Diabetes and Cardiovascular Disease in a Prospective Population Survey in Japan: The Hisayama Study
Abstract
To elucidate the effect of glucose intolerance on cardiovascular disease in the current Japanese population, we performed a 75-g oral glucose tolerance test in 2,427 Hisayama residents aged 40–79 years in 1988, who were free from a previous history of stroke or myocardial infarction, and followed them prospectively for 5 years. The prevalence of diabetes (NIDDM) among men was 13% and that of impaired glucose tolerance (IGT) was 20%; the corresponding values for women were 9 and 19%, respectively. The age- and sex-adjusted incidence of cerebral infarction (6.5 per 1,000 person-years, P 0.01) and coronary heart disease (5.0 per 1,000 person-years, P 0.05) was significantly higher in subjects with NIDDM than in those with normal glucose tolerance (1.9 and 1.6 per 1,000 person-years, respectively). In addition, subjects with IGT and NIDDM had a higher risk of cardiovascular disease including stroke and coronary heart disease than did those with normal glucose tolerance after adjustment for age and sex, namely the relative risk for IGT was 1.9 (95% CI 1.2–3.2), and the relative risk for NIDDM was 3.0 (95% CI 1.8–5.2). These associations remained significant even after controlling for six other risk factors including hypertension in multivariate analysis. Our data suggest that NIDDM is a significant risk factor for both cerebral infarction and coronary heart disease and also that IGT itself is a risk factor for cardiovascular disease in the general Japanese population today.
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In NIPPON-DATA80, diabetic patients had a 2.8 times higher risk of death from CAD than non-diabetic subjects.
“In NIPPON-DATA80, diabetic patients showed significantly higher risk of 2.8 times for death from CAD than non-diabetic subjects127).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [127]
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Self-citationSone, H., Kawai, K., Takagi, H., Yamada, N., & Kobayashi, M. (2006) · Internal Medicine · doi:10.2169/internalmedicine.45.1609 · Cited by 31 · see citing works
Is insulin resistance or diabetes mellitus associated with stroke?
Adachi, H., Hirai, Y., Tsuruta, M., Fujiura, Y., & Imaizuml, T. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(00)00236-9 · Cited by 31 · see citing works
Kondo, K., & Kadowaki, T. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01159.x · Cited by 28 · see citing works
“According to the Hisayama Study [16], onset risk of cerebral infarction and coronary heart disease is three times higher in Japanese diabetic patients than in non-diabetic individuals.”
BackgroundKanazawa, I., Yamaguchi, T., Yamamoto, M., Yamauchi, M., Kurioka, S., Yano, S., & Sugimoto, T. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07e-130 · Cited by 30 · see citing works
“The incidence of CVD is approximately two or three times as high in patients with type 2 diabetes as in agematched controls without diabetes [27, 28], and the risk of CVD increases with the duration of diabetes and with age [29–31].”
Background
- Authors
- Fujishima, M., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., & Yoshitake, T.
- Affiliations
- Kyushu University (JP)
- ORCID
- Kato, Isao
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1996-07-01
- Volume
- 45
- Issue
- Supplement_3
- Pages
- S14-S16
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W1987951971
- Cited by
- 258
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 9 · 2018: 16 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 4 · 2013: 17 · 2012: 7
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes, impaired glucose tolerance, cardiovascular disease, cerebral infarction, coronary artery disease, stroke, oral glucose tolerance test, Hisayama Study, hypertension, cardiovascular risk factors, Japanese population
- MeSH terms
- Adult, Aged, Alcohol Drinking, Cardiovascular Diseases, Cerebral Infarction, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Humans, Hyperlipidemias, Hypertension, Japan, Male, Middle Aged, Obesity, Risk, Smoking
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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