Iron supplementation in mouse expands cellular innate defences in spleen and defers lethal malaria infection
Open accessAbstract
The co-endemicity of malnutrition, erythrocytopathies, transmissible diseases and iron-deficiency contribute to the prevalence of chronic anaemia in many populations of the developing world. Although iron dietary supplementation is applied or recommended in at risk populations, its use is controversial due to undesirable outcomes, particularly regarding the response to infections, including highly prevalent malaria. We hypothesized that a boosted oxidative stress due to iron supplementation have a similar impact on malaria to that of hereditary anaemias, enhancing innate response and conditioning tissues to prevent damage during infection. Thus, we have analysed antioxidant and innate responses against lethal Plasmodium yoelii during the first five days of infection in an iron-supplemented mouse. This murine model showed high iron concentration in plasma with upregulated expression of hemoxygenase-1. The sustained homeostasis after this extrinsic iron conditioning, delayed parasitemia growth that, once installed, developed without anaemia. This protection was not conferred by the intrinsic iron overload of hereditary hemochromatosis. Upon iron-supplementation, a large increase of the macrophages/dendritic cells ratio and the antigen presenting cells was observed in the mouse spleen, independently of malaria infection. Complementary, malaria promoted the splenic B and T CD4 cells activation. Our results show that the iron supplementation in mice prepares host tissues for oxidative-stress and induces unspecific cellular immune responses, which could be seen as an advantage to promote early defences against malaria infection.
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Malaria promoted splenic B and T cells (CD4+) activation.
“malaria promoted splenic B and T cells (CD4+) activation”
From Iron in immune cell function and host defense (2021) · cites this paper as [125]
In a mouse model of malaria infection, iron supplementation causes an increase of the macrophages/dendritic cells ratio and in the relative percentage of antigen presenting cells, independently of malaria infection.
“In a mouse model of malaria infection it has been shown, that iron supplementation causes an increase of the macrophages/dendritic cells ratio and in the relative percentage of antigen presenting cells, independently of malaria infection.”
From Iron in immune cell function and host defense (2021) · cites this paper as [125]
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- Authors
- Azcárate, I. G., Sánchez-Jaut, S., Marín-García, P., Linares, M., Pérez-Benavente, S., García-Sánchez, M., Uceda, J., Kamali, A. N., Morán-Jiménez, M.-J., Puyet, A., Diez, A., & Bautista, J. M.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Corresponding author
- Bautista, José M.
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 1863
- Issue
- 12
- Pages
- 3049-3059
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2759458870
- Cited by
- 12
- References
- 73
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 4
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- BURJC Digital (King Juan Carlos University) (submittedVersion, cc-by)
- Hispana (submittedVersion, cc-by)
- Funders
- Fundación Ramón Areces (BIO2013-44565R)
- MINECO (BIO2016-77430R)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- iron supplementation, malaria, Plasmodium yoelii, innate immunity, oxidative stress, heme oxygenase-1, spleen, macrophages, dendritic cells, antigen-presenting cells, CD4+ T cells, B cells, anemia, hereditary hemochromatosis, iron overload, malnutrition, host-parasite interactions
- MeSH terms
- Superoxide Dismutase-1, Animals, Dendritic Cells, Disease Models, Animal, Female, Immunity, Innate, Iron, Lymphocyte Activation, Macrophages, Malaria, Membrane Proteins, Mice, Inbred BALB C, Plasmodium yoelii, RNA, Messenger, Spleen, CD4 Antigens, Oxidative Stress, Dietary Supplements, Mice, Heme Oxygenase-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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