Cited by 128Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismFolate and B Vitamins Research

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Reprogramming of serine, glycine and one-carbon metabolism in cancer

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Li, Albert M., Ye, Jiangbin·2020·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2020.165841PMC PMC7442608

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Abstract

Metabolic pathways leading to the synthesis, uptake, and usage of the nonessential amino acid serine are frequently amplified in cancer. Serine encounters diverse fates in cancer cells, including being charged onto tRNAs for protein synthesis, providing head groups for sphingolipid and phospholipid synthesis, and serving as a precursor for cellular glycine and one-carbon units, which are necessary for nucleotide synthesis and methionine cycle reloading. This review will focus on the participation of serine and glycine in the mitochondrial one-carbon (SGOC) pathway during cancer progression, with an emphasis on the genetic and epigenetic determinants that drive SGOC gene expression. We will discuss recently elucidated roles for SGOC metabolism in nucleotide synthesis, redox balance, mitochondrial function, and epigenetic modifications. Finally, therapeutic considerations for targeting SGOC metabolism in the clinic will be discussed.

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Authors: Li, A. M., & Ye, J.
Affiliations: Stanford Medicine (US)
Corresponding author: Ye, Jiangbin
ORCID: Li, Albert M.
Ye, Jiangbin
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2020-10
Volume: 1866
Issue: 10
Pages: 165841
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2020.165841
PMC: PMC7442608
OpenAlex: W3026201556
Cited by: 127
References: 131
Citations by year: 2026: 17 · 2025: 28 · 2024: 28 · 2023: 25 · 2022: 17 · 2021: 8 · 2020: 4
FWCI: 1.38
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Mary Kay Foundation
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Keywords: serine metabolism, glycine metabolism, one-carbon metabolism, cancer metabolism, nucleotide synthesis, methionine cycle, redox homeostasis, mitochondrial function, epigenetic modifications, epigenetic regulation
MeSH terms: Animals, Carbon, Glycine, Humans, Methionine, Mitochondria, Neoplasms, Protein Processing, Post-Translational, Serine, Transcription Factors, Metabolic Networks and Pathways, Cellular Reprogramming

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Reprogramming of serine, glycine and one-carbon metabolism in cancer

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