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Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology

Selman, Moisés, Pardo, Annie·2021·Ageing Research Reviews
DOI 10.1016/j.arr.2021.101393
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  • Aging causes numerous damages in the long-lived protein components of the extracellular matrix, including advanced glycation end products (AGE), carbonylation and carbamylation, elastin fragmentation, and collagen crosslinking, thus leading to tissue fibrosis (fibroaging).

    “Aging causes numerous damages in the long-lived protein components of the extracellular matrix, including advanced glycation end products (AGE), carbonylation and carbamylation, elastin fragmentation, and collagen crosslinking 244 , thus leading to tissue fibrosis (fibroaging) 245 .”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [245]

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  • ECM stiffness affects the function of senescent cells, which in turn secrete matrix metalloproteases that amplify the damage of the extracellular matrix, and proteolytically generate damage-associated molecular patterns to activate pro-senescent, pro-fibrotic and proinflammatory pathways.

    “Extracellular matrix stiffness also affects the function of senescent cells, which in turn secrete matrix metalloproteases that amplify the damage of the extracellular matrix 246 , and proteolytically generate damage-associated molecular patterns to activate pro-senescent, pro-fibrotic and proinflammatory pathways 245 .”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [245]

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Metadata

Authors
Selman, M., & Pardo, A.
ORCID
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2021-09
Volume
70
Pages
101393
ISSN
1568-1637
DOI
10.1016/j.arr.2021.101393
Cited by
211
References
13
Language
en
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