CoChat
Sign Up
Cited by 58Lipid metabolism and disordersCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Diurnal and acute patterns of postprandial apolipoprotein B-48 in VLDL, IDL, and LDL from normolipidemic humans.

Campos, Hannia, Khoo, Christina, Sacks, Frank M.·2005·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2004.12.045
Open this paper in CoChat — free account

Abstract

Smaller size particles of intestinal origin may be more relevant to atherosclerosis than larger particles because of easier transendothelial transport. We examined the diurnal pattern in response to low-fat high-carbohydrate meals and the effect of a single high-fat milkshake on apoB-48 in very light Sf degrees >400, light Sf degrees 60-400, and dense Sf degrees 20-60 VLDL, IDL, and LDL in 24 subjects (12 in each study). After the high-fat meal, apoB-48 concentrations peaked at 3 h for very light VLDL, 4 h for light VLDL, and 5 h for dense VLDL and IDL, suggesting a delipidation cascade. The diurnal pattern was characterized by a sharp increase in light and dense VLDL apoB-48 after breakfast, reaching the highest concentration 4-8h after breakfast. Less response was observed after lunch, dinner or snack, despite 75% of energy supplied by these meals. The proportion of apoB-48 in LDL in the fasting state ranged between 48 and 54%. LDL apoB-48 concentration decreased by 35% after the high-fat meal, and slowly recovered to near fasting concentrations after 10-12 h. In contrast, in the diurnal study, LDL apoB-48 concentration steady increased peaking 13 h after breakfast, followed by a sharp decrease. In sum, most intestinally synthesized apoB lipoproteins circulate in LDL, and are likely formed in the late postprandial period from larger VLDL-size particles. Although small apoB-48 lipoproteins may be atherogenic remnant particles, their very low concentration may diminish their clinical significance.

Integrity signals

Registry

Crossref · 10.1016/j.atherosclerosis.2004.12.045

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The concentration of VLDL cholesterol and apoB is at least 10 times higher than the corresponding chylomicron concentration, even after consumption of a large amount of fat.

    “The concentration of VLDL cholesterol and apoB is at least 10 times higher than the corresponding chylomicron concentration, even after consumption of a large amount of fat (56 -59).”

    From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [58]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Campos, H., Khoo, C., & Sacks, F. M.
Affiliations
Harvard University (US)
Corresponding author
Campos, Hannia
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2005-08
Volume
181
Issue
2
Pages
345-351
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/j.atherosclerosis.2004.12.045
OpenAlex
W2049419310
Cited by
58
References
32
Citations by year
2026: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 2
FWCI
2.03
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • National Heart, Lung, and Blood Institute (R01HL069376, R01HL056210, HL69376)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
apolipoprotein B-48, VLDL, IDL, low-density lipoprotein, postprandial lipemia, diurnal variation, high-fat meal, lipoprotein particle size
MeSH terms
Aged, Apolipoproteins B, Cholesterol, Circadian Rhythm, Dietary Carbohydrates, Female, Humans, Lipoproteins, Cholesterol, LDL, Middle Aged, Particle Size, Reference Values, Cholesterol, VLDL, Postprandial Period, Apolipoprotein B-48, Apolipoprotein B-100

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review