Cited by 79Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Transcriptional and conformational changes of the tau molecule in Alzheimer's disease

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Hyman, Bradley T., Augustinack, Jean C., Ingelsson, Martin·2005·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Abstract

Mutations in the tau gene cause frontotemporal dementia with parkinsonism, presumably by affecting the balance between tau isoforms (with either three or four microtubule-binding repeats) or by impairing tau-tubulin binding. Although to date no mutations have been found for Alzheimer's disease, it is plausible that tangle pathology in this disorder is also driven by similar molecular modifications. Investigations of Alzheimer brain tissue with new technologies such as laser capture microscopy, quantitative PCR and fluorescence lifetime imaging will shed light on whether transcriptional or conformational alterations play a role in Alzheimer pathogenesis.

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Crossref · 10.1016/j.bbadis.2004.06.015

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  • 4R tau expression is increased in vulnerable brain regions and NFT bearing neurons in AD brain.

    “Expression of tau isoforms in AD brain is complicated; although it is still under debate that whether the overall 3R:4R tau ratio is altered, several studies support a notion that 4R tau expression is increased in vulnerable brain regions and NFT bearing neurons in AD brain [111, 113–118].”

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Authors
Hyman, B. T., Augustinack, J. C., & Ingelsson, M.
Affiliations
Massachusetts General Hospital (US)
Corresponding author
Hyman, Bradley T.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher
Elsevier BV
Published
2005-01
Volume
1739
Issue
2-3
Pages
150-157
ISSN
0925-4439 (ISSN-L)
OpenAlex
W2037828638
Cited by
79
References
73
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 3 · 2014: 1 · 2013: 3 · 2012: 4
FWCI
0.47
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
tau protein, Alzheimer's disease, tau gene mutations, frontotemporal dementia with parkinsonism, tau isoforms, microtubule-binding repeats, neurofibrillary tangles
MeSH terms
Alzheimer Disease, Humans, Microtubules, Mutation, Protein Conformation, Transcription, Genetic, Gene Expression, Neurofibrillary Tangles, tau Proteins, Alternative Splicing

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