Effects of intralaminar thalamic stimulation on language functions
Abstract
Fifteen neurosurgical subjects, who were undergoing thalamic chronic electrode implants as a treatment for dyskinesia and chronic pain, were evaluated on a series of neurolinguistic functions to determine if the stimulation of the centromedianum nucleus of the thalamus affected language and cognitive processing. Analysis of the data revealed that the stimulation of the left centromedianum nucleus had resulted in a notable facilitatory influence on the processing of language functions; this facilitatory effect was measured in terms of the number of errors produced and the patients' response latency time. The facilitatory effect was also noted to have extended to other language functions. The nature of the facilitation from the stimulation of the left centromedianum nucleus, an extension of the brainstem reticular formation, on language functions is discussed.
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The putamen and thalamus are involved in initiating and organizing language representations and have been shown to be activated coincident with AVH occurrences.
“The first two were in the putamen and thalamus, which are involved in initiating and organizing language representations ordinarily (56–58), and have been shown to be activated coincident with AVH occurrences in two reports (26,59).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [57]
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- Authors
- BHATNAGAR, S., & MANDYBUR, G.
- Affiliations
- Marquette University (US)
- University of Cincinnati (US)
- Corresponding author
- BHATNAGAR, S
- Venue
- Brain and Language
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 92
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0093-934X (ISSN-L)
- OpenAlex
- W2008386371
- Cited by
- 22
- References
- 61
- Citations by year
- 2021: 3 · 2020: 1 · 2017: 1 · 2015: 2 · 2012: 2
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain and Language (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- centromedian nucleus, language processing, response latency, error rate, brainstem reticular formation, chronic pain, dyskinesia
- MeSH terms
- Adult, Aged, Brain Stem, Cognition, Electric Stimulation, Electrodes, Implanted, Female, Humans, Language, Male, Middle Aged, Reaction Time, Reticular Formation, Stereotaxic Techniques, Intralaminar Thalamic Nuclei, Dyskinesias
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