Relations between plasma asymmetric dimethylarginine (ADMA) and risk factors for coronary disease
Abstract
Background Elevated plasma levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide production, are reported to be associated with coronary artery disease (CAD). Methods We measured plasma levels of ADMA and related compounds, nitrate+nitrite (NO(x)), total homocysteine (tHCY) and assessed renal function and lipid profiles in 145 patients--75 with triple vessel coronary disease and 70 with no detectable coronary disease. Results Levels of ADMA, l-arginine, l-arginine/ADMA and plasma NO(x) were not different in the two groups but smokers with triple vessel disease had higher ADMA and lower NO(x) levels than the non-smokers, relationships also present for all smokers and non-smokers in the two groups combined. In all 145 patients ADMA, symmetric dimethylarginine (SDMA) and tHCY levels were significantly higher in patients with glomerular filtration rate (GFR) <81 mL/min/1.73 m(2) than in patients with GFR> or =81 mL/min/1.73 m(2). There was a modest positive correlation between tHCY and ADMA and both were strongly correlated with SDMA which is excreted by the kidney. ADMA, SDMA and tHCY were negatively correlated with GFR. Conclusions We suggest that the reported ADMA increases in CAD patients are due to an associated reduction in renal function and to smoking habit.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Individuals with atherosclerosis, chronic heart failure, hypertension, hypercholesterolemia, and diabetes mellitus, as well as women with PCOS, exhibit elevated levels of ADMA.
“Studies have demonstrated that individuals with atherosclerosis, chronic heart failure [16, 17], hypertension [18], hypercholesterolemia [19], and diabetes mellitus [20], as well as women with PCOS [21], exhibit elevated levels of ADMA [22].”
Cites
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742 · see citing works
Ridker, P. M., Buring, J. E., Cook, N. R., & Rifai, N. (2003) · Circulation · doi:10.1161/01.cir.0000055014.62083.05 · Cited by 2,292 · see citing works
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
Leone, A., Moncada, S., Vallance, P., Calver, A., & Collier, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)90865-z · Cited by 2,107 · see citing works
Relation between Renal Dysfunction and Cardiovascular Outcomes after Myocardial Infarction
Anavekar, N. S., McMurray, J. J. V., Velazquez, E. J., Solomon, S. D., Køber, L., Rouleau, J. L., White, H. D., Nordlander, R., Maggioni, A. P., Dickstein, K., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041365 · Cited by 1,913 · see citing works
Hyperhomocyst(e)inemia Is Associated With Impaired Endothelium-Dependent Vasodilation in Humans
Tawakol, A. A., Omland, T., Gerhard, M. D., Wu, J. T., & Creager, M. A. (1997) · Circulation · doi:10.1161/01.cir.95.5.1119 · Cited by 683 · see citing works
Homocysteine Impairs the Nitric Oxide Synthase Pathway
Stuehlinger, M., Tsao, P. S., Her, J. H., Kimoto, M., Balint, R. F., & Cooke, J. P. (2001) · Circulation · doi:10.1161/hc4601.098514 · Cited by 662 · see citing works
Novel Mechanism for Endothelial Dysfunction
Ito, A., Tsao, P. S., Adimoolam, S., Kimoto, M., Ogawa, T., & Cooke, J. P. (1999) · Circulation · doi:10.1161/01.cir.99.24.3092 · Cited by 629 · see citing works
Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction
Granger, D. L., Taintor, R. R., Boockvar, K. S., & Hibbs, J. B. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68016-1 · Cited by 511 · see citing works
Biological significance of endogenous methylarginines that inhibit nitric oxide synthases
Leiper, J. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00162-5 · Cited by 458 · see citing works
Teerlink, T., Nijveldt, R. J., de Jong, S., & van Leeuwen, P. A. M. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5575 · Cited by 417 · see citing works
The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor
Böger, R. H. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00500-5 · Cited by 393 · see citing works
Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis
Dayoub, H., Achan, V., Adimoolam, S., Jacobi, J., Stuehlinger, M. C., Wang, B., Tsao, P. S., Kimoto, M., Vallance, P. J., Patterson, A. J., et al. (2003) · Circulation · doi:10.1161/01.cir.0000101924.04515.2e · Cited by 340 · see citing works
Endothelial Dysfunction Induced by Hyperhomocyst(e)inemia
Stuehlinger, M., Oka, R. K., Graf, E. E., Schmoelzer, I., Upson, B. M., Kapoor, O., Szuba, A., Malinow, M. R., Wascher, T. C., Pachinger, O. M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000085067.55901.89 · Cited by 303 · see citing works
Böger, R. H., Bode‐Böger, S. M., Thiele, W., Creutzig, A., Alexander, K., & Frölich, J. C. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00375-1 · Cited by 263 · see citing works
An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes
Böger, R. H., Bode‐Böger, S. M., Tsao, P. S., Lin, P. S., Chan, J. R., & Cooke, J. P. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01013-5 · Cited by 227 · see citing works
Tarnow, L., Hovind, P. H., Teerlink, T., Stehouwer, C. D. A., & Parving, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.765 · Cited by 181 · see citing works
Cigarette smoke-induced endothelium dysfunction: role of superoxide anion
Raij, L. R., DeMaster, E. G., & Jaimes, E. A. (2001) · Journal of Hypertension · doi:10.1097/00004872-200105000-00009 · Cited by 165 · see citing works
Asymmetrical dimethylarginine: A novel risk factor for coronary artery disease
Lu, T., Ding, Y., Charng, M., & Lin, S. (2003) · Clinical Cardiology · doi:10.1002/clc.4960261006 · Cited by 77 · see citing works
Rapid reduction in coronary risk for those who quit cigarette smoking
McElduff, P., Dobson, A. J., Beaglehole, R., & Jackson, R. (1998) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.1998.tb01494.x · Cited by 56 · see citing works
Jonasson, T., Hedner, T., Hultberg, B., & Öhlin, H. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01184.x · Cited by 43 · see citing works
Evaluation of the Beckman Creatinine Analyzer 2
Cottrell, D. B., & Frings, C. S. (1979) · Clinical Biochemistry · doi:10.1016/s0009-9120(79)80081-8 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Schnabel, R. B., Blankenberg, S., Lubos, E., Lackner, K. J., Rupprecht, H. J., Espinola–Klein, C., Jachmann, N., Post, F., Peetz, D., Bickel, C., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000181286.44222.61 · Cited by 378 · see citing works
Symmetric dimethylarginine (SDMA) as endogenous marker of renal function–a meta-analysis
Kielstein, J. T., Salpeter, S. R., Bode-Boeger, S. M., Cooke, J. P., & Fliser, D. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl292 · Cited by 363 · see citing works
Palm, F., Onozato, M. L., Luo, Z., & Wilcox, C. S. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00998.2007 · Cited by 337 · see citing works
The role of asymmetric and symmetric dimethylarginines in renal disease
Schwedhelm, E., & Böger, R. H. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.31 · Cited by 262 · see citing works
Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA)
Tain, Y., & Hsu, C. (2017) · Toxins · doi:10.3390/toxins9030092 · Cited by 259 · see citing works
Unexpected Effect of Proton Pump Inhibitors
Ghebremariam, Y. T., LePendu, P., Lee, J. C., Erlanson, D. A., Slaviero, A., Shah, N. H., LEIPER, J. M., & Cooke, J. P. (2013) · Circulation · doi:10.1161/circulationaha.113.003602 · Cited by 258 · see citing works
Schulze, F., Lenzen, H., Hanefeld, C., Bartling, A., Osterziel, K. J., Goudeva, L., Schmidt‐Lucke, C., Kusus, M., Maas, R., Schwedhelm, E., et al. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.06.005 · Cited by 185 · see citing works
Juonala, M., Viikari, J. S. A., Alfthan, G., Marniemi, J., Kähönen, M. A. P., Taittonen, L. M., Laitinen, T. T., & Raitakari, O. T. (2007) · Circulation · doi:10.1161/circulationaha.107.690016 · Cited by 133 · see citing works
Angelantonio, E. D., Danesh, J., Eiríksdóttir, G., & Gudnason, V. G. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040270 · Cited by 131 · see citing works
Zakrzewicz, D., & Eickelberg, O. (2009) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-9-5 · Cited by 127 · see citing works
Nitric oxide-mediated blood flow regulation as affected by smoking and nicotine
Toda, N., & Toda, H. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.042 · Cited by 110 · see citing works
Meinitzer, A., Kielstein, J. T., Pilz, S., Drechsler, C., Ritz, E., Boehm, B. O., Winkelmann, B. R., & März, W. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.150854 · Cited by 104 · see citing works
Pikula, A., Böger, R. H., Beiser, A. S., Maas, R., DeCarli, C., Schwedhelm, E., Himali, J. J., Schulze, F., Au, R., Kelly-Hayes, M., et al. (2009) · Stroke · doi:10.1161/strokeaha.109.557116 · Cited by 85 · see citing works
Wilcken, D. E. L., Sim, A. S., Wang, J., & Wang, X. L. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.04.017 · Cited by 85 · see citing works
Self-citationThe biochemistry, measurement and current clinical significance of asymmetric dimethylarginine
Blackwell, S. (2009) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2009.009196 · Cited by 84 · see citing works
Lu, T., Chung, M., Lin, M., Hsu, C., & Lin, S. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.06.120 · Cited by 77 · see citing works
The Role of Asymmetric Dimethylarginine and Arginine in the Failing Heart and Its Vasculature
Visser, M., Paulus, W. J., Vermeulen, M. A. R., Richir, M. C., Davids, M., Wisselink, W., de Mol, B. A. J. M., & van Leeuwen, P. A. M. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq158 · Cited by 66 · see citing works
Involvement of DDAH/ADMA/NOS pathway in nicotine-induced endothelial dysfunction
Jiang, D., Jia, S., Jin, Y., Zhou, Z., Yuan, Q., & Li, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.115 · Cited by 63 · see citing works
Schwedhelm, E., Xanthakis, V., Maas, R., SULLIVAN, L. M., Schulze, F., Riederer, U., Benndorf, R. A., Böger, R. H., & Vasan, R. S. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.124263 · Cited by 62 · see citing works
Bolayırlı, M., Aslan, M., Balcı, H., Altuğ, T., Hacıbekiroğlu, M., & Seven, A. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.04.027 · Cited by 61 · see citing works
Wang, J., Sim, A. S., Wang, X. L., Salonikas, C., Moriatis, M., Naidoo, D., & Wilcken, D. E. L. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.07.034 · Cited by 56 · see citing works
Self-citationChapter 3 The Emerging Role of Symmetric Dimethylarginine in Vascular Disease
Mangoni, A. A. (2009) · Advances in clinical chemistry · doi:10.1016/s0065-2423(09)48003-x · Cited by 52 · see citing works
Ismaeel, A., Papoutsi, E., Miserlis, D., Lavado, R., Haynatzki, G. R., Casale, G. P., Bohannon, W. T., SMITH, R. S., Eidson, J. L., Brumberg, R. S., et al. (2020) · Antioxidants · doi:10.3390/antiox9070590 · Cited by 49 · see citing works
Proton pump inhibitors and vascular function: A prospective cross-over pilot study
Ghebremariam, Y. T., Cooke, J. P., Khan, F., Thakker, R., Chang, P., Shah, N. H., Nead, K. T., & Leeper, N. J. (2015) · Vascular Medicine · doi:10.1177/1358863x14568444 · Cited by 45 · see citing works
Atalar, M. N., Abuşoğlu, S., Ünlü, A., Tok, O., İpekçi, S. H., Baldane, S., & Kebapçılar, L. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116577 · Cited by 44 · see citing works
Dimethylarginines at the crossroad of insulin resistance and atherosclerosis
Zsuga, J., Török, J., Magyar, M. T., Valikovics, A., Gesztelyi, R., Lenkey, Á., Csiba, L., Kéki, S., Zsuga, M., & Bereczki, D. (2007) · Metabolism · doi:10.1016/j.metabol.2006.10.023 · Cited by 35 · see citing works
Korandji, C., Zeller, M., Guilland, J.-C., Vergely, C., Sicard, P., Duvillard, L., Gambert, P., Moreau, D., Cottin, Y., & Rochette, L. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.08.004 · Cited by 34 · see citing works
Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
Hsu, C., & Tain, Y. (2021) · Antioxidants · doi:10.3390/antiox10020247 · Cited by 33 · see citing works
Nakhjavani, M., Morteza, A., Asgarani, F., Khalilzadeh, O., Ghazizadeh, Z., Bathaie, S. Z., & Esteghamati, A. (2012) · Gene · doi:10.1016/j.gene.2012.01.085 · Cited by 30 · see citing works
Two Cardiovascular Risk Factors in One? Homocysteine and Its Relation to Glomerular Filtration Rate
Kielstein, J. T., Salpeter, S. R., Buckley, N. S., Cooke, J. P., & Fliser, D. (2008) · Kidney & Blood Pressure Research · doi:10.1159/000142725 · Cited by 29 · see citing works
Kayacelebi, A. A., Willers, J., Pham, V. V., Hahn, A., Schneider, J. Y., Rothmann, S., Frölich, J. C., & Tsikas, D. (2015) · Amino Acids · doi:10.1007/s00726-015-1915-3 · Cited by 29 · see citing works
Menopausal hormone treatment cardiovascular disease: another look at an unresolved conundrum
Harman, S. M. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.02.042 · Cited by 27 · see citing works
Plasma asymmetric dimethylarginine and L-arginine levels in patients with cardiac syndrome X
Okyay, K., Çengel, A., Şahinarslan, A., Tavıl, Y., Türkoğlu, S., Biberoglu, G., & Hasanoğlu, A. (2007) · Coronary Artery Disease · doi:10.1097/mca.0b013e3282f08ece · Cited by 24 · see citing works
Plasma Asymmetric Dimethylarginine Levels in Healthy People
Deneva-Koycheva, T. I., Vladimirova‐Kitova, L., Angelova, E., & Tsvetkova, T. Z. (2011) · Folia Medica · doi:10.2478/v10153-010-0024-z · Cited by 24 · see citing works
Rueda‐Clausen, C. F., Porras, A. C., Bedoya, G., Silva, F. A., Zarruk, J. G., López-Jaramillo, P. A., & Villa, L. A. (2011) · European Journal of Neurology · doi:10.1111/j.1468-1331.2011.03534.x · Cited by 22 · see citing works
Yücel, H., Özaydın, M., Doğan, A., Erdoğan, D., Türker, Y., Ceyhan, B. M., & Sütçü, R. (2012) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2012.699637 · Cited by 21 · see citing works
Wilcken, D. E. L., Wang, J., Sim, A. S., Green, K., & Wilcken, B. M. (2006) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-006-0208-0 · Cited by 21 · see citing works
Self-citationRezvan, S., Bahrami, F., Abedi, M., Macleod, C., Doost, H. T. N., & Ghasemi, V. (2013) · Europe PMC (PubMed Central) · Cited by 20 · see citing works
Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis
Lluch, P. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i32.9466 · Cited by 20 · see citing works
ADMA and SDMA levels in healthy men exposed to tobacco smoke
Sobczak, A., Goniewicz, M. L., & Szołtysek-Bołdys, I. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.039 · Cited by 19 · see citing works
Staab, E. B., Weigel, J., Xiao, F., Madayiputhiya, N., Wyatt, T. A., & Wells, S. M. (2014) · Journal of Immunotoxicology · doi:10.3109/1547691x.2014.961619 · Cited by 17 · see citing works
New Oxidative Stress Markers Useful in the Diagnosis of Acute Appendicitis in Children
Elmas, B., Yıldız, T., Yazar, H., İlçe, Z., Bal, C., İpteç, B. Ö., & Yürümez, Y. (2017) · Pediatric Emergency Care · doi:10.1097/pec.0000000000001339 · Cited by 17 · see citing works
Tobacco smoke exposure and endothelial dysfunction in patients with advanced coronary artery disease
Szpak, D., Grochowalski, A., Chrząszcz, R., Florek, E., Jawień, W., & Undas, A. (2013) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.1889 · Cited by 17 · see citing works
Napora, M., Graczykowska, A., Próchniewska, K., Zdrojewski, Z., Całka, A., Górny, J., & Stompór, T. P. (2012) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.1222 · Cited by 16 · see citing works
Dimethylarginine metabolism during acute and chronic rejection of rat renal allografts
Zakrzewicz, D., Zakrzewicz, A., Wilker, S., Boedeker, R., Padberg, W. M., Eickelberg, O., & Grau, V. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq392 · Cited by 15 · see citing works
Schroecksnadel, K., Weiss, G., Stanger, O., Teerlink, T., & Fuchs, D. (2007) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2007.01935.x · Cited by 15 · see citing works
Gad, M. Z., Hassanein, S. I., Abdel-Maksoud, S. M., Shaban, G. M., Abou‐Aisha, K., & Elgabarty, H. A. (2010) · Biomarkers · doi:10.3109/1354750x.2010.519784 · Cited by 15 · see citing works
Aktoz, T., Aktöz, M., Tatlı, E., Kaplan, M., Turan, F. N., Barutçu, A., Atakan, İ. H., Demir, M., & Altun, A. (2010) · International Urology and Nephrology · doi:10.1007/s11255-009-9696-9 · Cited by 15 · see citing works
Cardiovascular risk factors and the concentration of asymmetric dimethylarginine
Gać, P., Poręba, M., Jurdziak, M., Trzmielewska, E., Gocławska, K., Derkacz, A., Mazur, G., Szuba, A., & Poręba, R. (2020) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/111808 · Cited by 13 · see citing works
Asymmetric dimethylarginine and angiogenesis: biological significance
Wieczór, A. M., Wieczór, R., Kulwas, A., & Rość, D. (2018) · International Angiology · doi:10.23736/s0392-9590.18.04017-8 · Cited by 13 · see citing works
Hov, G. G., Sagen, E., Hatlen, G., Bigonah, A., Åsberg, A., & Aasarød, K. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.03.024 · Cited by 12 · see citing works
Arginine and Asymmetric Dimethylarginine in Pregnant Women With Major Depression
Raw, A., Gallaher, M. J., & Powers, R. W. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000077 · Cited by 12 · see citing works
Vladimirova‐Kitova, L., & Deneva-Koycheva, T. I. (2011) · Vascular Pharmacology · doi:10.1016/j.vph.2011.10.004 · Cited by 12 · see citing works
Effect of cigarette smoking on serum methylarginine and α-klotho levels
Onmaz, M., Demirbaş, N., Onmaz, D. E., Kutlu, R., & Ünlü, A. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.12.020 · Cited by 11 · see citing works
Murr, C., Meinitzer, A., Grammer, T. B., Schroecksnadel, K., Böhm, B. O., März, W., & Fuchs, D. (2009) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2009.02261.x · Cited by 11 · see citing works
Işıklar, Ö. Ö., Barutçuoğlu, B., Kabaroğlu, C., MUTAF, I., Özmen, D., Bayındır, O., Zoghi, M., & Uluer, H. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.06.024 · Cited by 10 · see citing works
Bima, C., Parasiliti‐Caprino, M., Rumbolo, F., Ponzetto, F., Gesmundo, I., Nonnato, A., Fornengo, P., Vaula, G., Ghigo, E., Mengozzi, G., et al. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.03.015 · Cited by 10 · see citing works
Trocha, M., Merwid‐Ląd, A., Szuba, A., Sozański, T., Magdalan, J., & Szeląg, A. (2010) · Advances in Clinical and Experimental Medicine · Cited by 9 · see citing works
Mokhtari, Z., Hosseini, S., Miri, R., Baghestani, A. R., Zahedirad, M., Rismanchi, M., & Nasrollahzadeh, J. (2015) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12311 · Cited by 9 · see citing works
Choi, H. R., Lee, S. W., Jeon, D.-H., Hur, N. W., Youm, Y., & Kim, H. C. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1388-4 · Cited by 8 · see citing works
Yokoro, M., Suzuki, M., YATANI, M., Yamashita, H., Takahashi, Y., Tsuji, H., & Kimoto, M. (2012) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110727 · Cited by 7 · see citing works
İlhan, N., Seçkin, D., İlhan, N., & Özbay, Y. (2006) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-006-9024-5 · Cited by 6 · see citing works
Cigarettes and ADMA: The Smoke Hasn’t Cleared Yet
Kielstein, J. T., Peter, C., & Adams, M. C. (2006) · Hypertension · doi:10.1161/01.hyp.0000240013.09503.0a · Cited by 6 · see citing works
The Role of Asymmetric Dimethylarginine (ADMA) and Leptin in Hypertensive Patients
Atamer, A., İlhan, N., Koçyiğit, Y., Toprak, G., Ozbay, M., & Çelik, Y. (2008) · Journal of International Medical Research · doi:10.1177/147323000803600108 · Cited by 5 · see citing works
Asymmetric dimethylarginine and impaired cardiovascular healing
Coluzzi, G., Santucci, E., Marzo, F., & Andreotti, F. (2007) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-007-0181-y · Cited by 4 · see citing works
Translational Vascular Medicine
Abraham, D., Coghlan, G., Dashwood, M. R., & Handler, C. E. (2011) · Springer eBooks · doi:10.1007/978-0-85729-920-8 · Cited by 7 · see citing works
Amirkhizi, F., Taghizadeh, M., Hamedi-Shahraki, S., & Asghari, S. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00932-1 · Cited by 3 · see citing works
“Studies have demonstrated that individuals with atherosclerosis, chronic heart failure [16, 17], hypertension [18], hypercholesterolemia [19], and diabetes mellitus [20], as well as women with PCOS [21], exhibit elevated levels of ADMA [22].”
Shao, Y., Fan, Y., Li, J., Cao, H., Liu, B., Wang, J., Yang, J., Zhang, Q., & Hu, X. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.10.121 · Cited by 3 · see citing works
Self-citationAsymmetric dimethylarginine—a determinant of the effect of the high dose Simvastatin
Vladimirova‐Kitova, L., & Deneva-Koicheva, T. I. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.04.054 · Cited by 3 · see citing works
Regulation of Nitric Oxide by Cigarette Smoke in Airway Cells
Liu, J., Wang, J., Sim, A. S., Mohan, N., Chow, S., Yates, D. H., Wang, X., & Thomas, P. S. (2012) · Open Journal of Respiratory Diseases · doi:10.4236/ojrd.2012.21002 · Cited by 3 · see citing works
Self-citationAlsagaff, M. Y., Thaha, M., Yogiarto, R. M., Aminuddin, M., Yogiantoro, R. M., Handajani, R., & Tomino, Y. (2013) · Open Journal of Nephrology · doi:10.4236/ojneph.2013.31013 · Cited by 3 · see citing works
Other Factors Ought to Be Kept in Mind When Analyzing Plasma Asymmetric Dimethylarginine Levels
Kurtoğlu, E., Balta, Ş., Karakuş, Y., & Yaşar, E. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpt275 · Cited by 3 · see citing works
Asymmetric dimethylarginine as a marker of metabolic dysfunction and cardiovascular disease
Pai, J. K. (2008) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-008-0028-x · Cited by 2 · see citing works
Sakin, A. (2021) · Eurasian Journal of Medical Investigation · doi:10.14744/ejmi.2021.18888 · Cited by 2 · see citing works
Alsagaff, M. Y., Thaha, M., Pikir, B. S., Susilo, H., Wungu, C. D. K., Suryantoro, S. D., Haryati, M. R., Ramadhani, R., Agustin, E. D., Putra, M. R. A., et al. (2022) · F1000Research · doi:10.12688/f1000research.74985.1 · Cited by 2 · see citing works
The Role of L-Arginine Metabolism and Endogenous Dimethylarginine in Chronic Venous Insufficiency
ÇOMAKLI, H., Bik, M. A., Ünlü, A., Abuşoğlu, S., Deniz, G., Mola, S., Karahasanoğlu, O., & Küçüker, Ş. A. (2025) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-025-01327-y · Cited by 2 · see citing works
Non-functioning adrenal incidentalomas may increase toxic metabolites
Karahan, İ., Ceylan, Ş. D., Güngüneş, A., Çi̇fci̇, A., Eker, F., & Kısa, Ü. (2021) · Wiener klinische Wochenschrift · doi:10.1007/s00508-021-01909-9 · Cited by 2 · see citing works
Arıcı, S., Kapuci, A., Kiyici, S. K., & Kısakol, G. (2020) · European Archives of Medical Research · doi:10.4274/eamr.galenos.2019.39200 · Cited by 1 · see citing works
Nitric Oxide Regulating Proteins as Biochemical and Genetic Markers of Coronary Artery Disease
Gad, M. Z., Abdel-Maksoud, S. M., Hassanein, S. I., Hashad, I. M., Rahman, M. F. A., el Maaty, M. A. A., Shaban, G. M., & Abou‐Aisha, K. (2015) · Springer eBooks · doi:10.1007/978-94-007-7741-5_34-1 · Cited by 1 · see citing works
Ghayour‐Mobarhan, M., Ayati, N., Sahebkar, A. H., Moohebati, M., Ayati, N., Elyasi, S., & Mohammadpour, A. H. (2018) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v89i2.5335 · Cited by 1 · see citing works
LEIPER, J. M., Arrigoni, F., & Ahmetaj, B. (2011) · Springer eBooks · doi:10.1007/978-0-85729-920-8_5 · Cited by 1 · see citing works
Kurtoğlu, E., Balta, Ş., Sıncer, İ., & Korkmaz, H. (2013) · Stroke · doi:10.1161/strokeaha.113.003236 · Cited by 1 · see citing works
Asimetrik Dimetil Arjinin (ADMA) Metabolizması
Aydın, M., Armutçu, F., & Yiğitoğlu, M. R. (2015) · DergiPark (Istanbul University)
Blackwell, S. (2013) · Enlighten: Theses (The University of Glasgow)
Khazaei, M., Zarei, M., & Esmaeil, N. (2012) · ISRN Hypertension · doi:10.5402/2013/516528
Ilic, M., Pavlović, R., Lazarević, G., Cvetković, T., Kocic, G. M., Ilić, S., & Stefanović, V. (2012) · Open Medicine · doi:10.2478/s11536-012-0031-y
Meinitzer, A., & März, W. (2007) · Journal of Laboratory Medicine · doi:10.1515/jlm.2007.020
Głowińska‐Olszewska, B., Urban, M., Łuczyński, W., Dobreńko, E., Urban, R., & Szczepański, W. (2009) · Via Medica Journals
Merwid‐Ląd, A., Szuba, A., Sozański, T., & Magdalan, J. (2010)
Can, F. (2012) · Istanbul Science University (Istanbul Bilim University)
Eloot, S., Glorieux, G., Deyn, P. P. D., & Vanholder, R. C. (2012) · doi:10.1002/9781118424032.ch9
Nitric Oxide Regulating Proteins as Biochemical and Genetic Markers of Coronary Artery Disease
Gad, M. Z., Abdel-Maksoud, S. M., Hassanein, S. I., Hashad, I. M., Rahman, M. F. A., el Maaty, M. A. A., Shaban, G. M., & Abou‐Aisha, K. (2016) · Springer eBooks · doi:10.1007/978-94-007-7678-4_34
Demirel, D., Aktaş, B. K., Kösem, A., Soydaş, T., Akpınar, Ç., Özgür, E. G., Özden, C., & Kayıgίl, Ö. (2025) · Medicine · doi:10.1097/md.0000000000041742
Zhussupbekova, L., Makhkamova, M., Мухтархановна, Н. Н., Nurkina, D., Yuldashov, F., & Ubaydullayev, D. (2026) · Biomedicines · doi:10.3390/biomedicines14091927
- Authors
- Wang, J., Sim, A. S., Wang, X. L., Salonikas, C., Naidoo, D., & Wilcken, D. E. L.
- Affiliations
- UNSW Sydney (AU)
- Baylor College of Medicine (US)
- Corresponding author
- Wilcken, David E.L.
- ORCID
- Wang, Jun
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 184
- Issue
- 2
- Pages
- 383-388
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2081828156
- Cited by
- 96
- References
- 21
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 6 · 2012: 10
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Keywords
- asymmetric dimethylarginine, coronary artery disease, nitric oxide, symmetric dimethylarginine, homocysteine, renal function, glomerular filtration rate, smoking, nitrite/nitrate, L-arginine, risk factors
- MeSH terms
- Adult, Aged, Arginine, Chromatography, High Pressure Liquid, Coronary Disease, Female, Follow-Up Studies, Glomerular Filtration Rate, Homocysteine, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Factors, Smoking, Biomarkers, Coronary Angiography, Disease Progression, Nitric Oxide Synthase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
