Mitochondrial dysfunction in autism spectrum disorders: Cause or effect?

Diagnostic and Statistical Manual of Mental Disorders

Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., & Sheu, S.-S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2004 · Cited by 2,575 · see citing works

Neuroglial activation and neuroinflammation in the brain of patients with autism

Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · see citing works

Behavioral manifestations of autism in the first year of life

Zwaigenbaum, L., Bryson, S., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.001 · Cited by 1,602 · see citing works

CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism

Splawski, I., Timothy, K. W., Sharpe, L. M., Decher, N., Kumar, P., Bloise, R., Napolitano, C., Schwartz, P. J., Joseph, R. M., Condouris, K., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.011 · Cited by 1,586 · see citing works

Autism spectrum disorders: developmental disconnection syndromes

Geschwind, D. H., & Levitt, P. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.009 · Cited by 1,411 · see citing works

Diagnostic and Statistical Manual of Mental Disorders

Preedy, V., & Watson, R. (2010) · Springer eBooks · doi:10.1007/978-0-387-78665-0_5485 · Cited by 1,146 · see citing works

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1611 · Cited by 955 · see citing works

Neuroanatomic observations of the brain in autism: a review and future directions

Bauman, M. L., & Kemper, T. L. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.09.006 · Cited by 919 · see citing works

Mapping early brain development in autism

Courchesne, E., Pierce, K., Schumann, C. M., Redcay, E., Buckwalter, J. A., Kennedy, D. P., & Morgan, J. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.016 · Cited by 860 · see citing works

Broader autism phenotype: evidence from a family history study of multiple-incidence autism families

(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.2.185 · Cited by 777 · see citing works

CD38 is critical for social behaviour by regulating oxytocin secretion

Jin, D., Liu, H.-X., Hirai, H., Torashima, T., Nagai, T., Lopatina, O., Shnayder, N. A., Yamada, K., Noda, M., Seike, T., et al. (2007) · Nature · doi:10.1038/nature05526 · Cited by 665 · see citing works

Oxidative stress in autism

Chauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656 · see citing works

Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

James, S. J., Melnyk, S., Jernigan, S., Cleves, M. A., Halsted, C. H., Wong, D. H., Cutler, P., Bock, K., Boris, M., Bradstreet, J., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30366 · Cited by 605 · see citing works

The prevalence of autism

Fombonne, E. (2003) · JAMA · doi:10.1001/jama.289.1.87 · Cited by 604 · see citing works

Searching for ways out of the autism maze: genetic, epigenetic and environmental clues

Persico, A. M., & Bourgeron, T. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.05.010 · Cited by 575 · see citing works

Mitochondria as all‐round players of the calcium game

Rizzuto, R., Bernardi, P., & Pozzan, T. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00037.x · Cited by 562 · see citing works

Longitudinal Magnetic Resonance Imaging Study of Cortical Development through Early Childhood in Autism

Schumann, C. M., Bloss, C. S., Barnes, C. C., Wideman, G. M., Carper, R. A., Akshoomoff, N., Pierce, K., Hagler, D., Schork, N., Lord, C., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5714-09.2010 · Cited by 554 · see citing works

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

Koya, D., Jirousek, M. R., Lin, Y. W., Ishii, H., Kuboki, K., & King, G. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119503 · Cited by 535 · see citing works

Mitochondrial disorders

Zeviani, M., & Spinazzola, A. (2003) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-003-0026-9 · Cited by 533 · see citing works

The immune response in autism: a new frontier for autism research

Ashwood, P., Wills, S., & Van de Water, J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205707 · Cited by 528 · see citing works

Incidence of autism spectrum disorders: Changes over time and their meaning*

Rutter, M. L. (2005) · Acta Paediatrica · doi:10.1111/j.1651-2227.2005.tb01779.x · Cited by 516 · see citing works

Citrin and aralar1 are Ca2+‐stimulated aspartate/glutamate transporters in mitochondria

Palmieri, L., Pardo, B., Lasorsa, F. M., del Arco, A., Kobayashi, K., Iijima, M., Runswick, M. J., Walker, J. E., Saheki, T., Satrústegui, J., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5060 · Cited by 504 · see citing works

Immunodeficiency in Protein Kinase Cβ-Deficient Mice

Leitges, M., Schmedt, C., Guinamard, R., Davoust, J. M., Schaal, S., Stabel, S., & Tarakhovsky, A. (1996) · Science · doi:10.1126/science.273.5276.788 · Cited by 440 · see citing works

Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin—the antioxidant proteins

Chauhan, A., Chauhan, V., Brown, W. T., & Cohen, I. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.038 · Cited by 424 · see citing works

Autism, the superior temporal sulcus and social perception

Zilbovicius, M., Meresse, I., Chabane, N., Brunelle, F., Samson, Y., & Boddaert, N. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.06.004 · Cited by 392 · see citing works

Mitochondrial disorders

Zeviani, M. (2004) · Brain · doi:10.1093/brain/awh259 · Cited by 387 · see citing works

Immune transcriptome alterations in the temporal cortex of subjects with autism

Garbett, K., Ebert, P. J., Mitchell, A., Lintas, C., Manzi, B., Mirnics, K., & Persico, A. M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.01.012 · Cited by 375 · cited 4× · see citing works

Troponin and Parvalbumin Calcium Binding Regions Predicted in Myosin Light Chain and T4 Lysozyme

Tufty, R. M., & Kretsinger, R. H. (1975) · Science · doi:10.1126/science.1111094 · Cited by 375 · see citing works

Mitochondrial dysfunction in autism spectrum disorders: a population-based study

Oliveira, G., Diogo, L. M., Grazina, M. M., Garcia, P., Ataíde, A., Marques, C., Miguel, T., Borges, L., Vicente, A., & Oliveira, C. R. (2005) · Developmental Medicine & Child Neurology · doi:10.1017/s0012162205000332 · Cited by 267 · see citing works

Mitochondrial Disease in Autism Spectrum Disorder Patients: A Cohort Analysis

Weissman, J. R., Kelley, R. I., Bauman, M. L., Cohen, B. H., Murray, K. F., Mitchell, R. L., Kern, R. L., & Natowicz, M. R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003815 · Cited by 264 · see citing works

Mitochondrial transporters as novel targets for intracellular calcium signaling.

Satrústegui, J., Pardo, B., & del Arco, A. (2007) · Physiological Reviews · doi:10.1152/physrev.00005.2006 · Cited by 256 · see citing works

Dual Effects of Antioxidants in Neurodegeneration: Direct Neuroprotection against Oxidative Stress and Indirect Protection via Suppression of Gliamediated Inflammation

Wang, J.-Y., Wen, L. L., Huang, Y.-N., Chen, Y.-T., & Ku, M.-C. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206778343109 · Cited by 250 · see citing works

Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism

Zoroğlu, S. S., Armutçu, F., Özen, Ş., Gürel, A., Sivaslı, E., Yetkin, O., & Meram, İ. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0456-7 · Cited by 235 · see citing works

Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism

James, S. J., Rose, S., Melnyk, S., Jernigan, S., Blossom, S. J., Pavliv, O., & Gaylor, D. W. (2009) · The FASEB Journal · doi:10.1096/fj.08-128926 · Cited by 223 · see citing works

Metabolic biomarkers related to oxidative stress and antioxidant status in Saudi autistic children

Al-Gadani, Y., El-Ansary, A. K., Al-Attas, O., & AL-Ayadhi, L. Y. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.03.011 · Cited by 216 · see citing works

Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1

Palmieri, L., Papaleo, V., Porcelli, V., Scarcia, P., Gaita, L., Sacco, R., Hager, J., Rousseau, F., Curatolo, P., Manzi, B., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.63 · Cited by 210 · see citing works

Investigation of antioxidant enzymes in children with autistic disorder

Yorbık, Ö., Sayal, A., Akay, C., Akbiyik, D. I., & Söhmen, T. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2002.0439 · Cited by 207 · see citing works

Linkage and Association of the Mitochondrial Aspartate/Glutamate Carrier SLC25A12 Gene With Autism

Ramoz, N., Reichert, J. G., Smith, C. J., Silverman, J. M., Bespalova, I. N., Davis, K. L., & Buxbaum, J. D. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.662 · Cited by 206 · see citing works

Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: Their Relationship to Gastrointestinal Symptoms and Dietary Intervention

Jyonouchi, H., Geng, L., Ruby, A., & Zimmerman-Bier, B. (2005) · Neuropsychobiology · doi:10.1159/000084164 · Cited by 201 · see citing works

Relative Carnitine Deficiency in Autism

Filipek, P. A., Juranek, J. J., Nguyen, M. T., Cummings, C., & Gargus, J. J. (2004) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-004-5283-1 · Cited by 197 · see citing works

Biomarkers of environmental toxicity and susceptibility in autism

Geier, D. A., Kern, J. K., Garver, C. R., Adams, J. B., AUDHYA, T. K., Nataf, R., & Geier, M. R. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.08.021 · Cited by 196 · see citing works

Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cβ–Null Mice

Ohshiro, Y., Ronald, C. W., Yasuda, Y., Hiraoka‐Yamamoto, J., Clermont, A. C., Isshiki, K., Yagi, K., Arikawa, E., Kern, T. S., & King, G. L. (2006) · Diabetes · doi:10.2337/db06-0895 · Cited by 189 · see citing works

A preliminary 31P MRS study of autism: Evidence for undersynthesis and increased degradation of brain membranes

Minshew, N. J., Goldstein, G., Dombrowski, S. M., Panchalingam, K., & Pettegrew, J. W. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90017-8 · Cited by 185 · see citing works

Association of a Functional Deficit of the BK Ca Channel, a Synaptic Regulator of Neuronal Excitability, With Autism and Mental Retardation

Laumonnier, F., Roger, S., Guérin, P., Molinari, F., Mrad, R., Cahard, D., Belhadj, A., Halayem, M. B., Persico, A. M., Elia, M., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1622 · Cited by 180 · see citing works

Autistic phenotypes and genetic testing: state-of-the-art for the clinical geneticist

Lintas, C., & Persico, A. M. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.060871 · Cited by 178 · see citing works

Eshkol–Wachman movement notation in diagnosis: The early detection of Asperger's syndrome

Teitelbaum, O., Benton, T., Shah, P. K., Prince, A., Kelly, J. L., & Teitelbaum, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403919101 · Cited by 177 · see citing works

AGC1 Deficiency Associated with Global Cerebral Hypomyelination

Wibom, R., Lasorsa, F. M., Töhönen, V., Barbaro, M., Sterky, F. H., Kucinski, T., Naess, K., Jönsson, M., Pierri, C. L., Palmieri, F., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900591 · Cited by 175 · see citing works

Autism Associated With the Mitochondrial DNA G8363A Transfer RNALys Mutation

Graf, W. D., Marı́n-Garcı́a, J., Gao, H.-G., Pizzo, S., Naviaux, R. K., Markusic, D. M., Barshop, B. A., Courchesne, E., & Haas, R. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500601 · Cited by 174 · see citing works

Evidence of altered energy metabolism in autistic children

Chugani, D. C., Sundram, B. S., Behen, M. E., Lee, M.-L., & Moore, G. J. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00022-6 · Cited by 169 · see citing works

Molecular mechanisms of autism: a possible role for Ca2+ signaling

Krey, J. F., & Dolmetsch, R. E. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.010 · Cited by 169 · see citing works

Reduced N-Acetylaspartate Levels in Mice Lacking Aralar, a Brain- and Muscle-type Mitochondrial Aspartate-glutamate Carrier

Jalil, M. A., Begum, L., Contreras, L., Pardo, B., Iijima, M., Li, M. X., Ramos, M., Mármol, P., Horiuchi, M., Shimotsu, K., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505286200 · Cited by 165 · see citing works

Why Bother About Clumsiness? The Implications of HavingDevelopmental Coordination Disorder (DCD)

Gillberg, C., & Kadesjö, B. (2003) · Neural Plasticity · doi:10.1155/np.2003.59 · Cited by 164 · see citing works

Autism: a mitochondrial disorder?

Lombard, J. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90270-5 · Cited by 158 · see citing works

Clinical presentation of mitochondrial disorders in childhood

Münnich, A., Rötig, A., Chrétien, D., Cormier‐Daire, V., Bourgeron, T., Bonnefont, J., Saudubray, J., & Rustin, P. (1996) · Journal of Inherited Metabolic Disease · doi:10.1007/bf01799112 · Cited by 154 · see citing works

Autism associated with conditions characterized by developmental errors in early embryogenesis: a mini review

Miller, M. T., Strömland, K., Ventura, L. O., Johansson, M., Bandim, J. M., & Gillberg, C. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.06.007 · Cited by 153 · see citing works

Mitochondrial dysfunction in autistic patients with 15q inverted duplication

Filipek, P. A., Juranek, J. J., Smith, M., Mays, L. Z., Ramos, E. R., Bocian, M. E., Masser‐Frye, D., Laulhere, T. M., Modahl, C., Spence, M. A., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10596 · Cited by 149 · see citing works

Oxidative Stress Induces Increase in Intracellular Amyloid β-Protein Production and Selective Activation of βI and βII PKCs in NT2 Cells

Paola, D., Domenicotti, C., Nitti, M., Vitali, A., Borghi, R., Cottalasso, D., Zaccheo, D., Odetti, P. R., Strocchi, P., Marinari, U. M., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2756 · Cited by 146 · see citing works

Oxidative Stress Induces Increase in Intracellular Amyloid β-Protein Production and Selective Activation of βI and βII PKCs in NT2 Cells

Paola, D., Domenicotti, C., Nitti, M., Vitali, A., Borghi, R., Cottalasso, D., Zaccheo, D., Odetti, P. R., Strocchi, P., Marinari, U. M., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2164 · Cited by 145 · see citing works

Mitochondrial Dysfunction in Patients With Hypotonia, Epilepsy, Autism, and Developmental Delay: HEADD Syndrome

Filiano, J. J., Goldenthal, M. J., Rhodes, C. H., & Marı́n-Garcı́a, J. (2002) · Journal of Child Neurology · doi:10.1177/088307380201700607 · Cited by 143 · see citing works

Autism and lactic acidosis

Coleman, M., & Blass, J. P. (1985) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01837894 · Cited by 140 · see citing works

Mitochondrial DNA abnormalities and autistic spectrum disorders

Pons, R. M., Andreu, A. L., Checcarelli, N., Vilà, M. R., Engelstad, K., Sue, C. M., Shungu, D. C., Haggerty, R., Vivo, D. C. D., & DiMauro, S. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.10.023 · Cited by 138 · see citing works

Recombinant Expression of the Ca2+-sensitive Aspartate/Glutamate Carrier Increases Mitochondrial ATP Production in Agonist-stimulated Chinese Hamster Ovary Cells

Lasorsa, F. M., Pinton, P., Palmieri, L., Fiermonte, G., Rizzuto, R., & Palmieri, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304988200 · Cited by 138 · see citing works

Altered Vascular Phenotype in Autism

Yao, Y., Walsh, W. J., McGinnis, W. R., & Praticò, D. (2006) · Archives of Neurology · doi:10.1001/archneur.63.8.1161 · Cited by 131 · see citing works

Expression and Maintenance of Mitochondrial DNA

Shadel, G. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071163 · Cited by 120 · see citing works

Clinical, Morphological, and Biochemical Correlates of Head Circumference in Autism

Sacco, R., Militerni, R., Frolli, A., Bravaccio, C., Gritti, A., Elia, M., Curatolo, P., Manzi, B., Trillo, S., Lenti, C., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.039 · Cited by 120 · see citing works

The uncoupling protein 2 modulates the cytokine balance in innate immunity☆

ROUSSET, S., EMRE, Y., JOINLAMBERT, O., HURTAUD, C., RICQUIER, D., & CASSARDDOULCIER, A. (2006) · Cytokine · doi:10.1016/j.cyto.2006.07.012 · Cited by 114 · see citing works

Brief Report: High Frequency of Biochemical Markers for Mitochondrial Dysfunction in Autism: No Association with the Mitochondrial Aspartate/Glutamate Carrier SLC25A12 Gene

Correia, C., Coutinho, A. M., Diogo, L. M., Grazina, M. M., Marques, C., Miguel, T. S., Ataíde, A., Almeida, J., Borges, L., Oliveira, C. R., et al. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0138-6 · Cited by 114 · see citing works

Fever Plus Mitochondrial Disease Could Be Risk Factors for Autistic Regression

Shoffner, J. M., Hyams, L., Langley, G. N., Cossette, S., Mylacraine, L., Dale, J., Ollis, L., Kuoch, S., Bennett, K., Aliberti, A., et al. (2009) · Journal of Child Neurology · doi:10.1177/0883073809342128 · Cited by 109 · see citing works

Oxidative stress modulation and T cell activation

Larbi, A., Kempf, J., & Pawelec, G. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.004 · Cited by 102 · cited 1× · see citing works

Novel plasma phospholipid biomarkers of autism: Mitochondrial dysfunction as a putative causative mechanism

Pastural, É., Ritchie, S. A., Lu, Y., Jin, W., Kavianpour, A., Su-Myat, K. K., Heath, D., Wood, P. L., Fisk, M., & Goodenowe, D. B. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.06.003 · Cited by 100 · see citing works

SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects

Lepagnol-Bestel, A.-M., Maussion, G., Boda, B., Cardona, A., Iwayama, Y., Delezoide, A.-L., Moalic, J.-M., Muller, D., Dean, B., Yoshikawa, T., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002120 · Cited by 93 · see citing works

Metabolic biomarkers related to energy metabolism in Saudi autistic children

Al-Mosalem, O. A., El-Ansary, A. K., Al-Attas, O., & AL-Ayadhi, L. Y. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.04.006 · Cited by 80 · see citing works

Clinical manifestations of a unique X‐linked retinal disorder in a large New Zealand family with a novel mutation in CACNA1F, the gene responsible for CSNB2

Hope, C., Sharp, D. M., Hemara‐Wahanui, A., Sissingh, J. I., Lundon-Treweek, P., Mitchell, E. A., Maw, M. A., & Clover, G. M. (2005) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2005.00987.x · Cited by 80 · see citing works

Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression

Lintas, C., Sacco, R., Garbett, K. A., Mirnics, K., Militerni, R., Bravaccio, C., Curatolo, P., Manzi, B., Schneider, C., Melmed, R. D., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.21 · Cited by 80 · see citing works

Serum serotonin, lactate and pyruvate levels in infantile autistic children

László, A., Horváth, E., Eck, E., & Fekete, M. (1994) · Clinica Chimica Acta · doi:10.1016/0009-8981(94)90243-7 · Cited by 75 · see citing works

HCV infection induces mitochondrial bioenergetic unbalance: Causes and effects

Piccoli, C., Quarato, G., Ripoli, M. C., D’Aprile, A., Scrima, R., Cela, O., Boffoli, D., Moradpour, D., & Capitanio, N. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.11.008 · Cited by 68 · see citing works

Slc25a12 Disruption Alters Myelination and Neurofilaments: A Model for a Hypomyelination Syndrome and Childhood Neurodevelopmental Disorders

Sakurai, T., Ramoz, N., Barreto, M., Gazdoiu, M., Takahashi, N., Gertner, M. J., Dorr, N. P., Sosa, M. A. G., Gasperi, R. D., Perez, G. M., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.042 · Cited by 68 · see citing works

Nuclear and Mitochondrial Genome Defects in Autisms

Smith, M., Spence, M. A., & Flodman, P. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03571.x · Cited by 67 · see citing works

Neurologic Presentations of Mitochondrial Disorders

Nissenkorn, A., Zeharia, A., Lev, D., Watemberg, N. M., Fattal‐Valevski, A., Barash, V., Gutman, A., Harel, S., & Lerman‐Sagie, T. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500110 · Cited by 66 · see citing works

Neuroimaging in Infantile Autism

Schifter, T., Hoffman, J. M., Hatten, H. P., Hanson, M. W., Coleman, R. E., & DeLong, G. R. (1994) · Journal of Child Neurology · doi:10.1177/088307389400900210 · Cited by 65 · see citing works

Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding

Domenicotti, C., Paola, D., Vitali, A., Nitti, M., d’Abramo, C., Cottalasso, D., Maloberti, G., Biasi, F., Poli, G., Chiarpotto, E., et al. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00429-9 · Cited by 53 · see citing works

Mitochondrial disorders

Zeviani, M., & Carelli, V. (2003) · Current Opinion in Neurology · doi:10.1097/00019052-200310000-00004 · Cited by 53 · see citing works

Protein Kinase C β Inhibitor LY333531 Attenuates Intercellular Adhesion Molecule-1 and Monocyte Chemotactic Protein-1 Expression in the Kidney in Diabetic Rats

Wu, Y., Wu, G., Qi, X., Lin, H., Qian, H., Shen, J., & Lin, S. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0050896 · Cited by 50 · see citing works

Decreased serum arylesterase activity in autism spectrum disorders

Gaita, L., Manzi, B., Sacco, R., Lintas, C., Altieri, L., Lombardi, F., Pawlowski, T. L., Redman, M., Craig, D. W., Huentelman, M. J., et al. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.04.010 · Cited by 39 · see citing works

Autistic Disorder in 2 Children With Mitochondrial Disorders

Tsao, C., & Mendell, J. R. (2007) · Journal of Child Neurology · doi:10.1177/0883073807306266 · Cited by 37 · see citing works

Paraoxonase 1 activities and polymorphisms in autism spectrum disorders

Pașca, S. P., Dronca, E., Nemeş, B., Kaucsár, T., Endreffy, E., Iftene, F., Benga, I., Cornean, R., & Dronca, M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00414.x · Cited by 28 · see citing works

An investigation of mitochondrial haplogroups in autism

Kent, L., Gallagher, L., Elliott, H. R., Mowbray, C., & Chinnery, P. F. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30687 · Cited by 23 · see citing works

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 913 · see citing works

Consensus Paper: Pathological Role of the Cerebellum in Autism

Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723 · see citing works

The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders

Loth, E., Charman, T., Mason, L., Tillmann, J., Jones, E. J. H., Wooldridge, C., Ahmad, J., Auyeung, B., Brogna, C., Ambrosino, S., et al. (2017) · Molecular Autism · doi:10.1186/s13229-017-0146-8 · Cited by 299 · see citing works

Autism genetics

Persico, A. M., & Napolioni, V. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.06.012 · Cited by 242 · see citing works

Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements.

Nicolson, G. L. (2014) · PubMed Central · Cited by 235 · see citing works

Biomarkers in Autism

Goldani, A. A. S., Downs, S. R., Widjaja, F., Lawton, B., & Hendren, R. L. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00100 · Cited by 204 · see citing works

Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: An overview of Down syndrome, autism, Fragile X and Rett syndrome

Valenti, D., Lidia de, B. A. R. I., Filippis, B. D., Henrion‐Caude, A., & Vacca, R. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.012 · Cited by 190 · see citing works

Mitochondrial Dysfunction as a Neurobiological Subtype of Autism Spectrum Disorder

Goh, S., Dong, Z., Zhang, Y., DiMauro, S., & Peterson, B. S. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.179 · Cited by 164 · see citing works

Alterations in mitochondrial DNA copy number and the activities of electron transport chain complexes and pyruvate dehydrogenase in the frontal cortex from subjects with autism

Gu, F., Chauhan, V. P. S., Kaur, K., Brown, W. T., LaFauci, G., Węgiel, J., & Chauhan, A. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.68 · Cited by 161 · see citing works

Perinatal stress, brain inflammation and risk of autism-Review and proposal

Angelidou, A., Asadi, S., Alysandratos, K., Karagkouni, A., Kourembanas, S., & Theoharides, T. C. (2012) · BMC Pediatrics · doi:10.1186/1471-2431-12-89 · Cited by 153 · see citing works

Brain region-specific altered expression and association of mitochondria-related genes in autism

Anitha, A., Nakamura, K., Thanseem, I., Yamada, K., Iwayama, Y., Toyota, T., Matsuzaki, H., Miyachi, T., Yamada, S., Tsujii, M., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-12 · Cited by 148 · see citing works

Mitochondrial Dysfunction in Autism Spectrum Disorders

SIDDIQUI, M., Elwell, C. E., & Johnson, M. H. (2016) · Autism - Open Access · doi:10.4172/2165-7890.1000190 · Cited by 138 · see citing works

Glutathione-Related Factors and Oxidative Stress in Autism, A Review

Ghanizadeh, A. J., Akhondzadeh, S., Hormozi, M., Makarem, A., Zarchi, M. A., & Firoozabadi, A. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712802002572 · Cited by 134 · see citing works

Mast cell activation and autism

Theoharides, T. C., Angelidou, A., Alysandratos, K.-D., Zhang, B., Asadi, S., Francis, K., Toniato, E., & Kalogeromitros, D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.017 · Cited by 125 · see citing works

Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome

Sotelo-Orozco, J., Hertz‐Picciotto, I., Abbeduto, L., & Slupsky, C. M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0578-3 · Cited by 117 · see citing works

Metabolic and mitochondrial disorders associated with epilepsy in children with Autism Spectrum Disorder

Frye, R. E. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.08.134 · Cited by 117 · see citing works

The Parvalbumin Hypothesis of Autism Spectrum Disorder

Filice, F., Janickova, L., Henzi, T., Bilella, A., & Schwaller, B. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.577525 · Cited by 112 · see citing works

The glial perspective of autism spectrum disorders

Zeidán‐Chuliá, F., Salmina, A. B., Malinovskaya, N. A., Noda, M., Verkhratsky, A., & Moreira, J. C. F. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.008 · Cited by 111 · see citing works

The neurobiology of acetyl-L-carnitine

Traina, G. (2016) · Frontiers in bioscience · doi:10.2741/4459 · Cited by 109 · see citing works

Downregulation of the Expression of Mitochondrial Electron Transport Complex Genes in Autism Brains

Anitha, A., Nakamura, K., Thanseem, I., Matsuzaki, H., Miyachi, T., Tsujii, M., Iwata, Y., Suzuki, K., Sugiyama, T., & Mori, N. (2012) · Brain Pathology · doi:10.1111/bpa.12002 · Cited by 109 · see citing works

Mitochondrial function and abnormalities implicated in the pathogenesis of ASD

Castora, F. J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.015 · Cited by 104 · see citing works

The neurobiology of autism spectrum disorders

Parellada, M., Penzol, M. J., Pina‐Camacho, L., Moreno, C., González‐Vioque, E., Zalsman, G., & Arango, C. (2013) · European Psychiatry · doi:10.1016/j.eurpsy.2013.02.005 · Cited by 101 · see citing works

Evidence of parallels between mercury intoxication and the brain pathology in autism

Kern, J. K., Geier, D. A., AUDHYA, T. K., King, P. G., Sykes, L. K., & Geier, M. R. (2012) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2012-1887 · Cited by 100 · see citing works

Resveratrol suppresses neuroinflammation in the experimental paradigm of autism spectrum disorders

Bhandari, R., & Kuhad, A. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.012 · Cited by 100 · see citing works

Genome-wide expression studies in Autism spectrum disorder, Rett syndrome, and Down syndrome

Lintas, C., Sacco, R., & Persico, A. M. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.11.010 · Cited by 96 · see citing works

Identification and treatment of pathophysiological comorbidities of autism spectrum disorder to achieve optimal outcomes

Frye, R. E., & Rossignol, D. A. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38337 · Cited by 96 · see citing works

Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia

Al-Yafee, Y. A., AL-Ayadhi, L. Y., Haq, S. H., & El-Ansary, A. K. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-139 · Cited by 93 · see citing works

Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children

Zhang, B., Angelidou, A., Alysandratos, K., Vasiadi, M., Francis, K., Asadi, S., Theoharides, A., Sideri, K., Lykouras, L., Kalogeromitros, D. C., et al. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-80 · Cited by 93 · see citing works

Animal model of autism induced by prenatal exposure to valproate: Altered glutamate metabolism in the hippocampus

Silvestrin, R. B., Bambini-Júnior, V., Galland, F., Bobermin, L. D., Quincozes‐Santos, A., Abib, R. T., Zanotto, C., Batassini, C., Brolese, G., Gonçalves, C., et al. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.048 · Cited by 91 · see citing works

Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies

Jha, M. K., Lee, I., & Suk, K. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.006 · Cited by 89 · see citing works

Mitochondrial Dysfunction in Autism

Legido, A., Jethva, R., & Goldenthal, M. J. (2013) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2013.10.008 · Cited by 90 · see citing works

Neuropsychopharmacotherapeutic efficacy of curcumin in experimental paradigm of autism spectrum disorders

Bhandari, R., & Kuhad, A. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.09.012 · Cited by 84 · see citing works

Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders

STRECK, E. L., Gonçalves, C. L., Furlanetto, C. B., Scaini, G., Dal‐Pizzol, F., & Quevedo, J. (2014) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1224 · Cited by 82 · see citing works

Proteomic analysis of post mortem brain tissue from autism patients: evidence for opposite changes in prefrontal cortex and cerebellum in synaptic connectivity-related proteins

Broek, J. A. C., Guest, P. C., Rahmoune, H., & Bahn, S. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-41 · Cited by 79 · see citing works

Measuring the Maturity of the Fast-Spiking Interneuron Transcriptional Program in Autism, Schizophrenia, and Bipolar Disorder

Gandal, M. J., Nesbitt, A. M., McCurdy, R. M., & Alter, M. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041215 · Cited by 67 · see citing works

The Mitochondrial Aspartate/Glutamate Carrier AGC1 and Calcium Homeostasis: Physiological Links and Abnormalities in Autism

Napolioni, V., Persico, A. M., Porcelli, V., & Palmieri, L. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8192-2 · Cited by 70 · see citing works

Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey

Frye, R. E., Sreenivasula, S., & Adams, J. B. (2011) · BMC Pediatrics · doi:10.1186/1471-2431-11-37 · Cited by 68 · see citing works

Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders

Stamova, B. S., Tian, Y., Nordahl, C. W., Shen, M. D., Rogers, S. J., Amaral, D. G., & Sharp, F. R. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-30 · Cited by 68 · see citing works

The inflammatory event of birth: How oxytocin signaling may guide the development of the brain and gastrointestinal system

Kingsbury, M. A., & Bilbo, S. D. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100794 · Cited by 64 · see citing works

Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin

Asadi, S., & Theoharides, T. C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-85 · Cited by 64 · see citing works

Molecular and biological functions of resveratrol in psychiatric disorders: a review of recent evidence

Shayganfard, M. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00491-3 · Cited by 61 · see citing works

Converging Evidence for an Association of ATP2B2 Allelic Variants with Autism in Male Subjects

Carayol, J., Sacco, R., Tores, F., Rousseau, F., Lewin, P., Hager, J., & Persico, A. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.020 · Cited by 59 · see citing works

The control of brain mitochondrial energization by cytosolic calcium: The mitochondrial gas pedal

Gellerich, F. N., Gizatullina, Z. Z., Gainutdinov, T. M., Muth, K. N., Seppet, E. K., Orynbayeva, Z., & Vielhaber, S. (2013) · IUBMB Life · doi:10.1002/iub.1131 · Cited by 59 · see citing works

Mitochondrial dysfunction and autism: comprehensive genetic analyses of children with autism and mtDNA deletion

Varga, N. Á., Pentelényi, K., Balicza, P., Gézsi, A., Reményi, V., Hársfalvi, V., Bencsik, R., Illés, A., Prekop, C., & Molnár, M. J. (2018) · Behavioral and Brain Functions · doi:10.1186/s12993-018-0135-x · Cited by 59 · see citing works

Cross-talk between HPA-axis-increased glucocorticoids and mitochondrial stress determines immune responses and clinical manifestations of patients with sepsis

Kasahara, E., & Inoue, M. (2014) · Redox Report · doi:10.1179/1351000214y.0000000107 · Cited by 60 · see citing works

Bridging the Gap Between Physical Health and Autism Spectrum Disorder

Sala, R., Amet, L., Blagojevic-Stokic, N., Shattock, P., & Whiteley, P. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s251394 · Cited by 61 · see citing works

Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches

Hassan, M. H., Desoky, T., Sakhr, H. M., Gabra, R. H., & Bakri, A. H. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1225-9 · Cited by 56 · see citing works

Analyzing the Potential Biological Determinants of Autism Spectrum Disorder: From Neuroinflammation to the Kynurenine Pathway

Savino, R., Carotenuto, M., Polito, A. N., Noia, S. D., Albenzio, M., Scarinci, A., Ambrosi, A., Sessa, F., Tartaglia, N., & Messina, G. (2020) · Brain Sciences · doi:10.3390/brainsci10090631 · Cited by 54 · see citing works

Predicting Autism Spectrum Disorder Using Blood-based Gene Expression Signatures and Machine Learning

Oh, D. H., Kim, I. B., Kim, S. H., & Ahn, D. H. (2017) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2017.15.1.47 · Cited by 53 · see citing works

Combined 1 H-NMR and 1 H– 13 C HSQC-NMR to improve urinary screening in autism spectrum disorders

Nadal‐Desbarats, L., Aïdoud, N., Emond, P., Blasco, H., Filipiak, I., Sarda, P., Bonnet‐Brilhault, F., Mavel, S., & Andres, C. R. (2014) · The Analyst · doi:10.1039/c4an00552j · Cited by 51 · see citing works

Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia

El-Ansary, A. K., Bacha, A. G. B., & AL-Ayadhi, L. Y. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-142 · Cited by 50 · see citing works

Non-protein-bound iron and 4-hydroxynonenal protein adducts in classic autism

Pecorelli, A., Leoncini, S., Felice, C. D., Signorini, C., Cerrone, C., Valacchi, G., Ciccoli, L., & Hayek, J. (2012) · Brain and Development · doi:10.1016/j.braindev.2012.03.011 · Cited by 49 · see citing works

Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, andβ-Actin Alterations: An Unrecognized Triad in Classical Autism

Ciccoli, L., Felice, C. D., Paccagnini, E., Leoncini, S., Pecorelli, A., Signorini, C., Belmonte, G., Guerranti, R., Cortelazzo, A., Gentile, M., et al. (2013) · Mediators of Inflammation · doi:10.1155/2013/432616 · Cited by 47 · see citing works

Modeling autism: a systems biology approach

Randolph-Gips, M. M., & Srinivasan, P. N. (2012) · Journal of Clinical Bioinformatics · doi:10.1186/2043-9113-2-17 · Cited by 48 · see citing works

Redox proteomic identification of carbonylated proteins in autism plasma: insight into oxidative stress and its related biomarkers in autism

Feng, C., Chen, Y., Pan, J., Yang, A., Niu, L., Min, J., Meng, X., Liao, L., Zhang, K., & Shen, L. (2017) · Clinical Proteomics · doi:10.1186/s12014-017-9138-0 · Cited by 47 · see citing works

Mitochondrial dysfunction in cognitive neurodevelopmental disorders: Cause or effect?

Anitha, A., Thanseem, I., Iype, M., & Thomas, S. V. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.01.002 · Cited by 47 · see citing works

Expression and oxidative modifications of plasma proteins in autism spectrum disorders: Interplay between inflammatory response and lipid peroxidation

Cortelazzo, A., Felice, C. D., Guerranti, R., Signorini, C., Leoncini, S., Zollo, G., Leoncini, R., Timperio, A. M., Zolla, L., Ciccoli, L., et al. (2016) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500076 · Cited by 46 · see citing works

Recent update of autism spectrum disorders

Kim, S. K. (2015) · Korean Journal of Pediatrics · doi:10.3345/kjp.2015.58.1.8 · Cited by 43 · see citing works

Higher Lactate Level and Lactate-to-Pyruvate Ratio in Autism Spectrum Disorder

Oh, M., Kim, S. A., & Yoo, H. J. (2020) · Experimental Neurobiology · doi:10.5607/en20030 · Cited by 40 · see citing works

Mitochondrial Dysfunction and Its Relationship with mTOR Signaling and Oxidative Damage in Autism Spectrum Disorders

Yui, K., Sato, A., & Imataka, G. (2015) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557515666150324122930 · Cited by 41 · see citing works

Autism Spectrum Disorder

Bertelli, M. O., Azeem, M. W., Underwood, L., Scattoni, M. L., Persico, A. M., Ricciardello, A., Sappok, T., Bergmann, T. J., Keller, R., Bianco, A., et al. (2022) · Springer eBooks · doi:10.1007/978-3-319-95720-3_16 · Cited by 41 · see citing works

Resveratrol in Autism Spectrum Disorders: Behavioral and Molecular Effects

Malaguarnera, M., Khan, H. Z., & Cauli, O. (2020) · Antioxidants · doi:10.3390/antiox9030188 · Cited by 38 · see citing works

Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation

Aguirre, A., Maturana, C. J., Harcha, P. A., & Sáez, J. C. (2013) · Mediators of Inflammation · doi:10.1155/2013/893521 · Cited by 37 · see citing works

Frequency and association of mitochondrial genetic variants with neurological disorders

da Cruz, A. C. P., Ferrasa, A., Muotri, A. R., & Herai, R. H. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.09.005 · Cited by 37 · see citing works

Autism and EMF? Plausibility of a pathophysiological link – Part I

Herbert, M. R., & Sage, C. (2013) · Pathophysiology · doi:10.1016/j.pathophys.2013.08.001 · Cited by 35 · see citing works

Oxidative pathways as a drug target for the treatment of autism

Villagonzalo, K.-A., Dodd, S., Dean, O. M., Gray, K. M., Tonge, B. J., & Berk, M. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.528394 · Cited by 36 · see citing works

The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice

Sobolewski, M., Conrad, K., Marvin, E., Eckard, M. L., Goeke, C. M., Merrill, A. K., Welle, K. A., Jackson, B. P., Gelein, R. M., Chalupa, D., et al. (2022) · Particle and Fibre Toxicology · doi:10.1186/s12989-022-00496-5 · Cited by 36 · see citing works

The Spectrum of Autism Spectrum Disorder: A Spectrum of Needs, Services, and Challenges

Jensen, V. K., & Spannagel, S. C. (2010) · Journal of Contemporary Psychotherapy · doi:10.1007/s10879-010-9161-1 · Cited by 35 · see citing works

MELAS syndrome, cardiomyopathy, rhabdomyolysis, and autism associated with the A3260G mitochondrial DNA mutation

Connolly, B. S., Feigenbaum, A. S. J., Robinson, B. H., Dipchand, A. I., Simon, D. K., & Tarnopolsky, M. A. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.060 · Cited by 35 · see citing works

Reassessing the role of mitochondrial DNA mutations in autism spectrum disorder

Álvarez‐Iglesias, V., Mosquera‐Miguel, A., Cuscó, I., Carracedo, Á., Jurado, L. A. P., & Salas, A. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-50 · Cited by 34 · see citing works

Dysfunction in Mitochondrial Electron Transport Chain Complex I, Pyruvate Dehydrogenase Activity, and Mutations in ND1 and ND4 Gene in Autism Spectrum Disorder Subjects from Tamil Nadu Population, India

Iyer, M., Subramaniam, M. D., Gopalakrishnan, A. V., & Vellingiri, B. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02492-w · Cited by 32 · see citing works

Integrating mitochondriomics in children's environmental health

Brunst, K. J., Baccarelli, A., & Wright, R. J. (2015) · Journal of Applied Toxicology · doi:10.1002/jat.3182 · Cited by 32 · see citing works

Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Janickova, L., Rechberger, K. F., Wey, L., & Schwaller, B. (2020) · Molecular Autism · doi:10.1186/s13229-020-00323-8 · Cited by 30 · see citing works

Decreased Mitochondrial Function and Increased Brain Inflammation in Bipolar Disorder and Other Neuropsychiatric Diseases

Theoharides, T. C., Zhang, B., & Conti, P. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318239c190 · Cited by 30 · see citing works

Methylglyoxal, advanced glycation end products and autism: Is there a connection?

Maher, P. A. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.01.032 · Cited by 29 · see citing works

Glutamatergic medication in the treatment of obsessive compulsive disorder (OCD) and autism spectrum disorder (ASD) – study protocol for a randomised controlled trial

Häge, A., Banaschewski, T., Buitelaar, J. K., Dijkhuizen, R. M., Franke, B., Lythgoe, D. J., Mechler, K., Williams, S., & Dittmann, R. (2016) · Trials · doi:10.1186/s13063-016-1266-8 · Cited by 29 · see citing works

Associations among exposure to methylmercury, reduced Reelin expression, and gender in the cerebellum of developing mice

Biamonte, F., Latini, L., Giorgi, F. S., Zingariello, M., Marino, R., Luca, R. D., D’Ilio, S., Majorani, C., Petrucci, F., Violante, N., et al. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.09.006 · Cited by 27 · see citing works

T. gondii Infection Acquired during Pregnancy and/or after Birth may be Responsible for Development of both Type 1 and 2 Diabetes Mellitus

Prandota, J. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000241 · Cited by 27 · see citing works

A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics

AL-Ayadhi, L. Y., Bacha, A. G. B., Kotb, M., & El-Ansary, A. K. (2012) · Behavioral and Brain Functions · doi:10.1186/1744-9081-8-4 · Cited by 26 · see citing works

The Synaptic Dysregulation in Adolescent Rats Exposed to Maternal Immune Activation

Cieślik, M., Gąssowska-Dobrowolska, M., Zawadzka, A., Frontczak‐Baniewicz, M., Gewartowska, M., Dominiak, A., Czapski, G. A., & Adamczyk, A. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.555290 · Cited by 26 · see citing works

Autism and EMF? Plausibility of a pathophysiological link part II

Herbert, M. R., & Sage, C. (2013) · Pathophysiology · doi:10.1016/j.pathophys.2013.08.002 · Cited by 27 · see citing works

Dietary Phytochemicals as Neurotherapeutics for Autism Spectrum Disorder: Plausible Mechanism and Evidence

Bhandari, R., Paliwal, J. K., & Kuhad, A. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-30402-7_23 · Cited by 25 · see citing works

The GLO1 C332 (Ala111) allele confers autism vulnerability: Family-based genetic association and functional correlates

Gabriele, S., Lombardi, F., Sacco, R., Napolioni, V., Altieri, L., Tirindelli, M. C., Gregorj, C., Bravaccio, C., Rousseau, F., & Persico, A. M. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.07.021 · Cited by 25 · see citing works

Novel Interactive Partners of Neuroligin 3: New Aspects for Pathogenesis of Autism

Shen, C., Huo, L.-R., Zhao, X., Wang, P., & Zhong, N. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0470-9 · Cited by 23 · see citing works

A Link between Mitochondrial Dysregulation and Idiopathic Autism Spectrum Disorder (ASD): Alterations in Mitochondrial Respiratory Capacity and Membrane Potential

Hassan, H., Zakaria, F., Makpol, S., & Karim, N. A. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43030157 · Cited by 21 · see citing works

Efficacy and Safety of Q10 Ubiquinol With Vitamins B and E in Neurodevelopmental Disorders: A Retrospective Chart Review

Cucinotta, F., Ricciardello, A., Turriziani, L., Mancini, A., Keller, R., Sacco, R., & Persico, A. M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.829516 · Cited by 21 · see citing works

Treatment of Autism Spectrum Disorders by Mitochondrial-targeted Drug: Future of Neurological Diseases Therapeutics

Nabi, S. U., Rehman, M. U., Arafah, A. M., Taifa, S., Khan, I. S., Khan, A., Rashid, S., Jan, F., Wani, H. A., & Ahmad, S. F. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221121095618 · Cited by 21 · see citing works

Human Platelets as A Platform to Monitor Metabolic Biomarkers Using Stable Isotopes and LC–MS

Basu, S. S., Deutsch, E. C., Schmaier, A. A., Lynch, D. R., & Blair, I. A. (2013) · Bioanalysis · doi:10.4155/bio.13.269 · Cited by 20 · see citing works

Update on Atypicalities of Central Nervous System in Autism Spectrum Disorder

Shuid, A. N., Jayusman, P. A., Shuid, N., Ismail, J., Nor, N. K., & Mohamed, I. N. (2020) · Brain Sciences · doi:10.3390/brainsci10050309 · Cited by 20 · see citing works

Weak association of glyoxalase 1 (GLO1) variants with autism spectrum disorder

Kovač, J., Podkrajšek, K. T., Macedoni-Lukšič, M., & Battelino, T. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0537-8 · Cited by 19 · see citing works

Parvalbumin-Deficiency Accelerates the Age-Dependent ROS Production in Pvalb Neurons in vivo: Link to Neurodevelopmental Disorders

Janickova, L., & Schwaller, B. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.571216 · Cited by 18 · see citing works

Increased seroprevalence of chronic toxoplasmosis in autistic children: Special reference to the pathophysiology of IFN-g and NO overproduction

Prandota, J., Elleboudy, N., Ismail, K., Zaki, O. K., & Shehata, H. (2015) · International Journal of Neurology Research · doi:10.17554/j.issn.2313-5611.2015.01.30 · Cited by 16 · see citing works

Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure

Wong, S., & Giulivi, C. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160413122624 · Cited by 18 · see citing works

Phospholipidomics of peripheral blood mononuclear cells (PBMCs): the tricky case of children with autism spectrum disorder (ASD) and their healthy siblings

Ventura, G., Calvano, C. D., Porcelli, V., Palmieri, L., GIACOMO, A. D., Yun Xu, A., Goodacre, R., Palmisano, F., & Cataldi, T. R. I. (2020) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-020-02817-z · Cited by 18 · see citing works

The need for a comprehensive molecular characterization of autism spectrum disorders

Broek, J. A. C., Brombacher, E., Stelzhammer, V., Guest, P. C., Rahmoune, H., & Bahn, S. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571300117x · Cited by 16 · see citing works

Gold nanoparticles and lipoic acid as a novel anti-inflammatory treatment for autism, a hypothesis

Ghanizadeh, A. J. (2012) · Journal of Medical Hypotheses and Ideas · doi:10.1016/j.jmhi.2012.03.004 · Cited by 17 · see citing works

Mitochondrial DNA Mutations in two Bulgarian Children with Autistic Spectrum Disorders

Avdjieva-Tzavella, D. M., Mihailova, S., Lukanov, T., Naumova, E. J., Simeonov, E., Tincheva, R. S., & Toncheva, D. I. (2012) · Balkan Journal of Medical Genetics · doi:10.2478/bjmg-2013-0006 · Cited by 16 · see citing works

Synaptic Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders

Czapski, G. A., Babiec, L., Jęśko, H. M., Gąssowska-Dobrowolska, M., Cieślik, M., Matuszewska, M., Frontczak‐Baniewicz, M., Zajdel, K., & Adamczyk, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810058 · Cited by 15 · see citing works

Red Flags in Primary Mitochondrial Diseases: What Should We Recognize?

Conti, F., Martino, S. D., Drago, F., Bucolo, C., Micale, V., Montano, V., Siciliano, G., Mancuso, M., & Lopriore, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316746 · Cited by 14 · see citing works

Cell Therapy Targets for Autism Spectrum Disorders: Hopes, Challenges and Future Directions

Larijani, B. A., Heravani, N. F., Alavi-Moghadam, S., Goodarzi, P., Rezaei–Tavirani, M., Payab, M., Gholami, M., Razi, F., & Arjmand, B. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_491 · Cited by 14 · see citing works

Mitochondrial Dysfunction in Autism

Chauhan, A., Gu, F., & Chauhan, V. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_17

Autism: a mitochondrial disorder?

Lombard, J. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90270-5 · Cited by 158 · see citing works

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 913 · see citing works

Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives

Hollis, F., Kanellopoulos, A. K., & Bagni, C. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.05.018 · Cited by 121 · see citing works

Mitochondrial Deficits/Disorders

Kopel, J. J. (2019) · Springer eBooks · doi:10.1007/978-1-4614-6435-8_1520-3