Inhibiting NF-κB activation by small molecules as a therapeutic strategy

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182

Signaling to NF-κB

Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842

Activators and target genes of Rel/NF-κB transcription factors

Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727

Missing Pieces in the NF-κB Puzzle

Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · cited 1×

Activators and Target Genes of Rel/NF-кB Transcription Factors

Loop, T., & Pahl, H. L. (2003) · Springer eBooks · doi:10.1007/978-94-010-0163-2_1 · Cited by 3,179

NF-κB: linking inflammation and immunity to cancer development and progression

Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,175

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90346-6 · Cited by 2,754

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

Wang, C.-Y., Mayo, M. W., & Baldwin, A. S. (1996) · Science · doi:10.1126/science.274.5288.784 · Cited by 2,586

Suppression of TNF-α-Induced Apoptosis by NF-κB

Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581

NF-κB in cancer: from innocent bystander to major culprit

Karin, M., Cao, Y., Greten, F. R., & Li, Z. (2002) · Nature reviews. Cancer · doi:10.1038/nrc780 · Cited by 2,476

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M. S., Mann, M., Manning, A. M., et al. (1997) · Science · doi:10.1126/science.278.5339.860 · Cited by 2,042

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., & Karin, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80406-7 · Cited by 1,814

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

Balkwill, F., Charles, K. A., & Mantovani, A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.013 · Cited by 1,769

Inhibition of NF-κB by Sodium Salicylate and Aspirin

Kopp, E. B., & Ghosh, S. (1994) · Science · doi:10.1126/science.8052854 · Cited by 1,744

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

Yin, M.-J., Yamamoto, Y., & Gaynor, R. B. (1998) · Nature · doi:10.1038/23948 · Cited by 1,596

Nuclear factor-κB

Aggarwal, B. B. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.003 · Cited by 1,586

NF-κB activation by reactive oxygen species: Fifteen years later

Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,561

Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation

Viatour, P., Merville, M., Bours, V., & Chariot, A. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.11.009 · Cited by 1,516

The IKK NF-κB system: a treasure trove for drug development

Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361

Shaping the nuclear action of NF-κB

Chen, L., & Greene, W. C. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1368 · Cited by 1,248

Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

Chen, L., Fischle, W., Verdin, E. M., & Greene, W. C. (2001) · Science · doi:10.1126/science.1062374 · Cited by 1,231

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., & Goeddel, D. V. (1997) · Science · doi:10.1126/science.278.5339.866 · Cited by 1,183

Identification and Characterization of an IκB Kinase

Régnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., & Rothe, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80344-x · Cited by 1,176

How NF-κB is activated: the role of the IκB kinase (IKK) complex

Karin, M. (1999) · Oncogene · doi:10.1038/sj.onc.1203219 · Cited by 1,160

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.

Natarajan, K., Singh, S., Burke, T. R., Grünberger, D., & Aggarwal, B. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9090 · Cited by 1,144

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

Wang, C.-Y., Cusack, J. C., Liu, R., & Baldwin, A. S. (1999) · Nature Medicine · doi:10.1038/7410 · Cited by 986

The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling

Karin, M., & Delhase, M. (2000) · Seminars in Immunology · doi:10.1006/smim.2000.0210 · Cited by 973

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

Staal, F. J. T., Roederer, M., Herzenberg, L. A., & Herzenberg, L. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9943 · Cited by 956

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

Dejardin, E., Droin, N. M., Delhase, M., Haas, E., Cao, Y., Makris, C., Li, Z., Karin, M., Ware, C. F., & Green, D. R. (2002) · Immunity · doi:10.1016/s1074-7613(02)00423-5 · Cited by 923

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

Lin, Y.-Z., Yao, S., Veach, R. A., Torgerson, T. R., & Hawiger, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14255 · Cited by 919

IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy

Luo, J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26322 · Cited by 898

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

Zhong, H., Suyang, H., Erdjument‐Bromage, H., Tempst, P., & Ghosh, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80222-6 · Cited by 828

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF‐κB

Chen, L., Mu, Y., & Greene, W. C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf660 · Cited by 827

Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38

Madrid, L. V., Mayo, M. W., Reuther, J. Y., & Baldwin, A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101103200 · Cited by 777

Transcriptional activation of the NF‐κB p65 subunit by mitogen‐ and stress‐activated protein kinase‐1 (MSK1)

Vermeulen, L., Wilde, G. D., Damme, P. V., Berghe, W. V., & Haegeman, G. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg139 · Cited by 760

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

Grilli, M., Pizzi, M., Memo, M., & Spano, P. (1996) · Science · doi:10.1126/science.274.5291.1383 · Cited by 751

Recognition and Signaling by Toll-Like Receptors

West, A. P., Koblansky, A. A., & Ghosh, S. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.115827 · Cited by 736

Role of NF-κB in p53-mediated programmed cell death

Ryan, K. M., Ernst, M. K., Rice, N. R., & Vousden, K. H. (2000) · Nature · doi:10.1038/35009130 · Cited by 735

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

Tovar, C., Rosinski, J., Filipovic, Z., Higgins, B., Kolinsky, K., Hilton, H., Zhao, X., Vu, B. T., Qing, W., Packman, K., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507493103 · Cited by 708

p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

Berghe, W. V., Plaisance, S., Boone, E., Bosscher, K. D., Schmitz, M. L., Fiers, W., & Haegeman, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3285 · Cited by 679

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

May, M. J., D’Acquisto, F., Madge, L. A., Glöckner, J., Pober, J. S., & Ghosh, S. (2000) · Science · doi:10.1126/science.289.5484.1550 · Cited by 678

Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

Perkins, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209937 · Cited by 674

IκB kinase complexes: gateways to NF-κB activation and transcription

Scheidereit, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209934 · Cited by 668

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

Imbert, V., Rupec, R. A., Livolsi, A., Pahl, H. L., Traenckner, E. B.-M., Mueller‐Dieckmann, C., Farahifar, D., Rossi, B., Auberger, P., Baeuerle, P. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80153-1 · Cited by 647

Inhibition of NF-κB Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

Shembade, N., Ma, A. I., & Harhaj, E. W. (2010) · Science · doi:10.1126/science.1182364 · Cited by 644

Transcriptional Cross Talk between NF-κB and p53

Webster, G. A., & Perkins, N. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3485 · Cited by 598

In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction

Morishita, R., Sugimoto, T., Aoki, M., Kida, I., Tomita, N., Moriguchi, A., Maeda, K., Sawa, Y., Kaneda, Y., Higaki, J., et al. (1997) · Nature Medicine · doi:10.1038/nm0897-894 · Cited by 584

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene‐inductive effects of TNF.

Schulze‐Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G., & Fiers, W. C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05978.x · Cited by 568

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1

Manna, S. K., Zhang, H. J., Yan, T., Oberley, L. W., & Aggarwal, B. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13245 · Cited by 563

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

Sizemore, N., Leung, S., & Stark, G. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4798 · Cited by 557

BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

Burke, J. R., Pattoli, M. A., Gregor, K. R., Brassil, P. J., MacMaster, J. F., McIntyre, K. W., Yang, X., Iotzova, V. S., Clarke, W., Strnad, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209677200 · Cited by 550

Post-activation Turn-off of NF-κB-dependent Transcription Is Regulated by Acetylation of p65

Kiernan, R. E., Brès, V., Ng, R. W. M., Coudart, M.-P., Messaoudi, S. E., Sardet, C., Jin, D., Emiliani, S., & Benkirane, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209572200 · Cited by 545

NF-κB, chemokine gene transcription and tumour growth

Richmond, A. J. (2002) · Nature reviews. Immunology · doi:10.1038/nri887 · Cited by 523

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase

Kwok, B. H. B., Koh, B. D., Ndubuisi, M. I., Elofsson, M., & Crews, C. M. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(01)00049-7 · Cited by 516

Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli

Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515

Hydrogen Peroxide Activates NF-κB through Tyrosine Phosphorylation of IκBα and Serine Phosphorylation of p65

Takada, Y., Mukhopadhyay, A., Kundu, G. C., Mahabeleshwar, G. H., Singh, S., & Aggarwal, B. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212389200 · Cited by 495

At the Crossroads of Inflammation and Cancer

Clevers, H. C. (2004) · Cell · doi:10.1016/j.cell.2004.09.005 · Cited by 494

Sulindac Inhibits Activation of the NF-κB Pathway

Yamamoto, Y., Yin, M.-J., Lin, K.-M., & Gaynor, R. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.27307 · Cited by 493

Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.

Sunwoo, J. B., Chen, Z., Dong, G., Yeh, N. T., Bancroft, C. C., Sausville, E. A., Adams, J., Elliott, P. J., & Waes, C. V. (2001) · PubMed · Cited by 473

Tumor Necrosis Factor α-induced Phosphorylation of RelA/p65 on Ser529 Is Controlled by Casein Kinase II

Wang, D., Westerheide, S. D., Ostrander, J. H., & Baldwin, A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001358200 · Cited by 454

Lymphoid Malignancies: the dark side of B-cell differentiation

Shaffer, A. L., Rosenwald, A., & Staudt, L. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri953 · Cited by 437

Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms

Li, N., & Karin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13012 · Cited by 429

Nuclear Factor-κB Activation: From Bench to Bedside

Sethi, G., Sung, B., & Aggarwal, B. B. (2008) · Experimental Biology and Medicine · doi:10.3181/0707-mr-196 · Cited by 423

Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones

García‐Piñeres, A., Castro, V., MORA, G. A., Schmidt, T. J., Strunck, E., Pahl, H. L., & Merfort, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101985200 · Cited by 413

Erratum: Ultraviolet irradiation of human skin causes functional vitamin A deficiency, preventable by all-trans retinoic acid pre-treatment

Wang, Z., Boudjelal, M., Kang, S., Voorhees, J. J., & Fisher, G. J. (1999) · Nature Medicine · doi:10.1038/10577 · Cited by 404

Inhibition of the Mitogen-Activated Protein Kinase Kinase Superfamily by a Yersinia Effector

Orth, K., Palmer, L. E., Bao, Z., Stewart, S., Rudolph, A. E., Bliska, J. B., & Dixon, J. E. (1999) · Science · doi:10.1126/science.285.5435.1920 · Cited by 402

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance

Bubici, C., Papa, S., Dean, K., & Franzoso, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209936 · Cited by 399

Distinct Roles of the IκB Kinase α and β Subunits in Liberating Nuclear Factor κB (NF-κB) from IκB and in Phosphorylating the p65 Subunit of NF-κB

Sizemore, N., Lerner, N., Dombrowski, N., Sakurai, H., & Stark, G. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110572200 · Cited by 391

Transcription factor cross-talk: the estrogen receptor and NF-κB

Kalaitzidis, D., & Gilmore, T. D. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.01.004 · Cited by 388

Evidence that reactive oxygen species do not mediate NF‐κB activation

Hayakawa, M., Miyashita, H., Sakamoto, I., Kitagawa, M., Tanaka, H., Yasuda, H., Karin, M., & Kikugawa, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg332 · Cited by 384

Anti-Cancer Potential of Sesquiterpene Lactones: Bioactivity and Molecular Mechanisms

Zhang, S., Won, Y.-K., Ong, C. N., & Shen, H. (2005) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011053765976 · Cited by 383

An injected bacterial effector targets chromatin access for transcription factor NF-κB to alter transcription of host genes involved in immune responses

Arbibe, L., Kim, D. W., Batsché, É., Pédron, T., Mateescu, B., Muchardt, C., Parsot, C., & Sansonetti, P. J. (2006) · Nature Immunology · doi:10.1038/ni1423 · Cited by 376

The alternative NF-κB pathway from biochemistry to biology: Pitfalls and promises for future drug development

Dejardin, E. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.007 · Cited by 361

Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase

Kapahi, P., Takahashi, T., Natoli, G., Adams, S., Chen, Y., Tsien, R. Y., & Karin, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007204200 · Cited by 359

Antigen-Receptor Signaling to Nuclear Factor κB

Schulze‐Luehrmann, J., & Ghosh, S. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.010 · Cited by 339

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

Pahl, H. L., Krauss, B., Schulze‐Osthoff, K., Decker, T., Traenckner, E. B.-M., Vogt, M., Myers, C., Parks, T., Warring, P., Mühlbacher, A., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1829 · Cited by 334

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF‐kappa B.

Frantz, B., Ec, N., Bren, G. D., Steffan, N. M., Paya, C. V., Kincaid, R. L., Tocci, M. J., O’Keefe, S. J., & O’Neill, E. A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06329.x · Cited by 331

PIDD Mediates NF-κB Activation in Response to DNA Damage

Janssens, S., Tinel, A., Lippens, S., & Tschopp, J. (2005) · Cell · doi:10.1016/j.cell.2005.09.036 · Cited by 319

CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

Kato, T., Delhase, M., Hoffmann, A., & Karin, M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00358-7 · Cited by 313

Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation

Takada, Y., Bhardwaj, A., Potdar, P. D., & Aggarwal, B. B. (2004) · Oncogene · doi:10.1038/sj.onc.1208169 · Cited by 309

The yopJ locus is required for Yersinia‐mediated inhibition of NF‐κB activation and cytokine expression: YopJ contains a eukaryotic SH2‐like domain that is essential for its repressive activity

Schesser, K., Spiik, A., Dukuzumuremyi, J., Neurath, M. F., Pettersson, S., & Wolf‐Watz, H. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00851.x · Cited by 280

Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling.

van Hogerlinden, M., Rozell, B., Ährlund‐Richter, L., & Toftgård, R. (1999) · PubMed · Cited by 277

Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway

Collier-Hyams, L. S., Zeng, H., Sun, J., Tomlinson, A. D., Bao, Z., Chen, H., Madara, J., Orth, K., & Neish, A. S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.2846 · Cited by 276

Inflammation-associated cancer: NF-κB is the lynchpin

Li, Q., Withoff, S., & Verma, I. M. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.04.003 · Cited by 270

Immunosuppressant PG490 (Triptolide) Inhibits T-cell Interleukin-2 Expression at the Level of Purine-box/Nuclear Factor of Activated T-cells and NF-κB Transcriptional Activation

Qiu, D., Zhao, G., Aoki, Y., Shi, L., Uyei, A., Nazarian, S., Ng, J. C.-H., & Kao, P. N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13443 · Cited by 269

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors

Gurova, K. V., Hill, J. E., Guo, C., Prokvolit, A., Burdelya, L. G., Samoylova, E. M., Khodyakova, A. V., Ganapathi, R. N., Ganapathi, M. K., Tararova, N. D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508888102 · Cited by 266

Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB–regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBα kinase, leading to potentiation of apoptosis

Sung, B., Pandey, M. K., Ahn, K. S., Yi, T., Chaturvedi, M. M., Liu, M., & Aggarwal, B. B. (2008) · Blood · doi:10.1182/blood-2007-10-117994 · Cited by 265

Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo.

Duffey, D. C., Chen, Z., Dong, G., Ondrey, F. G., Wolf, J. S., Brown, K., Siebenlist, U. K., & Waes, C. V. (1999) · PubMed · Cited by 263

p53 Induces NF-κB Activation by an IκB Kinase-independent Mechanism Involving Phosphorylation of p65 by Ribosomal S6 Kinase 1

Bohuslav, J., Chen, L., Kwon, H., Mu, Y., & Greene, W. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313509200 · Cited by 259

The pro‐ or anti‐apoptotic function of NF‐κB is determined by the nature of the apoptotic stimulus

Kaltschmidt, B., Kaltschmidt, C., Hofmann, T. G., Hehner, S. P., Dröge, W., & Schmitz, M. L. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01421.x · Cited by 252

Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives

Mihm, S., Ennen, J., Pessara, U., Kurth, R., & Dröge, W. (1991) · AIDS · doi:10.1097/00002030-199105000-00004 · Cited by 252

Manipulation of the nuclear factor-κB pathway and the innate immune response by viruses

Hiscott, J. B., Nguyen, T.-L. A., Argüello, M., Nakhaei, P., & Paz, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209941 · Cited by 251

Cross-talk between nuclear receptors and nuclear factor κB

Bosscher, K. D., Berghe, W. V., & Haegeman, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209935 · Cited by 250

Aggresome Disruption: A Novel Strategy to Enhance Bortezomib-Induced Apoptosis in Pancreatic Cancer Cells

Nawrocki, S. T., Carew, J. S., Pino, M. S., Highshaw, R. A., Andtbacka, R. H. I., Dunner, K., Pal, A., Bornmann, W. G., Chiao, P. J., Huang, P., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2961 · Cited by 240

Phosphorylation of CBP by IKKα Promotes Cell Growth by Switching the Binding Preference of CBP from p53 to NF-κB

Huang, W., Ju, T.-K., Hung, M., & Chen, C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.019 · Cited by 239

Inhibition of NF‐κB cellular function via specific targeting of the IκB‐ubiquitin ligase

Yaron, A., Gonen, H., Alkalay, I., Hatzubai, A., Jung, S., Beyth, S., Mercurio, F., Manning, A. M., Ciechanover, A. J., & Ben‐Neriah, Y. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6486 · Cited by 239

Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import

Mattioli, I., Sebald, A., Bucher, C., Charles, R., Nakano, H., Doi, T., Kracht, M., & Schmitz, M. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.6336 · Cited by 230

C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases

Li, J., & Fang, C. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.014 · Cited by 230

Role of glycogen synthase kinase-3 in TNF-α-induced NF-κB activation and apoptosis in hepatocytes

Schwabe, R. F., & Brenner, D. A. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00016.2002 · Cited by 229

Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation

Zhou, H., Monack, D. M., Kayagaki, N., Wertz, I. E., Yin, J., Wolf, B. B., & Dixit, V. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051194 · Cited by 226

Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation

Rodríguez, M. S., Thompson, J., Hay, R. T., & Dargemont, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.9108 · Cited by 224

Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells.

Jobin, C., Panja, A. B., Hellerbrand, C., Iimuro, Y., DiDonato, J. A., Brenner, D. A., & Sartor, R. B. (1998) · PubMed · Cited by 224

Negative regulation of NF‐κB action by Set9‐mediated lysine methylation of the RelA subunit

Yang, X., Huang, B., Li, M., Lamb, A., Kelleher, N. L., & Chen, L. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.55 · Cited by 218

TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105

Belich, M. P., Salmerón, A., Johnston, L. H., & Ley, S. C. (1999) · Nature · doi:10.1038/16946 · Cited by 213

Role of Rel/NF-κB transcription factors during the outgrowth of the vertebrate limb

Kanegae, Y., Tavares, A. T., Belmonte, J. C. I., & Verma, I. M. (1998) · Nature · doi:10.1038/33429 · Cited by 203

Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50.

Torgerson, T. R., Colosia, A. D., Donahue, J. P., Lin, Y. Z., & Hawiger, J. (1998) · PubMed · Cited by 180

WIP1 phosphatase is a negative regulator of NF-κB signalling

Chew, J., Biswas, S. K., Shreeram, S., Humaidi, M., Wong, E. T., Dhillon, M. K., Teo, H., Hazra, A., Fang, C. C., López‐Collazo, E., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1873 · Cited by 178

An IkappaB homolog encoded by African swine fever virus provides a novel mechanism for downregulation of proinflammatory cytokine responses in host macrophages

Powell, P. P., Dixon, L. K., & Parkhouse, R. M. E. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8527-8533.1996 · Cited by 171

The NF-κB Activation in Lymphotoxin β Receptor Signaling Depends on the Phosphorylation of p65 at Serine 536

Jiang, X., Takahashi, N., Matsui, N., Tetsuka, T., & Okamoto, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208696200 · Cited by 171

Inhibition of Proinflammatory Molecule Production by Adenovirus-Mediated Expression of a Nuclear Factor κB Super-Repressor in Human Intestinal Epithelial Cells

Jobin, C., Panja, A. B., Hellerbrand, C., Iimuro, Y., DiDonato, J. A., Brenner, D. A., & Sartor, R. B. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.1.410 · Cited by 171

Flavopiridol Inhibits NF-κB Activation Induced by Various Carcinogens and Inflammatory Agents through Inhibition of IκBα Kinase and p65 Phosphorylation

Takada, Y., & Aggarwal, B. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m304546200 · Cited by 170

Gallic Acid Suppresses Lipopolysaccharide-Induced Nuclear Factor-κB Signaling by Preventing RelA Acetylation in A549 Lung Cancer Cells

Choi, K., Lee, Y., Jung, M. G., Kwon, S. H., Kim, M., Jun, W. J., Lee, J., Lee, J. M., & Yoon, H. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0239 · Cited by 167

Regulation of NF-κB, AP-1, NFAT, and STAT1 Nuclear Import in T Lymphocytes by Noninvasive Delivery of Peptide Carrying the Nuclear Localization Sequence of NF-κB p50

Torgerson, T. R., Colosia, A. D., Donahue, J. P., Lin, Y.-Z., & Hawiger, J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6084 · Cited by 167

Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling

Fujita, F., Taniguchi, Y., Kato, T., Narita, Y., Furuya, A., Ogawa, T., Sakurai, H., Joh, T., Itoh, M., Delhase, M., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7780-7793.2003 · Cited by 164

Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts.

Williams, S. A., Pettaway, C. A., Song, R., Papandreou, C. N., Logothetis, C. J., & McConkey, D. J. (2003) · PubMed · Cited by 164

Glycogen Synthase Kinase-3β Regulates NF-κB1/p105 Stability

Demarchi, F., Bertoli, C., Sandy, P., & Schneider, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305676200 · Cited by 163

Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF‐κB activation

Meyer, S. M., Kohler, N. G., & Joly, A. H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00930-7 · Cited by 161

Inhibition of NF-κB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis

Bushdid, P. B., Brantley, D. M., Yull, F. E., Blaeuer, G. L., Hoffman, L. H., Niswander, L. A., & Kerr, L. D. (1998) · Nature · doi:10.1038/33435 · Cited by 158

Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways

Dey, A., Tergaonkar, V., & Lane, D. P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2759 · Cited by 151

Inhibitor κB-like proteins from a polydnavirus inhibit NF-κB activation and suppress the insect immune response

Thoetkiattikul, H., Beck, M. H., & Strand, M. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505240102 · Cited by 151

Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF-κB

Yang, X., Tajkhorshid, E., & Chen, L. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01343-09 · Cited by 149

The Replacement of ATP by the Competitive Inhibitor Emodin Induces Conformational Modifications in the Catalytic Site of Protein Kinase CK2

Battistutta, R., Sarno, S., Moliner, E. D., Papinutto, E., Zanotti, G., & Pinna, L. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004257200 · Cited by 148

Role of cysteine residues of p65/NF-$kappa;B on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential

García‐Piñeres, A., Lindenmeyer, M. T., & Merfort, I. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.01.024 · Cited by 147

NF-κB in cancer—a friend turned foe

Ravi, R. K. (2004) · Drug Resistance Updates · doi:10.1016/j.drup.2004.01.003 · Cited by 147

Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium

Broide, D. H., Lawrence, T., Doherty, T. A., Cho, J. Y., Miller, M., McElwain, K., McElwain, S., & Karin, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509235102 · Cited by 144

Overexpression of γ-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1

Manna, S. K., Kuo, M. T., & Aggarwal, B. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202811 · Cited by 143

The death domain kinase RIP has an essential role in DNA damage-induced NF-κB activationPreprint

Hur, G. M., Lewis, J., Yang, Q., Lin, Y., Nakano, H., Nedospasov, S. A., & Liu, Z.-G. (2003) · Genes & Development · doi:10.1101/gad.1062403 · Cited by 140

Inhibition of Nuclear Factor κB Activation by a Virus-encoded IκB-like Protein

Revilla, Y., Callejo, M., Rodríguez, J. M., Culebras, E., Nogal, M. L., Salas, M. L., Viñuela, E., & Fresno, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5405 · Cited by 139

NF-κB: arresting a major culprit in cancer

Haefner, B. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02309-7 · Cited by 138

Protein phosphatase 2A interacts with and directly dephosphorylates RelA

Yang, J., Fan, G.-H., Wadzinski, B. E., Sakurai, H., & Richmond, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106103200 · Cited by 130

Recruitment of IκBα to the hes1 promoter is associated with transcriptional repression

Aguilera, C. N., Hoya-Arias, R., Haegeman, G., Espinosa, L., & Bigas, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404429101 · Cited by 126

Aspirin Induces Apoptosis through the Inhibition of Proteasome Function

Dikshit, P., Chatterjee, M., Goswami, A., Mishra, A., & Jana, N. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602629200 · Cited by 126

Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors

Zhu, H., Zhang, L., Dong, F., Guo, W., Wu, S., Teraishi, F., Davis, J. J., Chiao, P. J., & Fang, B. (2005) · Oncogene · doi:10.1038/sj.onc.1208683 · Cited by 125

NF-κB in Human Disease: Current Inhibitors and Prospects for De Novo Structure Based Design of Inhibitors

Pande, V., & Ramos, M. J. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053363180 · Cited by 125

Protein-tyrosine Phosphatase Inhibitors Block Tumor Necrosis Factor-dependent Activation of the Nuclear Transcription Factor NF-kB

Singh, S., & Aggarwal, B. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10631 · Cited by 124

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products

Ahn, K. S., Sethi, G., Chao, T., Neuteboom, S., Chaturvedi, M. M., Palladino, M. A., Younes, A., & Aggarwal, B. B. (2007) · Blood · doi:10.1182/blood-2007-04-084996 · Cited by 123

Flavopiridol Induces p53 via Initial Inhibition of Mdm2 and p21 and, Independently of p53, Sensitizes Apoptosis-Reluctant Cells to Tumor Necrosis Factor

Demidenko, Z. N., & Blagosklonny, M. V. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0204 · Cited by 123

Nuclear Factor-κB Activation Mediates Cellular Transformation, Proliferation, Invasion Angiogenesis and Metastasis of Cancer

Shishodia, S., & Aggarwal, B. B. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7847-1_8 · Cited by 121

Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kappaB.

Mohan, R. R., Mohan, R. R., Kim, W. J., & Wilson, S. E. (2000) · PubMed · Cited by 119

Activation of p53 by roscovitine-mediated suppression of MDM2 expression

Lu, W., Chen, L., Peng, Y., & Chen, J. (2001) · Oncogene · doi:10.1038/sj.onc.1204412 · Cited by 117

Intratumoral injection of oligonucleotides to the NFκB binding site inhibits cachexia in a mouse tumor model

Kawamura, I., Morishita, R., Tomita, N., Lacey, E., Aketa, M., Tsujimoto, S., Manda, T., Tomoi, M., Kida, I., Higaki, J., et al. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300819 · Cited by 117

Inhibition of NF-κB Activation by Panepoxydone

Erkel, G., Anke, T., & Sterner, O. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1335 · Cited by 113

Gene Expression Profiling of Lymphoid Malignancies

Staudt, L. M. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.103941 · Cited by 112

Proteolytic Cleavage of the p65-RelA Subunit of NF-κB during Poliovirus Infection

Neznanov, N., Chumakov, K. M., Neznanova, L., Almasan, A., Banerjee, A. K., & Gudkov, A. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502303200 · Cited by 109

Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα

Sethi, G., Ahn, K. S., Chaturvedi, M., & Aggarwal, B. B. (2007) · Oncogene · doi:10.1038/sj.onc.1210544 · Cited by 104

Regulation of NF‐κB Action by Reversible Acetylation

Greene, W. C., & Chen, L. (2004) · Novartis Foundation symposium · doi:10.1002/0470862637.ch15 · Cited by 102

Inhibition of NF-kappa B activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3.

Kolenko, V. M., Bloom, T., Rayman, P. A., Bukowski, R. M., Hsi, E. D., & Finke, J. H. (1999) · PubMed · Cited by 102

Rho Kinase-2 Activation in Human Endothelial Cells Drives Lysophosphatidic Acid-mediated Expression of Cell Adhesion Molecules via NF-κB p65

Shimada, H., & Rajagopalan, L. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.099630 · Cited by 98

NF‐κB is involved in the survival of cerebellar granule neurons: association of Iκβ phosphorylation with cell survival

Koulich, E., Nguyen, T. N., Johnson, K., Giardina, C. A., & D’Mello, S. R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00134.x · Cited by 98

Nuclear factor‐KappaB modulation as a therapeutic approach in hematologic malignancies

Panwalkar, A. W., Verstovšek, S., & Giles, F. J. (2004) · Cancer · doi:10.1002/cncr.20182 · Cited by 97

Poxviral Regulation of the Host NF-κB Response: the Vaccinia Virus M2L Protein Inhibits Induction of NF-κB Activation via an ERK2 Pathway in Virus-Infected Human Embryonic Kidney Cells

Gedey, R., Jin, X.-L., Hinthong, O., & Shisler, J. L. (2006) · Journal of Virology · doi:10.1128/jvi.00935-06 · Cited by 97

Preadministration of High-Dose Salicylates, Suppressors of NF-κB Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation Therapy

McCarty, M. F., & Block, K. I. (2006) · Integrative Cancer Therapies · doi:10.1177/1534735406291499 · Cited by 96

Prostaglandins prevent inducible nitric oxide synthase protein expression by inhibiting nuclear factor‐κB activation in J774 macrophages

D’Acquisto, F., Sautebin, L., Iuvone, T., Rosa, M. D., & Carnuccio, R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01407-0 · Cited by 94

Inhibition of tumor growth by NF‐κB inhibitors

Umezawa, K. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00285.x · Cited by 91

Combined antitumor effect of radiation and ibuprofen in human prostate carcinoma cells.

Palayoor, S. T., Bump, E. A., Calderwood, S. K., Bartol, S., & Coleman, C. N. (1998) · PubMed · Cited by 91

FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells.

Venkataraman, L., Burakoff, S. J., & Sen, R. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.1091 · Cited by 90

Signal-Induced Degradation of IκBα: Association with NF-κB and the PEST Sequence in IκBα Are Not Required

Antwerp, D. J. V., & Verma, I. M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6037 · Cited by 90

A Novel TRAF6 Binding Site in MALT1 Defines Distinct Mechanisms of NF-κB Activation by API2·MALT1 Fusions

Noels, H., Loo, G., Hagens, S., Broeckx, V., Beyaert, R., Marynen, P., & Baens, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611038200 · Cited by 88

Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs.

Bentires‐Alj, M., Hellin, A., Ameyar‐Zazoua, M., Chouaı̈b, S., Merville, M. P., & Bours, V. (1999) · PubMed · Cited by 88

Tumor Suppressor MMAC/PTEN Inhibits Cytokine-induced NFκB Activation without Interfering with the IκB Degradation Pathway

Koul, D., Yao, Y., Abbruzzese, J. L., Yung, W. K. A., & Reddy, S. A. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007806200 · Cited by 87

Inhibition of NF-κB Activity in Human T Lymphocytes Induces Caspase-Dependent Apoptosis Without Detectable Activation of Caspase-1 and -3

Kolenko, V. M., Bloom, T., Rayman, P. A., Bukowski, R. M., Hsi, E. D., & Finke, J. H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.590 · Cited by 87

TAT Fusion Proteins Containing Tyrosine 42-deleted IκBα Arrest Osteoclastogenesis

Abu‐Amer, Y., Dowdy, S. F., Ross, F. P., Clohisy, J. C. F., & Teitelbaum, S. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104725200 · Cited by 85

Inhibition of transcription factor NF-κB signaling proteins IKKβ and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity

Liang, M., Bardhan, S., Pace, E. A., Rosman, D. S., Beutler, J. A., Porco, J. A. J., & Gilmore, T. D. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.11.013 · Cited by 83

Salicylates Inhibit NF-κB Activation and Enhance TNF-α-Induced Apoptosis in Human Pancreatic Cancer Cells

McDade, T. P., Perugini, R. A., Vittimberga, F. J., Carrigan, R. C., & Callery, M. P. (1999) · Journal of Surgical Research · doi:10.1006/jsre.1998.5560 · Cited by 82

A Virulence Factor of Myxoma Virus Colocalizes with NF-κB in the Nucleus and Interferes with Inflammation

Camus-Bouclainville, C., Fiette, L., Bouchiha, S., Pignolet, B., Counor, D., Filipe, C., Gelfi, J., & Messud-Petit, F. (2004) · Journal of Virology · doi:10.1128/jvi.78.5.2510-2516.2004 · Cited by 82

A Small Molecule Ubiquitination Inhibitor Blocks NF-κB-dependent Cytokine Expression in Cells and Rats

Swinney, D. C., Xu, Y.-Z., Scarafia, L. E., Lee, I., Mak, A. Y., Gan, Q.-F., Ramesha, C. S., Mulkins, M. A., Dunn, J., So, O., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200842200 · Cited by 82

Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKβ

Nagashima, K., Sasseville, V. G., Wen, D., Bielecki, A., Yang, H., Simpson, C., Grant, E. P., Hepperle, M. E., Harriman, G., Jaffee, B., et al. (2006) · Blood · doi:10.1182/blood-2005-09-3852 · Cited by 80

Cisplatin Mimics ARF Tumor Suppressor Regulation of RelA (p65) Nuclear Factor-κB Transactivation

Campbell, K. J., Witty, J., Rocha, S., & Perkins, N. D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2234 · Cited by 79

Activation of the Heat Shock Factor 1 by Serine Protease Inhibitors

Rossi, A., Elia, G., & Santoro, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16446 · Cited by 77

NF‐κB is involved in the survival of cerebellar granule neurons: association of IκBβ phosphorylation with cell survival

Koulich, E., Nguyen, T. N., Johnson, K., Giardina, C. A., & D’Mello, S. R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00303.x · Cited by 76

Deoxyspergualin inhibits kappa light chain expression in 70Z/3 pre-B cells by blocking lipopolysaccharide-induced NF-kappa B activation

Tepper, M. A., Nadler, S. G., Esselstyn, J. M., & STERBENZ, K. G. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.5.2427 · Cited by 74

R-Roscovitine simultaneously targets both the p53 and NF-κB pathways and causes potentiation of apoptosis: implications in cancer therapy

Dey, A., Wong, E. T., Cheok, C. F., Tergaonkar, V., & Lane, D. P. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402257 · Cited by 73

Bortezomib-Induced Apoptosis with Limited Clinical Response Is Accompanied by Inhibition of Canonical but not Alternative Nuclear Factor-κB Subunits in Head and Neck Cancer

Allen, C. T., Saigal, K., Nottingham, L. K., Arun, P., Chen, Z., & Waes, C. V. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4470 · Cited by 72

Nuclear transport as a target for cell growth

Kau, T. R., & Silver, P. A. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02562-x · Cited by 71

Nutlin-3 inhibits the NFκB Pathway in a p53 Dependent Manner: Implications in Lung Cancer Therapy

Dey, A., Wong, E. T., Bist, P., Tergaonkar, V., & Lane, D. (2007) · Cell Cycle · doi:10.4161/cc.6.17.4643 · Cited by 70

The c-Rel transcription factor can both induce and inhibit apoptosis in the same cells via the upregulation of MnSOD

Bernard, D., Monté, D., Vandenbunder, B., & Abbadie, C. (2002) · Oncogene · doi:10.1038/sj.onc.1205536 · Cited by 70

Potent Inhibitors of Proteasome

Iqbal, M. A., Chatterjee, S., Kauer, J. C., Das, M. K., Messina, P. A., Freed, B., Biazzo, W., & Siman, R. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00013a002 · Cited by 68

Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway.

Wechsler, A. S., Gordon, M., Dendorfer, U., & LeClair, K. P. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2515 · Cited by 67

Retroinfusion of NFκB decoy oligonucleotide extends cardioprotection achieved by CD18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs

Kupatt, C., Wichels, R., Deiss, M., Molnar, A., Lebherz, C., Raake, P. W. J., von Degenfeld, G., Hahnel, D., & Boekstegers, P. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301673 · Cited by 67

NF-kB inhibitor blocks B cell development at two checkpoints

Feng, B., Cheng, S., Pear, W. S., & Liou, H. (2004) · Medical Immunology · doi:10.1186/1476-9433-3-1 · Cited by 66

Denbinobin inhibits nuclear factor-κB and induces apoptosis via reactive oxygen species generation in human leukemic cells

Sánchez‐Duffhues, G., Calzado, M. A., de Vinuesa, A. G., Appendino, G., Fiebich, B. L., Loock, U., Lefarth‐Risse, A., Krohn, K., & Muñóz, E. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.01.004 · Cited by 65

Caspase‐8 and caspase‐10 activate NF‐κB through RIP, NIK and IKKα kinases

Shikama, Y., Yamada, M., & Miyashita, T. (2003) · European Journal of Immunology · doi:10.1002/eji.200324013 · Cited by 62

Expression and induction of nuclear factor-kappa B-related proteins in thymocytes.

Sen, J. M., Venkataraman, L., Shinkai, Y., Pierce, J. W., Alt, F. W., Burakoff, S. J., & Sen, R. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.7.3213 · Cited by 61

Synergistic Effect of Histone Deacetylase Inhibitors FK228 and m-Carboxycinnamic Acid Bis-Hydroxamide with Proteasome Inhibitors PSI and PS-341 against Gastrointestinal Adenocarcinoma Cells

Adachi, M., Zhang, Y., Zhao, X., Minami, T., Kawamura, R., Hinoda, Y., & Imai, K. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0806 · Cited by 59

Protease inhibitors differentially regulate tumor necrosis factor- induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation

Higuchi, M., Singh, S., Chan, H., & Aggarwal, B. B. (1995) · Blood · doi:10.1182/blood.v86.6.2248.bloodjournal8662248 · Cited by 58

Inhibition of NF-κB Acetylation and its Transcriptional Activity by Daxx

Park, J., Lee, J. H., La, M., Jang, M. J., Chae, G. W., Kim, S. B., Tak, H., Jung, Y., Byun, B., Ahn, J. K., et al. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.02.047 · Cited by 57

Identification of PP2A as a crucial regulator of the NF-κB feedback loop: its inhibition by UVB turns NF-κB into a pro-apoptotic factor

Barišić, S., Strozyk, E. A., Peters, N., Walczak, H., & Kulms, D. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.98 · Cited by 57

Naturally occurring and synthetic inhibitors of NF-kappaB functions.

Umezawa, K., Ariga, A., & Matsumoto, N. (2000) · PubMed · Cited by 56

The Non-ankyrin C Terminus of IκBα Physically Interacts with p53 in Vivo and Dissociates in Response to Apoptotic Stress, Hypoxia, DNA Damage, and Transforming Growth Factor-β1-mediated Growth Suppression

Chang, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106607200 · Cited by 54

Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation

Sreenivasan, Y., Sarkar, A., & Manna, S. K. (2003) · Oncogene · doi:10.1038/sj.onc.1206486 · Cited by 53

Changes of NF-κB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: role of reactive oxygen species

Li, H.-L. (2002) · World Journal of Gastroenterology · doi:10.3748/wjg.v8.i3.431 · Cited by 52

Development of a Structural Model for NF-κB Inhibition of Sesquiterpene Lactones Using Self-Organizing Neural Networks

Wagner, S., Hofmann, A., Siedle, B., Terfloth, L., Merfort, I., & Gasteiger, J. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051125n · Cited by 52

Targeting β-Transducin Repeat–Containing Protein E3 Ubiquitin Ligase Augments the Effects of Antitumor Drugs on Breast Cancer Cells

Tang, W., Li, Y., Yu, D., Thomas‐Tikhonenko, A., Spiegelman, V. S., & Fuchs, S. Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2597 · Cited by 52

NF‐κB and the link between inflammation and cancer

DiDonato, J. A., Mercurio, F., & Karin, M. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01099.x · Cited by 1,513

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

Shih, R., Wang, C.-Y., & Yang, C. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00077 · Cited by 935

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

Gupta, S. C., Kim, J. H., Prasad, S., & Aggarwal, B. B. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9235-2 · Cited by 817

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

Barnes, P. J. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1564 · Cited by 708

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation

Giridharan, S., & Srinivasan, M. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s140188 · Cited by 686

Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer

Yamamoto, Y., & Gaynor, R. B. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11914 · Cited by 1,593

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Yu, H., Lin, L., Zhang, Z., Zhang, H., & Hu, H. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00312-6 · Cited by 2,329

Inhibitors of NF-κB signaling: 785 and counting

Gilmore, T. D., & Herscovitch, M. (2006) · Oncogene · doi:10.1038/sj.onc.1209982 · Cited by 576

Design of small molecules targeting transcriptional activation by NF-κB: overview of recent advances

Straus, D. S. (2009) · Expert Opinion on Drug Discovery · doi:10.1517/17460440903143739 · Cited by 13

Nuclear Factor-κB: A Holy Grail in Cancer Prevention and Therapy

Aggarwal, B. B., Sethi, G., Nair, S. A., & Ichikawa, H. (2006) · Current Signal Transduction Therapy · doi:10.2174/157436206775269235 · Cited by 61