Shift in the ratio of three‐repeat tau and four‐repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Mild cognitive impairment as a diagnostic entity

Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works

Mild cognitive impairment – Beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment.

Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. ‐., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01380.x · Cited by 4,946 · see citing works

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., & Crowther, R. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90210-9 · Cited by 2,492 · see citing works

Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease

HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

Kosik, K. S., Joachim, C. L., & Selkoe, D. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4044 · Cited by 1,462 · see citing works

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

Lee, V. M.-Y., Balin, B. J., Otvos, L., & Trojanowski, J. Q. (1991) · Science · doi:10.1126/science.1899488 · Cited by 1,418 · see citing works

Tau is a candidate gene for chromosome 17 frontotemporal dementia

Poorkaj, P., Bird, T. D., Wijsman, E., Nemens, E., Garruto, R. M., Anderson, L., Andreadis, A., Wiederholt, W. C., Raskind, M., & Schellenberg, G. D. (1998) · Annals of Neurology · doi:10.1002/ana.410430617 · Cited by 1,374 · see citing works

Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

Goedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., & Crowther, R. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03390.x · Cited by 1,037 · see citing works

Natural history of mild cognitive impairment in older persons

Bennett, D. A., Wilson, R. S., Schneider, J. A., Evans, D. A., Beckett, L. A., Aggarwal, N. T., Barnes, L. L., Fox, J. H., & Bach, J. (2002) · Neurology · doi:10.1212/wnl.59.2.198 · Cited by 1,037 · see citing works

Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment

DeKosky, S. T., Ikonomovic, M. D., Styren, S. D., Beckett, L., Wisniewski, S., Bennett, D. A., Cochran, E. J., Kordower, J. H., & Mufson, E. J. (2002) · Annals of Neurology · doi:10.1002/ana.10069 · Cited by 686 · see citing works

Mutations causing neurodegenerative tauopathies

Goedert, M., & Jakes, R. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.08.007 · Cited by 438 · see citing works

Cholinergic nucleus basalis tauopathy emerges early in the aging‐MCI‐AD continuum

Mesulam, M. M., Shaw, P. L., Mash, D. C., & Weıntraub, S. (2004) · Annals of Neurology · doi:10.1002/ana.20100 · Cited by 365 · see citing works

Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain

Mufson, E. J., Bothwell, M. A., & Kordower, J. H. (1989) · Experimental Neurology · doi:10.1016/0014-4886(89)90124-6 · Cited by 279 · see citing works

Expression of NGF receptor in the developing and adult primate central nervous system

Schatteman, G., Gibbs, L., Lanahan, A. A., Claude, P., & Bothwell, M. A. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-03-00860.1988 · Cited by 251 · see citing works

Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: Colocalization with cholinergic neurons

Mufson, E. J., Bothwell, M. A., Hersh, L. B., & Kordower, J. H. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902850204 · Cited by 245 · see citing works

The Role of Nerve Growth Factor Receptors in Cholinergic Basal Forebrain Degeneration in Prodromal Alzheimer Disease

Counts, S., & Mufson, E. J. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.4.263 · Cited by 223 · see citing works

Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule‐binding repeat domains as demonstrated by new specific monoclonal antibodies

de Silva, R., Lashley, T., Gibb, G., Hanger, D. P., Hope, A., Reid, A. R., Bandopadhyay, R., Utton, M. A., Strand, C., Jowett, T. P., et al. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.00463.x · Cited by 220 · see citing works

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease

Mufson, E. J., Ma, S. Y., Cochran, E. J., Bennett, D. A., Beckett, L., Jaffar, S., Saragovi, H. U., & Kordower, J. H. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001106)427:1 · Cited by 216 · see citing works

Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques

Ginsberg, S. D., Crino, P. B., Lee, V. M. ‐., Eberwine, J. H., & Trojanowski, J. Q. (1997) · Annals of Neurology · doi:10.1002/ana.410410211 · Cited by 188 · see citing works

Reduction of cortical TrkA but not p75NTR protein in early‐stage Alzheimer's disease

Counts, S., Nadeem, M., Wuu, J., Ginsberg, S. D., Saragovi, H. U., & Mufson, E. J. (2004) · Annals of Neurology · doi:10.1002/ana.20233 · Cited by 183 · see citing works

Differential Assembly of Human Tau Isoforms in the Presence of Arachidonic Acid

King, M. E., Gamblin, T. C., Kuret, J., & Binder, L. I. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741749.x · Cited by 179 · see citing works

Gene Expression Profiles of Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease

Mufson, E. J., Counts, S., & Ginsberg, S. D. (2002) · Neurochemical Research · doi:10.1023/a:1020952704398 · Cited by 138 · see citing works

Three- and Four-repeat Tau Regulate the Dynamic Instability of Two Distinct Microtubule Subpopulations in Qualitatively Different Manners

Levy, S. F., LeBoeuf, A. C., Massie, M. R., Jordan, M. A., Wilson, L., & Feinstein, S. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413490200 · Cited by 102 · see citing works

Neuropathologic, Biochemical, and Molecular Characterization of the Frontotemporal Dementias

Mott, R. T., Dickson, D. W., Trojanowski, J. Q., Zhukareva, V., Lee, V. M., Forman, M. S., Deerlin, V. M. V., Ervin, J. F., Wang, D.-S., Schmechel, D. E., et al. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.5.420 · Cited by 100 · see citing works

Single-Cell Gene Expression Analysis: Implications for Neurodegenerative and Neuropsychiatric Disorders

Ginsberg, S. D., Elarova, I., Ruben, M., Tan, F., Counts, S. E., Eberwine, J. H., Trojanowski, J. Q., Hemby, S. E., Mufson, E. J., & Che, S. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000023593.77052.f7 · Cited by 97 · see citing works

Neuron‐specific age‐related decreases in dopamine receptor subtype mRNAs

Hemby, S. E., Trojanowski, J. Q., & Ginsberg, S. D. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10525 · Cited by 95 · see citing works

[18F]Fluorodeoxyglucose positron emission tomography in the diagnosis of cancer in patients with paraneoplastic neurological syndrome and anti-Hu antibodies

Antoine, J.-C. G., Cinotti, L., Tilikete, C., Bouhour, F., Camdessanch�, J. P., Confavreux, C., Vighetto, A., Renault‐Mannel, V., Michel, D., & Honnorat, J. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200007)48:1 · Cited by 86 · see citing works

RNA amplification strategies for small sample populations

Ginsberg, S. D. (2005) · Methods · doi:10.1016/j.ymeth.2005.09.003 · Cited by 85 · see citing works

Amplification of RNA transcripts using terminal continuation

Che, S., & Ginsberg, S. D. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700005 · Cited by 83 · see citing works

mRNA Expression Analysis of Tissue Sections and Single Cells

Eberwine, J. H., Kacharmina, J. E., Andrews, C., Miyashiro, K., McIntosh, T. K., Becker, K. G., Barrett, T., Hinkle, D., Dent, G. W., & Marciano, P. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08310.2001 · Cited by 80 · see citing works

Transcriptional and conformational changes of the tau molecule in Alzheimer's disease

Hyman, B. T., Augustinack, J. C., & Ingelsson, M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.015 · Cited by 79 · see citing works

Expression of tau mRNA and soluble tau isoforms in affected and non‐affected brain areas in Alzheimer's disease

Boutajangout, A., Boom, A., Leroy, K., & Brion, J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.09.011 · Cited by 77 · see citing works

Biochemical Analysis of τ Proteins in Argyrophilic Grain Disease, Alzheimer's Disease, and Pick's Disease

Zhukareva, V. A., Shah, K., Uryu, K., Braak, H., Tredici, K. D., Sundarraj, S., Clark, C. M., Trojanowski, J. Q., & Lee, V. M. ‐. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64390-8 · Cited by 75 · see citing works

Down‐regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease

Chu, Y., Cochran, E. J., Bennett, D. A., Mufson, E. J., & Kordower, J. H. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1284 · Cited by 69 · see citing works

RNA Amplification in Brain Tissues

Ginsberg, S. D., & Che, S. (2002) · Neurochemical Research · doi:10.1023/a:1020944502581 · Cited by 66 · see citing works

Combined histochemical staining, RNA amplification, regional, and single cell cDNA analysis within the hippocampus

Ginsberg, S. D., & Che, S. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700110 · Cited by 62 · see citing works

Accumulation of Intracellular Amyloid-β Peptide (Aβ 1–40) in Mucopolysaccharidosis Brains

Ginsberg, S. D., Galvin, J. E., Lee, V. M. ‐., RORKE, L. B., Dickson, D. W., Wolfe, J. H. N., JONES, M. Z., & Trojanowski, J. Q. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199908000-00004 · Cited by 61 · see citing works

Expression profile analysis within the human hippocampus: Comparison of CA1 and CA3 pyramidal neurons

Ginsberg, S. D., & Che, S. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20535 · Cited by 59 · see citing works

Selective reduction of soluble Tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study

Zhukareva, V. A., Sundarraj, S., Mann, D. M. A., Sjögren, M. J. C., Blenow, K., Clark, C. M., McKeel, D. W., Goate, A., Lippa, C. F., Vonsattel, J., et al. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0668-8 · Cited by 51 · see citing works

Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA

Yasojima, K., McGeer, E. G., & McGeer, P. L. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01486-9 · Cited by 51 · see citing works

Galanin Fiber Hypertrophy within the Cholinergic Nucleus Basalis during the Progression of Alzheimer’s Disease

Counts, S., Chen, E., Che, S., Ikonomović, M. D., Wuu, J., Ginsberg, S. D., DeKosky, S. T., & Mufson, E. J. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000090906 · Cited by 48 · see citing works

Molecular Pathology of Alzheimer’s Disease and Related Disorders

Ginsberg, S. D., Schmidt, M. L., Crino, P. B., Eberwine, J. H., Lee, V. M. ‐., & Trojanowski, J. Q. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_17 · Cited by 38 · see citing works

Expression profiling in the aging brain: A perspective

Galvin, J. E., & Ginsberg, S. D. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.06.009 · Cited by 32 · see citing works

Expression profiling and pharmacotherapeutic development in the central nervous system.

Galvin, J. E., & Ginsberg, S. D. (2005) · PubMed · Cited by 21 · see citing works

Untitled work

Kordower (1999) · doi:10.1002/1531-8249(199909)46:3

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

The cholinergic system in aging and neuronal degeneration

Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047 · see citing works

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

Barage, S. H., & Sonawane, K. D. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.06.008 · Cited by 579 · see citing works

Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease

Kelly, S. C., He, B., Perez, S. E., Ginsberg, S. D., Mufson, E. J., & Counts, S. E. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0411-2 · Cited by 286 · see citing works

Tau isoform composition influences rate and extent of filament formation

Zhong, Q., Congdon, E. E., Nagaraja, H. N., & Kuret, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.364067 · Cited by 122 · see citing works

Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (<i>Gorilla gorilla gorilla</i>)

Perez, S. E., Raghanti, M. A., Hof, P. R., Kramer, L., Ikonomovic, M. D., Lacor, P. N., Erwin, J. M., Sherwood, C. C., & Mufson, E. J. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23428 · Cited by 95 · see citing works

Single molecule profiling of tau gene expression in Alzheimer’s disease

Conrad, C., Zhu, J., Conrad, C., Schoenfeld, D., Fang, Z., Ingelsson, M., Stamm, S., Church, G., & Hyman, B. T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04857.x · Cited by 68 · see citing works

Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia

Iseki, E., Yamamoto, R., Murayama, N., Minegishi, M., Togo, T., Katsuse, O., Kosaka, K., Akiyama, H., Tsuchiya, K., Rohan, D. S., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.06.036 · Cited by 39 · see citing works

Nucleus Basalis Lesions and Recovery

Haroutunian, V. H., Wallace, W., & Davis, K. L. (1991) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4899-6738-1_14 · Cited by 2 · see citing works

Cortical Cholinergic Hypofunction and Behavioral Impairment Produced by Basal Forebrain Lesions in the Rat

Lerer, B. E., Gamzu, E., & Friedman, E. (1986) · Advances in behavioral biology · doi:10.1007/978-1-4684-5194-8_12

Cholinergic Hypofunction and Dementia: Relation of Neuronal Loss in Different Parts of the Nucleus Basalis to Cortical Neuropathological Changes

Bigl, V., Arendt, T., Tennstedt, A., et al. (1986) · Advances in behavioral biology · doi:10.1007/978-1-4684-5194-8_20

Pallial origin of basal forebrain cholinergic neurons in the nucleus basalis of Meynert and horizontal limb of the diagonal band nucleus

Pombero, A., Bueno, C., Saglietti, L., Rodenas, M., Guimerá, J., Bulfone, A., & Martı́nez, S. (2011) · Development · doi:10.1242/dev.069534 · Cited by 28 · see citing works

Basal forebrain neurons in the dementia of Parkinson disease

Whitehouse, P. J., Hedreen, J. C., White, C. L., & Price, D. L. (1983) · Annals of Neurology · doi:10.1002/ana.410130304 · Cited by 535 · see citing works