Cited by 94Cardiovascular Health and Disease PreventionCardiovascular Disease and AdiposityPeroxisome Proliferator-Activated Receptors

Fenofibrate and pioglitazone improve endothelial function and reduce arterial stiffness in obese glucose tolerant men

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Ryan, Kathryn E., McCance, D.R., Powell, L., McMahon, R., Trimble, E.R.·2007·Atherosclerosis

Abstract

Obesity is a low grade inflammatory state associated with premature cardiovascular morbidity and mortality. Along with traditional risk factors the measurement of endothelial function, insulin resistance, inflammation and arterial stiffness may contribute to the assessment of cardiovascular risk. We conducted a randomised placebo controlled trial to assess the effects of 12 weeks treatment with a PPAR alpha agonist (fenofibrate) and a PPAR gamma agonist (pioglitazone) on these parameters in obese glucose tolerant men. Arterial stiffness was measured using augmentation index and pulse wave velocity (PWV). E-selectin, VCAM-1 and ICAM-1 were used as markers of endothelial function. Insulin sensitivity improved with pioglitazone treatment (p=0.001) and, in keeping with this, adiponectin increased by 85.2% (p<0.001). Pro-inflammatory cytokine levels (TNFalpha, IL-6 and IL-1 beta) fell with both treatments (p<0.01 for TNFalpha and IL-1 beta, p<0.001 for IL-6). VCAM-1 and ICAM-1 were reduced with both treatments (p<0.001 for VCAM-1, p<0.05 for ICAM-1) and E-selectin improved with pioglitazone treatment (p=0.05). Both treatments resulted in a fall in augmentation index. PWV fell by 17.4% with fenofibrate treatment (p<0.001) and 16.3% with pioglitazone treatment (p<0.001). Pioglitazone and fenofibrate treatment of obese, glucose tolerant men reduces inflammation, improves markers of endothelial function and reduces arterial stiffness. These results suggest that treatment with PPAR agonists has potential to reduce the incidence of premature cardiovascular disease associated with obesity.

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Crossref · 10.1016/j.atherosclerosis.2006.11.007

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  • Fenofibrate treatment typically reduces serum triglycerides by a mean change of −93.7 mg/dL (−39.3%), increases high density lipoprotein cholesterol by +5.5 mg/dL (+12.4%), and reduces low density lipoprotein cholesterol by −17.9 mg/dL (−12.3%).

    “Typical changes in serum lipids as a result of FF treatment include clinically important mean reductions of serum triglycerides (TG) by a mean change of −93.7 mg/dL (−39.3%), increases of high density lipoprotein cholesterol (HDLC) by +5.5 mg/dL (+12.4%), and reductions in low density lipoprotein cholesterol (LDLC) by −17.9 mg/dL (−12.3%).”

    From Fenofibrate and metabolic syndrome (2010) · cites this paper as [41]

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Authors
Ryan, K. E., McCance, D. R., Powell, L., McMahon, R., & Trimble, E. R.
Affiliations
  • Royal Victoria Hospital (GB)
  • Queen's University Belfast (GB)
Corresponding author
Powell, L.
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2007-10
Volume
194
Issue
2
Pages
e123-e130
ISSN
0021-9150 (ISSN-L)
OpenAlex
W1982191008
Cited by
94
References
31
Citations by year
2025: 5 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 7
FWCI
4.95
Type
journal article
Language
en
Open access
Locations
  • Atherosclerosis (publishedVersion, other-oa)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
fenofibrate, pioglitazone, PPAR agonists, endothelial function, arterial stiffness, obesity, glucose tolerance, insulin sensitivity, adiponectin, inflammation, inflammatory cytokines, E-selectin, VCAM-1, ICAM-1, augmentation index, pulse wave velocity, cardiovascular risk
MeSH terms
Pioglitazone, Adult, Hypolipidemic Agents, Arteries, Blood Pressure, Double-Blind Method, Elasticity, Endothelium, Vascular, Humans, Hypoglycemic Agents, Inflammation, Male, Middle Aged, Obesity, Fenofibrate, Pulsatile Flow, Cell Adhesion Molecules, Cytokines, Thiazolidinediones, PPAR gamma

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