The DOI matches its Crossref record; 114 of the 115 references it cites were found in a registry or an index.
Peroxisomal ABC transporters: Structure, function and role in disease
Open accessAbstract
ATP-binding cassette (ABC) transporters belong to one of the largest families of membrane proteins, and are present in almost all living organisms from eubacteria to mammals. They exist on plasma membranes and intracellular compartments such as the mitochondria, peroxisomes, endoplasmic reticulum, Golgi apparatus and lysosomes, and mediate the active transport of a wide variety of substrates in a variety of different cellular processes. These include the transport of amino acids, polysaccharides, peptides, lipids and xenobiotics, including drugs and toxins. Three ABC transporters belonging to subfamily D have been identified in mammalian peroxisomes. The ABC transporters are half-size and assemble mostly as a homodimer after posttranslational transport to peroxisomal membranes. ABCD1/ALDP and ABCD2/ALDRP are suggested to be involved in the transport of very long chain acyl-CoA with differences in substrate specificity, and ABCD3/PMP70 is involved in the transport of long and branched chain acyl-CoA. ABCD1 is known to be responsible for X-linked adrenoleukodystrophy (X-ALD), an inborn error of peroxisomal β-oxidation of very long chain fatty acids. Here, we summarize recent advances and important points in our advancing understanding of how these ABC transporters target and assemble to peroxisomal membranes and perform their functions in physiological and pathological processes, including the neurodegenerative disease, X-ALD.
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“The dysfunction of ABCD1 results in impaired degradation of VLCFAs in peroxisomes and consequently leads to their accumulation in various lipid species in tissues and body fluids.7”
From The genetic landscape of X-linked adrenoleukodystrophy: inheritance, mutations, modifier genes, and diagnosis (2015) · cites this paper as [7]
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Cites
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Presenting your structures: theCCP4mgmolecular-graphics software
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Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
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Biochemistry of mammalian peroxisomes revisited
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Human ATP-binding cassette (ABC) transporter family
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Dermauw, W., & Leeuwen, T. V. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2013.11.001 · Cited by 654
Structural and Mechanistic Principles of ABC Transporters
Thomas, C., & Tampé, R. (2020) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-011520-105201 · Cited by 591
Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology
Sassa, T., & Kihara, A. (2014) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.017 · Cited by 302
Wu, C., Chakrabarty, S., Jin, M., Liu, K., & Xiao, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112829 · Cited by 229
Complexity of vitamin E metabolism
Schmölz, L. (2016) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v7.i1.14 · Cited by 223
Metadata
- Authors
- Morita, M., & Imanaka, T.
- Affiliations
- University of Toyama (JP)
- Corresponding author
- Imanaka, Tsuneo
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 1822
- Issue
- 9
- Pages
- 1387-1396
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W1987601583
- Cited by
- 183
- References
- 115
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 10 · 2023: 10 · 2022: 15 · 2021: 22 · 2020: 11 · 2019: 15 · 2018: 10 · 2017: 9 · 2016: 14 · 2015: 17 · 2014: 17 · 2013: 13 · 2012: 2
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (20590054, 22590060, 23590072)
- Ministry of Health, Labour and Welfare
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- peroxisomal ABC transporters, ABCD1, ABCD2, ABCD3, X-linked adrenoleukodystrophy, peroxisomal beta-oxidation, membrane protein targeting, neurodegenerative diseases
- MeSH terms
- Acyl Coenzyme A, Adrenoleukodystrophy, Animals, Biological Transport, Active, Humans, Neurons, Phylogeny, Protein Conformation, ATP-Binding Cassette Transporters, Peroxisomes, Protein Transport, Lipid Metabolism
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