The pharmacology of resveratrol in animals and humans

Cancer statistics, 2014

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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

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Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

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Concentration of the Phytoalexin Resveratrol in Wine

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Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

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AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

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AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

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Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

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Diabetes, oxidative stress and therapeutic strategies

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Classic and New Animal Models of Parkinson's Disease

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Animal Models of Depression: Molecular Perspectives

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Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

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High-Dose Resveratrol Supplementation in Obese Men

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Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

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Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases—Safety, Pharmacokinetics, and Pharmacodynamics

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Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.

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Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

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Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats

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Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S., Schechtman, K. B., Gu, C. C., Kunz, I., Fanelli, F. R., Patterson, B. W., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.015 · Cited by 389

Inhibition of cancer growth by resveratrol is related to its low bioavailability

Asensi, M., Medina, I., Ortega, A., Carretero, J., Baño, M. C., Obrador, E., & Estrela, J. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00911-5 · Cited by 388

Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2–Keap1 signaling

Periyasamy, P., & Subramanian, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.03.008 · Cited by 387

One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease

Tomé‐Carneiro, J., Larrosa, M., Yáñez-Gascón, M. J., Dávalos, A., Gil‐Zamorano, J., Gonzálvez, M., García‐Almagro, F. J., Ros, J. A. R., Tomás-Barberán, F. A., Espı́n, J. C., et al. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.03.011 · Cited by 384

Animal models of disease: Pre-clinical animal models of cancer and their applications and utility in drug discovery

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Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity

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Resveratrol Attenuates Obesity-Associated Peripheral and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet

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Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease

Magyar, K., Halmosi, R., Pálfi, A., Fehér, G., Czopf, L., Fulop, A., Battyány, I., Sümegi, B., Tóth, K., & Szabados, E. (2012) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2011-1424 · Cited by 364

Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats

Sinha, K., Chaudhary, G., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01691-0 · Cited by 356

Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice

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Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo

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Enhancing the bioavailability of resveratrol by combining it with piperine

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Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study

Chow, H. ‐. S., Garland, L. L., Hsu, C., Vining, D. R., Chew, W. M., Miller, J. A., Perloff, M., Crowell, J. A., & Alberts, D. S. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0155 · Cited by 333

Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.

Bhat, K., Lantvit, D. D., Christov, K. T., Mehta, R. G., Moon, R. C., & Pezzuto, J. M. (2001) · PubMed · Cited by 330

Resveratrol Isolated from Polygonum cuspidatum Root Prevents Tumor Growth and Metastasis to Lung and Tumor-Induced Neovascularization in Lewis Lung Carcinoma-Bearing Mice

Kimura, Y., & Okuda, H. (2001) · Journal of Nutrition · doi:10.1093/jn/131.6.1844 · Cited by 311

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

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Resveratrol Inhibits Breast Cancer Stem-Like Cells and Induces Autophagy via Suppressing Wnt/β-Catenin Signaling Pathway

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Anti-Inflammatory Effects of Resveratrol, Curcumin and Simvastatin in Acute Small Intestinal Inflammation

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Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

Sulaiman, M., Matta, M., Sunderesan, N. R., Gupta, M. P., Periasamy, M., & Gupta, M. P. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00418.2009 · Cited by 288

Resveratrol protects against age-associated infertility in mice

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Pilot study of resveratrol in older adults with impaired glucose tolerance

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Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21CIP expression

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Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease

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Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

Wong, R. H. X., Howe, P. R. C., Buckley, J. D., Coates, A. M., Kunz, I., & Berry, N. M. (2011) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.03.003 · Cited by 277

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

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Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase

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Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients

Movahed, A., Nabipour, I., Louis, X. L., Thandapilly, S. J., Yu, L., Kalantarhormozi, M., Rekabpour, S. J., & Netticadan, T. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/851267 · Cited by 265

Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice☆☆Part of this work was conducted at the Department of Dermatology, Case Western Reserve University and the Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106.

Afaq, F., Adhami, V. M., & Ahmad, N. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(02)00014-5 · Cited by 262

One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease

Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., Yáñez-Gascón, M. J., García‐Almagro, F. J., Ruiz‐Ros, J. A., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.03.030 · Cited by 260

Resveratrol, a Natural Product Present in Wine, Decreases Tumour Growth in a Rat Tumour Model

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A comparison of the anticarcinogenic properties of four red wine polyphenols

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Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet

Jiménez, Y., Mattison, J. A., Pearson, K. J., Martín‐Montalvo, A., Palacios, H. H., Sossong, A. M., Ward, T. M., Younts, C. M., Lewis, K. N., Allard, J. S., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.004 · Cited by 247

Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats

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Trans-Resveratrol Alters Mammary Promoter Hypermethylation in Women at Increased Risk for Breast Cancer

Zhu, W., Qin, W., Zhang, K., Rottinghaus, G. E., Chen, Y.-C., Kliethermes, B., & Sauter, E. R. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.654926 · Cited by 244

Grape Resveratrol Increases Serum Adiponectin and Downregulates Inflammatory Genes in Peripheral Blood Mononuclear Cells: A Triple-Blind, Placebo-Controlled, One-Year Clinical Trial in Patients with Stable Coronary Artery Disease

Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., Yáñez-Gascón, M. J., García‐Almagro, F. J., Ruiz‐Ros, J. A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2012) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6427-8 · Cited by 244

Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men

Gliemann, L., Schmidt, J. F., Olesen, J., Biensø, R. S., Peronard, S. L., Grandjean, S. U., Mortensen, S. P., Nyberg, M., Bangsbo, J., Pilegaard, H., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.258061 · Cited by 244

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

Lee, H., Zhang, P., Herrmann, A., Yang, C., Xin, H., Wang, Z., Hoon, D. S. �., Forman, S. J., Jove, R., Riggs, A. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205132109 · Cited by 241

Animal Models of Huntington's Disease

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Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor α in mice

Inoue, H., Jiang, X., Katayama, T., Osada, S., Umesono, K., & Namura, S. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.001 · Cited by 238

Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis

Kapadia, G. J., Azuine, M. A., Tokuda, H., Takasaki, M., Mukainaka, T., Konoshima, T., & Nishino, H. (2002) · Pharmacological Research · doi:10.1006/phrs.2002.0992 · Cited by 238

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

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Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats

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Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats

Periyasamy, P., & Subramanian, S. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.06.037 · Cited by 232

Grapes and Human Health: A Perspective

Pezzuto, J. M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf800898p · Cited by 232

Resveratrol‐enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice

Wang, B., Yang, Q., Sun, Y., Xing, Y., Wang, Y., Lu, X., Bai, W., Liu, X., & Zhao, Y. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12312 · Cited by 230

Resveratrol Reduces Prostate Cancer Growth and Metastasis by Inhibiting the Akt/MicroRNA-21 Pathway

Sheth, S., Jajoo, S., Kaur, T., Mukherjea, D., Sheehan, K., Rybak, L. P., & Ramkumar, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051655 · Cited by 225

Resveratrol Protects Rats from Aβ-induced Neurotoxicity by the Reduction of iNOS Expression and Lipid Peroxidation

Huang, T.-C., Lu, K., Wo, Y.-Y. P., Wu, Y.-J., & Yang, Y.-L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029102 · Cited by 223

Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis

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Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice

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Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?

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Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

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Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease

Chang, J., Rimando, A. M., Pallàs, M., Camins, A., Porquet, D., Reeves, J., Shukitt‐Hale, B., Smith, M. A., Joseph, J. A., & Casadesús, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.08.015 · Cited by 219

Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice

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Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice

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Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and A po B in patients undergoing primary prevention of cardiovascular disease: A triple‐blind, 6‐month follow‐up, placebo‐controlled, randomized trial

Tomé‐Carneiro, J., Gonzálvez, M., Larrosa, M., García‐Almagro, F. J., Avilés-Plaza, F. V., Parra, S., Yáñez-Gascón, M. J., Ruiz‐Ros, J. A., García‐Conesa, M., Tomás-Barberán, F. A., et al. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100673 · Cited by 211

Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice

Dolinsky, V. W., Chakrabarti, S., Pereira, T. J., Oka, T., Levasseur, J. L., Beker, D. L., Zordoky, B. N. M., Morton, J. S., Nagendran, J., Lopaschuk, G. D., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.018 · Cited by 209

Anti-Inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial

Bo, S., Ciccone, G., Castiglione, A., Gambino, R., Michieli, F. D., Villois, P., Durazzo, M., Cavallo‐Perin, P., & Cassader, M. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320100009 · Cited by 209

Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase

Pandey, P. R., Okuda, H., Watabe, M., Pai, S. K., Liu, W., Kobayashi, A., Xing, F., Fukuda, K., Hirota, S., Sugai, T., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1300-6 · Cited by 208

Pterostilbene Is More Potent than Resveratrol in Preventing Azoxymethane (AOM)-Induced Colon Tumorigenesis via Activation of the NF-E2-Related Factor 2 (Nrf2)-Mediated Antioxidant Signaling Pathway

Chiou, Y.-S., Tsai, M.-L., Nagabhushanam, K., Wang, Y.-J., Wu, C., Ho, C., & Pan, M. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2000103 · Cited by 205

Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic β‐cell dysfunction in streptozotocin‐nicotinamide‐induced diabetic rats

Periyasamy, P., & Subramanian, S. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22138 · Cited by 202

Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy

Kumar, A., Kaundal, R. K., Iyer, S. R., & Sharma, S. S. (2007) · Life Sciences · doi:10.1016/j.lfs.2006.12.036 · Cited by 200

Resveratrol Inhibits Intestinal Tumorigenesis and Modulates Host-Defense-Related Gene Expression in an Animal Model of Human Familial Adenomatous Polyposis

Schneider, Y., Duranton, B., Goss, F., Schleiffer, R., Seiler, N., & Raul, F. (2001) · Nutrition and Cancer · doi:10.1207/s15327914nc391_14 · Cited by 200

Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats

Schmatz, R., Pereira, L. B., Stefanello, N., Mazzanti, C. M. D. A., Spanevello, R. M., Gutierres, J. M., Bagatini, M. D., Martins, C. C., Abdalla, F. H., Serres, J. D. D. S., et al. (2011) · Biochimie · doi:10.1016/j.biochi.2011.08.005 · Cited by 192

Wine and Health: A Review

Guilford, J. M., & Pezzuto, J. M. (2011) · American Journal of Enology and Viticulture · doi:10.5344/ajev.2011.11013 · Cited by 191

Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system

Xu, Y., Wang, Z., You, W., Zhang, X., Li, S., Barish, P. A., Vernon, M. M., Du, X., Li, G., & Pan, J. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.02.013 · Cited by 190

Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway

Yong-na, Z., Li, W., Li, F. Y., Zhang, Z., Dai, Y.-D., Xu, A.-L., Cui, Q., Gao, J., & Gao, J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.025 · Cited by 187

Resveratrol, a Polyphenolic Phytoalexin, Attenuates Diabetic Nephropathy in Rats

Sharma, S., Anjaneyulu, M., Kulkarni, S., & Chopra, K. (2005) · Pharmacology · doi:10.1159/000089720 · Cited by 177

Resveratrol enhances GLUT‐4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium

Penumathsa, S. V., Thirunavukkarasu, M., Zhan, L., Maulik, G., Menon, V. P., Bagchi, D., & Maulik, N. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00251.x · Cited by 175

Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[ a ]pyrene

Revel, A., Raanani, H., Younglai, E. V., Xu, J., Rogers, I. M., Han, R. N. N., Savouret, J., & Casper, R. F. (2003) · Journal of Applied Toxicology · doi:10.1002/jat.916 · Cited by 174

Mouse models for liver cancer

Bakiri, L., & Wagner, E. F. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.01.005 · Cited by 173

Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

Semba, R. D., Ferrucci, L., Bartali, B., Urpí-Sardà, M., Zamora‐Ros, R., Sun, K., Cherubini, A., Bandinelli, S., & Andrés‐Lacueva, C. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.1582 · Cited by 172

Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation

Wightman, E. L., Reay, J. L., Haskell‐Ramsay, C. F., Williamson, G., Dew, T. P., & Kennedy, D. O. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000737 · Cited by 172

Resveratrol Prevents the Development of Pathological Cardiac Hypertrophy and Contractile Dysfunction in the SHR Without Lowering Blood Pressure

Thandapilly, S. J., Wojciechowski, P. W., Behbahani, J., Louis, X. L., Yu, L., Juric, D., Kopilas, M. A., Anderson, H. D., & Netticadan, T. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.228 · Cited by 172

Resveratrol Engages AMPK to Attenuate ERK and mTOR Signaling in Sensory Neurons and Inhibits Incision-Induced Acute and Chronic Pain

Tillu, D. V., Melemedjian, O. K., Asiedu, M. N., Qu, N., Felice, M. D., Dussor, G. O., & Price, T. J. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-5 · Cited by 170

Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: Inhibition of cell proliferation and induction of apoptosis

Bishayee, A., & Dhir, N. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.11.015 · Cited by 169

Resveratrol Increases Glucose Induced GLP-1 Secretion in Mice: A Mechanism which Contributes to the Glycemic Control

Dao, T.-M. A., Waget, A., Klopp, P., Sérino, M., Vachoux, C., Pechère, L., Drucker, D. J., Champion, S., Barthélemy, S., Barra, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020700 · Cited by 168

Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia

Huang, S. S., Tsai, M. C., Chih, C. L., Hung, L., & Tsai, S. K. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01195-x · Cited by 167

Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury

Liu, C., Shi, Z., Fan, L., Zhang, C., Wang, K., & Wang, B. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.061 · Cited by 167

Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4′‐tetramethoxystilbene (DMU‐212) on adenoma development in the ApcMin+ mouse and cyclooxygenase‐2 in human‐derived colon cancer cells

Sale, S., Tunstall, R. G., Ruparelia, K. C., Potter, G. A., Steward, W. P., & Gescher, A. J. (2005) · International Journal of Cancer · doi:10.1002/ijc.20884 · Cited by 166

Antidepressant effects of resveratrol in an animal model of depression

Hurley, L. L., Akinfiresoye, L. R., Kalejaiye, O., & Tizabi, Y. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.03.052 · Cited by 166

Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21CIP expression

Tessitore, L., Davit, A., Sarotto, I., et al. (2000) · Carcinogenesis · doi:10.1093/carcin/21.8.1619 · Cited by 164

Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults

Wong, R. H. X., Berry, N. M., Coates, A. M., Buckley, J. D., Bryan, J., Kunz, I., & Howe, P. R. C. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328362b9d6 · Cited by 162

Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: Effects on lipid profiles, inflammation markers, and quality of life

Militaru, C., Donoiu, I., Crăciun-Mirescu, A., Scorei, I. D., Bulearca, A. M., & Scorei, I. R. (2012) · Nutrition · doi:10.1016/j.nut.2012.07.006 · Cited by 161

Resveratrol Suppresses Oxidative Stress and Inflammatory Response in Diethylnitrosamine-Initiated Rat Hepatocarcinogenesis

Bishayee, A., Barnes, K. F., Bhatia, D., Darvesh, A. S., & Carroll, R. T. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0171 · Cited by 161

Resveratrol suppresses prostate cancer progression in transgenic mice

Harper, C., Patel, B. B., Wang, J., Arabshahi, A., Eltoum, I. A., & Lamartiniere, C. A. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm144 · Cited by 160

Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice

Hecht, S. S., Kenney, P. M. J., Wang, M., Trushin, N., Agarwal, S., Rao, A. V., & Upadhyaya, P. (1999) · Cancer Letters · doi:10.1016/s0304-3835(98)00326-7 · Cited by 159

Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats

Gupta, Y. K., Briyal, S., & Chaudhary, G. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00663-3 · Cited by 158

Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin

Reagan‐Shaw, S., Afaq, F., Aziz, M. H., & Ahmad, N. (2004) · Oncogene · doi:10.1038/sj.onc.1207666 · Cited by 158

Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats

Chi, T.-C., Chen, W.-P., Chi, T.-L., Kuo, T., Lee, S., Cheng, J., & Su, M. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.02.002 · Cited by 156

Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin–nicotinamide-induced diabetic rats

Periyasamy, P., & Subramanian, S. P. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.11.008 · Cited by 155

Advances in porcine genomics and proteomics--a toolbox for developing the pig as a model organism for molecular biomedical research

Bendixen, E., Danielsen, M., Larsen, K., & Bendixen, C. (2010) · Briefings in Functional Genomics · doi:10.1093/bfgp/elq004 · Cited by 155

Effects of resveratrol on 12-O-tetradecanoylphorbol-13-acetate-induced oxidative events and gene expression in mouse skin

Jang, M., & Pezzuto, J. M. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00250-x · Cited by 150

Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading to Heart Failure

Rimbaud, S., Ruiz, M., Piquereau, J., Matéo, P., Fortin, D., Veksler, V., Garnier, A., & Ventura‐Clapier, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026391 · Cited by 149

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

Ho, D. J., Calingasan, N. Y., Wille, E. J., Dumont, M., & Beal, M. F. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.05.006 · Cited by 148

Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin–nicotinamide-induced experimental diabetic rats

Periyasamy, P., Sivakumar, S., & Subramanian, S. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.03.028 · Cited by 145

Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats

Tsai, S.-K., Hung, L., Fu, Y.-T., Cheng, H., Nien, M.-W., Liu, H.-Y., Zhang, F. B.-Y., & Huang, S.-S. (2007) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2007.04.044 · Cited by 145

Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats

Miura, D., Miura, Y., & Yagasaki, K. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00469-7 · Cited by 145

Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner

Yang, Q., Wang, B., Zang, W., Wang, X., Liu, Z., Li, W., & Jia, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070627 · Cited by 141

Protective Effect of Resveratrol against Kainate-induced Temporal Lobe Epilepsy in Rats

Wu, Z., Xu, Q., Zhang, L., Kong, D., Ma, R., & Wang, L. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9920-0 · Cited by 140

Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

Fiori, J. L., Shin, Y., Kim, W., Krzysik-Walker, S. M., González‐Mariscal, I., Carlson, O. D., Sanghvi, M., Moaddel, R., Farhang, K., Gadkaree, S. K., et al. (2013) · Diabetes · doi:10.2337/db13-0266 · Cited by 140

Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium

Agarwal, B., Campen, M. J., Channell, M. M., Wherry, S. J., Varamini, B., Davis, J. G., Baur, J. A., & Smoliga, J. M. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.027 · Cited by 137

SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol

Boily, G., He, X. H., Pearce, B., Jardine, K. E., & McBurney, M. W. (2009) · Oncogene · doi:10.1038/onc.2009.147 · Cited by 137

Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats.

Whitsett, T. G., Carpenter, M., & Lamartiniere, C. A. (2006) · Journal of Carcinogenesis · doi:10.1186/1477-3163-5-15 · Cited by 135

Central nervous system protection by resveratrol in streptozotocin-induced diabetic rats

Ateş, Ö., Cayli, S. R., Yücel, N., Altınöz, E., Koçak, A., Durak, M. A., Türköz, Y., & Yoloğlu, S. (2007) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2005.12.010 · Cited by 135

Chemopreventive effect of trans -resveratrol - a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis

Murugan, S., Viswanathan, P., & Nalini, N. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi286 · Cited by 135

Resveratrol enhances insulin secretion by blocking KATP and KV channels of beta cells

Chen, W., Chi, T.-C., Chuang, L., & Su, M. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.04.062 · Cited by 134

Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in Parkinsonian rats

Wang, Y., Xu, H., Fu, Q., Ma, R., & Xiang, J. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.02.025 · Cited by 133

Cognitive Performances Are Selectively Enhanced during Chronic Caloric Restriction or Resveratrol Supplementation in a Primate

Dal‐Pan, A., Pifferi, F., Marchal, J., Picq, J., & Aujard, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016581 · Cited by 133

Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor

Ganapathy, S., Chen, Q., Singh, K. P., Shankar, S., & Srivastava, R. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015627 · Cited by 133

MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol

Yu, Y.-H., Chen, H.-A., Chen, P.-S., Cheng, Y.-J., Hsu, W.-H., Chang, Y.-W., Chen, Y.-H., Jan, Y., Hsiao, M., Chang, T.-Y., et al. (2012) · Oncogene · doi:10.1038/onc.2012.74 · Cited by 133

Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice

Dolinsky, V. W., Rogan, K. J., Sung, M. M., Zordoky, B. N., Haykowsky, M. J., Young, M. E., Jones, L. W., & Dyck, J. R. B. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00044.2013 · Cited by 133

Resveratrol Inhibits Growth of Orthotopic Pancreatic Tumors through Activation of FOXO Transcription Factors

Roy, S. K., Chen, Q., Fu, J., Shankar, S., & Srivastava, R. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025166 · Cited by 130

Resveratrol reduces the elevated level of MMP-9 induced by cerebral ischemia–reperfusion in mice

Gao, D., Zhang, X., Jiang, X., Peng, Y., Huang, W., Cheng, G. S., & Song, L. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.10.030 · Cited by 129

Resveratrol preserves cerebrovascular density and cognitive function in aging mice

Oomen, C. A. (2009) · Frontiers in Aging Neuroscience · doi:10.3389/neuro.24.004.2009 · Cited by 128

Resveratrol Prevents Light-Induced Retinal Degeneration via Suppressing Activator Protein-1 Activation

Kubota, S., Kurihara, T., Ebinuma, M., Kubota, M., Yuki, K., Sasaki, M., Noda, K., Ozawa, Y., Oike, Y., Ishida, S., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100098 · Cited by 127

Central Administration of Resveratrol Improves Diet-Induced Diabetes

Ramadori, G., Gautron, L., Fujikawa, T., Vianna, C. R., Elmquist, J. K., & Coppari, R. (2009) · Endocrinology · doi:10.1210/en.2009-0528 · Cited by 126

Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase

Chang, C., Chang, C.-Y., Wu, Y.-T., Huang, J., Yen, T., & Hung, L. (2011) · Journal of Biomedical Science · doi:10.1186/1423-0127-18-47 · Cited by 126

Protective effect of resveratrol against doxorubicin-induced cardiac toxicity and fibrosis in male experimental rats

Arafa, M. H., Mohammad, N. S., Atteia, H. H., & Abdel‐Aziz, H. R. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0339-y · Cited by 125

Resveratrol Suppresses Cancer Cell Glucose Uptake by Targeting Reactive Oxygen Species–Mediated Hypoxia-Inducible Factor-1α Activation

Jung, K., Lee, J. H., Quach, C. H. T., Paik, J.-Y., Oh, H., Park, J. W., Lee, E. J., Moon, S. H., & Lee, K.-H. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.115436 · Cited by 125

Resveratrol Attenuates Ovariectomy-Induced Hypertension and Bone Loss in Stroke-Prone Spontaneously Hypertensive Rats.

MIZUTANI, K., Ikeda, K., Kawai, Y., & Yamori, Y. (2000) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.46.78 · Cited by 125

Effect of resveratrol on the development of spontaneous mammary tumors in HER‐2/neu transgenic mice

Provinciali, M., Re, F., Donnini, A., Orlando, F., Bartozzi, B., Stasio, G. D., & Smorlesi, A. (2005) · International Journal of Cancer · doi:10.1002/ijc.20874 · Cited by 124

Resveratrol Protects Against Neurotoxicity Induced by Kainic Acid

Wang, Q., Yu, S. O., Simonyi, Á., Rottinghaus, G. E., Sun, G. Y., & Sun, A. Y. (2004) · Neurochemical Research · doi:10.1007/s11064-004-6883-z · Cited by 123

Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression

Saud, S. M., Li, W., Morris, N. L., Matter, M. S., Colburn, N. H., Kim, Y. S., & Young, M. R. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu209 · Cited by 122

Methylation and miRNA Effects of Resveratrol on Mammary Tumors vs. Normal Tissue

Qin, W., Zhang, K., Clarke, K., Weiland, T. L., & Sauter, E. R. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2014.868910 · Cited by 121

Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates

Roberts, V. H. J., Pound, L. D., Wesolowski, S. R., Gillingham, M. B., Thornburg, K. L. R., Friedman, J. E., Frias, A. E., & Grove, K. L. (2014) · The FASEB Journal · doi:10.1096/fj.13-245472 · Cited by 121

Metabolic Engineering of Yeast and Plants for the Production of the Biologically Active Hydroxystilbene, Resveratrol

Jeandet, P., Delaunois, B., Aziz, A., Donnez, D., Vasserot, Y., Cordelier, S., & Courot, É. (2012) · BioMed Research International · doi:10.1155/2012/579089 · Cited by 120

Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo

Wang, T.-C., Hudson, T., Wang, T.-C., Remsberg, C. M., Davies, N. M., Takahashi, Y., Kim, Y. S., Seifried, H. E., Vinyard, B. T., Perkins, S. N., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn131 · Cited by 119

Effect of Resveratrol on Growth of 4T1 Breast Cancer Cells in Vitro and in Vivo

Bove, K., Lincoln, D. W., & Tsan, M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6554 · Cited by 117

Chronic Resveratrol Enhances Endothelium-Dependent Relaxation but Does Not Alter eNOS Levels in Aorta of Spontaneously Hypertensive Rats

Rush, J. W. E., Quadrilatero, J., Levy, A. S., & Ford, R. J. (2007) · Experimental Biology and Medicine · doi:10.3181/00379727-232-2320814 · Cited by 115

Effects of different doses of resveratrol on body fat and serum parameters in rats fed a hypercaloric diet

Macarulla, M. T., Alberdi, G., Gómez‐Zorita, S., Tueros, I., Bald, C., Rodríguez, V. M., Martínez, J. A., & Portillo, M. P. (2009) · Journal of Physiology and Biochemistry · doi:10.1007/bf03185932 · Cited by 114

Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors

Dong, W., Li, N., Gao, D., Zhen, H., Zhang, X., & Li, F. (2008) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2008.04.007 · Cited by 113

Pharmacokinetics of drugs in rats with diabetes mellitus induced by alloxan or streptozocin: comparison with those in patients with type I diabetes mellitus

Lee, J. H., Yang, S., Oh, J. M., & Lee, M. G. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.62.01.0001 · Cited by 113

Resveratrol Improves Myocardial Perfusion in a Swine Model of Hypercholesterolemia and Chronic Myocardial Ischemia

Robich, M. P., Osipov, R. M., Nezafat, R., Feng, J., Clements, R., Bianchi, C. F., Boodhwani, M., Coady, M. A., Laham, R. J., & Sellke, F. W. (2010) · Circulation · doi:10.1161/circulationaha.109.920132 · Cited by 112

Resveratrol Alleviates Endotoxin-Induced Myocardial Toxicity via the Nrf2 Transcription Factor

Hao, E., Lang, F., Chen, Y., Zhang, H., Cong, X. Y., Shen, X., & Su, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069452 · Cited by 108

Antidepressant-like effect of trans-resveratrol in chronic stress model: Behavioral and neurochemical evidences

Yu, Y., Wang, R., Chen, C., Du, X., Ruan, L., Sun, J., Li, J., Zhang, L., O’Donnell, J. M., Pan, J., et al. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.10.018 · Cited by 108

Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFκB, AP-1, COX-2, and iNOS in mouse epidermis

Cichocki, M., Paluszczak, J., Szaefer, H., Piechowiak, A., Rimando, A. M., & Baer‐Dubowska, W. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700466 · Cited by 108

Resveratrol Promotes Foot Ulcer Size Reduction in Type 2 Diabetes Patients

Bashmakov, Y. K., Assaad-Khalil, S. H., Abou-Seif, M., Udumyan, R., Megallaa, M. H. Z., Rohoma, K. H., Zeitoun, M., & Petyaev, I. M. (2014) · ISRN Endocrinology · doi:10.1155/2014/816307 · Cited by 105

Resveratrol-Containing Gel for the Treatment of Acne Vulgaris

Fabbrocini, G., Staibano, S., Rosa, G. D., Battimiello, V., Fardella, N., Ilardi, G., Rotonda, M. I. L., Longobardi, A., Mazzella, M., Siano, M., et al. (2011) · American Journal of Clinical Dermatology · doi:10.2165/11530630-000000000-00000 · Cited by 104

Resveratrol prevents alcohol-induced cognitive deficits and brain damage by blocking inflammatory signaling and cell death cascade in neonatal rat brain

Tiwari, V., & Chopra, K. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07236.x · Cited by 104

Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents

Kang, W., Hong, H. J., Guan, J., Kim, D. G., Yang, E.-J., Koh, G., Park, D.-B., Han, C. H., Lee, Y. J., & Lee, D.-H. (2011) · Metabolism · doi:10.1016/j.metabol.2011.08.003 · Cited by 104

The Effects of Chronic Resveratrol Treatment on Vascular Responsiveness of Streptozotocin-Induced Diabetic Rats

Sılan, C. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.897 · Cited by 104

Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization

Kaneko, H., Anzai, T., Morisawa, M., Kohno, T., Nagai, T., Anzai, A., Takahashi, T., Shimoda, M., Sasaki, A., Maekawa, Y., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.03.042 · Cited by 104

Impairment of tumor‐initiating stem‐like property and reversal of epithelial–mesenchymal transdifferentiation in head and neck cancer by resveratrol treatment

Hu, F., Tsai, L., Yu, C., Chen, P., Chou, M., & Yu, C. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200150 · Cited by 103

Resveratrol Is Rapidly Metabolized in Athymic (Nu/Nu) Mice and Does Not Inhibit Human Melanoma Xenograft Tumor Growth

Niles, R. M., Cook, C. P., Meadows, G. G., Fu, Y., McLaughlin, J. L., & Rankin, G. O. (2006) · Journal of Nutrition · doi:10.1093/jn/136.10.2542 · Cited by 103

Pathology of Rodent Models of Intestinal Cancer: Progress Report and Recommendations

Washington, M. K., Powell, A. E., Sullivan, R., Sundberg, J. P., Wright, N., Coffey, R. J., & Dove, W. F. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.067 · Cited by 102

Resveratrol Restores Nrf2 Level and Prevents Ethanol-Induced Toxic Effects in the Cerebellum of a Rodent Model of Fetal Alcohol Spectrum Disorders

Kumar, A., Singh, C. K., LaVoie, H. A., DiPette, D. J., & Singh, U. S. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.071126 · Cited by 102

High-dose resveratrol treatment for 2 weeks inhibits intestinal and hepatic lipoprotein production in overweight/obese men

Dash, S., Xiao, C., Morgantini, C., Szeto, L., & Lewis, G. F. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.113.302342 · Cited by 102

Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis

Sengottuvelan, M., Senthilkumar, R., & Nalini, N. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.03.008 · Cited by 100

Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats

Gacar, N., Mutlu, O., Utkan, T., Celikyurt, I. K., Göçmez, S. S., & Ulak, G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.05.017 · Cited by 100

Protective Effect Of Resveratrol On Oxidative Damage In Male And Female Stroke‐Prone Spontaneously Hypertensive Rats

Mizutani, K., Ikeda, K., Kawai, Y., & Yamori, Y. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03415.x · Cited by 100

Pterostilbene Acts through Metastasis-Associated Protein 1 to Inhibit Tumor Growth, Progression and Metastasis in Prostate Cancer

Li, K., Dias, S. J., Rimando, A. M., Dhar, S., Mizuno, C. S., Penman, A. D., Lewin, J. R., & Levenson, A. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057542 · Cited by 98

Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV‐40 tag rats

Harper, C. E., Cook, L. M., Patel, B. B., Wang, J., Eltoum, I. A., Arabshahi, A., Shirai, T., & Lamartiniere, C. A. (2009) · The Prostate · doi:10.1002/pros.21017 · Cited by 98

Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit

Wang, J., Gao, J., Chen, J., Li, F., & Tian, J. (2011) · Rheumatology International · doi:10.1007/s00296-010-1720-y · Cited by 97

Neurodegeneration in Streptozotocin-Induced Diabetic Rats Is Attenuated by Treatment with Resveratrol

Jing, Y., Chen, K., Kuo, P., Pao, C.-C., & Chen, J. (2013) · Neuroendocrinology · doi:10.1159/000350435 · Cited by 97

Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development

Murugan, S., & Nalini, N. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061789 · Cited by 97

Trans- but Not Cis-Resveratrol Impairs Angiotensin-II–Mediated Vascular Inflammation through Inhibition of NF-κB Activation and Peroxisome Proliferator-Activated Receptor-γ Upregulation

Rius, C., Abu-Taha, M. I., Hermenegildo, C., Piqueras, L., Cerdá‐Nicolás, M., Issekutz, A. C., Estañ, L., Cortijo, J., Morcillo, E. J., Orallo, F., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001043 · Cited by 96

Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke

Shin, J. A., Lee, H.-A., Lim, Y.-K., Koh, Y., Choi, J. H., & Park, E. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.06.017 · Cited by 95

Resveratrol prevents oxidative stress and inhibition of Na+K+-ATPase activity induced by transient global cerebral ischemia in rats

Simão, F., Matté, A., Matté, C., Soares, F. M. S., Wyse, Â. T. D. S., Netto, C. A., & Salbego, C. G. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.07.013 · Cited by 94

Resveratrol increases anti-aging Klotho gene expression via the activating transcription factor 3/c-Jun complex-mediated signaling pathway

Hsu, S.-C., Huang, S., Chen, A., Sun, C.-Y., Lin, S., Chen, J., Liu, S., & Hsu, Y. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.06.002 · Cited by 94

The effect of resveratrol on FoxO1 expression in kidneys of diabetic nephropathy rats

Wu, L., Zhang, Y., Ma, X., Zhang, N., & Qin, G.-J. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1780-z · Cited by 92

Resveratrol Inhibits the Proliferation of Neural Progenitor Cells and Hippocampal Neurogenesis

Park, H. R., Kong, K. H., Yu, B. P., Mattson, M. P., & Lee, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.406413 · Cited by 92

Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model.

Seeni, A., Takahashi, S., Takeshita, K., Tang, M., Sugiura, S., Sato, S., & Shirai, T. (2008) · PubMed · Cited by 92

Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1

Zou, T., Yang, Y., Xia, F., Huang, A., Gao, X., Fang, D., Xiong, S., & Zhang, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075139 · Cited by 91

Resveratrol abrogates alcohol-induced cognitive deficits by attenuating oxidative–nitrosative stress and inflammatory cascade in the adult rat brain

Tiwari, V., & Chopra, K. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.02.012 · Cited by 91

Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities

Lee, E. O. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl055 · Cited by 91

Effect of Resveratrol on Oxidative and Inflammatory Stress in Liver and Spleen of Streptozotocin-Induced Type 1 Diabetic Rats

Chang, C. (2012) · The Chinese Journal of Physiology · doi:10.4077/cjp.2012.baa012 · Cited by 91

Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats

Liu, D., Zhang, Q., Gu, J., Wang, X., Xie, K., Xian, X., Wang, J., Jiang, H., & Wang, Z. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.017 · Cited by 90

Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin

Lee, T. H., Seo, J. O., Baek, S.-H., & Kim, S. Y. (2014) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2013.081 · Cited by 89

Effect of resveratrol, a polyphenolic phytoalexin, on thermal hyperalgesia in a mouse model of diabetic neuropathic pain

Sharma, S., Kulkarni, S. K., & Chopra, K. (2006) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2006.00455.x · Cited by 88

Resveratrol decreases fructose‐induced oxidative stress, mediated by NADPH oxidase via an AMPK ‐dependent mechanism

Cheng, P., Ho, W., Su, Y., Lu, P., Chen, B., Cheng, W., Lu, W., Sun, G., Yeh, T., Hsiao, M., et al. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12648 · Cited by 87

Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain

Maia, H., Haddad, Pinheiro, & Casoy, J. (2012) · International Journal of Women s Health · doi:10.2147/ijwh.s36825 · Cited by 87

Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: The HPA axis, BDNF expression and phosphorylation of ERK

Wang, Z., Gu, J., Wang, X., Xie, K., Luan, Q., Wan, N., Zhang, Q., Jiang, H., & Liu, D. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.10.007 · Cited by 85

Endoplasmic Reticulum Stress in Retinal Vascular Degeneration: Protective Role of Resveratrol

Li, C., Wang, L., Huang, K., & Zheng, L. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8406 · Cited by 85

Cerebroprotective effect of resveratrol through antioxidant and anti-inflammatory effects in diabetic rats

Orsu, P. (2013) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-013-0871-2 · Cited by 85

Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice

Han, S.-Y., Choi, J.-R., Shin, K. S., & Kang, S. J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.09.022 · Cited by 84

Resveratrol: A Double-Edged Sword in Health Benefits

Salehi, B., Mishra, A. P., Nigam, M., Şener, B., Kılıç, M., Sharifi‐Rad, M., Fokou, P. V. T., Martins, N. A., & Sharifi‐Rad, J. (2018) · Biomedicines · doi:10.3390/biomedicines6030091 · Cited by 1,195

Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

Brglez Mojzer, E., Knez Hrnčič, M., Škerget, M., Knez, Ž., & Bren, U. (2016) · Molecules · doi:10.3390/molecules21070901 · Cited by 1,096

Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents

Cragg, G. M. L., & Pezzuto, J. M. (2015) · Medical Principles and Practice · doi:10.1159/000443404 · Cited by 845

Resveratrol (RV): A pharmacological review and call for further research

Zhang, L., Li, C., Kakar, M. U., Khan, M. S., Wu, P.-F., Amir, R. M., Dai, D., Naveed, M., Li, Q., Saeed, M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112164 · Cited by 580

Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia

Dominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433

Resveratrol supplementation: Where are we now and where should we go?

Novelle, M. G., Wahl, D., Diéguez, C., Bernier, M., & de Cabo, R. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.002 · Cited by 254

Significance of Resveratrol in Clinical Management of Chronic Diseases

Wahab, A., Gao, K., Jia, C., Zhang, F., Tian, G., Murtaza, G., & Chen, J. (2017) · Molecules · doi:10.3390/molecules22081329 · Cited by 113

Resveratrol and health—A comprehensive review of human clinical trials

Smoliga, J. M., Baur, J. A., & Hausenblas, H. A. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100143 · Cited by 594

Pharmacological Aspects of Resveratrol

Bandyopadhyay, D. (2019) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2019.16.002815

Resveratrol in mammals: effects on aging biomarkers, age‐related diseases, and life span

Marchal, J., Pifferi, F., & Aujard, F. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12214 · Cited by 101