The DOI matches its Crossref record; 138 of the 140 references it cites were found in a registry or an index.
The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression
Open accessAbstract
During the last decades a considerable amount of research has been focused on cancer. Recently, tumor cell metabolism has been considered as a possible target for cancer therapy. It is widely accepted that tumors display enhanced glycolytic activity and impaired oxidative phosphorylation (Warburg effect). Therefore, it seems reasonable that disruption of glycolysis might be a promising candidate for specific anti-cancer therapy. Nevertheless, the concept of aerobic glycolysis as the paradigm of tumor cell metabolism has been challenged, as some tumor cells exhibit high rates of oxidative phosphorylation. Mitochondrial physiology in cancer cells is linked to the Warburg effect. Besides, its central role in apoptosis makes this organelle a promising "dual hit target" to selectively eliminate tumor cells. From a metabolic point of view, the fermenting yeast Saccharomyces cerevisiae and tumor cells share several features. In this paper we will review these common metabolic properties as well as the possible origins of the Crabtree and Warburg effects.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Otto Warburg observed that cancer cells rewire glucose metabolism for lactate synthesis even in normoxia, known as the Warburg Effect.14,21”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Why Do Cancers Have High Aerobic Glycolysis?
Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784
Cancer genes and the pathways they control
Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,346
Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Sonveaux, P., Végran, F., Schroeder, T., Wergin, M., Verrax, J., Rabbani, Z. N., Saedeleer, C. J. D., Kennedy, K. M., Diepart, C., Jordan, B. F., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36843 · Cited by 1,635
Fantin, V. R., St-Pierre, J., & Leder, P. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.023 · Cited by 1,635
Glycolysis inhibition for anticancer treatment
Pelicano, H., Martin, D. S., Xu, R., & Huang, P. (2006) · Oncogene · doi:10.1038/sj.onc.1209597 · Cited by 1,546
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
Le, A., Cooper, C. R., Gouw, A. M., Dinavahi, R., Maitra, A., Deck, L. M., Royer, R. E., Jagt, D. L. V., Semenza, G. L., & Dang, C. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914433107 · Cited by 1,528
ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis
Ishikawa, K., Takenaga, K., Akimoto, M., Koshikawa, N., Yamaguchi, A., Imanishi, H., Nakada, K., Honma, Y., & Hayashi, J.-I. (2008) · Science · doi:10.1126/science.1156906 · Cited by 1,444
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.
Reitzer, L. J., Wice, B. M., & Kennell, D. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30124-2 · Cited by 1,240
Understanding the control of metabolism
(1997) · Choice Reviews Online · doi:10.5860/choice.34-6252 · Cited by 1,230
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
Macheda, M. L., Rogers, S., & Best, J. D. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20166 · Cited by 1,229
Energy metabolism in tumor cells
Moreno‐Sánchez, R., Rodríguez‐Enríquez, S., Marín‐Hernández, Á., & Saavedra, E. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05686.x · Cited by 1,121
In yeast, RAS proteins are controlling elements of adenylate cyclase
Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J. R., Matsumoto, K., & Wigler, M. H. (1985) · Cell · doi:10.1016/0092-8674(85)90305-8 · Cited by 1,108
Tumor suppressors and cell metabolism: a recipe for cancer growth
Jones, R. G., & Thompson, C. B. (2009) · Genes & Development · doi:10.1101/gad.1756509 · Cited by 1,085
Cytosolic phosphorylation potential.
Veech, R. L., Lawson, J., Cornell, N. W., & Krebs, H. A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50401-4 · Cited by 919
Regulation of Longevity and Stress Resistance by Sch9 in Yeast
Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D. (2001) · Science · doi:10.1126/science.1059497 · Cited by 874
Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells
Rossignol, R., Gilkerson, R., Aggeler, R. J., Yamagata, K., Remington, S. J., & Capaldi, R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1101 · Cited by 871
Observations on the carbohydrate metabolism of tumours
Crabtree, H. G. (1929) · Biochemical Journal · doi:10.1042/bj0230536 · Cited by 864
Pyruvate kinase type M2 and its role in tumor growth and spreading
Mazurek, S., Boschek, C. B., Hugo, F., & Eigenbrodt, E. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.04.009 · Cited by 812
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W., & Friend, S. H. (1997) · Science · doi:10.1126/science.278.5340.1064 · Cited by 789
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
Hitosugi, T., Kang, S., Vander Heiden, M. G., Chung, T.-W., Elf, S., Lythgoe, K., Dong, S., Lonial, S., Wang, X., Chen, G. Z., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000431 · Cited by 784
Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast
Jorgensen, P., Nishikawa, J. L., Breitkreutz, B., & Tyers, M. (2002) · Science · doi:10.1126/science.1070850 · Cited by 764
Toda, T., Cameron, S., Sass, P. M., Zoller, M. J., & Wigler, M. H. (1987) · Cell · doi:10.1016/0092-8674(87)90223-6 · Cited by 694
Thevelein, J. M., & WINDE, J. H. D. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01538.x · Cited by 682
Seyfried, T. N., & Shelton, L. M. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-7 · Cited by 675
Jorgensen, P., Rupeš, I., Sharom, J. R., Schneper, L. M., Broach, J. R., & Tyers, M. (2004) · Genes & Development · doi:10.1101/gad.1228804 · Cited by 644
Mitochondrial tumour suppressors: a genetic and biochemical update
Gottlieb, E., & Tomlinson, I. P. M. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1737 · Cited by 626
Lactic Dehydrogenases: Functions of the Two Types
Dawson, D. M., Goodfriend, T. L., Kaplan, N. O., & Kaplan, N. O. (1964) · Science · doi:10.1126/science.143.3609.929 · Cited by 551
The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors
Halestrap, A. P. (1975) · Biochemical Journal · doi:10.1042/bj1480085 · Cited by 543
Toda, T., Cameron, S., Sass, P. M., Zoller, M. J., Scott, J. D., McMullen, B. A., Hurwitz, M. Y., Krebs, E. G., & Wigler, M. H. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.4.1371 · Cited by 493
Over-expression of facilitative glucose transporter genes in human cancer
Yamamoto, T., Seino, Y., Fukumoto, H., Koh, G., Yano, H., Inagaki, N., Yamada, Y., Inoue, K., Manabe, T., & Imura, H. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91263-r · Cited by 465
Yang, C., Sudderth, J., Dang, T. T., Bachoo, R. G., McDonald, J. G., & DeBerardinis, R. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2266 · Cited by 436
Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer
Yalçın, A., Telang, S., Clem, B. F., & Chesney, J. A. (2009) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2009.01.003 · Cited by 407
Thevelein, J. M. (1994) · Yeast · doi:10.1002/yea.320101308 · Cited by 383
Kraakman, L., Lemaire, K., Ma, P., Teunissen, A. W. R. H., Donaton, M. C. V., Dijck, P. V., Winderickx, J., de Winde, J. H., & Thevelein, J. M. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01413.x · Cited by 372
LACTIC DEHYDROGENASE IN HUMAN NEOPLASTIC TISSUES.
Goldman, R. D., Kaplan, N. O., & Hall, T. C. (1964) · PubMed · Cited by 355
Positron Emission Tomography Scanning: Current and Future Applications
Czernin, J. G., & Phelps, M. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104028 · Cited by 330
Atsumi, T., Chesney, J. A., Metz, C. N., Leng, L., Donnelly, S. C., Makita, Z., Mitchell, R., & Bucala, R. (2002) · PubMed · Cited by 322
Bustamante, E., Morris, H. P., & Pedersen, P. L. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68900-3 · Cited by 319
Greiner, E. F., Guppy, M., & Brand, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31720-4 · Cited by 307
Xue, Y., Batlle, M., & Hirsch, J. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.7.1996 · Cited by 306
Control of glucose utilization in working perfused rat heart.
Kashiwaya, Y., Sato, K., Tsuchiya, N., Thomas, S., Fell, D. A., Veech, R. L., & Passonneau, J. V. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47278-x · Cited by 303
Souba, W. W. (1993) · Annals of Surgery · doi:10.1097/00000658-199312000-00004 · Cited by 294
Energy Deregulation: Licensing Tumors to Grow
Garber, K. (2006) · Science · doi:10.1126/science.312.5777.1158 · Cited by 275
Guppy, M., Leedman, P. J., XinLin, Z. U., & Russell, V. R. (2002) · Biochemical Journal · doi:10.1042/bj3640309 · Cited by 262
Modulation of type M 2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein
Zwerschke, W., Mazurek, S., Massimi, P., Banks, L., EIGENBRODT, E., & Jansen‐Dürr, P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1291 · Cited by 257
Lorenz, M. C., Pan, X., Harashima, T., Cardenas, M. E., Xue, Y., Hirsch, J. P., & Heitman, J. (2000) · Genetics · doi:10.1093/genetics/154.2.609 · Cited by 250
The Warburg effect and mitochondrial stability in cancer cells
Gogvadze, V. G., Zhivotovsky, B., & Orrenius, S. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.12.004 · Cited by 235
Weinhouse, S. (1972) · PubMed · Cited by 230
The role of glutamine in the oxidative metabolism of malignant cells.
Kovacević, Z., & Morris, H. P. (1972) · PubMed · Cited by 225
Cao, X., Fang, L., Gibbs, S. T., Huang, Y. S., Dai, Z., Wen, P., Zheng, X., Sadée, W., & Sun, D. (2006) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-006-0291-9 · Cited by 222
Determining and understanding the control of glycolysis in fast‐growth tumor cells
Marín‐Hernández, Á., Rodríguez‐Enríquez, S., Vital‐González, P. A., Flores‐Rodríguez, F. L., Macías‐Silva, M., Sosa‐Garrocho, M., & Moreno‐Sánchez, R. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05214.x · Cited by 203
Toda, T., Cameron, S., Sass, P. M., & Wigler, M. H. (1988) · Genes & Development · doi:10.1101/gad.2.5.517 · Cited by 197
Wei, M., Fabrizio, P., Madia, F., Hu, J. H., Ge, H., Li, L. M., & Longo, V. D. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000467 · Cited by 196
Hohmann, S., & Cederberg, H. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15442.x · Cited by 168
Tatchell, K., Robinson, L. C., & Breitenbach, M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.11.3785 · Cited by 167
Transient-state analysis of metabolic fluxes in crabtree-positive and crabtree-negative yeasts
Van Urk, H., Voll, W. S. L., Scheffers, W. A., & Van Dijken, J. P. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.1.281-287.1990 · Cited by 163
Mitochondrial Oxidative Phosphorylation Is Regulated by Fructose 1,6-Bisphosphate
Díaz-Ruiz, R., Avéret, N., Araiza, D., Pinson, B., Uribe‐Carvajal, S., Devin, A., & Rigoulet, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800408200 · Cited by 155
Self-citationPhosphate Mediation of the Crabtree and Pasteur Effects
Koobs, D. H. (1972) · Science · doi:10.1126/science.178.4057.127 · Cited by 154
Brand, K. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022498714522 · Cited by 153
Energy metabolism transition in multi‐cellular human tumor spheroids
Rodríguez‐Enríquez, S., Gallardo‐Pérez, J. C., Avilés‐Salas, A., Marín‐Hernández, Á., Carreño‐Fuentes, L., Lagunas, V. M., & Moreno‐Sánchez, R. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21392 · Cited by 146
Multisite control of the Crabtree effect in ascites hepatoma cells
Rodríguez‐Enríquez, S., Juárez, O. X., Rodríguez‐Zavala, J. S., & Moreno‐Sánchez, R. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02140.x · Cited by 144
Parlo, R. A., & Coleman, P. S. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90917-8 · Cited by 139
Pedersen, P. L. (2008) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-008-9165-7 · Cited by 137
Organization and regulation of the cytosolic NADH metabolism in the yeast Saccharomyces cerevisiae
Rigoulet, M., Aguilaniu, H., Avéret, N., Bunoust, O., Camougrand, N. M., Grandier‐Vazeille, X., Larsson, C., Påhlman, I.-L., Manon, S., & Gustafsson, L. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000009888.79484.fd · Cited by 134
Self-citationTumor cell energy metabolism and its common features with yeast metabolism
Díaz-Ruiz, R., Uribe‐Carvajal, S., Devin, A., & Rigoulet, M. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.07.003 · Cited by 133
Self-citationMitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia
Smolková, K., Bellancé, N., Scandurra, F. M., Genot, E. M., Gnaiger, E., Plecitá‐Hlavatá, L., Ježek, P., & Rossignol, R. (2010) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9267-x · Cited by 117
Rodríguez‐Enríquez, S., Vital‐González, P. A., Flores‐Rodríguez, F. L., Marín‐Hernández, Á., Ruíz-Azuara, L., & Moreno‐Sánchez, R. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.02.005 · Cited by 116
Boles, E., Schulte, F., Miosga, T., Freidel, K., Schlüter, E., Zimmermann, F. K., Hollenberg, C. P., & Heinisch, J. J. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.9.2987-2993.1997 · Cited by 115
Saks, V. A., Guzun, R., Timohhina, N., Tepp, K., Varikmaa, M., Monge, C., Béraud, N., Käämbre, T., Kuznetsov, A. V., Kadaja, L., et al. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.011 · Cited by 111
Tomiyama, A., Serizawa, S., Tachibana, K., Sakurada, K., Samejima, H., Kuchino, Y., & Kitanaka, C. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj395 · Cited by 106
Béraud, N., Pelloux, S., Usson, Y., Kuznetsov, A. V., Ronot, X., Tourneur, Y., & Saks, V. A. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9214-x · Cited by 105
Regulatory Mechanisms in Carbohydrate Metabolism
Gatt, S., & Racker, E. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98122-6 · Cited by 104
Jiang, Y., Davis, C., & Broach, J. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6942 · Cited by 101
Vora, S., Seaman, C., Durham, S., & Piomelli, S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.1.62 · Cited by 100
Kinetics of transport and phosphorylation of glucose in cancer cells
Rodríguez‐Enríquez, S., Marín‐Hernández, Á., Gallardo‐Pérez, J. C., & Moreno‐Sánchez, R. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21885 · Cited by 94
Mechanisms of mitochondrial response to variations in energy demand in eukaryotic cells
Devin, A., & Rigoulet, M. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00208.2006 · Cited by 92
Self-citationCatabolite repression in yeasts is not associated with low levels of cAMP
Eraso, P., & Gancedo, J. M. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08174.x · Cited by 90
Vora, S., Halper, J. P., & Knowles, D. M. (1985) · PubMed · Cited by 89
Regulation of cellular energy metabolism. The Crabtree effect
Sussman, I., Erecińska, M., & Wilson, D. F. (1980) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(80)90153-x · Cited by 83
Gey, U., Czupalla, C., Hoflack, B., Rödel, G., & Krause‐Buchholz, U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708779200 · Cited by 83
Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae
Hildyard, J. C. W., & Halestrap, A. P. (2003) · Biochemical Journal · doi:10.1042/bj20030995 · Cited by 82
Russell, M., Bradshaw-Rouse, J. J., Markwardt, D. D., & Heideman, W. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.7.757 · Cited by 78
Hue, L., & Rousseau, G. G. (1993) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(93)90011-2 · Cited by 75
Chevtzoff, C., Yoboue, E. D., Galinier, A., Casteilla, L., Daignan‐Fornier, B., Rigoulet, M., & Devin, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019570 · Cited by 72
Self-citationMatsuno, T., & Goto, I. (1992) · PubMed · Cited by 71
Reibstein, D., den Hollander, J. A., Pilkis, S. J., & Shulman, R. G. (1986) · Biochemistry · doi:10.1021/bi00349a031 · Cited by 71
A Mitochondrial Pyruvate Dehydrogenase Bypass in the YeastSaccharomyces cerevisiae
Boubekeur, S., Bunoust, O., Camougrand, N. M., Castroviejo, M., Rigoulet, M., & Guérin, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21044 · Cited by 71
Self-citationThe oncoprotein H-RasV12 increases mitochondrial metabolism
Telang, S., Lane, A. N., Nelson, K. K., Arumugam, S., & Chesney, J. A. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-77 · Cited by 71
Anmann, T., Guzun, R., Béraud, N., Pelloux, S., Kuznetsov, A. V., Kogerman, L., Käämbre, T., Sikk, P., Paju, K., Peet, N., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.09.008 · Cited by 71
Regulatory function of the Saccharomyces cerevisiae RAS C-terminus.
Marshall, M. S., Gibbs, W. W., Scolnick, E. M., & Sigal, I. S. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.7.2309 · Cited by 69
Yeast mitochondrial metabolism: From in vitro to in situ quantitative study
Avéret, N., Fitton‐Ouhabi, V., Bunoust, O., Rigoulet, M., & Guérin, B. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006830810440 · Cited by 69
Self-citationYeast mitochondrial metabolism: From in vitro to in situ quantitative study
Avéret, N., Fitton‐Ouhabi, V., Bunoust, O., Rigoulet, M., & Guérin, B. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5653-4_6 · Cited by 68
Self-citationLavoie, H., & Whiteway, M. S. (2008) · Eukaryotic Cell · doi:10.1128/ec.00330-07 · Cited by 68
Boy‐Marcotte, E., Tadi, D., Perrot, M., Boucherie, H., & Jacquet, M. (1996) · Microbiology · doi:10.1099/13500872-142-3-459 · Cited by 66
Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast
Dejean, L. M., Beauvoit, B. P., Bunoust, O., Guérin, B., & Rigoulet, M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00391-1 · Cited by 65
Self-citationChevtzoff, C., Vallortigara, J., Avéret, N., Rigoulet, M., & Devin, A. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.10.001 · Cited by 64
Self-citationDisposition of Phenylbutyrate and its Metabolites, Phenylacetate and Phenylacetylglutamine
Piscitelli, S. C., Thibault, A., Figg, W. D., Tompkins, A. C., Headlee, D. J., Lieberman, R., Samid, D., & Myers, C. E. (1995) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1995.tb04075.x · Cited by 61
RÔLE OF GLUTAMINE IN PROTEIN SYNTHESIS BY THE EHRLICH ASCITES CARCINOMA
RABINOVITZ, M., Olson, M., & Greenberg, D. M. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89945-1 · Cited by 58
Pyruvate transport in tumour-cell mitochondria
Eboli, M. L., Paradies, G., Galeotti, T., & Papa, S. (1977) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(77)90166-9 · Cited by 57
Martin, M., Beauvoit, B. P., Voisin, P. J., Canioni, P., Guérin, B., & Rigoulet, M. (1998) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1020584517588 · Cited by 56
Self-citationDistinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes
Eimre, M., Paju, K., Pelloux, S., Béraud, N., Roosimaa, M., Kadaja, L., Puurand, M., Peet, N., Orlova, E., Remmelkoor, R., et al. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.019 · Cited by 56
Transport of pyruvate in mitochondria from different tumor cells.
Paradies, G., Capuano, F., Palombini, G., Galeotti, T., & Papa, S. (1983) · PubMed · Cited by 55
Short-term regulation of the mammalian pyruvate dehydrogenase complex.
Strumiło, S. (2005) · Acta Biochimica Polonica · doi:10.18388/abp.2005_3387 · Cited by 53
Wojtczak, L., Teplova, V. V., Bogucka, K., Czyż, A., Makowska, A., Wieckowski, M. R., Duszyński, J., & Evtodienko, Y. V. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00522.x · Cited by 52
Parlo, R. A., & Coleman, P. S. (1986) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(86)90134-5 · Cited by 52
Cuezva, J. M., Sánchez‐Aragó, M., Sala, S., Blanco-Rivero, A., & Ortega, A. D. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-007-9087-9 · Cited by 51
Phosphorylation-dephosphorylation of pyruvate dehydrogenase from bakers' yeast
Uhlinger, D. J., Yang, C. Y., & Reed, L. J. (1986) · Biochemistry · doi:10.1021/bi00367a049 · Cited by 50
Krause‐Buchholz, U., Gey, U., Wünschmann, J., Becker, S., & Rödel, G. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.002 · Cited by 50
Pasdois, P., Deveaud, C., Voisin, P. J., Bouchaud, V., Rigoulet, M., & Beauvoit, B. P. (2003) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1027391831382 · Cited by 48
Self-citationOxidoreductase activities in normal rat liver, tumor-bearing rat liver, and hepatoma HC-252.
Sun, A. S. K., & Cederbaum, A. I. (1980) · PubMed · Cited by 47
Saks, V. A., Belikova, Y., Vasilyeva, E. V., Kuznetsov, A. V., Fontaine, E. M., Kériel, C., & Leverve, X. M. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1422 · Cited by 45
Transcriptional control of yeast phosphofructokinase gene expression
Heinisch, J. J., Vogelsang, K., & Hollenberg, C. P. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80912-m · Cited by 36
Roy, D., & Dawes, I. W. (1987) · Microbiology · doi:10.1099/00221287-133-4-925 · Cited by 36
A selection system for human apoptosis inhibitors using yeast
Greenhalf, W., Lee, J. S., & Chaudhuri, B. (1999) · Yeast · doi:10.1002/(sici)1097-0061(19990930)15:13 · Cited by 36
Dejean, L. M., Beauvoit, B. P., Alonso, A. P., Bunoust, O., Guérin, B., & Rigoulet, M. (2002) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(02)00240-2 · Cited by 36
Self-citationGlycolytic sequence and respiration of Debaryomyces hansenii as compared to Saccharomyces cerevisiae
Sánchez, N. S., Calahorra, M., González‐Hernández, J. C., & Peña, A. (2006) · Yeast · doi:10.1002/yea.1360 · Cited by 36
Dietzen, D. J., & Davis, E. J. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1397 · Cited by 35
Entian, K.-D., Fröhlich, K.-U., & Mecke, D. (1984) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(84)90293-9 · Cited by 35
Baggetto, L. G., & Lehninger, A. L. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47966-5 · Cited by 34
Pallotta, M. L., Valenti, D., Iacovino, M., & Passarella, S. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2003.10.008 · Cited by 34
Pérez‐Vázquez, V., Saavedra‐Molina, A., & Uribe‐Carvajal, S. (2003) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1024659615022 · Cited by 33
Schlisio, S. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00881.x · Cited by 33
Baggetto, L. G., & Lehninger, A. L. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91300-3 · Cited by 31
Growth Yield Homeostasis in Respiring Yeast Is Due to a Strict Mitochondrial Content Adjustment
Devin, A., Dejean, L. M., Beauvoit, B. P., Chevtzoff, C., Avéret, N., Bunoust, O., & Rigoulet, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604800200 · Cited by 31
Self-citationGlutamine synthetase and glutaminase activities in various hepatoma cells.
Matsuno, T., & Hirai, H. (1989) · PubMed · Cited by 29
Chan, S. H. P., & Barbour, R. L. (1983) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(83)90014-2 · Cited by 27
Transport of pyruvate and lactate in yeast mitochondria
Briquet, M. (1977) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(77)90029-9 · Cited by 25
Distribution of hexokinase isoenzymes depending on a carbon source in Saccharomyces cerevisiae
Muratsubaki, H., & Katsume, T. (1979) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(79)90220-1 · Cited by 25
Zaragoza, Ó., Lindley, C., & Gancedo, J. M. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.8.2640-2642.1999 · Cited by 23
Evtodienko, Y. V., Teplova, V. V., Duszyński, J., Bogucka, K., & Wojtczak, L. (1994) · Cell Calcium · doi:10.1016/0143-4160(94)90108-2 · Cited by 17
Kinetic activation of yeast mitochondrial d-lactate dehydrogenase by carboxylic acids
Mourier, A., Vallortigara, J., Yoboue, E. D., Rigoulet, M., & Devin, A. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.06.007 · Cited by 15
Self-citationGlucose-induced inactivation of mitochondrial enzymes in the yeast Saccharomyces cerevisiae
Takeda, M. (1981) · Biochemical Journal · doi:10.1042/bj1980281 · Cited by 13
Lüftner, D., Mazurek, S., Henschke, P., Mesterharm, J., Schildhauer, S., Geppert, R., Wernecke, K. D., & Possinger, K. (2003) · PubMed · Cited by 8
Regulation of anaerobic glycolysis in Ehrlich ascites tumour cells
Schulz, J., Baufeld, A., Hofmann, E., Rapoport, T. A., Heinrich, R., & Rapoport, S. M. (1977) · De Gruyter eBooks · doi:10.1515/9783112650103-003 · Cited by 8
Flagged first, then by citations
2 of the 140 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Colowick, 1973, Group Transfer, Part A, Third Edition, 1
Cited by
Sorted by citations
The multifaceted contributions of mitochondria to cellular metabolism
Spinelli, J. B., & Haigis, M. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0124-1 · Cited by 1,935
How the Warburg effect supports aggressiveness and drug resistance of cancer cells?
Icard, P., Shulman, S. D., Farhat, D., Steyaert, J., Alifano, M., & Lincet, H. (2018) · Drug Resistance Updates · doi:10.1016/j.drup.2018.03.001 · Cited by 664
Increased demand for NAD(+) relative to ATP drives aerobic glycolysis
Luengo, A., Li, Z., Gui, D. Y., Sullivan, L. B., Zagorulya, M., Do, B. T., Ferreira, R., Naamati, A., Ali, A., Lewis, C. A., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.012 · Cited by 547
Cancer as a metabolic disease: implications for novel therapeutics
Seyfried, T. N., Flores, R. E., Poff, A. M., & D’Agostino, D. P. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt480 · Cited by 497
Energy metabolism in health and diseases
Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 484
Metadata
- Authors
- Diaz-Ruiz, R., Rigoulet, M., & Devin, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Devin, Anne
- ORCID
- Devin, Anne
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 1807
- Issue
- 6
- Pages
- 568-576
- ISSN
- 0005-2728 (ISSN-L)
- OpenAlex
- W2091739490
- Cited by
- 486
- References
- 140
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 15 · 2023: 29 · 2022: 31 · 2021: 38 · 2020: 36 · 2019: 44 · 2018: 45 · 2017: 54 · 2016: 37 · 2015: 37 · 2014: 31 · 2013: 28 · 2012: 18
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- Warburg effect, Crabtree effect, cancer cell energy metabolism, aerobic glycolysis, oxidative phosphorylation, mitochondrial physiology, glucose repression, Saccharomyces cerevisiae, cancer metabolism, cancer therapy, apoptosis
- MeSH terms
- Animals, Cells, Energy Metabolism, Biological Evolution, Glucose, Humans, Models, Biological, Models, Theoretical, Neoplasms, Yeasts, Down-Regulation, Gene Expression Regulation, Fungal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review