The DOI matches its Crossref record; 128 of the 131 references it cites were found in a registry or an index.
Reprogramming of serine, glycine and one-carbon metabolism in cancer
Open accessAbstract
Metabolic pathways leading to the synthesis, uptake, and usage of the nonessential amino acid serine are frequently amplified in cancer. Serine encounters diverse fates in cancer cells, including being charged onto tRNAs for protein synthesis, providing head groups for sphingolipid and phospholipid synthesis, and serving as a precursor for cellular glycine and one-carbon units, which are necessary for nucleotide synthesis and methionine cycle reloading. This review will focus on the participation of serine and glycine in the mitochondrial one-carbon (SGOC) pathway during cancer progression, with an emphasis on the genetic and epigenetic determinants that drive SGOC gene expression. We will discuss recently elucidated roles for SGOC metabolism in nucleotide synthesis, redox balance, mitochondrial function, and epigenetic modifications. Finally, therapeutic considerations for targeting SGOC metabolism in the clinic will be discussed.
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“One-carbon metabolism (1CM) is commonly dysregulated in cancer due to its contribution to core cellular building blocks (e.g., purine and pyrimidine nucleotides), epigenetics, post-translational modifications (PTMs), and redox homeostasis, and it is comprised of a complex network of enzymes.”
From A review of small-molecule inhibitors of one-carbon enzymes: SHMT2 and MTHFD2 in the spotlight (2021) · cites this paper as [2]
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Metadata
- Authors
- Li, A. M., & Ye, J.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Ye, Jiangbin
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 1866
- Issue
- 10
- Pages
- 165841
- ISSN
- 0925-4439 (ISSN-L)
- PMC
- PMC7442608
- OpenAlex
- W3026201556
- Cited by
- 127
- References
- 131
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 28 · 2023: 25 · 2022: 17 · 2021: 8 · 2020: 4
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Mary Kay Foundation
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Keywords
- serine metabolism, glycine metabolism, one-carbon metabolism, cancer metabolism, nucleotide synthesis, methionine cycle, redox homeostasis, mitochondrial function, epigenetic modifications, epigenetic regulation
- MeSH terms
- Animals, Carbon, Glycine, Humans, Methionine, Mitochondria, Neoplasms, Protein Processing, Post-Translational, Serine, Transcription Factors, Metabolic Networks and Pathways, Cellular Reprogramming
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