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The role of neuronal signaling in controlling cerebral blood flow
Abstract
Well-regulated blood flow within the brain is vital to normal function. The brain's requirement for sufficient blood flow is ensured by a tight link between neural activity and blood flow. The link between regional synaptic activity and regional cerebral blood flow, termed functional hyperemia, is the basis for several modern imaging techniques that have revolutionized the study of human brain activity. Here, we review the mechanisms of functional hyperemia and their implications for interpreting the blood oxygen level-dependent (BOLD) contrast signal used in functional magnetic resonance imaging (fMRI).
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“This corresponds to speed in venules and arterioles but may exclude capillaries where numerous neurovascular processes occur44.”
From Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep (2018) · cites this paper as [44]
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Metadata
- Authors
- DRAKE, C., & IADECOLA, C.
- Affiliations
- Cornell University (US)
- Corresponding author
- DRAKE, C
- ORCID
- Venue
- Brain and Language
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 102
- Issue
- 2
- Pages
- 141-152
- ISSN
- 0093-934X (ISSN-L)
- OpenAlex
- W2144914358
- Cited by
- 177
- References
- 132
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 10 · 2016: 19 · 2015: 11 · 2014: 13 · 2013: 14 · 2012: 6
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain and Language (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cerebral blood flow, functional hyperemia, neuronal signaling, neuronal activity, synaptic activity, BOLD signal, functional MRI, neurovascular coupling, blood flow regulation
- MeSH terms
- Brain, Cerebrovascular Circulation, Humans, Hyperemia, Magnetic Resonance Imaging, Neurons
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