Cited by 297Antioxidant Activity and Oxidative StressRedox biology and oxidative stressPhytochemicals and Antioxidant Activities

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Biomarkers of lipid peroxidation in clinical material

Niki, Etsuo·2014·Biochimica et Biophysica Acta (BBA) - General Subjects

DOI 10.1016/j.bbagen.2013.03.020

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Abstract

Background Free radical-mediated lipid peroxidation has been implicated in a number of human diseases. Diverse methods have been developed and applied to measure lipid peroxidation products as potential biomarkers to assess oxidative stress status in vivo, discover early indication of disease, diagnose progression of disease, and evaluate the effectiveness of drugs and antioxidants for treatment of disease and maintenance of health, respectively. However, standardized methods are not yet established. Scope of review Characteristics of various lipid peroxidation products as biomarkers are reviewed on the basis of mechanisms and dynamics of their formation and metabolism and also on the methods of measurement, with an emphasis on the advantages and limitations. Major conclusions Lipid hydroxides such as hydroxyoctadecadienoic acids (HODE), hydroxyeicosatetraenoic acids (HETE), and hydroxycholesterols may be recommended as reliable biomarkers. Notably, the four HODEs, 9-cis,trans, 9-trans,trans, 13-cis,trans, and 13-trans,trans-HODE, can be measured separately by LC-MS/MS and the trans,trans-forms are specific marker of free radical mediated lipid peroxidation. Further, isoprostanes and neuroprostanes are useful biomarker of lipid peroxidation. It is important to examine the distribution and temporal change of these biomarkers. General significance Despite the fact that lipid peroxidation products are non-specific biomarkers, they will enable to assess oxidative stress status, d…

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Authors: Niki, E.
Affiliations: National Institute of Advanced Industrial Science and Technology (JP)
Corresponding author: Niki, Etsuo
Venue: Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher: Elsevier BV
Published: 2014-02
Volume: 1840
Issue: 2
Pages: 809-817
ISSN: 0304-4165 (ISSN-L)
DOI: 10.1016/j.bbagen.2013.03.020
OpenAlex: W1989877335
Cited by: 297
References: 110
Citations by year: 2026: 17 · 2025: 16 · 2024: 11 · 2023: 22 · 2022: 20 · 2021: 26 · 2020: 23 · 2019: 21 · 2018: 27 · 2017: 30 · 2016: 35 · 2015: 23 · 2014: 20
FWCI: 2.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: lipid peroxidation, biomarkers, oxidative stress, hydroxyoctadecadienoic acids, hydroxyeicosatetraenoic acids, hydroxycholesterol, isoprostanes, neuroprostanes, antioxidants
MeSH terms: Humans, Mass Spectrometry, Lipid Peroxidation, Biomarkers, Oxidative Stress

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Biomarkers of lipid peroxidation in clinical material

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