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Cited by 124Congenital Heart Disease StudiesCardiovascular Conditions and TreatmentsCongenital heart defects research

Early Primary Repair of Tetralogy of Fallot in Neonates and Infants Less Than Four Months of Age

Tamesberger, Melanie I., Lechner, Evelyn, Mair, Rudolf, Hofer, Anna, Sames-Dolzer, Eva, Tulzer, Gerald·2008·The Annals of Thoracic Surgery
DOI 10.1016/j.athoracsur.2008.07.019
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Abstract

Background The ideal age for correction of tetralogy of Fallot is still under discussion. The aim of this study was to analyze morbidity and mortality in patients who underwent early primary repair of tetralogy of Fallot at the age of less than 4 months and to assess whether neonates, who needed early repair within the first 4 weeks of life, faced an increased risk. Methods From 1995 to 2006, 90 consecutive patients with tetralogy of Fallot and pulmonary stenosis underwent early primary repair. Patient charts were analyzed retrospectively for two groups: group A, 25 neonates younger than 28 days who needed early operation owing to duct-dependent pulmonary circulation or severe hypoxemia; and group B, 65 infants younger than 4 months of age who underwent elective early repair. Results There was no 30-day mortality; late mortality was 2% after a median follow-up time of 4.7 years. Seven of 88 patients (8%) needed reoperation and twelve of 88 patients (14%) needed reintervention. Groups A and B did not differ significantly in terms of intensive care unit stay, days of mechanical ventilation, overall hospital stay, major or minor complications, or reoperation. Significant differences were found in a more frequent use of a transannular patch (p = 0.045) and more reinterventions (p = 0.046) in group A. Conclusions Early primary repair of tetralogy of Fallot can be performed safely and effectively in infants younger than 4 months of age and even in neonates younger than 28 days with duct-dependent pulmonary circulation or severe hypoxemia.

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Authors
Tamesberger, M. I., Lechner, E., Mair, R., Hofer, A., Sames-Dolzer, E., & Tulzer, G.
ORCID
Venue
The Annals of Thoracic Surgery
Publisher
Elsevier BV
Published
2008-12
Volume
86
Issue
6
Pages
1928-1935
ISSN
0003-4975 (ISSN-L)
DOI
10.1016/j.athoracsur.2008.07.019
OpenAlex
W2051098343
Cited by
124
References
27
Citations by year
2026: 1 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 13 · 2020: 6 · 2019: 11 · 2018: 10 · 2017: 7 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 15 · 2012: 6
FWCI
3.48
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Annals of Thoracic Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
tetralogy of Fallot, neonates, infants, pulmonary stenosis, duct-dependent pulmonary circulation, severe hypoxemia, transannular patch, reintervention, reoperation, postoperative morbidity and mortality, timing of surgical repair
MeSH terms
Age Factors, Cause of Death, Female, Follow-Up Studies, Cardiac Surgical Procedures, Humans, Infant, Infant, Newborn, Male, Postoperative Complications, Probability, Pulmonary Valve Stenosis, Retrospective Studies, Sensitivity and Specificity, Tetralogy of Fallot, Time Factors, Echocardiography, Doppler, Cohort Studies, Survival Rate, Treatment Outcome, Hospital Mortality, Risk Assessment, Statistics, Nonparametric, Kaplan-Meier Estimate

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