Cited by 486Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer and biochemical research

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The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression

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Diaz-Ruiz, Rodrigo, Rigoulet, Michel, Devin, Anne·2011·Biochimica et Biophysica Acta (BBA) - Bioenergetics

DOI 10.1016/j.bbabio.2010.08.010

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Abstract

During the last decades a considerable amount of research has been focused on cancer. Recently, tumor cell metabolism has been considered as a possible target for cancer therapy. It is widely accepted that tumors display enhanced glycolytic activity and impaired oxidative phosphorylation (Warburg effect). Therefore, it seems reasonable that disruption of glycolysis might be a promising candidate for specific anti-cancer therapy. Nevertheless, the concept of aerobic glycolysis as the paradigm of tumor cell metabolism has been challenged, as some tumor cells exhibit high rates of oxidative phosphorylation. Mitochondrial physiology in cancer cells is linked to the Warburg effect. Besides, its central role in apoptosis makes this organelle a promising "dual hit target" to selectively eliminate tumor cells. From a metabolic point of view, the fermenting yeast Saccharomyces cerevisiae and tumor cells share several features. In this paper we will review these common metabolic properties as well as the possible origins of the Crabtree and Warburg effects.

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Authors: Diaz-Ruiz, R., Rigoulet, M., & Devin, A.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Devin, Anne
ORCID: Devin, Anne
Venue: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher: Elsevier BV
Published: 2011-06
Volume: 1807
Issue: 6
Pages: 568-576
ISSN: 0005-2728 (ISSN-L)
DOI: 10.1016/j.bbabio.2010.08.010
OpenAlex: W2091739490
Cited by: 486
References: 140
Citations by year: 2026: 15 · 2025: 20 · 2024: 15 · 2023: 29 · 2022: 31 · 2021: 38 · 2020: 36 · 2019: 44 · 2018: 45 · 2017: 54 · 2016: 37 · 2015: 37 · 2014: 31 · 2013: 28 · 2012: 18
FWCI: 1.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1267 d)
Locations: Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: Warburg effect, Crabtree effect, cancer cell energy metabolism, aerobic glycolysis, oxidative phosphorylation, mitochondrial physiology, glucose repression, Saccharomyces cerevisiae, cancer metabolism, cancer therapy, apoptosis
MeSH terms: Animals, Cells, Energy Metabolism, Biological Evolution, Glucose, Humans, Models, Biological, Models, Theoretical, Neoplasms, Yeasts, Down-Regulation, Gene Expression Regulation, Fungal

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The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression

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