The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin
Open accessAbstract
The receptor for advanced glycation end products (RAGE), a newly-identified member of the immunoglobulin superfamily, mediates interactions of advanced glycation end product (AGE)-modified proteins with endothelium and other cell types. Survey of normal tissues demonstrated RAGE expression in situations in which accumulation of AGEs would be unexpected, leading to the hypothesis that under physiologic circumstances, RAGE might mediate interaction with ligands distinct from AGEs. Sequential chromatography of bovine lung extract identified polypeptides with M(r) values of approximately 12,000 (p12) and approximately 23,000 (p23) which bound RAGE. NH2-terminal and internal protein sequence data for p23 matched that reported previously for amphoterin. Amphoterin purified from rat brain or recombinant rat amphoterin bound to purified sRAGE in a saturable and dose-dependent manner, blocked by anti-RAGE IgG or a soluble form of RAGE (sRAGE). Cultured embryonic rat neurons, which express RAGE, displayed dose-dependent binding of 125I-amphoterin which was prevented by blockade of RAGE using antibody to the receptor or excess soluble receptor (sRAGE). A functional correlate of RAGE-amphoterin interaction was inhibition by anti-RAGE F(ab')2 and sRAGE of neurite formation by cortical neurons specifically on amphoterin-coated substrates. Consistent with a potential role for RAGE-amphoterin interaction in development, amphoterin and RAGE mRNA/antigen were co-localized in developing rat brain. These data indicate that RAGE has physiologically relevant ligands distinct from AGEs which are likely, via their interaction with the receptor, to participate in physiologic processes outside of the context of diabetes and accumulation of AGEs.
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Cites
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572 · see citing works
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222 · see citing works
Integrins: Versatility, modulation, and signaling in cell adhesion
Hynes, R. O. (1992) · Cell · doi:10.1016/0092-8674(92)90115-s · Cited by 9,857 · see citing works
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791 · see citing works
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512 · see citing works
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,542 · see citing works
Self-citationYan, S. D., Schmidt, A. M., Anderson, G. M., Zhang, J., Brett, J., Zou, Y., Pinsky, D. J., & Stern, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36966-1 · Cited by 1,305 · see citing works
Self-citationStructure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix
Sell, D. R., & Monnier, V. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88225-8 · Cited by 1,082 · see citing works
Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils
Kodama, T., Freeman, M. W., Rohrer, L., Zabrecky, J. R., Matsudaira, P. T., & Krieger, M. (1990) · Nature · doi:10.1038/343531a0 · Cited by 1,039 · see citing works
Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J., & Stern, D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118175 · Cited by 896 · see citing works
Self-citationProtein kinase C as a possible receptor protein of tumor‐promoting phorbol esters
Kikkawa, U., Takai, Y., Tanaka, Y., Miyake, R., & Nishizuka, Y. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44245-1 · Cited by 881 · see citing works
Schmidt, A. M., Vianna, M., Gerlach, M. L., Brett, J., Ryan, J., Kao, J. J., Esposito, C., Hegarty, H. M., Hurley, W. L., & Clauss, M. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42137-0 · Cited by 833 · see citing works
Self-citationBrett, J., Schmidt, A. M., Yan, S. D., Zou, Y. S., Weidman, E., Pinsky, D. J., Nowygrod, R., Neeper, M. P., Przysiecki, C. T., & SHAW, A. R. (1993) · PubMed Central · Cited by 776 · see citing works
Self-citationSchmidt, A. M., Hori, O., Brett, J., Yan, S. D., Wautier, J., & Stern, D. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.10.1521 · Cited by 636 · see citing works
Self-citationLipid advanced glycosylation: pathway for lipid oxidation in vivo.
Bucala, R., Makita, Z., Koschinsky, T., Cerami, A., & Vlassara, H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6434 · Cited by 571 · see citing works
Hunt, J. V., Smith, C. C., & Wolff, S. P. (1990) · Diabetes · doi:10.2337/diab.39.11.1420 · Cited by 553 · see citing works
[2] Production of antisera with small doses of immunogen: multiple intradermal injections
Vaitukaitis, J. L. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(81)73055-6 · Cited by 439 · see citing works
Glucose and diabetic vascular disease 1
Ruderman, N. B., Williamson, J. R., & Brownlee, M. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.11.1644256 · Cited by 375 · see citing works
Schmidt, A. M., Hasu, M., Popov, D., Zhang, J. H., Chen, J., Yan, S. D., Brett, J., Cao, R. Y., Kuwabara, K., & Costache, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8807 · Cited by 327 · see citing works
Self-citationSchmidt, A. M., Yan, S. D., Brett, J., Mora, R., Nowygrod, R., & Stern, D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116442 · Cited by 297 · see citing works
Self-citationMerenmies, J. M., Pihlaskari, R., Laitinen, J., Wartiovaara, J., & Rauvala, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55361-8 · Cited by 242 · see citing works
Techniques in Protein Chemistry IV
(1993) · Elsevier eBooks · doi:10.1016/c2013-0-10295-4 · Cited by 230 · see citing works
Parkkinen, J., Raulo, E., Merenmies, J. M., Nolo, R. M., Kajander, E. O., Baumann, M., & Rauvala, H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36575-5 · Cited by 216 · see citing works
Rauvala, H., & Pihlaskari, R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49302-7 · Cited by 211 · see citing works
Yang, Z., Makita, Z., Horii, Y., Brunelle, S., Cerami, A., Sehajpal, P. K., Suthanthiran, M., & Vlassara, H. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.3.515 · Cited by 191 · see citing works
Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors.
Khoury, J. B. E., Thomas, C. A., Loike, J. D., Hickman, S., Cao, L., & Silverstein, S. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34043-7 · Cited by 181 · see citing works
Parkkinen, J., & Rauvala, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55362-x · Cited by 142 · see citing works
Schmidt, A. M., Mora, R., Cao, R. Y., Yan, S. D., Brett, J., Ramakrishnan, R., Tsang, T. C., Simionescu, M., & Stern, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36965-x · Cited by 123 · see citing works
Self-citationNeurite growth-promoting protein (amphoterin, p30) binds syndecan
Salmivirta, M., Rauvala, H., Elenius, K., & Jalkanen, M. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90194-d · Cited by 97 · see citing works
Catalysis of lipid peroxidation by glucose and glycosylated collagen
Hicks, M., Delbridge, L., Yue, D. K., & Reeve, T. S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80330-9 · Cited by 92 · see citing works
Sulfoglycolipids bind to adhesive protein amphoterin (P30) in the nervous system
Mohan, P. S., Laitinen, J., Merenmies, J. M., et al. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91787-q · Cited by 45 · see citing works
Mohanty, J. G., & Elazhary, Y. (1989) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/0147-9571(89)90064-7 · Cited by 25 · see citing works
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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works
Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051 · see citing works
DAMPs, PAMPs and alarmins: all we need to know about danger
Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794 · see citing works
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works
Self-citationRAGE Mediates a Novel Proinflammatory Axis
Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80801-6 · Cited by 1,864 · see citing works
Self-citationHMGB1 is a therapeutic target for sterile inflammation and infection
Andersson, U., & Tracey, K. J. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101323 · Cited by 1,437 · see citing works
Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372 · see citing works
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
Taguchi, A., Blood, D. C., del Toro, G., Canet, A., Lee, D. C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., et al. (2000) · Nature · doi:10.1038/35012626 · Cited by 1,217 · see citing works
Self-citationRole of advanced glycation end products in cellular signaling
Ott, C., Jacobs, K., Haucke, E., Navarrete Santos, A., Grune, T., & Simm, A. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.016 · Cited by 1,150 · see citing works
Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095 · see citing works
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Yu, M., Wang, H., Ding, A., Golenbock, D. T., Latz, E., Czura, C. J., Fenton, M. J., Tracey, K. J., & Yang, H. (2006) · Shock · doi:10.1097/01.shk.0000225404.51320.82 · Cited by 832 · see citing works
HMGB1: Endogenous Danger Signaling
Klune, J. R., Dhupar, R., Cardinal, J., Billiar, T. R., & Tsung, A. (2008) · Molecular Medicine · doi:10.2119/2008-00034.klune · Cited by 762 · see citing works
YONEKURA, H., YAMAMOTO, Y., SAKURAI, S., PETROVA, R. G., ABEDIN, M. J., LI, H., YASUI, K., TAKEUCHI, M., MAKITA, Z., TAKASAWA, S., et al. (2003) · Biochemical Journal · doi:10.1042/bj20021371 · Cited by 716 · see citing works
HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease
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The cytokine activity of HMGB1
Yang, H., Wang, H., Czura, C. J., & Tracey, K. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1104648 · Cited by 545 · see citing works
Li, J., & Schmidt, A. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.26.16498 · Cited by 525 · see citing works
Self-citationYan, S. F., Ramasamy, R., Naka, Y., & Schmidt, A. M. (2003) · Circulation Research · doi:10.1161/01.res.0000103862.26506.3d · Cited by 513 · see citing works
Self-citationDumitriu, I. E., Baruah, P., Valentinis, B., Voll, R. E., Herrmann, M., Nawroth, P. P., Arnold, B., Bianchi, M. E., Manfredi, A. A., & Rovere-Querini, P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7506 · Cited by 503 · see citing works
McKeon, R. J., Jurynec, M. J., & Buck, C. R. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-24-10778.1999 · Cited by 480 · see citing works
Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice
Yamamoto, Y., Kato, I., Doi, T., Yonekura, H., Ohashi, S., Takeuchi, M., Watanabe, T., Yamagishi, S.-I., Sakurai, S., Takasawa, S., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11771 · Cited by 475 · see citing works
HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
Bertheloot, D., & Latz, E. (2017) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.34 · Cited by 455 · see citing works
Lue, L.-F., Walker, D. G., Brachova, L., Beach, T. G., Rogers, J., Schmidt, A. M., Stern, D. M., & Yan, S. D. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7732 · Cited by 439 · see citing works
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Targeting HMGB1 in inflammation
Yang, H., & Tracey, K. J. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.11.019 · Cited by 351 · see citing works
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Bucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., Taguchi, A., Yan, S. F., Yan, S. D., Stern, D. M., et al. (2002) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-002-8491-x · Cited by 304 · see citing works
Self-citationRAGE: therapeutic target and biomarker of the inflammatory response—the evidence mounts
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Self-citationYoun, J. H., Oh, Y. J., Kim, E. S., Choi, J. E., & Shin, J.-S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.5067 · Cited by 281 · see citing works
Wendt, T., Tanji, N., Guo, J., Hudson, B. I., Bierhaus, A., Ramasamy, R., Arnold, B., Nawroth, P. P., Yan, S. F., D’Agati, V., et al. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000065100.17349.ca · Cited by 239 · see citing works
Self-citationAntoine, D. J., Williams, D. P., Kipar, A., Jenkins, R. E., Regan, S. L., Sathish, J. G., Kitteringham, N. R., & Park, B. K. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp235 · Cited by 223 · see citing works
Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin)
Rouhiainen, A., Tumova, S., Valmu, L., Kalkkinen, N., & Rauvala, H. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306200 · Cited by 214 · see citing works
Sousa, M. M., Du Yan, S., Fernandes, R., Guimarães, A., Stern, D., & Saraiva, M. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07576.2001 · Cited by 212 · see citing works
Self-citationIshihara, K., Tsutsumi, K., Kawane, S., Nakajima, M., & Kasaoka, T. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00846-9 · Cited by 201 · see citing works
HMGB1 in Development and Diseases of the Central Nervous System
Fang, P., Schachner, M., & Shen, Y.-Q. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8264-y · Cited by 193 · see citing works
High‐mobility group box‐1 in sterile inflammation
Tsung, A., Tohme, S., & Billiar, T. R. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12276 · Cited by 187 · see citing works
Fehrenbach, H., Weiskirchen, R., Kasper, M., & Gressner, A. M. (2001) · Hepatology · doi:10.1053/jhep.2001.28788 · Cited by 154 · see citing works
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Xiang, M., Shi, X., Li, Y., Xu, J., Yin, L., Xiao, G., Scott, M. J., Billiar, T. R., Wilson, M. A., & Fan, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102093 · Cited by 155 · see citing works
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Holmlund, U., Wähämaa, H., Bachmayer, N., Bremme, K., Sverremark‐Ekström, E., & Palmblad, K. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02662.x · Cited by 83 · see citing works
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Su, Z., Sun, C., Zhou, C., Liu, Y., Zhu, H., Sandoghchian, S., Zheng, D., Peng, T., Zhang, Y., Jiao, Z., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201141879 · Cited by 81 · see citing works
Ueno, H., Koyama, H., Shoji, T., Monden, M., Fukumoto, S., Tanaka, S., Otsuka, Y., Mima, Y., Morioka, T., Mori, K., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.04.006 · Cited by 65 · see citing works
RAGE mediates vascular injury and inflammation after global cerebral ischemia
Kamide, T., Kitao, Y., Takeichi, T., Okada, A., Mohri, H., Schmidt, A. M., Kawano, T., Munesue, S., Yamamoto, Y., Yamamoto, H., et al. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2011.12.008 · Cited by 60 · see citing works
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Nakamura, T., Sato, E., Fujiwara, N., Kawagoe, Y., Ueda, Y., Suzuki, T., Yamada, S., Takeuchi, M., Fukami, K., Ueda, S., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.05.018 · Cited by 53 · see citing works
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Rouillard, M. E., Hu, J., Sutter, P. A., Kim, H. W., Huang, J. K., & Crocker, S. J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.833186 · Cited by 35 · see citing works
Su, Z., Yin, J., Wang, T., Sun, Y., Ni, P., Ma, R., Zhu, H., Zheng, D., Shen, H., Xu, W., et al. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12324 · Cited by 33 · see citing works
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- Authors
- Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J. X., Nagashima, M., Lundh, E. R., Vijay, S., Nitecki, D., Morser, J., Stern, D., & Schmidt, A. M.
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- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p50hl021006-17)
- National Institute on Aging (AG00602)
- National Heart, Lung, and Blood Institute (HL 21006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
- Keywords
- receptor for advanced glycation end products, RAGE, amphoterin, RAGE ligands, soluble RAGE, neurite outgrowth, cortical neurons, brain development, immunoglobulin superfamily receptors, ligand-receptor interactions, embryonic neurons
- MeSH terms
- Receptor for Advanced Glycation End Products, Animals, Base Sequence, Carrier Proteins, Cattle, Cells, Cultured, Cerebral Cortex, Chromatography, Affinity, High Mobility Group Proteins, Immunohistochemistry, Ligands, Lung, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Protein Binding, Receptors, Immunologic, RNA, Messenger, Neurites, Rats, Wistar, In Situ Hybridization, HMGB1 Protein, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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