Serine, glycine and one‑carbon metabolism in cancer (Review)

On the origin of cancer cells

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The emerging hallmarks of cancer metabolism

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Fundamentals of Cancer Metabolism

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The integrated stress response

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Understanding the Intersections between Metabolism and Cancer Biology

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One-Carbon Metabolism in Health and Disease

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Chemotherapy and the war on cancer

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Putting p53 in context

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The multifaceted roles of fatty acid synthesis in cancer

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MYC, Metabolism, and Cancer

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Cancer epigenetics reaches mainstream oncology

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

David, C. J., Chen, M., Assanah, M., Canoll, P., & Manley, J. L. (2010) · Nature · doi:10.1038/nature08697 · Cited by 1,179 · see citing works

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

Roesch, A., Fukunaga‐Kalabis, M., Schmidt, E. C., Zabierowski, S. E., Brafford, P. A., Vultur, A., Basu, D., Gimotty, P. A., VOGT, T. M., & Herlyn, M. (2010) · Cell · doi:10.1016/j.cell.2010.04.020 · Cited by 1,162 · see citing works

Quantitative flux analysis reveals folate-dependent NADPH production

Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., & Rabinowitz, J. D. (2014) · Nature · doi:10.1038/nature13236 · Cited by 1,114 · see citing works

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

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NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

Xiao, W., Wang, R., Handy, D. E., & Loscalzo, J. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7216 · Cited by 1,074 · see citing works

Serine and glycine metabolism in cancer

Amelio, I., Cutruzzolà, F., Antonov, A., Agostini, M., & Melino, G. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.004 · Cited by 1,056 · see citing works

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Maddocks, O. D. K., Berkers, C. R., Mason, S. M., Zheng, L., Blyth, K., Gottlieb, E., & Vousden, K. H. (2013) · Nature · doi:10.1038/nature11743 · Cited by 1,007 · see citing works

Serine and one-carbon metabolism in cancer

Yang, M., & Vousden, K. H. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.81 · Cited by 992 · see citing works

Targeting Metabolism for Cancer Therapy

Luengo, A., Gui, D. Y., & Vander Heiden, M. G. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.08.028 · Cited by 971 · see citing works

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

Vaupel, P. W., Schmidberger, H., & Mayer, A. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2019.1589653 · Cited by 901 · see citing works

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

Lu, J., Tan, M., & Cai, Q. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.04.001 · Cited by 800 · see citing works

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Ben-Sahra, I., Hoxhaj, G., Ricoult, S. J. H., Asara, J. M., & Manning, B. D. (2016) · Science · doi:10.1126/science.aad0489 · Cited by 795 · see citing works

Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

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NRF2 regulates serine biosynthesis in non–small cell lung cancer

DeNicola, G. M., Chen, P.-H., Mullarky, E., Sudderth, J., Hu, Z., Wu, D., Tang, H., Xie, Y., Asara, J. M., Huffman, K. E., et al. (2015) · Nature Genetics · doi:10.1038/ng.3421 · Cited by 747 · see citing works

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1

Ben-Sahra, I., Howell, J. J., Asara, J. M., & Manning, B. D. (2013) · Science · doi:10.1126/science.1228792 · Cited by 739 · see citing works

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Chaneton, B., Hillmann, P., Zheng, L., Martin, A. C. L., Maddocks, O. D. K., Chokkathukalam, A., Coyle, J. E., Jankevics, A., Holding, F. P., Vousden, K. H., et al. (2012) · Nature · doi:10.1038/nature11540 · Cited by 661 · see citing works

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis

Zhang, W. C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B. S., Sun, L. L., Tai, B. C., Nga, M. E., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.050 · Cited by 660 · see citing works

Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells

Hosios, A. M., Hecht, V. C., Danai, L. V., Johnson, M. O., Rathmell, J. C., Steinhauser, M. L., Manalis, S. R., & Vander Heiden, M. G. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.02.012 · Cited by 641 · see citing works

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

Wortel, I. M. N., van der Meer, L. T., Kilberg, M. S., & van Leeuwen, F. N. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.07.003 · Cited by 613 · see citing works

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

Nilsson, R., Jain, M., Madhusudhan, N., Sheppard, N. G., Strittmatter, L., Kampf, C., Huang, J., Asplund, A., & Mootha, V. K. (2014) · Nature Communications · doi:10.1038/ncomms4128 · Cited by 607 · see citing works

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Maddocks, O. D. K., Athineos, D., Cheung, E. C., Lee, P., Zhang, T., van den Broek, N. J. F., Mackay, G. M., Labuschagne, C. F., Gay, D., Kruiswijk, F., et al. (2017) · Nature · doi:10.1038/nature22056 · Cited by 603 · see citing works

Choline and betaine in health and disease

Ueland, P. M. (2010) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-010-9088-4 · Cited by 577 · see citing works

Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells

Labuschagne, C. F., van den Broek, N. J. F., Mackay, G. M., Vousden, K. H., & Maddocks, O. D. K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.045 · Cited by 576 · see citing works

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

Lewis, C. A., Parker, S. J., Fiske, B. P., McCloskey, D., Gui, D. Y., Green, C. R., Vokes, N. I., Feist, A. M., Vander Heiden, M. G., & Metallo, C. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.008 · Cited by 562 · see citing works

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Pacold, M. E., Brimacombe, K. R., Chan, S. H., Rohde, J. M., Lewis, C. A., Swier, L. J. Y. M., Possemato, R., Chen, W. W., Sullivan, L. B., Fiske, B. P., et al. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2070 · Cited by 553 · see citing works

The impact of cellular metabolism on chromatin dynamics and epigenetics

Reid, M. A., Dai, Z., & Locasale, J. W. (2017) · Nature Cell Biology · doi:10.1038/ncb3629 · Cited by 515 · see citing works

One-carbon metabolism in cancer

Newman, A. C., & Maddocks, O. D. K. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.118 · Cited by 509 · see citing works

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

Walz, S., Lorenzin, F., Morton, J. P., Wiese, K. E., von Eyß, B., Herold, S., Rycak, L., Dumay‐Odelot, H., Karim, S. A., Bartkuhn, M., et al. (2014) · Nature · doi:10.1038/nature13473 · Cited by 502 · see citing works

One‐carbon metabolism and epigenetics: understanding the specificity

Mentch, S. J., & Locasale, J. W. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12956 · Cited by 481 · see citing works

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Ye, J., Fan, J., Venneti, S., Wan, Y.-W., Pawel, B. R., Zhang, J., Finley, L. W. S., Lu, C., Lindsten, T., Cross, J. R., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0250 · Cited by 452 · see citing works

DNA methylation: An epigenetic mark of cellular memory

Kim, M., & Costello, J. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.10 · Cited by 450 · see citing works

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

Ulanovskaya, O. A., Zuhl, A. M., & Cravatt, B. F. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1204 · Cited by 444 · see citing works

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

Maddocks, O. D. K., Labuschagne, C. F., Adams, P. D., & Vousden, K. H. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.014 · Cited by 440 · see citing works

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

Bao, X. R., Ong, S., Goldberger, O., Peng, J., Sharma, R., Thompson, D. A., Vafai, S. B., Cox, A. G., Marutani, E., Ichinose, F., et al. (2016) · eLife · doi:10.7554/elife.10575 · Cited by 439 · see citing works

Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway

Ducker, G. S., Chen, L., Morscher, R. J., Ghergurovich, J. M., Esposito, M., Teng, X., Kang, Y., & Rabinowitz, J. D. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.016 · Cited by 419 · see citing works

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism

Chen, L., Zhang, Z., Hoshino, A., Zheng, H. D., Morley, M. P., Arany, Z. P., & Rabinowitz, J. D. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0043-x · Cited by 419 · see citing works

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

Ye, J., Mancuso, A., Tong, X., Ward, P. S., Fan, J., Rabinowitz, J. D., & Thompson, C. B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204176109 · Cited by 410 · see citing works

The importance of serine metabolism in cancer

Mattaini, K. R., Sullivan, M. R., & Heiden, M. G. V. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201604085 · Cited by 409 · see citing works

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

Rabinovich, S., Adler, L., Yizhak, K., Sarver, A., Silberman, A., Agron, S., Stettner, N., Sun, Q., Brandis, A., Helbling, D., et al. (2015) · Nature · doi:10.1038/nature15529 · Cited by 382 · see citing works

Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Kim, D., Fiske, B. P., Birsoy, K., Freinkman, E., Kami, K., Possemato, R. L., Chudnovsky, Y., Pacold, M. E., Chen, W. W., Cantor, J. R., et al. (2015) · Nature · doi:10.1038/nature14363 · Cited by 368 · see citing works

Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

Sun, L., Suo, C., Li, S., Zhang, H., & Gao, P. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.005 · Cited by 366 · see citing works

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

Kottakis, F., Nicolay, B. N., Roumane, A., Karnik, R., Gu, H., Nagle, J. M., Boukhali, M., Hayward, M. C., Li, Y. Y., Chen, T., et al. (2016) · Nature · doi:10.1038/nature20132 · Cited by 348 · see citing works

Serine Metabolism Supports Macrophage IL-1β Production

Rodriguez, A. E., Ducker, G. S., Billingham, L. K., Martinez, C. A., Mainolfi, N., Suri, V., Friedman, A. A., Manfredi, M. G., Weinberg, S. E., Rabinowitz, J. D., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.014 · Cited by 346 · see citing works

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Mullarky, E., Lucki, N. C., Beheshti Zavareh, R., Anglin, J. L., Gomes, A. P., Nicolay, B. N., Wong, J. C. Y., Christen, S., Takahashi, H., Singh, P. K., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521548113 · Cited by 333 · see citing works

Histidine catabolism is a major determinant of methotrexate sensitivity

Kanarek, N., Keys, H. R., Cantor, J. R., Lewis, C. A., Chan, S. H., Kunchok, T., Abu-Remaileh, M., Freinkman, E., Schweitzer, L. D., & Sabatini, D. M. (2018) · Nature · doi:10.1038/s41586-018-0316-7 · Cited by 321 · see citing works

Inhibitors of Protein Methyltransferases and Demethylases

Kanıskan, H. Ü., Martini, M. L., & Jin, J. J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00801 · Cited by 320 · see citing works

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

Sun, L., Song, L., Wan, Q., Wu, G., Li, X., Wang, Y., Wang, J., Liu, Z., Zhong, X., He, X., et al. (2015) · Cell Research · doi:10.1038/cr.2015.33 · Cited by 311 · see citing works

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

Dey, S., Sayers, C. M., Verginadis, I. I., Lehman, S. L., Cheng, Y., Cerniglia, G. J., Tuttle, S. W., Feldman, M. D., Zhang, P. J. L., Fuchs, S. Y., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78031 · Cited by 282 · see citing works

Mitochondrial translation requires folate-dependent tRNA methylation

Morscher, R. J., Ducker, G. S., Li, H., Mayer, J., Gitai, Z., Sperl, W., & Rabinowitz, J. D. (2018) · Nature · doi:10.1038/nature25460 · Cited by 278 · see citing works

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

Villa, E., Ali, E. S., Sahu, U., & Ben‐Sahra, I. (2019) · Cancers · doi:10.3390/cancers11050688 · Cited by 276 · see citing works

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

Tameire, F., Verginadis, I. I., Leli, N. M., Polte, C., Conn, C. S., Ojha, R., Salinas, C. S., Chinga, F., Monroy, A. M., Fu, W., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0347-9 · Cited by 269 · see citing works

A Metabolic Function for Phospholipid and Histone Methylation

Ye, C., Sutter, B. M., Wang, Y., Kuang, Z., & Tu, B. P. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.026 · Cited by 266 · see citing works

Metformin in cancer

Mallik, R., & Chowdhury, T. A. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.05.023 · Cited by 266 · see citing works

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

Tedeschi, P. M., Markert, E. K., Gounder, M. K., Lin, H., Dvorzhinski, D., Dolfi, S. C., Chan, L. L.-Y., Qiu, J., DiPaola, R. S., Hirshfield, K. M., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.393 · Cited by 261 · see citing works

One-carbon metabolism and epigenetics

Friso, S., Udali, S., Santis, D. D., & Choi, S. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.11.007 · Cited by 251 · see citing works

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism

Gao, X., Lee, K., Reid, M. A., Sanderson, S. M., Qiu, C., Li, S., Liu, J., & Locasale, J. W. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.017 · Cited by 249 · see citing works

Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome

Mahmoud, A. M., & Ali, M. M. (2019) · Nutrients · doi:10.3390/nu11030608 · Cited by 249 · see citing works

The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation

Ding, J., Li, T., Wang, X., Zhao, E., Choi, J.-H., Yang, L., Zha, Y., Dong, Z., Huang, S., Asara, J. M., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.004 · Cited by 244 · see citing works

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

Park, Y., Reyna‐Neyra, A., Philippe, L., & Thoreen, C. C. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.042 · Cited by 242 · see citing works

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

Sullivan, M. R., Mattaini, K. R., Dennstedt, E. A., Nguyen, A. A., Sivanand, S., Reilly, M. F., Meeth, K. M., Muir, A., Darnell, A. M., Bosenberg, M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.015 · Cited by 242 · see citing works

Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children’s Oncology Group AALL0434 Methotrexate Randomization

Winter, S. S., Dunsmore, K. P., Devidas, M., Wood, B. L., Esiashvili, N., Chen, Z., Eisenberg, N., Briegel, N., Hayashi, R. J., Gastier, J. M., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.77.7250 · Cited by 241 · see citing works

MYC-Driven Pathways in Breast Cancer Subtypes

Fallah, Y., Brundage, J., Allegakoen, P., & Shajahan‐Haq, A. N. (2017) · Biomolecules · doi:10.3390/biom7030053 · Cited by 229 · see citing works

Cancer metabolism at a glance

Vazquez, A., Kamphorst, J. J., Markert, E. K., Schug, Z. T., Tardito, S., & Gottlieb, E. (2016) · Journal of Cell Science · doi:10.1242/jcs.181016 · Cited by 225 · see citing works

Glucose Metabolism in Cancer

Bose, S., & Le, A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77736-8_1 · Cited by 216 · see citing works

The role of DNA methylation in ageing and cancer

Morgan, A. E., Davies, T. J., & Auley, M. T. M. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118000150 · Cited by 211 · see citing works

Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis

Ma, L., Tao, Y., Durán, Á., Lladó, V., Galvez, A. S., Barger, J. F., Castilla, E. A., Chen, J., Yajima, T., Porollo, A., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.028 · Cited by 204 · see citing works

Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients

Fine, E. J., Segal-Isaacson, C. J., Feinman, R. D., Herszkopf, S., Romano, M. C., Tomuta, N., Bontempo, A., Negassa, A., & Sparano, J. A. (2012) · Nutrition · doi:10.1016/j.nut.2012.05.001 · Cited by 200 · see citing works

Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation

Wang, L. W., Shen, H., Nobre, L., Ersing, I., Paulo, J. A., Trudeau, S., Wang, Z., Smith, N. A., Ma, Y., Reinstadler, B., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.003 · Cited by 190 · see citing works

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

Reina‐Campos, M., Linares, J. F., Durán, Á., Cordes, T., L’Hermitte, A., Badur, M. G., Bhangoo, M. S., Thorson, P. K., Richards, A. C., Rooslid, T., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.01.018 · Cited by 187 · see citing works

Molecular and cellular mechanisms of chemoresistance in pancreatic cancer

Adamska, A., Elaskalani, O., Emmanouilidi, A., Kim, M. K., Razak, N. B. A., Metharom, P., & Falasca, M. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.11.007 · Cited by 184 · see citing works

PHGDH defines a metabolic subtype in lung adenocarcinomas with poor prognosis

Zhang, B., Zheng, A., Hydbring, P., Ambroise, G., Ouchida, A. T., Goiny, M., Vakifahmetoglu-Norberg, H., & Norberg, E. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.067 · Cited by 178 · see citing works

A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers

Diesch, J., Zwick, A., Garz, A.-K., Palau, A., Buschbeck, M., & Götze, K. S. S. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0237-y · Cited by 173 · see citing works

A landscape of metabolic variation across tumor types

Reznik, E., Luna, A., Aksoy, B. A., Liu, E. M., La, K., Ostrovnaya, I., Creighton, C. J., Hakimi, A. A., & Sander, C. (2018) · Cell Systems · doi:10.1016/j.cels.2017.12.014 · Cited by 172 · see citing works

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

Carabet, L. A., Rennie, P. S., & Cherkasov, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010120 · Cited by 172 · see citing works

Serine and Functional Metabolites in Cancer

Newman, A. C., & Maddocks, O. D. K. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.05.001 · Cited by 168 · see citing works

Role of the Transcription Factor ATF4 in the Anabolic Actions of Insulin and the Anti-anabolic Actions of Glucocorticoids

Adams, C. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610510200 · Cited by 165 · see citing works

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

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Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism

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20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells

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Metabolic Reprogramming Shapes the Progression and Therapeutic Landscape of Ovarian Cancer

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Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment

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Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

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Menin in Cancer

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Application of Machine Learning to Metabolomic Profile Characterization in Glioblastoma Patients Undergoing Concurrent Chemoradiation

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Serum Metabolomic and Lipoprotein Profiling of Pancreatic Ductal Adenocarcinoma Patients of African Ancestry

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Joint analysis of the metabolomics and transcriptomics uncovers the dysregulated network and develops the diagnostic model of high-risk neuroblastoma

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Comparative transcriptome analysis of hepatopancreas reveals the potential mechanism of shrimp resistant to Vibrio parahaemolyticus infection

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Effect of Air Drying on the Metabolic Profile of Fresh Wild and Artificial Cordyceps sinensis

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Advanced progress of spatial metabolomics in head and neck cancer research

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SHMT2 regulates serine metabolism to promote the progression and immunosuppression of papillary renal cell carcinoma

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The Metabolic Landscape of Breast Cancer and Its Therapeutic Implications

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The Evolutionary Origin of Mitochondria and Mitochondrion-Related Organelles

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Evaluation of Different Drying Methods on the Quality Parameters of Acanthopanax senticosus Fruits

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SHMT as a Potential Therapeutic Target for Renal Cell Carcinoma

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Phosphatases of regenerating liver are key regulators of metabolism in cancer cells - role of Serine/Glycine metabolism

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Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?

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Molecular Response and Metabolic Reprogramming of the Spleen Coping with Cold Stress in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis)

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The role and research progress of serine metabolism in tumor cells

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Metabolite profiling of abalone (Haliotis iris) energy metabolism: a Chatham Islands case study

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Targeting Oncometabolites in Peritoneal Cancers: Preclinical Insights and Therapeutic Strategies

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Accelerated Exosomal Metabolic Profiling Enabled by Robust On‐Target Array Sintering with Metal–Organic Frameworks

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SFXN3 is Associated with Poor Clinical Outcomes and Sensitivity to the Hypomethylating Therapy in Non-M3 Acute Myeloid Leukemia Patients

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20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells

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Flavonoids as modulators of metabolic reprogramming in renal cell carcinoma (Review)

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Analysis of microarray and single-cell RNA-seq identifies gene co-expression, cell–cell communication, and tumor environment associated with metabolite interconversion enzyme in prostate cancer

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De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma

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Uterine histotroph and conceptus development. IV. Metabolomic analyses of uterine luminal fluid reveals regulatory landscapes during the peri-implantation period of pregnancy in pigs

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Phosphatases of regenerating liver are key regulators of metabolism in cancer cells – role of Serine/Glycine metabolism

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Transcriptome Analysis of Breast Muscle Reveals Pathways Related to Protein Deposition in High Feed Efficiency of Native Turkeys

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TFE3 and HIF1α regulates the expression of SHMT2 isoforms via alternative promoter utilization in ovarian cancer cells

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The “serine code” of metabolic reprogramming: multidimensional roles of the serine synthesis pathway in tumors and novel breakthroughs for targeted therapy

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Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy

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An update on malignant tumor-related stiff person syndrome spectrum disorders: clinical mechanism, treatment, and outcomes

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Causal effects of human serum metabolites on occurrence and progress indicators of chronic kidney disease: a two-sample Mendelian randomization study

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Advancements in Analyzing Tumor Metabolites through Chemical Derivatization-Based Chromatography

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Mitochondrial One-Carbon Metabolism Drives CD34-Lineage Cells to Differentiate Into T Follicular Helper Cells to Form Tertiary Lymphoid Organs in Transplant Arteriosclerosis

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C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension

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New insights into the tumor immune microenvironment and immunotherapy of thyroid cancer

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Co-treatment with melatonin and ortho-topolin riboside reduces cell viability by altering metabolic profiles in non-small cell lung cancer cells

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New Borane-Protected Derivatives of α-Aminophosphonous Acid as Anti-Osteosarcoma Agents: ADME Analysis and Molecular Modeling, In Vitro Studies on Anti-Cancer Activities, and NEP Inhibition as a Possible Mechanism of Anti-Proliferative Activity

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Tracing the electron flow in redox metabolism: The appropriate distribution of electrons is essential to maintain redox balance in cancer cells

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Untargeted Plasma Metabolomics Unravels a Metabolic Signature for Tissue Sensitivity to Glucocorticoids in Healthy Subjects: Its Implications in Dietary Planning for a Healthy Lifestyle

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Biochemical and Proteomic Analyses in Drought-Tolerant Wheat Mutants Obtained by Gamma Irradiation

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MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction

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Effect of copper exposure on the silkworm Bombyx mori : Insights into the changes of metabolism, gut microbial composition and gene expression

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Unveiling Metabolic Signatures as Potential Biomarkers in Common Cancers: Insights from Lung, Breast, Colorectal, Liver, and Gastric Tumours

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