Specificity of islet cell autoantibodies and coexistence with other organ specific autoantibodies in type 1 diabetes mellitus

Tsirogianni, Alexandra; Pipi, Elena; Soufleros, Konstantinos

doi:10.1016/j.autrev.2009.02.019

Cited by 56Diabetes and associated disordersT-cell and B-cell ImmunologyCeliac Disease Research and Management

Specificity of islet cell autoantibodies and coexistence with other organ specific autoantibodies in type 1 diabetes mellitus

Tsirogianni, Alexandra, Pipi, Elena, Soufleros, Konstantinos·2009·Autoimmunity Reviews

DOI 10.1016/j.autrev.2009.02.019

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Abstract

Type 1 diabetes mellitus (T1DM) has been shown to be a disease characterized by immune-mediated destruction of the insulin-producing islet beta-cells (beta-cells) in the pancreas. Intensive studies, in both patients and animal models are trying to elucidate the specific antigenic targets that are responsible for islet cell autoimmunity. So far, the most important molecules that have been recognized are the native insulin, the 65-kDa form of glutamic acid decarboxylase (GAD(65)) and the insulinoma-antigen 2 (IA-2). Identification of those specific autoantibodies that are involved in the primary immunological events of the autoimmune disease process will allow the development of novel diagnostic procedures for early detection and initiation of potential therapy prior to irreversible loss of beta-cells. Within the framework of polyglandular disorders, T1DM may coexist with other organ specific autoimmune diseases such as autoimmune thyroid disease (ATD), autoimmune gastritis (AG), celiac disease (CD) and Addison's disease (AD), which are associated with the production of organ-specific autoantibodies. So, as a subset of patients with those autoantibodies will develop clinical disease, screening T1DM patients could prognosticate morbidity relative to unrecognised clinical entities. The close follow-up of patients with organ-specific autoantibodies could lead to seasonable identification of those requiring therapy.

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Epidemiology of type 1 diabetes
Maahs, D. M., West, N. A., Lawrence, J. M., & Mayer-Davis, E. J. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.05.011 · Cited by 1,092 · see citing works
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Authors: Tsirogianni, A., Pipi, E., & Soufleros, K.
Affiliations: Evangelismos Hospital (GR)
Corresponding author: Tsirogianni, Alexandra
ORCID: Tsirogianni, Alexandra
Pipi, Elena
Venue: Autoimmunity Reviews
Publisher: Elsevier BV
Published: 2009-07
Volume: 8
Issue: 8
Pages: 687-691
ISSN: 1568-9972 (ISSN-L)
DOI: 10.1016/j.autrev.2009.02.019
OpenAlex: W2011614956
Cited by: 56
References: 43
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 1 · 2012: 6
FWCI: 0.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Autoimmunity Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
Keywords: type 1 diabetes, islet autoantibodies, autoantibody specificity, GAD65, islet autoimmunity, autoimmune thyroid disease, autoimmune gastritis, celiac disease, Addison's disease, organ-specific autoantibodies, early diagnosis, screening
MeSH terms: Autoantibodies, Diabetes Mellitus, Type 1, Glutamate Decarboxylase, Humans, Insulin, Islets of Langerhans, Receptor-Like Protein Tyrosine Phosphatases, Class 8

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Specificity of islet cell autoantibodies and coexistence with other organ specific autoantibodies in type 1 diabetes mellitus

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