CD38 is critical for social behaviour by regulating oxytocin secretion
Abstract
CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the formation of Ca2+ signalling molecules, but its role in the neuroendocrine system is unknown. Here we show that adult CD38 knockout (CD38-/-) female and male mice show marked defects in maternal nurturing and social behaviour, respectively, with higher locomotor activity. Consistently, the plasma level of oxytocin (OT), but not vasopressin, was strongly decreased in CD38-/- mice. Replacement of OT by subcutaneous injection or lentiviral-vector-mediated delivery of human CD38 in the hypothalamus rescued social memory and maternal care in CD38-/- mice. Depolarization-induced OT secretion and Ca2+ elevation in oxytocinergic neurohypophysial axon terminals were disrupted in CD38-/- mice; this was mimicked by CD38 metabolite antagonists in CD38+/+ mice. These results reveal that CD38 has a key role in neuropeptide release, thereby critically regulating maternal and social behaviours, and may be an element in neurodevelopmental disorders.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oxytocin receptor and D2 receptor activation must occur concurrently for partner preference to develop in female prairie voles.
“A seminal study showed that OTR and D2 receptor activation must occur concurrently for partner preference to develop in female prairie voles [66].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
Transmembrane glycoprotein CD38 plays a central role in oxytocin neuropathways and in the release of oxytocin from axon terminals.
“In addition, research has pointed to the central role of transmembrane glycoprotein CD38 in OT neuropathways and in the release of OT from axon terminalis (Jin et al., 2007), and recent findings showed associations between plasma OT, genetic variability in the CD38 rs3796863 SNP, and the degree of reciprocity and touch between parents and their infants (Feldman et al., in press), pointing to the”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Jin et al., 2007
Blockade of OTR in the NAcc shell prevented D2 receptor mediated partner preferences in female prairie voles.
“Blockade of D2 receptors in the NAcc shell prevented OT-mediated partner preferences, while blockade of OTR in the NAcc shell prevented D2 receptor mediated partner preferences in female prairie voles.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
Blockade of D2 receptors in the nucleus accumbens shell prevented oxytocin-mediated partner preferences.
“Blockade of D2 receptors in the NAcc shell prevented OT-mediated partner preferences,”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
Blockade of D2 receptors in the NAcc shell prevented OT-mediated partner preferences in female prairie voles.
“Blockade of D2 receptors in the NAcc shell prevented OT-mediated partner preferences, while blockade of OTR in the NAcc shell prevented D2 receptor mediated partner preferences in female prairie voles.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
CD38 uses NAD+ to synthesize cADPR and plays key roles in immunity, metabolism, inflammation, and social behaviors.
“CD38 catalyzes the synthesis of the Ca2+-responsive messenger cyclic ADP-ribose (cADPR) by use of NAD+ and plays a key role in multiple physiological processes such as immunity, metabolism, inflammation, and even social behaviors (Jin et al., 2007).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Jin et al., 2007
CD38 affects social behaviour, as does its homologue CD157.
“CD38 was also reported to affect social behaviour, as was its homologue CD157 (REFS166,167)”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [166]
Mice with impaired oxytocin release or signalling show impairments in maternal responsiveness.
“Mice with impaired OT release or signalling display impairments in maternal responsiveness (3,4).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [3]
The role of the OXT system has been investigated in rodent models, but uniquely using OXT-related mutant mice and giving OXT through intracerebroventricular (ICV), intraperitoneal (IP) and subcutaneous (SC) injections.
“The role of the OXT system has been investigated in rodent models, but uniquely using OXT-related mutant mice and giving OXT through intracerebroventricular (ICV), intraperitoneal (IP) and subcutaneous (SC) injections (Bielsky and Young, 2004;Jin et al, 2007;Popik et al, 1996;Sala et al, 2012;Sala et al, 2011;Takayanagi et al, 2005;Winslow and Insel, 2002).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Jin et al, 2007
CD38 is involved in oxytocin secretion via Ca2+ release.
“Specifically, CD38 is involved in oxytocin secretion via Ca2+ release15”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [15]
Peripheral oxytocin replacement restores normal maternal behaviour in Oxt−/− and Cd38−/− mice but not Oxtr−/− mice, implying that circulating oxytocin crosses the blood-brain barrier.
“Normal maternal behaviour is restored by peripheral oxcytocin replacement in Oxt−/− and Cd38−/−, but not Oxtr−/− mice, implying that circulating oxcytocin crosses the blood-brain barrier.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [5]
Loss of maternal nurturing and social interactive behaviours in Cd38−/− mice are restored following peripheral oxytocin, consistent with transport of peripherally administered oxytocin into the brain.
“Loss of maternal nurturing and social interactive behaviours in Cd38−/− mice have been restored following peripheral administration of oxytocin, consistent with transport of peripherally administered exogenous oxytocin into brain5.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [5]
In Fragile X syndrome, oxytocin administered to eight adolescent and adult males significantly increased overall eye gaze during a brief social interaction compared to placebo, and lower doses appeared to show a greater effect than higher doses.
“Compared to placebo, oxytocin administered to eight adolescent and adult males with FXS significantly increased overall eye gaze during a brief social interaction.59 Interestingly, lower doses of oxytocin in this sample appeared to show a greater effect than the higher administered dose, consistent with a recent study in healthy adults.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [60]
Recent investigations into dose-dependent effects of oxytocin on social cognition have demonstrated superior effects at lower (8 IU) doses.
“recent investigations into dose-dependent effects of oxytocin on social cognition have demonstrated superior effects at lower (8 IU) doses.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [60]
Initial evidence suggests that lower dose (8 IU) oxytocin delivered via the Breath Powered device is effective in modulating aspects of emotional behaviour.
“Initial evidence suggests that lower dose (8IU) oxytocin delivered via this device is effective in modulating aspects of emotional behaviour.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [60]
CD38 -/- mice have reduced OXT levels in the plasma and cerebrospinal fluid but elevated levels in the hypothalamus and pituitary tissues.
“In comparison with wild-type mice, CD38 -/-mice have reduced OXT levels in the plasma and cerebrospinal fluid (CSF) (Jin et al., 2007) but elevated levels in the hypothalamus and pituitary tissues.”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
CD38 is required for normal social behavior in mice.
“It is also required for normal social behavior in mice (Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
CD38 is required for some social behaviors in mice via the regulation of OXT secretion from the hypothalamus and pituitary.
“We have recently shown that CD38 is required, as shown by the decreased formation of cADPR and by CICR, for some social behaviors in mice via the regulation of OXT secretion from the hypothalamus and pituitary (Jin et al., 2007;Higashida et al., 2010;Salmina et al., 2010).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
Re-expression of CD38 in CD38 knockout mice normalizes plasma and CSF OXT levels and social memory.
“We used a genetic approach to re-express CD38 by infusing a virus carrying the human CD38 gene into the third ventricle of knockout mice.This procedure resulted in the normalization of the plasma and CSF OXT levels, thereby normalizing social memory (see Fig. 2 of Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
Social amnesia is not rescued by local expression of human R140W-CD38 in the hypothalamus of CD38 knockout mice.
“In addition, social amnesia was not rescued by the local expression of human R140W-CD38, via a lentiviral infection, in the hypothalamus of CD38 knockout mice (Fig. 2 of Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
The behavioral phenotype of CD38 -/- mice can be normalized by a single subcutaneous OXT injection.
“The behavioral phenotype of CD38 -/-mice could be normalized by a single subcutaneous OXT injection because OXT is able to enter into the brain, probably through the blood-brain barrier (see Supplementary Fig. S7 of Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
CD38 -/- males show sustained high levels of investigation at every encounter with the same female.
“In contrast, CD38 -/-males showed sustained high levels of investigation at every encounter with the same female (Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
CD38 may have an important role in OT release in the human hypothalamus, as in mice.
“These results suggested that CD38 may have an important role in OT release in the human hypothalamus, as in the mice (Jin et al., 2007;Liu et al., 2008).”
From Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010) · cites this paper as Jin et al., 2007
CD38 regulates OT secretion in the mouse hypothalamus and posterior pituitary, which is critical for mouse social behavior.
“They showed that CD38 regulates OT secretion in the mouse hypothalamus and posterior pituitary, which is critical for mouse social behavior (Jin et al., 2007;Liu et al., 2008).”
From Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010) · cites this paper as Jin et al., 2007
Social amnesia in Cd38 null mice was not rescued by local re-expression of human W140-CD38 in the hypothalamus.
“Moreover, social amnesia was not rescued by local re-expression of human W140-CD38 in the hypothalamus in the Cd38 null mice (Jin et al., 2007).”
From Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010) · cites this paper as Jin et al., 2007
Cites
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · see citing works
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,448 · see citing works
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173 · see citing works
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · see citing works
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505312102 · Cited by 806 · see citing works
Formation and Hydrolysis of Cyclic ADP-Ribose Catalyzed by Lymphocyte Antigen CD38
Howard, M., Grimaldi, J. C., Bazán, J. F., Lund, F. E., Santos‐Argumedo, L., Parkhouse, R. M. E., Walseth, T. F., & Lee, H. C. (1993) · Science · doi:10.1126/science.8235624 · Cited by 737 · see citing works
Plasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728 · see citing works
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689 · see citing works
Fries, A. B. W., Ziegler, T. E., Kurian, J. R., Jacoris, S., & Pollak, S. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504767102 · Cited by 570 · see citing works
HOW THE BRAIN PROCESSES SOCIAL INFORMATION: Searching for the Social Brain
Insel, T. R., & Fernald, R. D. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144148 · Cited by 556 · see citing works
Hatton, G. I. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90017-b · Cited by 439 · see citing works
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers
Lee, H. C. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.317 · Cited by 433 · see citing works
Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.031 · Cited by 367 · see citing works
Neural control of maternal behaviour and olfactory recognition of offspring
Kendrick, K. M., Da Costa, A. P. C., Broad, K. D., Ohkura, S., Guevara, R., Lévy, F., & Keverne, E. B. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00218-9 · Cited by 311 · see citing works
The magnocellular oxytocin system, the fount of maternity: Adaptations in pregnancy
Russell, J. A., Leng, G., & Douglas, A. J. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00104-8 · Cited by 295 · see citing works
Takasawa, S., Tohgo, A., Noguchi, N., Koguma, T., Nata, K., Sugimoto, T., Yonekura, H., & Okamoto, H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74275-6 · Cited by 273 · see citing works
Self-citationAutocrine and Paracrine Calcium Signaling by the CD38/NAD+/Cyclic ADP‐Ribose System
FLORA, A. D., Zocchi, E., Guida, L., Franco, L., & Bruzzone, S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1322.021 · Cited by 237 · see citing works
Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus
Argiolas, A., & Melis, M. R. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.002 · Cited by 227 · see citing works
Vasopressin, oxytocin and social behaviour
Keverne, E. B., & Curley, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.006 · Cited by 215 · see citing works
Low doses of oxytocin facilitate social recognition in rats
Popik, P., Vetulani, J., & van Ree, J. M. (1992) · Psychopharmacology · doi:10.1007/bf02253591 · Cited by 212 · see citing works
Kato, I., Yamamoto, Y., Fujimura, M., Noguchi, N., Takasawa, S., & Okamoto, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.1869 · Cited by 211 · see citing works
Self-citationOrganelle Selection Determines Agonist-specific Ca2+ Signals in Pancreatic Acinar and β Cells
Yamasaki, M., Masgrau, R., Morgan, A. J., Churchill, G. C., Patel, S., Ashcroft, S. J. H., & Galione, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311088200 · Cited by 201 · see citing works
Belin, V., & Moos, F. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016192 · Cited by 163 · see citing works
Gerasimenko, J. V., Sherwood, M. W., Tepikin, A. V., Petersen, O. H., & Gerasimenko, O. V. (2006) · Journal of Cell Science · doi:10.1242/jcs.02721 · Cited by 153 · see citing works
Deaglio, S., Vaisitti, T., Aydin, S., Ferrero, E., & Malavasi, F. (2006) · Blood · doi:10.1182/blood-2006-01-013003 · Cited by 145 · see citing works
Recent Advances in the Okamoto Model
Okamoto, H., & Takasawa, S. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s462 · Cited by 142 · see citing works
Self-citationJohnson, J. D., & Misler, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222099799 · Cited by 137 · see citing works
Neuropeptides and the social brain: potential rodent models of autism
Lim, M. M., Bielsky, I. F., & Young, L. J. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.006 · Cited by 129 · see citing works
Novel mechanism of intracellular calcium release in pituitary cells.
Koshiyama, H., Lee, H. C., & Tashjian, A. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47328-6 · Cited by 125 · see citing works
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling
Lee, H. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.r500012200 · Cited by 121 · see citing works
Chini, E. N., Chini, C. C. S., Kato, I., Takasawa, S., & OKAMOTO, H. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3620125 · Cited by 96 · see citing works
Self-citationCrescenzo, V. D., ZhuGe, R., Velázquez‐Marrero, C., Lifshitz, L. M., Custer, E. E., Carmichael, J. D., Lai, F. A., Tuft, R. A., Fogarty, K. E., Lémos, J. R., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4286-03.2004 · Cited by 85 · see citing works
Yagui, K., Shimada, F., Mimura, M., Hashimoto, N., Suzuki, Y., Tokuyama, Y., Nata, K., Tohgo, A., Ikehata, F., Takasawa, S., et al. (1998) · Diabetologia · doi:10.1007/s001250051026 · Cited by 74 · see citing works
Self-citationHigashida, H., Hashii, M., Yokoyama, S., Hoshi, N., Chen, X.-L., Egorova, A., Noda, M., & Zhang, J.-S. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00142-5 · Cited by 61 · see citing works
Self-citationChini, E. N., Chini, C. C. S., Kato, I., et al. (2002) · Biochemical Journal · doi:10.1042/bj3620125 · Cited by 60 · see citing works
Self-citationIn vivo transduction of murine cerebellar Purkinje cells by HIV-derived lentiviral vectors
Torashima, T., Okoyama, S., Nishizaki, T., & Hirai, H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.104 · Cited by 58 · see citing works
Self-citationThe independent effect of drug resistance on T cell activation in HIV infection
Hunt, P. W., Deeks, S. G., Bangsberg, D. R., Moss, A. R., Sinclair, E., Liegler, T. J., Bates, M. P., Tsao, G. J., Lampiris, H. W., Hoh, R., et al. (2006) · AIDS · doi:10.1097/01.aids.0000216369.30948.18 · Cited by 40 · see citing works
Yamashita, M., Glasgow, E. F., Zhang, B.-J., Kusano, K., & Gainer, H. (2002) · Endocrinology · doi:10.1210/en.2002-220516 · Cited by 33 · see citing works
Ca2+ clearance mechanisms in neurohypophysial terminals of the rat
Sasaki, N., Dayanithi, G., & Shibuya, I. (2004) · Cell Calcium · doi:10.1016/j.ceca.2004.06.007 · Cited by 28 · see citing works
Soares, S. M., Thompson, M., & Chini, E. N. (2005) · Endocrinology · doi:10.1210/en.2004-1298 · Cited by 11 · see citing works
Ouyang, W., Wang, G., & Hemmings, H. C. (2004) · Brain Research · doi:10.1016/j.brainres.2004.07.068 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617 · see citing works
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
Malavasi, F., Deaglio, S., Funaro, A., Ferrero, E., Horenstein, A. L., Ortolan, E., Vaisitti, T., & Aydin, S. (2008) · Physiological Reviews · doi:10.1152/physrev.00035.2007 · Cited by 862 · see citing works
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856 · see citing works
“Expressing CD-38 in the hypothalamus using a lenti-viral vector or by infusing OT was able to rescue this deficit [21].”
BackgroundMethodNAD+ in Brain Aging and Neurodegenerative Disorders
Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790 · see citing works
Oxytocin and social affiliation in humans
Feldman, R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.008 · Cited by 767 · see citing works
Brain oxytocin: A key regulator of emotional and social behaviours in both females and males
Neumann, I. D. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01726.x · Cited by 743 · see citing works
Feldman, R., Gordon, I., Influs, M., Gutbir, T., & Ebstein, R. P. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.22 · Cited by 622 · see citing works
Satomoto, M., Satoh, Y., Terui, K., Miyao, H., Takishima, K., Ito, M., & Imaki, J. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181974fa2 · Cited by 496 · see citing works
The expectant brain: adapting for motherhood
Brunton, P. J., & Russell, J. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2280 · Cited by 407 · see citing works
Is oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394 · see citing works
Sensitive Parenting Is Associated with Plasma Oxytocin and Polymorphisms in the OXTR and CD38 Genes
Feldman, R., Zagoory-Sharon, O., Weisman, O., Schneiderman, I., Gordon, I., Maoz, R., Shalev, I., & Ebstein, R. P. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.025 · Cited by 393 · see citing works
Sala, M., Braida, D., Lentini, D., Busnelli, M., Bulgheroni, E., Capurro, V., Finardi, A., Donzelli, A., Pattini, L., Rubino, T., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.022 · Cited by 375 · see citing works
Numan, M., & Young, L. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.015 · Cited by 355 · see citing works
Oxytocin pathway gene networks in the human brain
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova-Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2019) · Nature Communications · doi:10.1038/s41467-019-08503-8 · Cited by 354 · see citing works
Feldman, R., Monakhov, M., Pratt, M., & Ebstein, R. P. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.008 · Cited by 352 · see citing works
Urinary oxytocin and social bonding in related and unrelated wild chimpanzees
Crockford, C., Wittig, R. M., Langergraber, K., Ziegler, T. E., Zuberbühler, K., & Deschner, T. (2013) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2012.2765 · Cited by 347 · see citing works
Neuroendocrine regulation of maternal behavior
Bridges, R. S. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.11.007 · Cited by 346 · see citing works
Dopaminergic-neuropeptide interactions in the social brain
Skuse, D. H., & Gallagher, L. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.09.007 · Cited by 340 · see citing works
Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin
Szeto, A., McCabe, P. M., Nation, D. A., Tabak, B. A., Rossetti, M. A., McCullough, M. E., Schneiderman, N., & Mendez, A. J. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31821df0c2 · Cited by 330 · see citing works
Genetics of Human Social Behavior
Ebstein, R. P., Israel, S., Chew, S. H., Zhong, S., & Knafo, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.020 · Cited by 323 · see citing works
Schneiderman, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.021 · Cited by 317 · see citing works
Braidy, N., Berg, J., Clement, J., Khorshidi, F., Poljak, A., Jayasena, T., Grant, R., & Sachdev, P. S. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7269 · Cited by 286 · see citing works
The contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283 · see citing works
Valstad, M., Alvares, G. A., Egknud, M., Matziorinis, A. M., Andreassen, O. A., Westlye, L. T., & Quintana, D. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.017 · Cited by 277 · see citing works
CD38 and CD157: A long journey from activation markers to multifunctional molecules
Quarona, V., Zaccarello, G., Chillemi, A., Brunetti, E., Singh, V. K., Ferrero, E., Funaro, A., Horenstein, A. L., & Malavasi, F. (2013) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.21092 · Cited by 269 · see citing works
The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology
Chen, J. A., Peñagarikano, O., Belgard, T. G., Swarup, V., & Geschwind, D. H. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040405 · Cited by 254 · see citing works
Johnson, Z. V., & Young, L. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.034 · Cited by 242 · see citing works
Wittig, R. M., Crockford, C., Deschner, T., Langergraber, K. E., Ziegler, T. E., & Zuberbühler, K. (2014) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2013.3096 · Cited by 235 · see citing works
Baribeau, D. A., & Anagnostou, E. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00335 · Cited by 229 · see citing works
CD38 and chronic lymphocytic leukemia: a decade later
Malavasi, F., Deaglio, S., Damle, R. N., Cutrona, G., Ferrarini, M., & Chiorazzi, N. (2011) · Blood · doi:10.1182/blood-2011-06-275610 · Cited by 224 · see citing works
The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies
Modi, M. E., & Young, L. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.010 · Cited by 218 · see citing works
Palmieri, L., Papaleo, V., Porcelli, V., Scarcia, P., Gaita, L., Sacco, R., Hager, J., Rousseau, F., Curatolo, P., Manzi, B., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.63 · Cited by 210 · see citing works
Zhang, G., Bai, H., Zhang, H., Dean, C., Wu, Q., Li, J., Guariglia, S., Meng, Q., & Cai, D. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.036 · Cited by 208 · see citing works
Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience
Kumsta, R., Hummel, E., Chen, F. S., & Heinrichs, M. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00083 · Cited by 207 · see citing works
Neuroendocrinology of social information processing in rats and mice
Choleris, E., Clipperton-Allen, A. E., Phan, A., & Kavaliers, M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.003 · Cited by 205 · see citing works
Chronic and acute intranasal oxytocin produce divergent social effects in mice
Huang, H., Michetti, C., Busnelli, M., Managò, F., Sannino, S., Scheggia, D., Giancardo, L., Sona, D., Murino, V., Chini, B., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.310 · Cited by 199 · see citing works
Continuous neurogenesis in the adult forebrain is required for innate olfactory responses
Sakamoto, M., Imayoshi, I., Ohtsuka, T., Yamaguchi, M., Mori, K., & Kageyama, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018782108 · Cited by 198 · see citing works
Oxytocin role in enhancing well-being: A literature review
IsHak, W. W., Kahloon, M., & Fakhry, H. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.001 · Cited by 198 · see citing works
Freeman, S. M., & Young, L. J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12382 · Cited by 196 · see citing works
“Mice with impaired OT release or signalling display impairments in maternal responsiveness (3,4).”
BackgroundLee, H. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.349464 · Cited by 196 · see citing works
Dynamic changes in oxytocin receptor expression and activation at parturition in the rat brain
Meddle, S. L., Bishop, V. R., Gkoumassi, E., van Leeuwen, F. W., & Douglas, A. J. (2007) · Endocrinology · doi:10.1210/en.2007-0615 · Cited by 195 · see citing works
Arginine Vasopressin and Oxytocin Modulate Human Social Behavior
Ebstein, R. P., Israel, S., Lerer, E., Uzefovsky, F., Shalev, I., Gritsenko, I., Riebold, M., Salomon, S., & Yirmiya, N. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04541.x · Cited by 194 · see citing works
Chini, E. N. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209787185788 · Cited by 193 · see citing works
Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse
Schorscher-Petcu, A., Sotocinal, S., Ciura, S., Dupre, A., Ritchie, J., Sorge, R. E., Crawley, J. N., Hu, S.-B., Nishimori, K., Young, L. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1594-10.2010 · Cited by 189 · see citing works
Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism
Aoki, Y., Yahata, N., Watanabe, T., Takano, Y., Kawakubo, Y., Kuwabara, H., Iwashiro, N., Natsubori, T., Inoue, H., Suga, M., et al. (2014) · Brain · doi:10.1093/brain/awu231 · Cited by 187 · see citing works
Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Aoki, Y., Takao, H., Kawakubo, Y., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3181 · Cited by 183 · see citing works
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181 · see citing works
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls
Munesue, T., Yokoyama, S., Nakamura, K., Anitha, A., Yamada, K., Hayashi, K., Asaka, T., Liu, H.-X., Jin, D., Koizumi, K., et al. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.03.004 · Cited by 177 · see citing works
Self-citationDevelopmental Perspectives on Oxytocin and Vasopressin
Hammock, E. A. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.120 · Cited by 177 · see citing works
Mitochondrial dysfunction in autism spectrum disorders: Cause or effect?
Palmieri, L., & Persico, A. M. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.04.018 · Cited by 173 · see citing works
The Membrane-Bound Enzyme CD38 Exists in Two Opposing Orientations
Zhao, Y. J., Lam, C. M. C., & Lee, H. C. (2012) · Science Signaling · doi:10.1126/scisignal.2002700 · Cited by 173 · see citing works
Making room for oxytocin in understanding depression
McQuaid, R. J., McInnis, O. A., Abizaid, A. B., & Anisman, H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.005 · Cited by 172 · see citing works
McGregor, I. S., Callaghan, P. D., & Hunt, G. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.132 · Cited by 171 · see citing works
Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice
Yamamoto, Y., Liang, M., Munesue, S., Deguchi, K., Harashima, A., Furuhara, K., Yuhi, T., Zhong, J., Akther, S., Goto, H., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0325-6 · Cited by 171 · see citing works
Self-citationOxytocin enhances observational fear in mice
Pisansky, M. T., Hanson, L. R., Gottesman, I. I., & Gewirtz, J. C. (2017) · Nature Communications · doi:10.1038/s41467-017-02279-5 · Cited by 167 · see citing works
Association between the oxytocin receptor gene and amygdalar volume in healthy adults
Inoue, H., Yamasue, H., Tochigi, M., Abe, O., Liu, X., Kawamura, Y., Takei, K., Suga, M., Yamada, H., Rogers, M. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.019 · Cited by 164 · see citing works
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162 · see citing works
Oxytocin and the maternal brain
LENG, G., MEDDLE, S., & DOUGLAS, A. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.07.001 · Cited by 158 · see citing works
Anxiolytic-like effect of oxytocin in the simulated public speaking test
de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111400642 · Cited by 154 · see citing works
Kong, X.-J., Liu, J., Liu, K., Koh, M., Sherman, H., Liu, S., Tian, R., Sukijthamapan, P., Wang, J., Fong, M., et al. (2021) · Nutrients · doi:10.3390/nu13051552 · Cited by 150 · see citing works
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149 · see citing works
ERK2 Contributes to the Control of Social Behaviors in Mice
Satoh, Y., Endo, S., Nakata, T., Kobayashi, Y., Yamada, K., Ikeda, T., Takeuchi, A., Hiramoto, T., Watanabe, Y., & Kazama, T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2349-11.2011 · Cited by 145 · see citing works
Self-citationCD38 in Neurodegeneration and Neuroinflammation
Guerreiro, S., Privat, A.-L., Bressac, L., & Toulorge, D. (2020) · Cells · doi:10.3390/cells9020471 · Cited by 143 · see citing works
Social circuits and their dysfunction in autism spectrum disorder
Sato, M., Nakai, N., Fujima, S., Choe, K. Y., & Takumi, T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02201-0 · Cited by 142 · see citing works
Oxytocin and experimental therapeutics in autism spectrum disorders
BARTZ, J., & HOLLANDER, E. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00435-4 · Cited by 139 · see citing works
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Effects of oxytocin administration on spirituality and emotional responses to meditation
Cappellen, P. V., Way, B. M., Isgett, S. F., & Fredrickson, B. L. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw078 · Cited by 138 · see citing works
Cambronne, X. A., & Kraus, W. L. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.05.010 · Cited by 137 · see citing works
Neural Circuits for Social Cognition: Implications for Autism
Fernández, M. C., Mollinedo-Gajate, I., & Peñagarikano, O. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.013 · Cited by 137 · see citing works
Kuroda, K. O., Tachikawa, K., Yoshida, S., Tsuneoka, Y., & Numan, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.02.008 · Cited by 134 · see citing works
Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing
Reiten, O. K., Wilvang, M. A., Mitchell, S. J., Hu, Z., & Fang, E. F. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111567 · Cited by 133 · see citing works
<scp>O</scp>xytocin modulation of neural circuits for social behavior
Marlin, B. J., & Froemke, R. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22452 · Cited by 130 · see citing works
Carson, D. S., Hunt, G. E., Guastella, A. J., Barber, L., Cornish, J. L., Arnold, J. C., Boucher, A. A., & McGregor, I. S. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00247.x · Cited by 126 · see citing works
A primer of NAADP-mediated Ca2+ signalling: From sea urchin eggs to mammalian cells
Galione, A. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.09.010 · Cited by 122 · see citing works
Oxytocin in the socioemotional brain: implications for psychiatric disorders
Kirsch, P. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.4/pkirsch · Cited by 122 · see citing works
Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders
Grinevich, V., Desarménien, M. G., Chini, B., Tauber, M., & Muscatelli, F. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00164 · Cited by 121 · see citing works
Sex, Receptors, and Attachment: A Review of Individual Factors Influencing Response to Oxytocin
MacDonald, K. S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00194 · Cited by 119 · see citing works
Kosaka, H., Okamoto, Y., Munesue, T., Yamasue, H., Inohara, K., Fujioka, T., Anme, T., Orisaka, M., Ishitobi, M., Jung, M., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.152 · Cited by 117 · see citing works
Self-citationModeling Social Influences on Human Health
Karelina, K., & DeVries, A. C. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182002116 · Cited by 115 · see citing works
Hammock, E. A. D. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00195 · Cited by 115 · see citing works
Liu, J., Liu, X., Xiong, X.-Q., Yang, T., Cui, T., Hou, N.-L., Lai, X., Liu, S., Guo, M., Liang, X.-H., et al. (2017) · BMC Microbiology · doi:10.1186/s12866-017-1096-1 · Cited by 115 · see citing works
NAD+-Metabolizing Ectoenzymes in Remodeling Tumor–Host Interactions: The Human Myeloma Model
Horenstein, A. L., Chillemi, A., Quarona, V., Zito, A., Roato, I., Morandi, F., Marimpietri, D., Bolzoni, M., Toscani, D., Oldham, R. J., et al. (2015) · Cells · doi:10.3390/cells4030520 · Cited by 113 · see citing works
Carter, M. D., Shah, C. R., Muller, C. L., Crawley, J. N., Carneiro, A. M. D., & Veenstra-VanderWeele, J. M. (2011) · Autism Research · doi:10.1002/aur.180 · Cited by 112 · see citing works
The glial perspective of autism spectrum disorders
Zeidán‐Chuliá, F., Salmina, A. B., Malinovskaya, N. A., Noda, M., Verkhratsky, A., & Moreira, J. C. F. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.008 · Cited by 111 · see citing works
Self-citationNinan, I. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07430.x · Cited by 110 · see citing works
Bertoni, A., Schaller, F., Tyzio, R., Gaillard, S., Santini, F., Xolin, M., Diabira, D., Vaidyanathan, R., Matarazzo, V. A., Medina, I., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01227-6 · Cited by 110 · see citing works
Douglas, A. J., Johnstone, L. E., & Leng, G. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.012 · Cited by 108 · see citing works
RAGE regulates oxytocin transport into the brain
Yamamoto, Y., & Higashida, H. (2020) · Communications Biology · doi:10.1038/s42003-020-0799-2 · Cited by 106 · see citing works
Self-citationLopatina, O. L., Yoshihara, T., Nishimura, T., Zhong, J., Akther, S., Fakhrul, A. A. K. M., Liang, M., Higashida, C., Sumi, K., Furuhara, K., et al. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00133 · Cited by 106 · see citing works
Self-citationDisplays of paternal mouse pup retrieval following communicative interaction with maternal mates
Liu, H.-X., Lopatina, O., Higashida, C., Fujimoto, H., Akther, S., Ивановна, И. А., Liang, M., Zhong, J., Tsuji, T., Yoshihara, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2336 · Cited by 105 · see citing works
Self-citationLerer, E., Levi, S., Israel, S., Yaari, M., Nemanov, L., Mankuta, D., Yirmiya, N., & Ebstein, R. P. (2010) · Autism Research · doi:10.1002/aur.156 · Cited by 104 · see citing works
Maejima, Y., Sakuma, K., Santoso, P., Gantulga, D., Katsurada, K., Ueta, Y., Hiraoka, Y., Nishimori, K., Tanaka, S., Shimomura, K., et al. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.10.010 · Cited by 103 · see citing works
Self-citationSelective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors
Busnelli, M., Bulgheroni, E., Manning, M., Kleinau, G., & Chini, B. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.202994 · Cited by 102 · see citing works
Oxytocin and Parental Behaviors
Yoshihara, C., Numan, M., & Kuroda, K. O. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_11 · Cited by 102 · see citing works
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
Francis, S. M., Sagar, A., Levin-Decanini, T., Liu, W., Carter, C. S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.021 · Cited by 101 · see citing works
Long-term alterations in neural and endocrine processes induced by motherhood in mammals
Bridges, R. S. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.09.001 · Cited by 100 · see citing works
Sala, M., Braida, D., Donzelli, A., Martucci, R., Busnelli, M., Bulgheroni, E., Rubino, T., Parolaro, D., Nishimori, K., & Chini, B. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02385.x · Cited by 99 · see citing works
- Authors
- Jin, D., Liu, H.-X., Hirai, H., Torashima, T., Nagai, T., Lopatina, O., Shnayder, N. A., Yamada, K., Noda, M., Seike, T., Fujita, K., Takasawa, S., Yokoyama, S., Koizumi, K., Shiraishi, Y., Tanaka, S., Hashii, M., Yoshihara, T., Higashida, K., Islam, M. S., Yamada, N., Hayashi, K., Noguchi, N., Kato, I., Okamoto, H., Matsushima, A., Salmina, A., Munesue, T., Shimizu, N., Mochida, S., Asano, M., & Higashida, H.
- Affiliations
- Kanazawa University (JP)
- Kyushu University (JP)
- University of Toyama (JP)
- Tohoku University (JP)
- Nanao hospital (JP)
- Krasnoyarsk State Medical University (RU)
- Kanazawa University Hospital (JP)
- Tokyo Medical University (JP)
- Corresponding author
- Hirai, Hirokazu
- Higashida, Haruhiro
- ORCID
- Venue
- Nature
- Published
- 2007-02-07
- Volume
- 446
- Issue
- 7131
- Pages
- 41-45
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2048596172
- Cited by
- 665
- References
- 44
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 34 · 2023: 26 · 2022: 30 · 2021: 44 · 2020: 47 · 2019: 31 · 2018: 34 · 2017: 53 · 2016: 40 · 2015: 42 · 2014: 45 · 2013: 39 · 2012: 36
- FWCI
- 41.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- CD38, oxytocin secretion, social behavior, maternal behavior, ADP-ribosyl cyclase, neuropeptide release, neuroendocrine regulation, hypothalamus, neurohypophysis, calcium signaling, CD38 knockout mice, social memory, neurodevelopmental disorders
- MeSH terms
- Amnesia, Animals, Calcium, Female, Gene Expression Regulation, Humans, Injections, Male, Maternal Behavior, Memory, Motor Activity, Oxytocin, Social Behavior, Vasopressins, Calcium Signaling, Mice, ADP-ribosyl Cyclase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
