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The role of neuronal signaling in controlling cerebral blood flow

DRAKE, C, IADECOLA, C·2007·Brain and Language

DOI 10.1016/j.bandl.2006.08.002

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Abstract

Well-regulated blood flow within the brain is vital to normal function. The brain's requirement for sufficient blood flow is ensured by a tight link between neural activity and blood flow. The link between regional synaptic activity and regional cerebral blood flow, termed functional hyperemia, is the basis for several modern imaging techniques that have revolutionized the study of human brain activity. Here, we review the mechanisms of functional hyperemia and their implications for interpreting the blood oxygen level-dependent (BOLD) contrast signal used in functional magnetic resonance imaging (fMRI).

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Authors: DRAKE, C., & IADECOLA, C.
Affiliations: Cornell University (US)
Corresponding author: DRAKE, C
ORCID: DRAKE, C
IADECOLA, C
Venue: Brain and Language
Publisher: Elsevier BV
Published: 2007-08
Volume: 102
Issue: 2
Pages: 141-152
ISSN: 0093-934X (ISSN-L)
DOI: 10.1016/j.bandl.2006.08.002
OpenAlex: W2144914358
Cited by: 177
References: 132
Citations by year: 2025: 3 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 10 · 2016: 19 · 2015: 11 · 2014: 13 · 2013: 14 · 2012: 6
FWCI: 5.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain and Language (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: cerebral blood flow, functional hyperemia, neuronal signaling, neuronal activity, synaptic activity, BOLD signal, functional MRI, neurovascular coupling, blood flow regulation
MeSH terms: Brain, Cerebrovascular Circulation, Humans, Hyperemia, Magnetic Resonance Imaging, Neurons

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The role of neuronal signaling in controlling cerebral blood flow

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