Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism
Open accessAbstract
Disorders of lipid and lipoprotein metabolism and transport are responsible for the development of a large spectrum of pathologies, ranging from cardiovascular diseases, to metabolic syndrome, even to tumour development. Recently, a deeper knowledge of the molecular mechanisms that control our biological clock and circadian rhythms has been achieved. From these studies it has clearly emerged how the molecular clock tightly regulates every aspect of our lives, including our metabolism. This review analyses the organisation and functioning of the circadian clock and its relevance in the regulation of physiological processes. We also describe metabolism and transport of lipids and lipoproteins as an essential aspect for our health, and we will focus on how the circadian clock and lipid metabolism are greatly interconnected. Finally, we discuss how a deeper knowledge of this relationship might be useful to improve the recent spread of metabolic diseases.
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Circadian clocks play a major role in lipid homeostasis in humans and animals, particularly in relation to CVD but also nutrition and other body functions.
“As a result, mounting evidence now suggests that circadian clocks play a major role in lipid homeostasis both in humans and animals, particularly in relation to CVD but also nutrition and other body functions.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [70]
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- [5]Bünning E. The Physiological Clock–Circadian Rhythms in Biological Chronometry The English University Press Ltd. London, UK 1973
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St-Onge, M.-P., Ard, J., Baskin, M. L., Chiuve, S. E., Johnson, H. M., Kris-Etherton, P., & Varady, K. (2017) · Circulation · doi:10.1161/cir.0000000000000476 · Cited by 728 · see citing works
The Circadian Syndrome: is the Metabolic Syndrome and much more!
Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387 · see citing works
Bharaj, I. S., Brar, A. S., Kahlon, J., Singh, A., Hotwani, P., Kumar, V., Sohal, A., & Batta, A. (2025) · World Journal of Cardiology · doi:10.4330/wjc.v17.i6.106147 · Cited by 19 · see citing works
- Authors
- Gnocchi, D., Pedrelli, M., Hurt-Camejo, E., & Parini, P.
- Affiliations
- Karolinska University Hospital (SE)
- Strategy and Externalization, CVMD iMED, AstraZeneca, R&D, Mölndal, SE-431 83, Sweden
- Corresponding author
- Parini, Paolo
- Venue
- Biology
- Publisher
- MDPI AG
- Published
- 2015-02-05
- Volume
- 4
- Issue
- 1
- Pages
- 104-132
- ISSN
- 2079-7737 (ISSN-L)
- PMC
- PMC4381220
- OpenAlex
- W1978120649
- Cited by
- 115
- References
- 180
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 10 · 2023: 15 · 2022: 5 · 2021: 5 · 2020: 11 · 2019: 19 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Funders
- Swedish Heart-Lung Fundation
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- circadian rhythm, circadian clock, lipid metabolism, lipoprotein metabolism, lipid transport, metabolic disorders, cardiovascular disease, metabolic syndrome, carcinogenesis, clock genes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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