Cited by 115Circadian rhythm and melatoninLipid metabolism and biosynthesisLipid metabolism and disorders

Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism

Open access
Gnocchi, Davide, Pedrelli, Matteo, Hurt-Camejo, Eva, Parini, Paolo·2015·Biology

Abstract

Disorders of lipid and lipoprotein metabolism and transport are responsible for the development of a large spectrum of pathologies, ranging from cardiovascular diseases, to metabolic syndrome, even to tumour development. Recently, a deeper knowledge of the molecular mechanisms that control our biological clock and circadian rhythms has been achieved. From these studies it has clearly emerged how the molecular clock tightly regulates every aspect of our lives, including our metabolism. This review analyses the organisation and functioning of the circadian clock and its relevance in the regulation of physiological processes. We also describe metabolism and transport of lipids and lipoproteins as an essential aspect for our health, and we will focus on how the circadian clock and lipid metabolism are greatly interconnected. Finally, we discuss how a deeper knowledge of this relationship might be useful to improve the recent spread of metabolic diseases.

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Crossref · 10.3390/biology4010104

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  • Circadian clocks play a major role in lipid homeostasis in humans and animals, particularly in relation to CVD but also nutrition and other body functions.

    “As a result, mounting evidence now suggests that circadian clocks play a major role in lipid homeostasis both in humans and animals, particularly in relation to CVD but also nutrition and other body functions.”

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Cites

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Research works printed but not linked: 1

  1. [5]Bünning E. The Physiological Clock–Circadian Rhythms in Biological Chronometry The English University Press Ltd. London, UK 1973

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Authors
Gnocchi, D., Pedrelli, M., Hurt-Camejo, E., & Parini, P.
Affiliations
  • Karolinska University Hospital (SE)
  • Strategy and Externalization, CVMD iMED, AstraZeneca, R&D, Mölndal, SE-431 83, Sweden
Corresponding author
Parini, Paolo
Venue
Biology
Publisher
MDPI AG
Published
2015-02-05
Volume
4
Issue
1
Pages
104-132
ISSN
2079-7737 (ISSN-L)
OpenAlex
W1978120649
Cited by
115
References
180
Citations by year
2026: 8 · 2025: 18 · 2024: 10 · 2023: 15 · 2022: 5 · 2021: 5 · 2020: 11 · 2019: 19 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 2
FWCI
0.87
Type
journal article
Language
en
Open access
Locations
  • Biology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Funders
Swedish Heart-Lung Fundation
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
circadian rhythm, circadian clock, lipid metabolism, lipoprotein metabolism, lipid transport, metabolic disorders, cardiovascular disease, metabolic syndrome, carcinogenesis, clock genes

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