The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Biomarkers of lipid peroxidation in clinical material
Abstract
Background Free radical-mediated lipid peroxidation has been implicated in a number of human diseases. Diverse methods have been developed and applied to measure lipid peroxidation products as potential biomarkers to assess oxidative stress status in vivo, discover early indication of disease, diagnose progression of disease, and evaluate the effectiveness of drugs and antioxidants for treatment of disease and maintenance of health, respectively. However, standardized methods are not yet established. Scope of review Characteristics of various lipid peroxidation products as biomarkers are reviewed on the basis of mechanisms and dynamics of their formation and metabolism and also on the methods of measurement, with an emphasis on the advantages and limitations. Major conclusions Lipid hydroxides such as hydroxyoctadecadienoic acids (HODE), hydroxyeicosatetraenoic acids (HETE), and hydroxycholesterols may be recommended as reliable biomarkers. Notably, the four HODEs, 9-cis,trans, 9-trans,trans, 13-cis,trans, and 13-trans,trans-HODE, can be measured separately by LC-MS/MS and the trans,trans-forms are specific marker of free radical mediated lipid peroxidation. Further, isoprostanes and neuroprostanes are useful biomarker of lipid peroxidation. It is important to examine the distribution and temporal change of these biomarkers. General significance Despite the fact that lipid peroxidation products are non-specific biomarkers, they will enable to assess oxidative stress status, d…
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“This approach is the method of choice for the quantification of free MDA due to simplicity and low costs, but is often criticized as being unspecific and rather measuring total oxidative stress instead of MDA alone [181,182].”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [181]
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Cites
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Self-citationImmunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.
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Alves, G. D. A. D., de Souza, R. O., Rogez, H., Masaki, H., & Fonseca, M. J. V. (2016) · Industrial Crops and Products · doi:10.1016/j.indcrop.2016.09.064 · Cited by 20
1,5-Benzodiazepin-2(3H)-ones: In Vitro Evaluation as Antiparkinsonian Agents
Ortíz de Zárate, A., Pérez-Torralba, M., Bonet Isidro, I., López, C., Claramunt, R. M., Martínez-Casanova, D., Sánchez-Vera, I., Jiménez-González, J., & Lavandera, J. L. (2021) · Antioxidants · doi:10.3390/antiox10101584 · Cited by 11
“Malondialdehyde (MDA) is a secondary product of lipid peroxidation that is used as a biomarker of oxidative stress [91,173], and it is measured by its reaction with thiobarbituric acid [91,174].”
Background
Metadata
- Authors
- Niki, E.
- Affiliations
- National Institute of Advanced Industrial Science and Technology (JP)
- Corresponding author
- Niki, Etsuo
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 1840
- Issue
- 2
- Pages
- 809-817
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W1989877335
- Cited by
- 297
- References
- 110
- Citations by year
- 2026: 17 · 2025: 16 · 2024: 11 · 2023: 22 · 2022: 20 · 2021: 26 · 2020: 23 · 2019: 21 · 2018: 27 · 2017: 30 · 2016: 35 · 2015: 23 · 2014: 20
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- lipid peroxidation, biomarkers, oxidative stress, hydroxyoctadecadienoic acids, hydroxyeicosatetraenoic acids, hydroxycholesterol, isoprostanes, neuroprostanes, antioxidants
- MeSH terms
- Humans, Mass Spectrometry, Lipid Peroxidation, Biomarkers, Oxidative Stress
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