Cited by 351Advanced Glycation End Products researchImmune Response and InflammationS100 Proteins and Annexins

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Targeting HMGB1 in inflammation

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Yang, Huan, Tracey, Kevin J.·2010·Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI 10.1016/j.bbagrm.2009.11.019PMC PMC4533842

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Abstract

High mobility group box 1 (HMGB1), a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. Elevated levels of HMGB1 in serum and tissues occur during sterile tissue injury and during infection, and targeting HMGB1 with antibodies or specific antagonists is protective in established preclinical inflammatory disease models including lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury. Future advances in this field will stem from understanding the biological basis for the success of targeting HMGB1 to therapeutic improvement in the treatment of inflammation, infection and ischemia-reperfusion induced injury.

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Authors: Yang, H., & Tracey, K. J.
Affiliations: Feinstein Institute for Medical Research (US)
Corresponding author: Yang, Huan
ORCID: Yang, Huan
Tracey, Kevin J.
Venue: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Publisher: Elsevier BV
Published: 2010-01
Volume: 1799
Issue: 1-2
Pages: 149-156
ISSN: 1874-9399 (ISSN-L)
DOI: 10.1016/j.bbagrm.2009.11.019
PMC: PMC4533842
OpenAlex: W1983348216
Cited by: 351
References: 113
Citations by year: 2026: 9 · 2025: 16 · 2024: 4 · 2023: 9 · 2022: 24 · 2021: 20 · 2020: 28 · 2019: 14 · 2018: 24 · 2017: 25 · 2016: 23 · 2015: 27 · 2014: 34 · 2013: 23 · 2012: 34
FWCI: 15.12
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM062508)
National Center for Research Resources (MOL RR018535, M01RR018535)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Keywords: HMGB1, high mobility group box 1, inflammation, infection, endotoxemia, sepsis, collagen-induced arthritis, ischemia-reperfusion injury, inflammatory disease therapy
MeSH terms: Animals, Disease, Humans, Immunity, Inflammation, Receptors, Immunologic, Cytokines, HMGB1 Protein

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