The DOI matches its Crossref record; 380 of the 382 references it cites were found in a registry or an index.
The pharmacology of resveratrol in animals and humans
Open accessAbstract
In addition to thousands of research papers related to resveratrol (RSV), approximately 300 review articles have been published. Earlier research tended to focus on pharmacological activities of RSV related to cardiovascular systems, inflammation, and carcinogenesis/cancer development. More recently, the horizon has been broadened by exploring the potential effect of RSV on the aging process, diabetes, neurological dysfunction, etc. Herein, we primarily focus on the in vivo pharmacological effects of RSV reported over the past 5 years (2009-2014). In addition, recent clinical intervention studies performed with resveratrol are summarized. Some discrepancies exist between in vivo studies with animals and clinical studies, or between clinical studies, which are likely due to disparate doses of RSV, experimental settings, and subject variation. Nevertheless, many positive indications have been reported with mammals, so it is reasonable to advocate for the conduct of more definitive clinical studies. Since the safety profile is pristine, an added advantage is the use of RSV as a dietary supplement. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.
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“Traditionally, equol is classified as a polyphenolic compound.”
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3 retracted
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RetractedSiegel, R., Ma, J., Zou, Z., & Jemal, A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21208 · Cited by 11,499
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
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Wine, alcohol, platelets, and the French paradox for coronary heart disease
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2 of the 382 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Takaoka, 1939, Resveratrol, a new phenolic compound, from Veratrum grandiflorum, J. Chem. Soc. Jpn., 60, 1090
- Doustar, 2012, Immunohistochemical study of the effect of resveratrol on the expression of β-catenin protein in experimental colonic carcinoma of rat, J. Anim. Vet. Adv., 11, 4472
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Resveratrol: A Double-Edged Sword in Health Benefits
Salehi, B., Mishra, A. P., Nigam, M., Şener, B., Kılıç, M., Sharifi‐Rad, M., Fokou, P. V. T., Martins, N. A., & Sharifi‐Rad, J. (2018) · Biomedicines · doi:10.3390/biomedicines6030091 · Cited by 1,195
Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects
Brglez Mojzer, E., Knez Hrnčič, M., Škerget, M., Knez, Ž., & Bren, U. (2016) · Molecules · doi:10.3390/molecules21070901 · Cited by 1,096
Cragg, G. M. L., & Pezzuto, J. M. (2015) · Medical Principles and Practice · doi:10.1159/000443404 · Cited by 845
Resveratrol (RV): A pharmacological review and call for further research
Zhang, L., Li, C., Kakar, M. U., Khan, M. S., Wu, P.-F., Amir, R. M., Dai, D., Naveed, M., Li, Q., Saeed, M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112164 · Cited by 580
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Metadata
- Authors
- Park, E.-J., & Pezzuto, J. M.
- Affiliations
- University of Hawaii at Hilo (US)
- Corresponding author
- Pezzuto, John M.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 1852
- Issue
- 6
- Pages
- 1071-1113
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2079262741
- Cited by
- 302
- References
- 382
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 27 · 2023: 15 · 2022: 25 · 2021: 27 · 2020: 33 · 2019: 35 · 2018: 27 · 2017: 28 · 2016: 46 · 2015: 19
- FWCI
- 20.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- resveratrol, pharmacology, cardiovascular effects, inflammation, carcinogenesis, aging, diabetes mellitus, neurological disorders, dietary supplements, safety profile, preclinical to clinical translation
- MeSH terms
- Resveratrol, Animals, Clinical Trials as Topic, Humans, Periodicals as Topic, Stilbenes
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