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Cited by 60Cardiovascular Health and Disease PreventionDiabetes, Cardiovascular Risks, and LipoproteinsCardiac Imaging and Diagnostics

Maximum carotid intima-media thickness improves the prediction ability of coronary artery stenosis in type 2 diabetic patients without history of coronary artery disease

Irie, Yoko, Katakami, Naoto, Kaneto, Hideaki, Kasami, Ryuichi, Sumitsuji, Satoru, Yamasaki, Keita, Tachibana, Kouichi, Kuroda, Tadashi +5 more·2012·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2012.01.022
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Abstract

Objective Carotid intima-media thickness (CIMT), a marker of early atherosclerosis and vascular remodelling, is one of the independent predictors of coronary artery disease (CAD). However, it is unknown whether ultrasonic assessment of carotid atherosclerosis, including CIMT, improves the prediction ability for CAD over and above conventional coronary risk factors in the diabetic patients.Methods Ultrasonic scanning of the common carotid artery (CCA), the carotid bulb (Bul), and the internal carotid artery (ICA) was performed. The site with the greatest IMT, including plaque lesions, was sought along the arterial walls and max-IMT (the greatest IMT in the observation-possible areas of the CCA, Bul and ICA) was measured. The association of max-IMT with coronary artery stenosis assessed by coronary computed tomography angiography and the incremental effect of adding max-IMT to the conventional risk factors for predicting coronary artery stenosis were evaluated in 241 asymptomatic type 2 diabetic patients.Results Multiple logistic regression analyses showed that max-IMT was significantly associated with coronary artery stenosis even after adjustment for conventional risk factors. ROC curve analysis revealed that the AUC significantly increased after addition of max-IMT to conventional coronary risk factors [from 0.64 (95% CI; 0.57-0.71) to 0.74 (95% CI; 0.67-0.80), p = 0.020]. The addition of max-IMT to conventional coronary risk factors increased the AUC in obese patients (from 0.58 to 0.76, p = 0.012) but not in non-obese patients (from 0.68 to 0.72, NS).Conclusions In type 2 diabetic patients without apparent cardiovascular disease, the addition of max-IMT to conventional risk factors substantially improves the risk stratification for CAD.

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Authors
Irie, Y., Katakami, N., Kaneto, H., Kasami, R., Sumitsuji, S., Yamasaki, K., Tachibana, K., Kuroda, T., Sakamoto, K., Umayahara, Y., Ueda, Y., Kosugi, K., & Shimomura, I.
Affiliations
  • The University of Osaka (JP)
  • Osaka Prefectural Medical Center (JP)
  • Osaka Police Hospital (JP)
Corresponding author
Kaneto, Hideaki
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2012-04
Volume
221
Issue
2
Pages
438-444
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/j.atherosclerosis.2012.01.022
OpenAlex
W2085752652
Cited by
60
References
28
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 9 · 2013: 11 · 2012: 1
FWCI
5.97
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
carotid intima-media thickness, coronary artery stenosis, type 2 diabetes, coronary heart disease risk prediction, asymptomatic diabetic patients, carotid atherosclerosis, vascular remodeling, obesity, risk stratification, coronary CT angiography
MeSH terms
Aged, Carotid Arteries, Carotid Artery Diseases, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Humans, Japan, Male, Middle Aged, Predictive Value of Tests, Prognosis, Risk Factors, ROC Curve, Tomography, X-Ray Computed, Multivariate Analysis, Chi-Square Distribution, Logistic Models, Coronary Angiography, Risk Assessment, Area Under Curve, Coronary Stenosis, Carotid Intima-Media Thickness

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