Cited by 182Systemic Lupus Erythematosus ResearchReproductive System and PregnancyPregnancy and preeclampsia studies

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The efficacy of hydroxychloroquine for obstetrical outcome in anti-phospholipid syndrome: Data from a European multicenter retrospective study

Mekinian, Arsène, Lazzaroni, Maria Grazia, Kuzenko, Anna, Alijotas-Reig, Jaume, Ruffatti, Amelia, Levy, Pierre, Canti, Valentina, Bremme, Katarina, Bezanahary, Holy, Bertero, Tiziana, Dhote, Robin, Maurier, Francois, Andreoli, Laura, Benbara, Amélie, Tigazin, Ahmed, Carbillon, Lionel, Nicaise-Roland, Pascale, Tincani, Angela, Fain, Olivier·2015·Autoimmunity Reviews

DOI 10.1016/j.autrev.2015.01.012

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Abstract

In European multicenter study, we aimed to describe the real-life hydroxychloroquine use in APS patients during pregnancy and determine its benefit in refractory obstetrical APS. We analyzed the outcome of pregnancies treated by hydroxychloroquine in patients with APS or asymptomatic antiphospholipid (aPL) antibodies carriers. Thirty patients with APS with 35 pregnancies treated by hydroxychloroquine were analyzed. Comparing the outcome of pregnancies treated by the addition of hydroxychloroquine to previous pregnancies under the conventional treatment, pregnancy losses decreased from 81% to 19% (p<0.05), without differences in the associated treatments. The univariate analysis showed that the previous intrauterine deaths and higher hydroxychloroquine amount (400mg per day) were the factors associated with pregnancy outcome. Considering 14 patients with previous refractory obstetrical APS (n=5 with obstetrical and thrombotic primary APS and n=9 with purely obstetrical APS), all with previous pregnancy losses under treatment (aspirin with LMWH in 11 cases and LMWH in 3 cases), the addition of hydroxychloroquine resulted in live born babies in 11/14 (78%) cases (p<0.05). Our study shows the benefit of hydroxychloroquine addition in patients with refractory obstetrical APS and raises the need of prospective studies to confirm our preliminary study.

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Authors: Mekinian, A., Lazzaroni, M. G., Kuzenko, A., Alijotas-Reig, J., Ruffatti, A., Levy, P., Canti, V., Bremme, K., Bezanahary, H., Bertero, T., Dhote, R., Maurier, F., Andreoli, L., Benbara, A., Tigazin, A., Carbillon, L., Nicaise-Roland, P., Tincani, A., & Fain, O.
Affiliations: Assistance Publique – Hôpitaux de Paris (FR)
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
A. O. Ordine Mauriziano di Torino (IT)
University of Padua (IT)
IRCCS Ospedale San Raffaele (IT)
Karolinska Institutet (SE)
Université Sorbonne Paris Nord (FR)
ORCID: Mekinian, Arsène
Lazzaroni, Maria Grazia
Ruffatti, Amelia
Canti, Valentina
Maurier, Francois
Benbara, Amélie
Carbillon, Lionel
Fain, Olivier
Venue: Autoimmunity Reviews
Publisher: Elsevier BV
Published: 2015-06
Volume: 14
Issue: 6
Pages: 498-502
ISSN: 1568-9972 (ISSN-L)
DOI: 10.1016/j.autrev.2015.01.012
OpenAlex: W1966792319
Cited by: 182
References: 22
Citations by year: 2026: 7 · 2025: 11 · 2024: 13 · 2023: 8 · 2022: 16 · 2021: 14 · 2020: 23 · 2019: 21 · 2018: 24 · 2017: 14 · 2016: 20 · 2015: 11
FWCI: 19.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Autoimmunity Reviews (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: hydroxychloroquine, antiphospholipid syndrome, pregnancy outcomes, miscarriage, antiphospholipid antibodies, low molecular weight heparin, aspirin, live birth, intrauterine fetal death
MeSH terms: Female, Humans, Hydroxychloroquine, Pregnancy, Pregnancy Outcome, Retrospective Studies, Multicenter Studies as Topic, Antiphospholipid Syndrome, Antibodies, Antiphospholipid

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The efficacy of hydroxychloroquine for obstetrical outcome in anti-phospholipid syndrome: Data from a European multicenter retrospective study

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