into the Brain After Ischemic Stroke in Humans Compared to Mice and Rats: a Systematic Review and Meta-Analysis

Beuker, C., Strecker, J., Rawal, R., Schmidt‐Pogoda, A., Ruck, T., Wiendl, H., Klotz, L., Schäbitz, W., Sommer, C., Minnerup, H., et al. (2021) · Translational Stroke Research · doi:10.1007/s12975-021-00887-4 · Cited by 85

C-reactive protein in intracerebral hemorrhage

Napoli, M. D., Godoy, D. A., Campi, V., Masotti, L., Smith, C. J., Parry‐Jones, A., Hopkins, S. J., SLEVIN, M. A., Papa, F., Mogoantă, L., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318264e3be · Cited by 84

Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease

Sagare, A. P., Deane, R., Zetterberg, H., Wallin, A., Blennow, K., & Zloković, B. V. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101248 · Cited by 83

Innate Immunity in the Central Nervous System: A Missing Piece of the Autoimmune Encephalitis Puzzle?

Wesselingh, R., Butzkueven, H., Buzzard, K., Tarlinton, D., O'Brien, T. J., & Monif, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02066 · Cited by 83

Proteinase-activated receptor 1 (PAR-1) and cell apoptosis

Flynn, A. N., & Buret, A. G. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000045784.49886.96 · Cited by 82

Histological and Direct Evidence for the Role of Complement in the Neuroinflammation of AD

Veerhuis, R. (2011) · Current Alzheimer Research · doi:10.2174/156720511794604589 · Cited by 80

Fibrinogen induces alterations of endothelial cell tight junction proteins

Patibandla, P. K., Tyagi, N., Dean, W. L., Tyagi, S. C., Roberts, A. M., & Lominadze, D. G. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21845 · Cited by 80

Nervous System Pathology: The Fibrin Perspective

Akassoglou, K., & Strickland, S. (2002) · Biological Chemistry · doi:10.1515/bc.2002.004 · Cited by 76

Melatonin alleviates lipopolysaccharide-compromised integrity of blood-brain barrier through activating AMP-activated protein kinase in old mice

Wang, X., Xue, G.-X., Liu, W.-C., Shu, H. G., Wang, M., Sun, Y., Liu, X., Sun, Y. E., Liu, C., Liu, J., et al. (2017) · Aging Cell · doi:10.1111/acel.12572 · Cited by 76

Endothelial LRP1 – A Potential Target for the Treatment of Alzheimer’s Disease

Storck, S. E., & Pietrzik, C. U. (2017) · Pharmaceutical Research · doi:10.1007/s11095-017-2267-3 · Cited by 74

A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid

Sweeney, M. D., Sagare, A. P., Pachicano, M., Harrington, M. G., Joe, E., Chui, H. C., Schneider, L. S. S., Montagne, A., Ringman, J. M., Fagan, A. M., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12061 · Cited by 74

New advances on glial activation in health and disease

Lee, K. M. (2015) · World Journal of Virology · doi:10.5501/wjv.v4.i2.42 · Cited by 73

Increased cerebral matrix metalloprotease‐9 activity is associated with compromised recovery in the diabetic db/db mouse following a stroke

Kumari, R., Willing, L. B., Patel, S. D., Baskerville, K. A., & Simpson, I. A. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07487.x · Cited by 72

Strategies to increase the activity of microglia as efficient protectors of the brain against infections

Nau, R., Ribes, S., Djukic, M., & Eiffert, H. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00138 · Cited by 71

ApoE Influences the Blood-Brain Barrier Through the NF-κB/MMP-9 Pathway After Traumatic Brain Injury

Teng, Z., Guo, Z., Zhong, J., Cheng, C., Huang, Z., Wu, Y., Tang, S., Luo, C., Peng, X., Wu, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06932-3 · Cited by 68

C-reactive protein induces M-CSF release and macrophage proliferation

Devaraj, S., Yun, J., Duncan‐Staley, C., & Jialal, I. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0808458 · Cited by 66

Licensing Adaptive Immunity by NOD-Like Receptors

Liu, D., Rhebergen, A. M., & Eisenbarth, S. C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00486 · Cited by 66

Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson’s disease

Shin, W.-H., Jeon, M., Leem, E., Won, S.-Y., Jeong, K. H., Park, S., McLean, C., Lee, S. J., Jin, B. K., Jung, U. J., et al. (2015) · Scientific Reports · doi:10.1038/srep14764 · Cited by 65

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

Lazić, D., Sagare, A. P., Nikolakopoulou, A. M., Griffin, J. H., Vassar, R. J., & Zloković, B. V. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181035 · Cited by 65

Sequence γ377−395(P2), but Not γ190−202(P1), Is the Binding Site for the αMI-Domain of Integrin αMβ2 in the γC-Domain of Fibrinogen

Ugarova, T. P., Lishko, V. K., Podolnikova, N. P., Okumura, N., Merkulov, S. M., Yakubenko, V. P., Yee, V. C., Lord, S. T., & Haas, T. A. (2003) · Biochemistry · doi:10.1021/bi034057k · Cited by 64

Swallowing therapy in patients with neurological disorders causing cricopharyngeal dysfunction

Bartolome, G., & Neumann, S. (1993) · Dysphagia · doi:10.1007/bf02266995 · Cited by 59

Fibrinogen and Neuroinflammation During Traumatic Brain Injury

Sulimai, N., & Lominadze, D. G. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02012-2 · Cited by 59

Activation of the Protease-Activated Thrombin Receptor (PAR)-1 Induces Motoneuron Degeneration in the Developing Avian Embryo

Turgeon, V. L., Milligan, C. E., & Houenou, L. J. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199905000-00009 · Cited by 57

Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy

Mendiola, A. S., Garza, R., Cardona, S. M., Mythen, S. A., Lira, S. A., Akassoglou, K., & Cardona, A. E. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00303 · Cited by 57

Glutamate Induces Blood–Brain Barrier Permeability through Activation ofN-Methyl-D-Aspartate Receptors

Xhima, K., Weber‐Adrian, D., & Silburt, J. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2962-16.2016 · Cited by 54

CD8 signaling in microglia/macrophage M1 polarization in a rat model of cerebral ischemia

Boddaert, J., Bielen, K., ’s Jongers, B., Manocha, E., Yperzeele, L., Cras, P., Pirici, D., & Kumar-Singh, S. (2018) · PLOS ONE · doi:10.1371/journal.pone.0186937 · Cited by 54

Cordycepin attenuates traumatic brain injury-induced impairments of blood-brain barrier integrity in rats

Yuan, J., Wang, A., He, Y., Si, Z., Xu, S., Zhang, S., Wang, K., Wang, D., & Liu, Y.-M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.09.010 · Cited by 53

C-Reactive Protein Promotes Inflammation through FcγR-Induced Glycolytic Reprogramming of Human Macrophages

Newling, M., Sritharan, L., van der Ham, A. J., Hoepel, W., Fiechter, R. H., de Boer, L., Zaat, S. A. J., Bisoendial, R. J., Baeten, D., Everts, B., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900172 · Cited by 52

Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β‐amyloid fibrinogen interaction

Chung, Y. C., Kruyer, A., Yao, Y., Feierman, E. R., Richards, A., Strickland, S., & Norris, E. H. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13340 · Cited by 51

Bidirectional Crosstalk between C5a Receptors and the NLRP3 Inflammasome in Macrophages and Monocytes

Haggadone, M. D., Grailer, J. J., Fattahi, F., Zetoune, F. S., & Ward, P. A. (2016) · Mediators of Inflammation · doi:10.1155/2016/1340156 · Cited by 50

Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding

Shackleton, B., Crawford, F., & Bachmeier, C. J. (2016) · Fluids and Barriers of the CNS · doi:10.1186/s12987-016-0038-x · Cited by 49

Aging Neurovascular Unit and Potential Role of DNA Damage and Repair in Combating Vascular and Neurodegenerative Disorders

Li, Y., Xie, L., Huang, T., Zhang, Y., Zhou, J., Qi, B., Wang, X., Chen, Z., & Li, P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00778 · Cited by 47

Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia

Cockram, T. O. J., Puigdellívol, M., & Brown, G. C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02647 · Cited by 47

IL-22, GM-CSF and IL-17 in peripheral CD4+ T cell subpopulations during multiple sclerosis relapses and remission. Impact of corticosteroid therapy

Muls, N., Nasr, Z., Dang, H. A., Sindic, C., & Pesch, V. V. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173780 · Cited by 46

Perspective: Therapeutic Potential of Flavonoids as Alternative Medicines in Epilepsy

Kwon, J. Y., Jeon, M., Jung, U. J., Kim, D. W., Moon, G. J., & Kim, S. R. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz047 · Cited by 46

Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells

Kang, Y.-H., Urban, B. C., Sim, R. B., & Kishore, U. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.10.008 · Cited by 44

Prothrombin kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation

Kim, S. R., Chung, E. S., Bok, E., Baik, H. H., Chung, Y. C., Won, S. Y., Joe, E., Kim, T. H., Kim, S. S., Jin, M. Y., et al. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22318 · Cited by 43

Methamphetamine alters the TLR4 signaling pathway, NF-κB activation, and pro-inflammatory cytokine production in LPS-challenged NR-9460 microglia-like cells

Vargas, A. M., Rivera-Rodriguez, D. E., & Martinez, L. R. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.03.013 · Cited by 40

Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts

Tasaki, K., Shintani, Y., Saotome, T., Andoh, A., Fujiyama, Y., Hozawa, S., & Bamba, T. (2003) · Pancreatology · doi:10.1159/000073889 · Cited by 37

Lipopolysaccharide administration for a mouse model of cerebellar ataxia with neuroinflammation

Hong, J., Yoon, D., Nam, Y., Seo, D., Kim, J., Kim, M. S., Lee, T. Y., Kim, K. S., Ko, P., Lee, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70390-7 · Cited by 37

Prothrombin Kringle-2 Activates Cultured Rat Brain Microglia

Ryu, J., Min, K., Rhim, T. Y., Kim, T. H., Pyo, H., Jin, B.-K., Kim, S.-U., Jou, I., Kim, S. S., & Joe, E.-H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5805 · Cited by 36

Species‐dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity

Guo, H., Wang, Y., Singh, I., Liu, D., Fernández, J. A., Griffin, J. H., Chow, N., & Zloković, B. V. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05921.x · Cited by 35

Neuroinflammation by Cytotoxic T-Lymphocytes Impairs Retrograde Axonal Transport in an Oligodendrocyte Mutant Mouse

Ip, C. W., Kroner, A., Groh, J., Huber, M., Klein, D., Spahn, I., Diem, R., Williams, S. K., Nave, K., Edgar, J. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042554 · Cited by 34

CRP-induced levels of oxidative stress are higher in brain than aortic endothelial cells

Closhen, D., Bender, B., Luhmann, H. J., & Kuhlmann, C. R. W. (2010) · Cytokine · doi:10.1016/j.cyto.2010.02.011 · Cited by 34

New hopes and challenges for treatment of neurodegenerative disorders: great opportunities for young neuroscientists.

Kiaei, M. (2013) · PubMed · Cited by 33

Fibrinogen up-regulates the expression of monocyte chemoattractant protein 1 in human saphenous vein endothelial cells

Harley, S. L., & Powell, J. T. (1999) · Biochemical Journal · doi:10.1042/bj3410739 · Cited by 27

Effect of thrombin on blood brain barrier permeability and its mechanism.

Guan, J., Sun, S., Cao, X., Chen, Z. Z., & Tong, E. (2004) · PubMed · Cited by 26

Fingolimod reduces circulating tight-junction protein levels and in vitro peripheral blood mononuclear cells migration in multiple sclerosis patients

Annunziata, P., Cioni, C., Masi, G., Tassi, M., Marotta, G., & Severi, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-33672-9 · Cited by 24

Specific Changes of Serum Proteins in Parkinson's Disease Patients

Lu, W., Wan, X., Liu, B., Rong, X., Zhu, L., Li, P., Li, J., Wang, L., Cui, L., & Wang, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095684 · Cited by 22

Role of Circulating Immune Cells in Stroke and Preconditioning-Induced Protection

Gesuete, R., Stevens, S. L., & Stenzel‐Poore, M. P. (2016) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-319-18497-5_7 · Cited by 22

Sphingolipids affect fibrinogen-induced caveolar transcytosis and cerebrovascular permeability

Muradashvili, N., Khundmiri, S. J., Tyagi, R., Gartung, A., Dean, W. L., Lee, M.-J., & Lominadze, D. G. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00305.2013 · Cited by 21

Inflammatory mediators in major depression and bipolar disorder

Poletti, S., Mazza, M. G., & Benedetti, F. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02921-z · Cited by 195

C-Reactive protein as a biomarker for major depressive disorder?

Orsolini, L., Pompili, S., Tempia Valenta, S., Salvi, V., & Volpe, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031616 · Cited by 171

The Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases

Zang, X., Chen, S., Zhu, J., Ma, J., & Zhai, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.872134 · Cited by 139

Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis

Kim, K. Y., Shin, K. Y., & Chang, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020602 · Cited by 139

Neuroinflammation and peripheral immunity: Focus on ischemic stroke

Wang, H., Zhang, S., Xie, L., Zhe, Z., & Yan, F. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110332 · Cited by 123

The blood–brain barrier in neurodegenerative disease: a rhetorical perspective

Carvey, P. M., Hendey, B., & Monahan, A. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06319.x · Cited by 259

The Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases

Zang, X., Chen, S., Zhu, J., Ma, J., & Zhai, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.872134 · Cited by 139

Peripheral Routes to Neurodegeneration: Passing Through the Blood–Brain Barrier

Giannoni, P., Claeysen, S., Noè, F. M., & Marchi, N. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00003 · Cited by 25

Activation of the innate immune response and its consequences for the cental nervous system

Simard, A. R. (2004) · Lu Zone Ul (Laurentian University)

Blood–brain barrier endothelial cells in neurodegenerative diseases: Signals from the “barrier”

Yuan, Y., Sun, J., Dong, Q., & Cui, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1047778 · Cited by 90