Cited by 771NF-κB Signaling PathwaysNatural Compounds in Disease TreatmentSignaling Pathways in Disease

The DOI matches its Crossref record; 231 of the 232 references it cites were found in a registry or an index.

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

Open access

Gupta, Subash C., Sundaram, Chitra, Reuter, Simone, Aggarwal, Bharat B.·2010·Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI 10.1016/j.bbagrm.2010.05.004PMC PMC2955987

Open this paper in CoChat — free account

Abstract

Because nuclear factor-κB (NF-κB) is a ubiquitously expressed proinflammatory transcription factor that regulates the expression of over 500 genes involved in cellular transformation, survival, proliferation, invasion, angiogenesis, metastasis, and inflammation, the NF-κB signaling pathway has become a potential target for pharmacological intervention. A wide variety of agents can activate NF-κB through canonical and noncanonical pathways. Canonical pathway involves various steps including the phosphorylation, ubiquitination, and degradation of the inhibitor of NF-κB (IκBα), which leads to the nuclear translocation of the p50-p65 subunits of NF-κB followed by p65 phosphorylation, acetylation and methylation, DNA binding, and gene transcription. Thus, agents that can inhibit protein kinases, protein phosphatases, proteasomes, ubiquitination, acetylation, methylation, and DNA binding steps have been identified as NF-κB inhibitors. Because of the critical role of NF-κB in cancer and various chronic diseases, numerous inhibitors of NF-κB have been identified. In this review, however, we describe only small molecules that suppress NF-κB activation, and the mechanism by which they block this pathway.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbagrm.2010.05.004

Cites

231 of 231 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

2 retracted

RETRACTED ARTICLE: Local administration of transcription factor decoy oligonucleotides to nuclear factor-κB prevents carrageenin-induced inflammation in rat hind paw
D’Acquisto, F., Ialenti, A., Ianaro, A., Vaio, R. D., & Carnuccio, R. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301295 · Cited by 65
Retracted
Histone Deacetylase Inhibitors Activate NF-κB in Human Leukemia Cells through an ATM/NEMO-related Pathway
Rosato, R. R., Kolla, S. S., Hock, S. K., Almenara, J. A., Patel, A. K., Amin, S., Atadja, P. W., Fisher, P. B., Dent, P., & Grant, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.095208 · Cited by 64
Retracted
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182
Signaling to NF-κB
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · cited 1×
“In resting cells, NF-κB proteins are kept in the cytoplasm in association with inhibitory IkB proteins including IκBα, IκBβ, and IκBε [15] among which IκBα is the most abundant.”
Activators and Target Genes of Rel/NF-кB Transcription Factors
Loop, T., & Pahl, H. L. (2003) · Springer eBooks · doi:10.1007/978-94-010-0163-2_1 · Cited by 3,179
NF-κB: linking inflammation and immunity to cancer development and progression
Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,175
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90346-6 · Cited by 2,754
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750

Flagged first, then by citations

Show all 232 references

1 of the 232 references couldn’t be matched to a known paper.

Sorted by citations

Items 301–400 of 771

Glaucine inhibits breast cancer cell migration and invasion by inhibiting MMP-9 gene expression through the suppression of NF-κB activation
Kang, H., Jang, S., Pak, J. H., & Shim, S. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2339-9 · Cited by 34
Trianthema portulacastrum Linn. Displays Anti-Inflammatory Responses during Chemically Induced Rat Mammary Tumorigenesis through Simultaneous and Differential Regulation of NF-κB and Nrf2 Signaling Pathways
Mandal, A., & Bishayee, A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16022426 · Cited by 34
Repurposing Thioridazine (TDZ) as an anti-inflammatory agent
Baig, M. S., Roy, A., Saqib, U., Rajpoot, S., Srivastava, M., Naim, A., Liu, D., Saluja, R., Faisal, S. M., Pan, Q., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-30763-5 · Cited by 34
Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes
Grenier, D., Marcoux, E., Azelmat, J., Lagha, A. B., & Gauthier, P. (2020) · AMB Express · doi:10.1186/s13568-020-01056-w · Cited by 31
Bharangin, a Diterpenoid Quinonemethide, Abolishes Constitutive and Inducible Nuclear Factor-κB (NF-κB) Activation by Modifying p65 on Cysteine 38 Residue and Reducing Inhibitor of Nuclear Factor-κB α Kinase Activation, Leading to Suppression of NF-κB-Regulated Gene Expression and Sensitization of Tumor Cells to Chemotherapeutic Agents
Gupta, S. C., Kannappan, R., Kim, J., Rahman, G. M. S., Francis, S. K., Raveendran, R., Nair, M. S., Das, J., & Aggarwal, B. B. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.073122 · Cited by 34
Self-citation
Evaluation of Some Natural Antioxidant Sources in Broiler Diets: 1-Effect on Growth, Physiological, Microbiological and Immunological Performance of Broiler Chicks
Selim, N. A., youssef, S. F., Abdel-Salam, A. F., & Nada, S. A. (2013) · International Journal of Poultry Science · doi:10.3923/ijps.2013.561.571 · Cited by 34
Cynandione A attenuates lipopolysaccharide-induced production of inflammatory mediators via MAPK inhibition and NF-κB inactivation in RAW264.7 macrophages and protects mice against endotoxin shock
Kim, S. H., Lee, T. H., Lee, S. M., Park, J. H., Park, K. H., Jung, M., Jung, H., Mohamed, M. A. A., Baek, N., Chung, I. S., et al. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214558022 · Cited by 34
STC1 promotes cell apoptosis via NF-κB phospho-P65 Ser536 in cervical cancer cells
Pan, X., Jiang, B., Liu, J., Ding, J., Li, Y., Sun, R., Peng, L., Qin, C., Fang, S., & Li, G. (2017) · Oncotarget · doi:10.18632/oncotarget.17641 · Cited by 35
Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Antiinflammatory and Anticancer Properties
Zhang, L. J., Shi, L., Soars, S. M., Kamps, J. T., & Yin, H. H. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01557 · Cited by 33
Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function
Li, Y., Zhang, X., & Li, Y. (2019) · CNS Spectrums · doi:10.1017/s1092852919001603 · Cited by 33
Sustained Inhibition of NF-κB Activity Mitigates Retinal Vasculopathy in Diabetes
Homme, R. P., Sandhu, H. S., George, A. K., Tyagi, S. C., & Singh, M. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.01.016 · Cited by 33
Dietary Carotenoids in Head and Neck Cancer—Molecular and Clinical Implications
Starska, K. (2022) · Nutrients · doi:10.3390/nu14030531 · Cited by 33
NF ‐κ BP 65 promotes invasion and metastasis of oesophageal squamous cell cancer by regulating matrix metalloproteinase‐9 and epithelial‐to‐mesenchymal transition
Wang, F., He, W., Fanghui, P., Wang, L., & Fan, Q. (2013) · Cell Biology International · doi:10.1002/cbin.10089 · Cited by 33
The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias
Carrà, G., Torti, D., Crivellaro, S., Panuzzo, C., Taulli, R., Cilloni, D., Guerrasio, A., Saglio, G. N., & Morotti, A. (2016) · Oncotarget · doi:10.18632/oncotarget.11507 · Cited by 37
Alcohol-induced liver injury in signalling pathways and curcumin's therapeutic potential
Subramaniyan, V., Lubau, N. S. A., Mukerjee, N., & Kumarasamy, V. (2023) · Toxicology Reports · doi:10.1016/j.toxrep.2023.10.005 · Cited by 35
The Roles of RhoA/ROCK/NF-κB Pathway in Microglia Polarization Following Ischemic Stroke
Lu, W., Wang, Y., & Wen, J. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10118-w · Cited by 32
Anti-Inflammatory Effects of a Mytilus coruscus α-d-Glucan (MP-A) in Activated Macrophage Cells via TLR4/NF-κB/MAPK Pathway Inhibition
Liu, F., Zhang, X., Li, Y., Chen, Q., Liu, F., Zhu, X., Li, M., Song, X., Liu, X., Song, Z., et al. (2017) · Marine Drugs · doi:10.3390/md15090294 · Cited by 32
Targeting the NF-κB/IκBα complex via fragment-based E-Pharmacophore virtual screening and binary QSAR models
Kanan, T., Kanan, D., Erol, İ., Yazdi, S., Stein, M., & Durdağı, S. (2018) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2018.09.014 · Cited by 32
Green chicory leaf extract exerts anti-inflammatory effects through suppressing LPS-induced MAPK/NF-κB activation and hepatoprotective activity in vitro
Bayazid, A. B., Park, S. H., Kim, J. G., & Lim, B. O. (2020) · Food and Agricultural Immunology · doi:10.1080/09540105.2020.1742667 · Cited by 32
Inhibition of HDAC Enzymes Contributes to Differential Expression of Pro-Inflammatory Proteins in the TLR-4 Signaling Cascade
Weiss, U., Möller, M., Husseini, S. A., Manderscheid, C., Häusler, J., Geißlinger, G., & Niederberger, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238943 · Cited by 31
Celecoxib Repurposing in Cancer Therapy: Molecular Mechanisms and Nanomedicine-Based Delivery Technologies
Khafaga, A. F., Shamma, R. N., Abdeen, A., Barakat, A. E. M., Noreldin, A. E., Elzoghby, A. O., & Sallam, M. A. (2021) · Nanomedicine · doi:10.2217/nnm-2021-0086 · Cited by 32
TNFR1 signaling kinetics: Spatiotemporal control of three phases of IKK activation by posttranslational modification
Workman, L. M., & Habelhah, H. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.04.005 · Cited by 34
Synthesis and Mechanistic Studies of a Novel Homoisoflavanone Inhibitor of Endothelial Cell Growth
Basavarajappa, H. D., Lee, B., Fei, X., Lim, D., Callaghan, B., Mund, J. A., Case, J., Gangaraju, R., Seo, S., & Corson, T. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095694 · Cited by 32
IKK2 Inhibition Attenuates Laser-Induced Choroidal Neovascularization
Lü, H., Lu, Q., Gaddipati, S., Kasetti, R. B., Wang, W., Pasparakis, M., Kaplan, H. J., & Li, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087530 · Cited by 32
Shepherd’s Purse Polyphenols Exert Its Anti-Inflammatory and Antioxidative Effects Associated with Suppressing MAPK and NF-κB Pathways and Heme Oxygenase-1 Activation
Peng, J., Hu, T., Li, J., Du, J., Zhu, K.-R., Cheng, B., & Li, K. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7202695 · Cited by 32
Wogonin attenuates endotoxin‐induced prostaglandin E2 and nitric oxide production via Src‐ERK1/2‐NFκB pathway in BV‐2 microglial cells
Yeh, C., Yang, M., Lee, C., Yang, C., Li, Y., Chen, C., & Kuan, Y. (2013) · Environmental Toxicology · doi:10.1002/tox.21847 · Cited by 31
Anti-inflammatory Effects of a P-coumaric Acid and Kojic Acid Derivative in LPS-stimulated RAW264.7 Macrophage Cells
Lee, M., Rho, H. S., & Choi, K. (2019) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-018-0492-1 · Cited by 33
Effects of 1,25-Dihydroxyvitamin D3 on the Inflammatory Responses of Stromal Vascular Cells and Adipocytes from Lean and Obese Mice
Park, C. Y., Kim, T. Y., Yoo, J. S., Seo, Y., Pae, M., & Han, S. N. (2020) · Nutrients · doi:10.3390/nu12020364 · Cited by 32
Quercetin ameliorates Di (2-ethylhexyl) phthalate-induced nephrotoxicity by inhibiting NF-κB signaling pathway
Ashari, S., Karami, M. Y., Shokrzadeh, M., Bagheri, A., Ghandadi, M., Ranaee, M., Dashti, A., & Mohammadi, H. (2022) · Toxicology Research · doi:10.1093/toxres/tfac006 · Cited by 32
Future Nanomedicine for The Diagnosis and Treatment of Osteoarthritis
Eichaker, L. R., Cho, H., Duvall, C. L., Werfel, T. A., & Hasty, K. A. (2014) · Nanomedicine · doi:10.2217/nnm.14.138 · Cited by 31
The performance of an orthosilicic acid-releasing silica gel fiber fleece in wound healing
Grotheer, V., Goergens, M., Fuchs, P. C., Dunda, S. E., Pallua, N., Windolf, J., & Suschek, C. V. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.06.012 · Cited by 31
A nuclear factor kappa B-derived inhibitor tripeptide inhibits UVB-induced photoaging process
Oh, J. E., Kim, M. S., Jeon, W.-K., Seo, Y., Kim, B.-C., Hahn, J. H., & Park, C. S. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.10.002 · Cited by 31
Inhibition of the NF-κB Signaling Pathway by a Novel Heterocyclic Curcumin Analogue
Katsori, A., Palagani, A., Bougarne, N., Hadjipavlou‐Litina, D., Haegeman, G., & Berghe, W. V. (2015) · Molecules · doi:10.3390/molecules20010863 · Cited by 31
Click Hybridization of Immune Cells and Polyamidoamine Dendrimers
Xu, L., Zolotarskaya, O. Y., Yeudall, W. A., & Yang, H. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201300515 · Cited by 30
Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock
Sari, A. N., Korkmaz, B., Serin, M. S., Kacan, M., Unsal, D., Buharalioglu, C. K., Fırat, S. Ş., Manthati, V. L., Falck, J. R., Malik, K. U., et al. (2014) · Inflammation Research · doi:10.1007/s00011-014-0747-z · Cited by 30
Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products
Shi, H. R., Ma, J., Mi, C., Li, J., Wang, F., Lee, J. J., & Jin, X. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.04.016 · Cited by 30
Consumption of a baked corn and bean snack reduced chronic colitis inflammation in CD-1 mice via downregulation of IL-1 receptor, TLR, and TNF-α associated pathways
Luzardo-Ocampo, I., Campos-Vega, R., de Mejı́a, E. G., & Loarca-Piña, G. F. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109097 · Cited by 31
Phenolic compounds from Chaenomeles speciosa alleviate inflammation in lipopolysaccharide-treated RAW264.7 macrophages via the NF-κB and MAPK pathways
Hu, F., Liu, C., Wang, F., Zhou, C., Zhu, M., Sun‐Waterhouse, D., & Wang, Z. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.10.025 · Cited by 32
Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway
Zhao, D. F., Gu, M., Xu, J. L., Zhang, L. J., Ryu, S. Y., & Yang, H. O. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.104 · Cited by 30
Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation
Chen, Y., Wu, T., Li, H., Li, X., Li, Q., Zhu, X., Yu, M., Kuo, S., Huang, F., & Wu, Y. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00044 · Cited by 30
Neuroprotective effects of glucomoringin-isothiocyanate against H2O2-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells
Mohammed, J. S., Nordin, N., Rosli, R., Shaari, K., Bako, H. Y., Saad, N., Noor, N. M., & Razis, A. F. A. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.09.008 · Cited by 33
Epigallocatechin-3-gallate exerts protective effects against heat stress through modulating stress-responsive transcription factors in poultry
Orhan, C., Tuzcu, M., Gençoğlu, H., Şahin, N., Hayırlı, A., & Şahin, K. (2013) · British Poultry Science · doi:10.1080/00071668.2013.806787 · Cited by 30
Osteoprotegerin Exerts Its Pro-inflammatory Effects Through Nuclear Factor-κB Activation
Nahidi, L., Leach, S. T., Lemberg, D. A., & Day, A. S. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2851-2 · Cited by 28
The Endometriotic Tissue Lining the Internal Surface of Endometrioma: Hormonal, Genetic, Epigenetic Status, and Gene Expression Profile
Sanchez, A. M., Viganò, P., Somigliana, E., Cioffi, R., Panina‐Bordignon, P., & Candiani, M. (2014) · Reproductive Sciences · doi:10.1177/1933719114529374 · Cited by 30
The inhibitory effects of plumbagin on the NF-қB pathway and CCL2 release in racially different triple-negative breast cancer cells
Messeha, S. S., Zarmouh, N. O., Mendonca, P., Alwagdani, H., Kolta, M. G., & Soliman, K. F. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201116 · Cited by 29
Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell–derived factors
Smith, E. J., Beaumont, R. E., McClellan, A., Sze, C., Lago, E. P., Hazelgrove, L., Dudhia, J., Smith, R. K. W., & Guest, D. J. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03726-6 · Cited by 30
A novel limonin derivate modulates inflammatory response by suppressing the TLR4/NF-κB signalling pathway
Jin, S., Wang, J., Chen, S., Jiang, A., Jiang, M., Su, Y., Yan, W., Xu, Y., & Gong, G. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.046 · Cited by 29
Cancer gene therapy by NF-κB-activated cancer cell-specific expression of CRISPR/Cas9 targeting telomeres
Dai, W., Wu, J., Wang, D., & Wang, J. (2020) · Gene Therapy · doi:10.1038/s41434-020-0128-x · Cited by 30
The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII
Farina, A. R., Cappabianca, L. A., Ruggeri, P., Gneo, L., Pellegrini, C., Fargnoli, M. C., & Mackay, A. R. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0786-3 · Cited by 30
Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock
Tunçtan, B., Şenol, Ş. P., Temiz-Reşitoğlu, M., Güden, D. S., Şahan-Fırat, S., Falck, J. R., & Malik, K. U. (2019) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2019.106377 · Cited by 30
Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation
Xie, H., Gu, Y., Wang, W., Wang, X., Ye, X., Xin, C., Lü, M., Reddy, B. A., & Shu, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-57698-0 · Cited by 28
Avoiding or Co-Opting ATP Inhibition: Overview of Type III, IV, V, and VI Kinase Inhibitors
Martinez, R., Defnet, A. E., & Shapiro, P. (2020) · Springer eBooks · doi:10.1007/978-3-030-48283-1_3 · Cited by 30
A polyphenolic cinnamon fraction exhibits anti-inflammatory properties in a monocyte/macrophage model
Lagha, A. B., Azelmat, J., Vaillancourt, K., & Grenier, D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244805 · Cited by 30
miRNA 146A-5P-Loaded Poly( D , L -Lactic-Co-Glycolic Acid) Nanoparticles Impair Pain Behaviors by Inhibiting Multiple Inflammatory Pathways in Microglia
Phạm, T. L., Yin, Y., Kwon, H. H., Shin, N., Kim, S. I., Park, H., Shin, J., Shin, H. J., Hwang, J., Song, H., et al. (2020) · Nanomedicine · doi:10.2217/nnm-2019-0462 · Cited by 28
Crosstalk between Myopia and Inflammation: A Mini Review
Xin, J., Bo, B., Liu, J., Ma, Z., Zhang, M., Bi, H., & Guo, D. (2024) · International Journal of Medical Sciences · doi:10.7150/ijms.94826 · Cited by 28
RETRACTED ARTICLE: TNF receptor-associated factor 6 regulates proliferation, apoptosis, and invasion of glioma cells
Zhang, P., Yue, S., Yongjie, J., Xinjun, Z., & Ying, L. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1573-2 · Cited by 27
Retracted
Comparative binding studies of curcumin and tangeretin on up-stream elements of NF-kB cascade: a combined molecular docking approach
Cheemanapalli, S., Nagaraju, C., Shaikh, N. M., Vutharadhi, S., Pamuru, R. R., & Chitta, S. K. (2019) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-019-0196-2 · Cited by 27
Role of the Dietary Phytochemical Curcumin in Targeting Cancer Cell Signalling Pathways
Mishra, A. P., Swetanshu, Singh, P., Yadav, S., Nigam, M., Seidel, V., & Rodrigues, C. F. (2023) · Plants · doi:10.3390/plants12091782 · Cited by 28
The inhibitory effects of Geranium thunbergii on interferon-γ- and LPS-induced inflammatory responses are mediated by Nrf2 activation
Choi, H.-J., Choi, H., Park, M.-J., Lee, J., Jeong, S.-I., LEE, S., Kim, K. H., Joo, M., Jeong, H.-S., Kim, J., et al. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2128 · Cited by 27
Changes of KEAP1/NRF2 and IKB/NF‐κB Expression Levels Induced by Cell‐Free DNA in Different Cell Types
Kostyuk, S. V., Porokhovnik, L. N., Ershova, E. S., Malinovskaya, E. M., Konkova, M. S., Kameneva, L. V., Dolgikh, O. А., Вейко, В. П., Писарев, В. М., Martynov, A. V., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1052413 · Cited by 27
Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators
Elkamhawy, A., Kim, N. Y., Hassan, A. H. E., Park, J.-E., Yang, J.-E., Oh, K., Lee, B. H., Lee, M. Y., Shin, K. J., Lee, K., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.020 · Cited by 27
Comprehensive overview of glucosinolates in crucifers: occurrence, roles, metabolism, and transport mechanisms—a review
Sharma, S., Rani, H., Kaur, G., Kumar, S., Sheikh, S., & Samota, M. K. (2024) · Phytochemistry Reviews · doi:10.1007/s11101-024-10021-5 · Cited by 26
Synovial fibroblast‐targeting liposomes encapsulating an NF ‐κB‐blocking peptide ameliorates zymosan‐induced synovial inflammation
You, C., Zu, J., Liu, X., Kong, P., Song, C., Wei, R., Zhou, C., Wang, Y., & Yan, J. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13549 · Cited by 27
Evodiamine inactivates NF-κB and potentiates the antitumor effects of gemcitabine on tongue cancer both in vitro and in vivo
Guo, Q. J., Liu, Y., Zhao, J., Wang, J., Li, Y., Pang, Y., Chen, J., & Wang, J. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s181062 · Cited by 26
Retracted
Mesenchymal stromal cells induce inhibitory effects on hepatocellular carcinoma through various signaling pathways
Ai, J., Ketabchi, N., Verdi, J., Gheibi, N., Haghighian, H. K., & Kavianpour, M. (2019) · Cancer Cell International · doi:10.1186/s12935-019-1038-0 · Cited by 26
Design, synthesis, docking, molecular dynamics and bioevaluation studies on novel N-methylpicolinamide and thienopyrimidine derivatives with inhibiting NF-κB and TAK1 activities: Cheminformatics tools RDKit applied in drug design
Wang, L., Zhang, Q., Wang, Z., Zhu, W., & Tan, N. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113576 · Cited by 26
Lavandula x intermedia—A Bastard Lavender or a Plant of Many Values? Part II. Biological Activities and Applications of Lavandin
Pokajewicz, K., Czarniecka‐Wiera, M., Krajewska, A., Maciejczyk, E., & Wieczorek, P. P. (2023) · Molecules · doi:10.3390/molecules28072986 · Cited by 29
Role of T cell–nuclear factor κB in transplantation
Molinero, L. L., & Alegre, M. (2011) · Transplantation Reviews · doi:10.1016/j.trre.2011.07.005 · Cited by 27
Kaposi’s Sarcoma Associated Herpesvirus Encoded Viral FLICE Inhibitory Protein K13 Activates NF-κB Pathway Independent of TRAF6, TAK1 and LUBAC
Matta, H., Ramakrishnan, G., Graham, C., Tolani, B., Khanna, A., Yi, H., Suo, Y., & Chaudhary, P. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036601 · Cited by 26
Curcumin Exerted Neuroprotection against Ozone‐Induced Oxidative Damage and Decreased NF‐κB Activation in Rat Hippocampus and Serum Levels of Inflammatory Cytokines
Nery‐Flores, S. D., Mendoza-Magaña, M. L., Ramírez-Herrera, M. A., Ramírez-Vázquez, J. D. J., Romero‐Prado, M. M. D. J., Cortez-Álvarez, C. R., & Ramírez-Mendoza, A. A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9620684 · Cited by 26
Catcher in the rel: Nanoparticles-antibody conjugate as NF-κB nuclear translocation blocker
Chen, Y., Chen, C.-T., Liu, T., Chien, F., Wu, S., Chen, P., & Mou, C. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119997 · Cited by 26
Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity
Stunnenberg, M., Sprokholt, J. K., van Hamme, J. L., Kaptein, T. M., Willems, E., Gringhuis, S. I., & Geijtenbeek, T. B. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00008 · Cited by 27
Piperlongumine, a piper alkaloid, enhances the efficacy of doxorubicin in breast cancer: involvement of glucose import, ROS, NF-κB and lncRNAs
Awasthee, N., Shekher, A., Rai, V., Verma, S. S., Mishra, S., Dhasmana, A., & Gupta, S. C. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01711-6 · Cited by 25
Self-citation
Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling
Yin, Q.-Q., Liu, C., Wu, Y., Wu, S.-F., Wang, Y., Zhang, X., Hu, X.-J., Pu, J., Lu, Y., Zhou, H.-C., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203546 · Cited by 26
Suppression of Choroidal Neovascularization Through Inhibition of APE1/Ref-1 Redox Activity
Li, Y., Liu, X., Zhou, T., Kelley, M. R., Edwards, P. A., Gao, H., & Qiao, X. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14451 · Cited by 25
Arsenic Trioxide Exerts Antimyeloma Effects by Inhibiting Activity in the Cytoplasmic Substrates of Histone Deacetylase 6
Qu, X., Du, J., Zhang, C., Fu, W., Xi, H., Zou, J., & Hou, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032215 · Cited by 25
NEMO Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Encoded vFLIP K13-Induced Gene Expression and Protection against Death Receptor-Induced Cell Death, and Its N-Terminal 251 Residues Are Sufficient for This Process
Tolani, B., Matta, H., Ramakrishnan, G., Punj, V., & Chaudhary, P. M. (2014) · Journal of Virology · doi:10.1128/jvi.00028-14 · Cited by 25
Molecular stripping, targets and decoys as modulators of oscillations in the NF-κB/IκBα/DNA genetic network
Wang, Z., Potoyan, D. A., & Wolynes, P. G. (2016) · Journal of The Royal Society Interface · doi:10.1098/rsif.2016.0606 · Cited by 24
Facile endothelium protection from TNF-α inflammatory insult with surface topography
Stefopoulos, G., Giampietro, C., Falk, V., Dimos Poulikakos, A., & Ferrari, A. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.039 · Cited by 25
Modulation of NF-κB and Nrf2 pathways by lycopene supplementation in heat-stressed poultry
Şahin, K. (2015) · World s Poultry Science Journal · doi:10.1017/s0043933915000288 · Cited by 26
Aspergillus fumigatus‐derived gliotoxin impacts innate immune cell activation through modulating lipid mediator production in macrophages
Günther, K., Nischang, V., Cseresnyés, Z., Krüger, T., Sheta, D., Abboud, Z., Heinekamp, T., Werner, M., Kniemeyer, O., Beilhack, A., et al. (2024) · Immunology · doi:10.1111/imm.13857 · Cited by 24
NF-κB controls four genes encoding core enzymes of tricarboxylic acid cycle
Zhou, F., Xu, X., Wu, J., Wang, D., & Wang, J. (2017) · Gene · doi:10.1016/j.gene.2017.04.012 · Cited by 24
The human amniotic fluid stem cell secretome triggers intracellular Ca2+ oscillations, NF‐κB nuclear translocation and tube formation in human endothelial colony‐forming cells
Balducci, V., Faris, P. S., Balbi, C., Costa, A., Negri, S., Rosti, V., Bollini, S., & Moccia, F. D. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16739 · Cited by 23
Advanced phosphocreatine-grafted chitosan hydrogel promote wound healing by macrophage modulation
Sheng, W., Qin, H., Wang, T., Zhao, J., Fang, C., Zhang, P., Liu, P., Udduttula, A., Zeng, H., & Chen, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1199939 · Cited by 24
Anti-tumor activity of dehydroxymethylepoxyquinomicin against human oral squamous cell carcinoma cell lines in vitro and in vivo
Yasuda, A., Kondo, S., Nagumo, T., Tsukamoto, H., Mukudai, Y., Umezawa, K., & Shintani, S. (2011) · Oral Oncology · doi:10.1016/j.oraloncology.2011.03.001 · Cited by 24
Effects of histone deacetylase inhibitors on regenerative cell responses in human dental pulp cells
Luo, Z., Wang, Z., He, X., Liu, N., Liu, B., Sun, L., Wang, J., Ma, F., Duncan, H. F., He, W., et al. (2017) · International Endodontic Journal · doi:10.1111/iej.12779 · Cited by 24
Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common β-Chain Cytokines IL-5 and GM-CSF
Nelson, R. K., Brickner, H., Panwar, B., Ramírez-Suástegui, C., de la Mata, S. H., Liu, N., Díaz, D., Alexander, L. E. C., Ay, F., Vijayanand, P., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801668 · Cited by 24
Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell
Tien, P., Lin, C.-H., Chen, C.-S., Chang, C., Ku, H., Gan, D., Tsai, Y., Chen, J. J.-Y., Lin, H., & Wan, L. (2021) · Mediators of Inflammation · doi:10.1155/2021/6660640 · Cited by 23
Advances in Immunosuppressive Agents Based on Signal Pathway
Xu, Z., & Chu, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.917162 · Cited by 24
Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors
Mediouni, S., Lyu, S., Schader, S. M., & Valente, S. T. (2022) · Viruses · doi:10.3390/v14091980 · Cited by 24
Vitamin D analogue TX 527 down‐regulates the NF ‐κ B pathway and controls the proliferation of endothelial cells transformed by K aposi sarcoma herpesvirus
Pardo, V. G., Verstuyf, A., Boland, R., & de Boland, A. R. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12219 · Cited by 23
One Special Question to Start with: Can HIF/NFkB be a Target in Inflammation?
Russo, M. A., Sansone, L., Carnevale, I., Limana, F., Runci, A., Polletta, L., Perrone, G. A., Santis, E. D., & Tafani, M. (2015) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530315666150316120112 · Cited by 23
Hyperhomocysteinemia-Induced Monocyte Chemoattractant Protein-1 Promoter DNA Methylation by Nuclear Factor-κB/DNA Methyltransferase 1 in Apolipoprotein E–Deficient Mice
Ju, W., Jiang, Y., Yang, A., Sun, W., Ma, C., Ma, S., Gong, H., Shi, Y., & Wei, J. (2013) · BioResearch open access · doi:10.1089/biores.2012.0300 · Cited by 23
Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-κB and Increased STAT5 Signals
Iguchi-Hashimoto, M., Usui, T., Yoshifuji, H., Shimizu, M., Kobayashi, S., Ito, Y., Murakami, K., Shiomi, A., Yukawa, N., Kawabata, D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027020 · Cited by 23
Effect of NF-κB inhibition on chemoresistance in biliary–pancreatic cancer
Uwagawa, T., & Yanaga, K. K. (2015) · Surgery Today · doi:10.1007/s00595-015-1129-z · Cited by 23
Caffeic Acid 3,4-Dihydroxy-Phenethyl Ester Induces Cancer Cell Senescence by Suppressing Twist Expression
Dong, A., Fang, Y., Zhang, L., Xie, J., Wu, X. G., Zhang, L., Lian, X., Chen, Y., Luo, J., & Liu, M. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.181081 · Cited by 23
Bexarotene, a Selective RXRα Agonist, Reverses Hypotension Associated with Inflammation and Tissue Injury in a Rat Model of Septic Shock
Tunçtan, B., Kucukkavruk, S. P., Temiz-Reşitoğlu, M., Güden, D. S., Sari, A. N., & Şahan-Fırat, S. (2017) · Inflammation · doi:10.1007/s10753-017-0691-5 · Cited by 23
Biologically Active Ajuga Species Extracts Modulate Supportive Processes for Cancer Cell Development
Rauca, V. F., Vlase, L., Casian, T., Sesărman, A., Gheldiu, A.-M., Mocan, A., Banciu, M., & Toiu, A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00334 · Cited by 23
3-Formylchromone Interacts with Cysteine 38 in p65 Protein and with Cysteine 179 in IκBα Kinase, Leading to Down-regulation of Nuclear Factor-κB (NF-κB)-regulated Gene Products and Sensitization of Tumor Cells
Yadav, V. R., Prasad, S., Gupta, S. C., Sung, B., Phatak, S. S., Zhang, S., & Aggarwal, B. B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274613 · Cited by 22
Self-citation
Retracted
Bortezomib Inhibits Giant Cell Tumor of Bone through Induction of Cell Apoptosis and Inhibition of Osteoclast Recruitment, Giant Cell Formation, and Bone Resorption
Xu, L., Luo, J., Jin, R., Yue, Z., Sun, P., Yang, Z., Yang, X., Wan, W., Zhang, J., Li, S., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0669 · Cited by 22

Authors: Gupta, S. C., Sundaram, C., Reuter, S., & Aggarwal, B. B.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Aggarwal, Bharat B.
ORCID: Gupta, Subash C.
Aggarwal, Bharat B.
Venue: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Publisher: Elsevier BV
Published: 2010-10
Volume: 1799
Issue: 10-12
Pages: 775-787
ISSN: 1874-9399 (ISSN-L)
DOI: 10.1016/j.bbagrm.2010.05.004
PMC: PMC2955987
OpenAlex: W1973354681
Cited by: 762
References: 232
Citations by year: 2026: 38 · 2025: 32 · 2024: 39 · 2023: 36 · 2022: 42 · 2021: 59 · 2020: 63 · 2019: 66 · 2018: 70 · 2017: 63 · 2016: 45 · 2015: 45 · 2014: 41 · 2013: 50 · 2012: 35
FWCI: 3.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (CA-16672, P01CA091844, P01CA124787, CA-124787-01A2, P30CA016672)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: NF-κB signaling, NF-κB inhibitors, small molecules, canonical NF-κB pathway, non-canonical NF-κB signaling, protein kinases, proteasome inhibitors, protein phosphatase, inflammation, cancer, chronic disease
MeSH terms: Animals, Cell Survival, Cell Transformation, Neoplastic, Gene Expression Regulation, Humans, Inflammation, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Phosphorylation, Signal Transduction, NF-kappa B, Neovascularization, Physiologic, Cell Proliferation, I-kappa B Kinase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks