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Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
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“Telomere dysfunction also promotes progerin production in normal human fibroblasts upon prolonged in vitro culture, suggesting intimate links between telomere maintenance and progerin expression during normal aging (Cao et al., 2011).”
From The Hallmarks of Aging (2013) · cites this paper as Cao et al., 2011
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Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
Genomic instability in laminopathy-based premature aging
Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J.-D., Li, K. M., Chau, P. Y., Chen, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1266 · Cited by 650
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Varela, I., Cadiñanos, J., Pendás, A. M., Gutiérrez-Fernández, A., Folgueras, A. R., Sánchez, L. M., Zhou, Z., Rodríguez, F. J., Stewart, C. L., Vega, J. A., et al. (2005) · Nature · doi:10.1038/nature04019 · Cited by 466
Armanios, M., Chen, J.-L., Chang, Y.-P. C., Brodsky, R. A., Hawkins, A., Griffin, C. A., Eshleman, J. R., Cohen, A. R., Chakravarti, A., Hamosh, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508124102 · Cited by 452
Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
Jacobs, J. J. L., & de Lange, T. (2004) · Current Biology · doi:10.1016/j.cub.2004.12.025 · Cited by 237
Zhu, D., Xu, G., Ghandhi, S., & Hubbard, K. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10147 · Cited by 49
Research works printed but not linked: 46
- 10.1016/0047-6374(84)90018-6 · DOI
- 10.1016/j.mad.2008.04.001 · DOI
- 10.1016/0531-5565(96)00005-8 · DOI · Paper page
- 10.1038/350569a0 · DOI · Paper page
- 10.1146/annurev.bi.65.070196.002005 · DOI
- 10.1078/0171-9335-00335 · DOI
- 10.1002/(SICI)1521-1878(199812)20:12<977::AID-BIES3>3.0.CO;2-E · DOI
- 10.1016/j.mad.2007.11.007 · DOI
- 10.1038/nrg1906 · DOI
- 10.1038/nature01629 · DOI · Paper page
- 10.1101/gad.960502 · DOI
- 10.1016/j.advenzreg.2008.12.003 · DOI
- 10.1101/gad.1652708 · DOI · Paper page
- 10.1056/NEJMoa0706898 · DOI
- 10.1126/science.1084125 · DOI · Paper page
- 10.1161/ATVBAHA.110.209460 · DOI
- 10.1073/pnas.0402943101 · DOI · Paper page
- 10.1073/pnas.0602569103 · DOI · Paper page
- 10.1126/science.287.5462.2486 · DOI · Paper page
- 10.1111/j.1474-9728.2004.00105.x · DOI
- 10.1073/pnas.0611640104 · DOI
- 10.1073/pnas.0700854104 · DOI
- 10.1073/pnas.0600012103 · DOI
- Sinensky, 1994, J Cell Sci., 107, 61, 10.1242/jcs.107.1.61 · DOI
- 10.1073/pnas.0504641102 · DOI
- 10.1073/pnas.0506001102 · DOI
- 10.1073/pnas.0807840105 · DOI
- 10.1172/JCI28968 · DOI · Paper page
- 10.1126/science.1124875 · DOI
- 10.1126/science.1127168 · DOI · Paper page
- 10.1371/journal.pone.0001269 · DOI
- 10.1038/ejhg.2008.270 · DOI
- 10.1172/JCI27820 · DOI
- 10.1073/pnas.95.18.10614 · DOI
- 10.1136/gut.45.5.723 · DOI
- 10.1016/j.yexcr.2004.01.017 · DOI · Paper page
- 10.1016/j.exger.2003.12.015 · DOI
- 10.1038/ncb1708 · DOI
- 10.1016/j.mad.2009.03.001 · DOI
- 10.1242/jcs.067306 · DOI
- Magnuson, 1991, J Biol Chem., 266, 14654, 10.1016/S0021-9258(18)98735-1 · DOI
- 10.1007/s00418-005-0766-5 · DOI
- 10.1007/s004180100325 · DOI · Paper page
- Mayeda, 1994, Embo J., 13, 5483, 10.1002/j.1460-2075.1994.tb06883.x · DOI
- 10.1006/excr.1995.1152 · DOI
- 10.1073/pnas.0511133103 · DOI
Cited by
Sorted by citations
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363
Diversity and biology of cancer-associated fibroblasts
Biffi, G., & Tuveson, D. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00048.2019 · Cited by 1,265
Human iPSC-based modeling of late-onset disease via progerin-induced aging
Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777
The senescence-associated secretory phenotype and its regulation
Lopes-Paciencia, S., Saint-Germain, E., Rowell, M.-C., Ruiz, A. F., Kalegari, P., & Ferbeyre, G. (2019) · Cytokine · doi:10.1016/j.cyto.2019.01.013 · Cited by 601
Metadata
- Authors
- Cao, K., Blair, C. D., Faddah, D. A., Kieckhaefer, J. E., Olive, M., Erdos, M. R., Nabel, E. G., & Collins, F. S.
- Venue
- Journal of Clinical Investigation
- Published
- 2011-07-01
- Volume
- 121
- Issue
- 7
- Pages
- 2833-2844
- ISSN
- 0021-9738
- Cited by
- 284
- References
- 9
- Language
- en
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- CoChat. (2026). Citation check: Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts. https://app.cochat.ai/papers/10.1172/jci43578
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- Cao, K., Blair, C. D., Faddah, D. A., Kieckhaefer, J. E., Olive, M., Erdos, M. R., Nabel, E. G., & Collins, F. S. (2011). Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts. Journal of Clinical Investigation. https://doi.org/10.1172/jci43578
