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Targeting HMGB1 in inflammation
Open accessAbstract
High mobility group box 1 (HMGB1), a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. Elevated levels of HMGB1 in serum and tissues occur during sterile tissue injury and during infection, and targeting HMGB1 with antibodies or specific antagonists is protective in established preclinical inflammatory disease models including lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury. Future advances in this field will stem from understanding the biological basis for the success of targeting HMGB1 to therapeutic improvement in the treatment of inflammation, infection and ischemia-reperfusion induced injury.
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“Past research conducted on peripheral immune cells demonstrates that HMGB-1 is a potent proinflammatory signaling molecule that is released under inflammatory conditions, including sepsis and ischemia (Yang and Tracey, 2009).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Yang and Tracey, 2009
In the citing paper
“Typically, neuronal release of HMGB-1 occurs during necrotic conditions, such as ischemia (Yang and Tracey, 2009) and sepsis (Yang et al, 2004).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Yang and Tracey, 2009
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Cites
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
Self-citationApetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056
Self-citationSecretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,582
Physiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563
Self-citationAndersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401
Self-citationMonocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Bonaldi, T., Talamo, F., Scaffidi, P., Ferrera, D., Porto, A., Bachi, A., Rubartelli, A., Agresti, A., & Bianchi, M. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg516 · Cited by 1,252
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
Taguchi, A., Blood, D. C., del Toro, G., Canet, A., Lee, D. C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., et al. (2000) · Nature · doi:10.1038/35012626 · Cited by 1,217
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170
Self-citationTracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154
Self-citationThe Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin
Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J. X., Nagashima, M., Lundh, E. R., Vijay, S., Nitecki, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25752 · Cited by 1,151
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
Yang, H., Ochani, M., Li, J., Qiang, X., Tanovic, M., Harris, H. E., Susarla, S. M., Ulloa, L., Wang, H., DiRaimo, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2434651100 · Cited by 1,126
Self-citationThe nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
Tsung, A., Sahai, R., Tanaka, H., Nakao, A., Fink, M. P., Lotze, M. T., Yang, H., Li, J., Tracey, K. J., Geller, D. A., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042614 · Cited by 1,113
Self-citationHigh mobility group box 1 protein interacts with multiple Toll-like receptors
Park, J. S., Gamboni-Robertson, F., He, Q., Svetkauskaite, D., Kim, J., Strassheim, D., Sohn, J.-W., Yamada, S., Maruyama, I., Banerjee, A. M., et al. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00401.2005 · Cited by 934
Gardella, S., Andrei, C., Ferrera, D., Lotti, L. V., Torrisi, M. R., Bianchi, M. E., & Rubartelli, A. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf198 · Cited by 926
HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2
Yu, M., Wang, H., Ding, A., Golenbock, D. T., Latz, E., Czura, C. J., Fenton, M. J., Tracey, K. J., & Yang, H. (2006) · Shock · doi:10.1097/01.shk.0000225404.51320.82 · Cited by 832
Self-citationInflammation-promoting activity of HMGB1 on human microvascular endothelial cells
Fiuza, C., Bustin, M., Talwar, S., Tropea, M., Gerstenberger, E. P., Shelhamer, J. H., & Suffredini, A. F. (2003) · Blood · doi:10.1182/blood-2002-05-1300 · Cited by 737
Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation
Abraham, E. H., Arcaroli, J. J., Carmody, A., Wang, H., & Tracey, K. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.2950 · Cited by 692
Self-citationLotze, M. T., Zeh, H. J., Rubartelli, A., Sparvero, L. J., Amoscato, A. A., Washburn, N. R., DeVera, M., Liang, X., Tör, M., & Billiar, T. R. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00579.x · Cited by 658
High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart
Andrassy, M., Volz, H. C., Igwe, J. C., Funke, B., Eichberger, S. N., Kaya, Z., Buss, S. J., Autschbach, F., Pleger, S. T., Lukić, I. K., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.769331 · Cited by 635
Kazama, H., Ricci, J.-E., Herndon, J. M., Hoppe, G., Green, D. R., & Ferguson, T. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.013 · Cited by 627
Tsung, A., Klune, J. R., Zhang, X., Jeyabalan, G., Cao, Z., Peng, X., Stolz, D. B., Geller, D. A., Rosengart, M. R., & Billiar, T. R. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070247 · Cited by 622
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
Ulloa, L., Ochani, M., Yang, H., Tanovic, M., Halperin, D. M., Yang, R., Czura, C. J., Fink, M. P., & Tracey, K. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192222999 · Cited by 585
Self-citationKim, J.-B., Choi, J., Yu, Y., Nam, K., Piao, C.-S., Kim, S.-W., Lee, M., Han, P., Park, J. S., & Lee, J.-K. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3815-05.2006 · Cited by 580
Abeyama, K., Stern, D. M., Ito, Y., Kawahara, K., Yoshimoto, Y., Tanaka, M., Uchimura, T., Ida, N., Yamazaki, Y., Yamada, S., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22782 · Cited by 547
The cytokine activity of HMGB1
Yang, H., Wang, H., Czura, C. J., & Tracey, K. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1104648 · Cited by 545
Self-citationThe extracellular release of HMGB1 during apoptotic cell death
Bell, C. W., Jiang, W., Reich, C. F., & Pisetsky, D. S. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00616.2005 · Cited by 538
HMGB1 as a Late Mediator of Lethal Systemic Inflammation
Wang, H., Yang, H., Czura, C. J., Sama, A. E., & Tracey, K. J. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.10.2106117 · Cited by 490
Self-citationTaniguchi, N., Kawahara, K.-I., Yone, K., Hashiguchi, T., Yamakuchi, M., Goto, M., Inoue, K., Yamada, S., Ijiri, K., Matsunaga, S., et al. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10859 · Cited by 482
Degryse, B., Bonaldi, T., Scaffidi, P., Müller, S., Resnati, M., Sanvito, F., Arrigoni, G., & Bianchi, M. E. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.6.1197 · Cited by 451
Thomas, L. (1971) · New England Journal of Medicine · doi:10.1056/nejm197105132841908 · Cited by 422
The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage
Muhammad, S., Barakat, W., Stoyanov, S., Murikinati, S. R., Yang, H., Tracey, K. J., Bendszus, M., Rossetti, G., Nawroth, P. P., Bierhaus, A., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2435-08.2008 · Cited by 416
Self-citationEarly Release of HMGB-1 from Neurons after the Onset of Brain Ischemia
Qiu, J., Nishimura, M., Wang, Y., Sims, J. R., Qiu, S., Savitz, S. I., Salomone, S., & Moskowitz, M. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600582 · Cited by 412
Role of HMGB1 in apoptosis-mediated sepsis lethality
Qin, S., Wang, H., Yuan, R., Li, H., Ochani, M., Ochani, K., Rosas‐Ballina, M., Czura, C. J., Huston, J. M., Miller, E., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052203 · Cited by 401
Self-citationHMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines
Sha, Y., Zmijewski, J. W., Xu, Z., & Abraham, E. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2531 · Cited by 395
Rage and arthritis: The G82S polymorphism amplifies the inflammatory response
Hofmann, M. A., Drury, S., Hudson, B. I., Gleason, M. R., Qu, W., Lu, Y., Lalla, E., Chitnis, S., Monteiro, J., Stickland, M. H., et al. (2002) · Genes & Immunity · doi:10.1038/sj.gene.6363861 · Cited by 383
Structural Basis for the Proinflammatory Cytokine Activity of High Mobility Group Box 1
Li, J., Kokkola, R., TABIBZADEH, S. S., Yang, R., Ochani, M., Qiang, X., Harris, H. E., Czura, C. J., Wang, H., Ulloa, L., et al. (2003) · Molecular Medicine · doi:10.1007/bf03402105 · Cited by 371
Self-citationLiu, K., Mori, S., Takahashi, H. K., Tomono, Y., Wake, H., Kanke, T., Sato, Y., Hiraga, N., Adachi, N., Yoshino, T., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-8770com · Cited by 362
Contributions of High Mobility Group Box Protein in Experimental and Clinical Acute Lung Injury
Ueno, H., Matsuda, T., Hashimoto, S., Amaya, F., Kitamura, Y., Tanaka, M., Kobayashi, A., Maruyama, I., Yamada, S., Hasegawa, N., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-188oc · Cited by 360
Pavlov, V. A., Ochani, M., Yang, L., Gallowitsch‐Puerta, M., Ochani, K., Lin, X., Levi, J., Parrish, W. R., Rosas‐Ballina, M., Czura, C. J., et al. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000259381.56526.96 · Cited by 357
Self-citationKrüger, B., Krick, S., Dhillon, N. K., Lerner, S., Ames, S. A., Bromberg, J. S., Lin, M., Walsh, L., Vella, J. P., Fischereder, M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810169106 · Cited by 355
Martínez Martínez, L. (1990) · PubMed · Cited by 334
Kokkola, R., Li, J., Sundberg, E., Aveberger, A.-C., Palmblad, K., Yang, H., Tracey, K. J., Andersson, J., & Harris, H. E. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11161 · Cited by 325
Self-citationSappington, P. L., Yang, R., Yang, H., Tracey, K. J., Delude, R. L., & Fink, M. P. (2002) · Gastroenterology · doi:10.1053/gast.2002.35391 · Cited by 319
Self-citationHemorrhagic Shock Induces NAD(P)H Oxidase Activation in Neutrophils: Role of HMGB1-TLR4 Signaling
Fan, J., Li, Y., Levy, R. M., Fan, J., Hackam, D. J., Vodovotz, Y., Yang, H., Tracey, K. J., Billiar, T. R., & Wilson, M. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6573 · Cited by 307
Self-citationHuston, J. M., Gallowitsch‐Puerta, M., Ochani, M., Ochani, K., Yuan, R., Rosas‐Ballina, M., Ashok, M., Goldstein, R. S., Chavan, S. S., Pavlov, V. A., et al. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000288102.15975.ba · Cited by 307
Self-citationWang, H., Vishnubhakat, J. M., Bloom, O., Zhang, M., Ombrellino, M., Sama, A. E., & Tracey, K. J. (1999) · Surgery · doi:10.1016/s0039-6060(99)70182-0 · Cited by 298
Self-citation(2002) · PubMed · Cited by 292
High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis
Kokkola, R., Sundberg, E., Ulfgren, A. ‐., Palmblad, K., Li, J., Wang, H., Ulloa, L., Yang, H., Yan, X. ‐., Furie, R., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10540 · Cited by 290
Self-citationYoun, J. H., Oh, Y. J., Kim, E. S., Choi, J. E., & Shin, J.-S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.5067 · Cited by 281
Stern, D. M., Yan, S. D., Yan, S. F., & Schmidt, A. M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00160-6 · Cited by 281
Stimulation of nicotinic acetylcholine receptors attenuates collagen‐induced arthritis in mice
van Maanen, M. A., Lebre, M. C., van der Poll, T., LaRosa, G. J., Elbaum, D., Vervoordeldonk, M. J., & Tak, P. P. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24177 · Cited by 276
van Zoelen, M. A. D., Yang, H., Florquin, S., Meijers, J. C. M., Akira, S., Arnold, B., Nawroth, P. P., Bierhaus, A., Tracey, K. J., & van der Poll, T. (2009) · Shock · doi:10.1097/shk.0b013e318186262d · Cited by 262
Self-citationEthyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice
Miyaji, T., Hu, X., Yuen, P. S. T., Muramatsu, Y., Iyer, S. N., Hewitt, S. M., & Star, R. A. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00268.x · Cited by 260
ELEVATED HIGH-MOBILITY GROUP BOX 1 LEVELS IN PATIENTS WITH CEREBRAL AND MYOCARDIAL ISCHEMIA
Goldstein, R. S., Gallowitsch‐Puerta, M., Yang, L., Rosas‐Ballina, M., Huston, J. M., Czura, C. J., Lee, D. C., Ward, M. F., Bruchfeld, A. N., Wang, H., et al. (2006) · Shock · doi:10.1097/01.shk.0000209540.99176.72 · Cited by 259
Self-citationA signature for the HMG‐1 box DNA‐binding proteins
Landsman, D., & Bustin, M. (1993) · BioEssays · doi:10.1002/bies.950150807 · Cited by 257
HMGB1 contributes to the development of acute lung injury after hemorrhage
Kim, J. Y., Park, J. S., Strassheim, D., Douglas, I. S., del Valle, F. D., Asehnoune, K., Mitra, S., Kwak, S. H., Yamada, S., Maruyama, I., et al. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00359.2004 · Cited by 250
Faraco, G., Fossati, S., Bianchi, M. E., Patrone, M., Pedrazzi, M., Sparatore, B., Moroni, F., & Chiarugi, A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04788.x · Cited by 232
Yang, R., Harada, T., Mollen, K. P., Prince, J. M., Levy, R. M., Englert, J. A., Gallowitsch‐Puerta, M., Yang, L., Yang, H., Tracey, K. J., et al. (2006) · Molecular Medicine · doi:10.2119/2006-00010.yang · Cited by 221
Self-citationHigh‐mobility group box 1 protein promotes development of microvascular thrombosis in rats
Ito, T., Kawahara, K., Nakamura, T., Yamada, S., Nakamura, T., Abeyama, K., Hashiguchi, T., & Maruyama, I. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02255.x · Cited by 210
Angus, D. C., Yang, L., Kong, L., Kellum, J. A., Delude, R. L., Tracey, K. J., & Weissfeld, L. A. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000259534.68873.2a · Cited by 210
Self-citationKim, J., Lim, C., Yu, Y., & Lee, J.-K. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21555 · Cited by 199
High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis
Pullerits, R., Jonsson, I., Verdrengh, M., Bokarewa, M. I., Andersson, U., Erlandsson-Harris, H., & Tarkowski, A. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11028 · Cited by 191
Tsoyi, K., Lee, T. Y., Lee, Y. S., Kim, H. J., Seo, H. G., Lee, J. H., & Chang, K. C. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.055137 · Cited by 190
Goldstein, R. S., Bruchfeld, A. N., Yang, L., Qureshi, A. R., Gallowitsch‐Puerta, M., Patel, N. B., Huston, B. J., Chavan, S. S., Rosas‐Ballina, M., Gregersen, P. K., et al. (2007) · Molecular Medicine · doi:10.2119/2006-00108.goldstein · Cited by 189
Self-citationThe Role of High Mobility Group Box1 in Pulmonary Fibrosis
Hamada, N., Maeyama, T., Kawaguchi, T., Yoshimi, M., Fukumoto, J., Yamada, M., Yamada, S., Kuwano, K., & Nakanishi, Y. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0330oc · Cited by 188
Lutterloh, E. C., Opal, S. M., Pittman, D. D., Keith, J. C., Tan, X., Clancy, B. M., Palmer, H. S., Milarski, K. L., Sun, Y., Palardy, J. E., et al. (2007) · Critical Care · doi:10.1186/cc6184 · Cited by 169
Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock
Ombrellino, M., Wang, H., Ajemian, M. S., Talhouk, A., Scher, L. A., Friedman, S. G., & Tracey, K. J. (1999) · The Lancet · doi:10.1016/s0140-6736(99)02658-6 · Cited by 168
Self-citationMatot, I., & Sprung, C. L. (2001) · Intensive Care Medicine · doi:10.1007/pl00003795 · Cited by 153
Li, W., Li, J.-H., Ashok, M., Wu, R.-Q., Chen, D., Yang, L.-H., Yang, H., Tracey, K., Wang, P., Sama, A., et al. (2007) · Journal of Immunology · doi:10.4049/jimmunol.178.6.3856 · Cited by 151
Self-citationLiu, S., Stolz, D. B., Sappington, P. L., Macias, C. A., Killeen, M. E., Tenhunen, J. J., Delude, R. L., & Fink, M. P. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00308.2005 · Cited by 150
Huang, Y., Yin, H., Han, J.-Y., Huang, B., Xu, J., Zheng, F., Tan, Z., Fang, M., Rui, L., Chen, D., et al. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.01734.x · Cited by 147
Contribution of High-Mobility Group Box-1 to the Development of Ventilator-induced Lung Injury
Ogawa, E. N., Ishizaka, A., Tasaka, S., Koh, H., Ueno, H., Amaya, F., Ebina, M., Yamada, S., Funakoshi, Y., Soejima, J., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200605-699oc · Cited by 146
A Major Ingredient of Green Tea Rescues Mice from Lethal Sepsis Partly by Inhibiting HMGB1
Li, W., Ashok, M., Li, J., Yang, H., Sama, A. E., & Wang, H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001153 · Cited by 145
Self-citationde Wouwer, M. V., Plaisance, S., Vriese, A. D., Waelkens, E., Collen, D., Persson, J., Daha, M. R., & Conway, E. M. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02033.x · Cited by 140
Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis
Sawa, H. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i47.7666 · Cited by 132
Hemorrhage-induced acute lung injury is TLR-4 dependent
Barsness, K. A., Arcaroli, J. J., Harken, A. H., Abraham, E. H., Banerjee, A. M., Reznikov, L. L., & McIntyre, R. C. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00412.2003 · Cited by 131
Hamada, T., Torikai, M., Kuwazuru, A., Tanaka, M., Horai, N., Fukuda, T., Yamada, S., Nagayama, S., Hashiguchi, K., Sunahara, N., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23729 · Cited by 130
NOVEL HMGB1-INHIBITING THERAPEUTIC AGENTS FOR EXPERIMENTAL SEPSIS
Wang, H., Ward, M. F., & Sama, A. E. (2009) · Shock · doi:10.1097/shk.0b013e3181a551bd · Cited by 125
Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury
Tsung, A., Zheng, N., Jeyabalan, G., Izuishi, K., Klune, J. R., Geller, D. A., Lotze, M. T., Lü, L., & Billiar, T. R. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0706468 · Cited by 118
Maeda, S., Hikiba, Y., Shibata, W., Ohmae, T., Yanai, A., Ogura, K., Yamada, S., & Omata, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.065 · Cited by 106
Kaczorowski, D. J., Nakao, A., Vallabhaneni, R., Mollen, K. P., Sugimoto, R., Kohmoto, J., Zuckerbraun, B. S., McCurry, K. R., & Billiar, T. R. (2009) · Transplantation · doi:10.1097/tp.0b013e3181a36e5e · Cited by 106
Anti‐High‐Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Sepsis
Suda, K., Kitagawa, Y., Ozawa, S., Saikawa, Y., Ueda, M., Ebina, M., Yamada, S., Hashimoto, S., FUKATA, S., Abraham, E. H., et al. (2006) · World Journal of Surgery · doi:10.1007/s00268-005-0369-2 · Cited by 100
Nagato, M., Okamoto, K., Abe, Y., Higure, A., & Yamaguchi, K. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a55184 · Cited by 98
Leelahavanichkul, A., Yasuda, H., Doi, K., Hu, X., Zhou, H., Yuen, P. S. T., & Star, R. A. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90442.2008 · Cited by 91
High-Mobility Group Protein Box-1 and its Relevance to Cerebral Ischemia
Yang, Q., Wang, J., Li, J., Zhou, Y. J., Qizhong, Lu, F.-L., & Xiang, J. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.202 · Cited by 87
Ilmakunnas, M., Tukiainen, E. M., Rouhiainen, A., Rauvala, H., Arola, J., Nordin, A. J., Mäkisalo, H., Höckerstedt, K., & Isoniemi, H. (2008) · Liver Transplantation · doi:10.1002/lt.21573 · Cited by 81
Abad, C., Martínez, C., Leceta, J., Gomariz, R. P., & Delgado, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3182 · Cited by 75
The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock
Raman, K. G., Sappington, P. L., Yang, R., Levy, R. M., Prince, J. M., Liu, S., Watkins, S. C., Schmidt, A. M., Billiar, T. R., & Fink, M. P. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00055.2006 · Cited by 74
Pedrazzi, M., Raiteri, L., Bonanno, G., Patrone, M., Ledda, S., Passalacqua, M., Milanese, M., Melloni, E., Raiteri, M., Pontremoli, S., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04120.x · Cited by 73
Kocsis, Á. K., Szabolcs, A., Hofner, P., Takács, T., Farkas, G., Boda, K., & Mándi, Y. (2009) · Pancreatology · doi:10.1159/000181172 · Cited by 70
Gong, Q., Xu, J., Yin, H., Liu, S., Duan, L. ‐., & Bian, Z. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02194.x · Cited by 66
Natural killer T cell-mediated immunotherapy for malignant diseases
Motohashi, S. (2009) · Frontiers in Bioscience-Elite · doi:10.2741/e10 · Cited by 62
Protective Effect of HMGB1 A Box on Organ Injury of Acute Pancreatitis in Mice
Yuan, H., Jin, X., Sun, J.-B., Li, F., Feng, Q., Zhang, W., Cao, Y., & Wang, Y. (2009) · Pancreas · doi:10.1097/mpa.0b013e31818166b4 · Cited by 61
Ding, B., Hong, N., Christofidou‐Solomidou, M., Gottstein, C., Albelda, S. Μ., Cines, D. B., Fisher, A. B., & Muzykantov, V. R. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200809-1433oc · Cited by 59
Cheng, B.-Q., Liu, C., Li, W.-J., Fan, W. Q., Zhong, N., Zhang, Y., Jia, X., & Shang-zhong, Z. (2007) · Pancreas · doi:10.1097/mpa.0b013e318064678a · Cited by 55
Sparatore, B., Passalacqua, M., Patrone, M., Melloni, E., & Pontremoli, S. (1996) · Biochemical Journal · doi:10.1042/bj3200253 · Cited by 55
Zetterström, C. K., Jiang, W., Wähämaa, H., Östberg, T., Aveberger, A.-C., Schierbeck, H., Lotze, M. T., Andersson, U., Pisetsky, D. S., & Harris, H. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0507323 · Cited by 54
Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia
Yang, R., Miki, K., Oksala, N., Nakao, A., Lindgren, L., Killeen, M. E., Mennander, A., Fink, M. P., & Tenhunen, J. J. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00184.2009 · Cited by 48
Ethyl Pyruvate Ameliorates Liver Injury Secondary to Severe Acute Pancreatitis
Yang, R., Shaufl, A. L., Killeen, M. E., & Fink, M. P. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.04.004 · Cited by 47
Yasuda, T., Ueda, T., Shinzeki, M., Sawa, H., Nakajima, T., Takeyama, Y., & Kuroda, Y. (2007) · Pancreas · doi:10.1097/mpa.0b013e31804154e4 · Cited by 47
Yang, Z., Yan, L., Yin, T., Tao, J., Xiong, J., Wu, H., & Wang, C. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.4546 · Cited by 46
Sakamoto, Y., Mashiko, K., Matsumoto, H., Hara, Y., Kutsukata, N., & Yamamoto, Y. (2007) · ASAIO Journal · doi:10.1097/mat.0b013e3180340301 · Cited by 36
Jiang, W., & Pisetsky, D. S. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0379 · Cited by 32
Tang, Y., Lv, B., Wang, H., Xiao, X., & Zuo, X. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.07.014 · Cited by 32
Hussein, M. H., Kato, T., Sugiura, T., Daoud, G. A.-H., Suzuki, S. O., Fukuda, S., Sobajima, H., Kato, I., & Togari, H. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000169995.25333.f7 · Cited by 27
Pan, P., Cardinal, J. S., Dhupar, R., Rosengart, M. R., Lotze, M. T., Geller, D. A., Billiar, T. R., & Tsung, A. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1108713 · Cited by 27
Susa, Y., Masuda, Y., Imaizumi, H., & Namiki, A. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a930f7 · Cited by 26
Nakamura, T., Fujiwara, N., Sato, E., Kawagoe, Y., Ueda, Y., Yamada, S., & Koide, H. (2009) · ASAIO Journal · doi:10.1097/mat.0b013e3181a5290f · Cited by 26
Bonanno, G., Raiteri, L., Milanese, M., Zappettini, S., Melloni, E., Pedrazzi, M., Passalacqua, M., Tacchetti, C., Usai, C., & Sparatore, B. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82004-6 · Cited by 20
Linking proximal and downstream signalling events in hepatic ischaemia/reperfusion injury
Jeyabalan, G., Tsung, A., & Billiar, T. R. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340957 · Cited by 11
Flagged first, then by citations
1 of the 113 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- [4]Dinarello CA Interleukin-1 family Thomson AW Lotze MT Cytokine Handbook 4 Academic Press 2003 643 662
- [5]Kishmoto T Interleukin 6 Thomson AW Lotze MT Cytokine Handbook 4 1 Academic Press 2003 281 295
- [30]Kaczorowski DJ Tsung A Billiar TR Innate immune mechanisms in ischemia/reperfusion Front Biosci (Elite Ed) 1 2009 91 98 19482628
- [43]Yang H Wang H Ochani M Ochani K Rosas-Ballina M Parrish WR Tracey KJ Endogenous mammalian HMGB1, devoid of any contaminants introduced by purification of recombinant proteins, mediates anorexia, weight loss, and increased TNF levels 31st Annual Conference on Shock Cologne, Germany, Shock 29 2008 Supp 91
Cited by
Sorted by citations
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304
Neuroinflammation: friend and foe for ischemic stroke
Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1516-2 · Cited by 1,479
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Qin, C., Yang, S., Chu, Y., Zhang, H., Pang, X., Chen, L., Zhou, L., Chen, M., Tian, D., & Wang, W. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01064-1 · Cited by 997
Yang, H., Hreggvidsdottir, H. S., Palmblad, K., Wang, H., Ochani, M., Li, J., Lü, B., Chavan, S. S., Rosas‐Ballina, M., Al‐Abed, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003893107 · Cited by 812
Self-citationTargeting Inflammation Driven by HMGB1
Yang, H., Wang, H., & Andersson, U. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00484 · Cited by 662
Self-citation
Metadata
- Authors
- Yang, H., & Tracey, K. J.
- Affiliations
- Feinstein Institute for Medical Research (US)
- Corresponding author
- Yang, Huan
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 1799
- Issue
- 1-2
- Pages
- 149-156
- ISSN
- 1874-9399 (ISSN-L)
- PMC
- PMC4533842
- OpenAlex
- W1983348216
- Cited by
- 351
- References
- 113
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 4 · 2023: 9 · 2022: 24 · 2021: 20 · 2020: 28 · 2019: 14 · 2018: 24 · 2017: 25 · 2016: 23 · 2015: 27 · 2014: 34 · 2013: 23 · 2012: 34
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM062508)
- National Center for Research Resources (MOL RR018535, M01RR018535)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- HMGB1, high mobility group box 1, inflammation, infection, endotoxemia, sepsis, collagen-induced arthritis, ischemia-reperfusion injury, inflammatory disease therapy
- MeSH terms
- Animals, Disease, Humans, Immunity, Inflammation, Receptors, Immunologic, Cytokines, HMGB1 Protein
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