Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux

Gu, Hong-mei; Wang, Fa-qi; Zhang, Da-wei

doi:10.1016/j.bbalip.2014.02.002

Cited by 39Cholesterol and Lipid MetabolismCaveolin-1 and cellular processesDrug Transport and Resistance Mechanisms

Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux

Gu, Hong-mei, Wang, Fa-qi, Zhang, Da-wei·2014·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/j.bbalip.2014.02.002

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Abstract

ATP-binding cassette transporter G1 (ABCG1) plays an important role in macrophage reverse cholesterol transport in vivo by promoting cholesterol efflux onto lipidated apoA-I. However, the underlying mechanism is unclear. Here, we found that ABCG1 co-immunoprecipitated with caveolin-1 (CAV1) but not with flotillin-1 and -2. Knockdown of CAV1 expression using siRNAs significantly reduced ABCG1-mediated cholesterol efflux without detectable effect on ABCA1-mediated cholesterol efflux. Disruption of the putative CAV1 binding site in ABCG1, through replacement of tyrosine residues at positions 487 and 489 or at positions 494 and 495 with alanine (Y487AY489A and Y494AY495A), impaired the interaction of ABCG1 with CAV1 and significantly decreased ABCG1-mediated cholesterol efflux. The substitution of Tyr494 and Tyr495 with Phe or Trp that resulted in an intact CAV1 binding site had no effect. Furthermore, Y494AY495A affected trafficking of ABCG1 to the cell surface. The mutant protein is mainly located intracellularly. Finally, we found that CAV1 co-immunoprecipitated with ABCG1 and regulated cholesterol efflux to reconstituted HDL in THP-1-derived macrophages upon the liver X receptor agonist treatment. These findings indicate that CAV1 interacts with ABCG1 and regulates ABCG1-mediated cholesterol efflux.

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CAV1 has been proposed to participate in the regulation of cholesterol efflux to HDL, possibly in interaction with ABCG1.
“CAV1 has been proposed to participate in the regulation of cholesterol efflux to HDL6061, possibly in interaction with ABCG161.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [61]
Some other studies have not found an effect of CAV1 on cholesterol efflux, and the overall effect of CAV1 on cholesterol efflux is complex.
“Some other studies have not found an effect6263, and the overall effect of CAV1 on cholesterol efflux is complex61.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [61]

Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757 · cited 1× · see citing works
“The Triton X-100 insoluble plasma membrane microdomains float in a sucrose density gradient [37].”
Background
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
Dráb, M., Verkade, P., Elger, M., Kasper, M. E., Löhn, M., Lauterbach, B., Menne, J., Lindschau, C., Mende, F., Luft, F. C., et al. (2001) · Science · doi:10.1126/science.1062688 · Cited by 1,555 · see citing works
Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities
Razani, B., Engelman, J. A., Wang, X., Schubert, W., Zhang, X. L., Marks, C. B., Macaluso, F., Russell, R. G., Li, M., Pestell, R. G., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105408200 · Cited by 1,163 · see citing works
ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins
Wang, N., Lan, D., Chen, W., Matsuura, F., & Tall, A. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403506101 · Cited by 1,059 · see citing works
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
Joseph, S. B., McKilligin, E., Pei, L., Watson, M. A., Collins, A. R., Laffitte, B. A., Chen, M., Noh, G. J., Goodman, J., Hagger, G. N., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112059299 · Cited by 950 · see citing works
VIP21/caveolin is a cholesterol-binding protein.
Murata, M., Peränen, J., Schreiner, R., Wieland, F., Kurzchalia, T. V., & Simons, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10339 · Cited by 899 · see citing works
ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation
Kennedy, M. A., Barrera, G. C., Nakamura, K., Baldán, Á., Tarr, P. T., Fishbein, M. C., Frank, J. S., Francone, O. L., & Edwards, P. A. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.002 · Cited by 885 · see citing works
Interaction of a Receptor Tyrosine Kinase, EGF-R, with Caveolins
Couët, J., Sargiacomo, M., & Lisanti, M. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30429 · Cited by 665 · see citing works
Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo
Wang, X., Collins, H. L., Ranalletta, M., Fuki, I. V., Billheimer, J. T., Rothblat, G. H., Tall, A. R., & Rader, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32057 · Cited by 593 · see citing works
VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles.
Kurzchalia, T. V., Dupree, P., Parton, R. G., Kellner, R., Virta, H., Lehnert, M., & Simons, K. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.5.1003 · Cited by 559 · see citing works
Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane
Röper, K., Corbeil, D., & Huttner, W. Β. (2000) · Nature Cell Biology · doi:10.1038/35023524 · Cited by 555 · see citing works
Oligomeric structure of caveolin: implications for caveolae membrane organization.
Sargiacomo, M., Scherer, P. E., Tang, Z., Kübler, E., Song, K. S., Sanders, M. C., & Lisanti, M. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9407 · Cited by 548 · see citing works
ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport
Klucken, J., Büchler, C., Orsó, E., Kaminski, W. E., Özcürümez, M. K., Liebisch, G., Kapinsky, M., Diederich, W., Drobnik, W., Dean, M. C., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.817 · Cited by 543 · see citing works
Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
Yvan-Charvet, L., Ranalletta, M., Wang, N., Han, S., Terasaka, N., Li, R., Welch, C., & Tall, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33372 · Cited by 536 · see citing works
ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I
Gelissen, I. C., Harris, M., Rye, K., Quinn, C. M., Brown, A. J., Kockx, M., Cartland, S. P., Packianathan, M., Kritharides, L., & Jessup, W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000200082.58536.e1 · Cited by 430 · see citing works
Murine SR-BI, a High Density Lipoprotein Receptor That Mediates Selective Lipid Uptake, Is N-Glycosylated and Fatty Acylated and Colocalizes with Plasma Membrane Caveolae
Babitt, J. L., Trigatti, B. L., Rigotti, A., Smart, E. J., Anderson, R. G. W., Xu, S., & Krieger, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13242 · Cited by 376 · see citing works
Regulation of caveolin and caveolae by cholesterol in MDCK cells
Hailstones, D., Sleer, L. S., Parton, R. G., & Stanley, K. K. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33898-0 · Cited by 306 · see citing works
Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface
Graf, G. A., Li, W., Gerard, R. D., Gelissen, I. C., White, A. L., Cohen, J. C., & Hobbs, H. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16000 · Cited by 305 · see citing works
ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL
Vaughan, A. M., & Oram, J. F. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600218-jlr200 · Cited by 283 · see citing works
Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface
Graf, G. A., Li, W., Gerard, R. D., Gelissen, I. C., White, A. L., Cohen, J. C., & Hobbs, H. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216000 · Cited by 283 · see citing works
ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density Lipoprotein but Not by Lipid-depleted Apolipoproteins
Vaughan, A. M., & Oram, J. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505368200 · Cited by 266 · see citing works
Characterization of the Human ABCG1 Gene
Kennedy, M. A., Venkateswaran, A., Tarr, P. T., Xénarios, I., Kudoh, J., Shimizu, N., & Edwards, P. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105863200 · Cited by 253 · see citing works
Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol
Bist, A., Fielding, P. E., & Fielding, C. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10693 · Cited by 252 · see citing works
Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae
Liu, P., Ying, Y., & Anderson, R. G. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13666 · Cited by 221 · see citing works
LXR-Induced Redistribution of ABCG1 to Plasma Membrane in Macrophages Enhances Cholesterol Mass Efflux to HDL
Wang, N., Ranalletta, M., Matsuura, F., Peng, F., & Tall, A. R. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000218998.75963.02 · Cited by 220 · see citing works
Caveolin-2 Localizes to the Golgi Complex but Redistributes to Plasma Membrane, Caveolae, and Rafts when Co-expressed with Caveolin-1
Mora, R. C., Bonilha, V. L., Marmorstein, A. D., Scherer, P. E., Brown, D., Lisanti, M. P., & Rodriguez-Boulan, E. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25708 · Cited by 216 · see citing works
Oligomerization of VIP21‐caveolin in vitro is stabilized by long chain fatty acylation or cholesterol
Monier, S., Dietzen, D. J., Hastings, W. R., et al. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00519-4 · Cited by 209 · see citing works
Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1
Kobayashi, A., Takanezawa, Y., Hirata, T., Shimizu, Y., Misasa, K., Kioka, N., Arai, H., Ueda, K., & Matsuo, M. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500546-jlr200 · Cited by 207 · see citing works
Expression of Caveolin-1 Is Required for the Transport of Caveolin-2 to the Plasma Membrane
Parolini, I., Sargiacomo, M., Galbiati, F., Rizzo, G., Grignani, F., Engelman, J. A., Okamoto, T., Ikezu, T., Scherer, P. E., Mora, R. C., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25718 · Cited by 207 · see citing works
Macrophage ABCG1 Deletion Disrupts Lipid Homeostasis in Alveolar Macrophages and Moderately Influences Atherosclerotic Lesion Development in LDL Receptor-Deficient Mice
Out, R., Hoekstra, M., Hildebrand, R. B., Kruit, J. K., Meurs, I., Li, Z., Kuipers, F., van Berkel, T. J. C., & Eck, M. V. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000237629.29842.4c · Cited by 204 · see citing works
Caveolin-1 Interacts with the Insulin Receptor and Can Differentially Modulate Insulin Signaling in Transfected Cos-7 Cells and Rat Adipose Cells
Nyström, F. H., Chen, H., Cong, L.-N., Li, Y., & Quon, M. J. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.12.0392 · Cited by 203 · see citing works
Stimulation of Cholesterol Efflux by LXR Agonists in Cholesterol-Loaded Human Macrophages Is ABCA1-Dependent but ABCG1-Independent
Larrède, S., Quinn, C. M., Jessup, W., Frisdal, É., Olivier, M., Hsieh, V., Kim, M., Eck, M. V., Couvert, P., Carrié, A., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.194548 · Cited by 202 · see citing works
CAVEOLIN-1: Role in Cell Signaling
Boscher, C., & Nabi, I. R. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-1222-9_3 · Cited by 199 · see citing works
Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels
Out, R., Hoekstra, M., Habets, K. L. L., Meurs, I., de Waard, V., Hildebrand, R. B., Wang, Y., Chimini, G., Kuiper, J., van Berkel, T. J. C., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.156935 · Cited by 199 · see citing works
Impaired Development of Atherosclerosis in Hyperlipidemic Ldlr −/− and ApoE −/− Mice Transplanted With Abcg1 −/− Bone Marrow
Baldán, Á., Pei, L., Lee, R. G., Tarr, P. T., Tangirala, R. K., Weinstein, M. M., Frank, J. S., Li, A. C., Tontonoz, P., & Edwards, P. A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000240051.22944.dc · Cited by 166 · see citing works
Caveolin-1 is required for fatty acid translocase (FAT/CD36) localization and function at the plasma membrane of mouse embryonic fibroblasts
Ring, A., Lay, S. L., Pohl, J., Verkade, P., & Stremmel, W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.03.016 · Cited by 164 · see citing works
The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver
Sabol, S. L., Brewer, H. B., & Santamarina-Fojo, S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500080-jlr200 · Cited by 162 · see citing works
Caveolin-1 and regulation of cellular cholesterol homeostasis
Frank, P. G., Cheung, M. W.-C., Pavlides, S., Llaverı́as, G., Park, D. S., & Lisanti, M. P. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01092.2005 · Cited by 160 · see citing works
Decreased Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice Transplanted With Abcg1 −/− Bone Marrow
Ranalletta, M., Wang, N., Han, S., Yvan‐Charvet, L., Welch, C. L., & Tall, A. R. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000242275.92915.43 · Cited by 154 · see citing works
GPS2 Is Required for Cholesterol Efflux by Triggering Histone Demethylation, LXR Recruitment, and Coregulator Assembly at the ABCG1 Locus
Jakobsson, T., Venteclef, N., Toresson, G., Damdimopoulos, A. E., Ehrlund, A., Lou, X., Sanyal, S., Steffensen, K. R., Gustafsson, J.-Α., & Treuter, E. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.05.006 · Cited by 131 · see citing works
Expression of Caveolin-1 Enhances Cholesterol Efflux in Hepatic Cells
Fu, Y., Hoang, A., Escher, G., Parton, R. G., Krozowski, Z. S., & Sviridov, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311061200 · Cited by 115 · see citing works
ATP-Binding Cassette Transporter G1 and High-Density Lipoprotein Promote Endothelial NO Synthesis Through a Decrease in the Interaction of Caveolin-1 and Endothelial NO Synthase
Terasaka, N., Westerterp, M., Koetsveld, J., Fernández-Hernando, C., Yvan-Charvet, L., Wang, N., Sessa, W. C., & Tall, A. R. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.110.213215 · Cited by 107 · see citing works
Stabilization of Caveolin-1 by Cellular Cholesterol and Scavenger Receptor Class B Type I
Frank, P. G., Marcel, Y. L., Connelly, M. A., Lublin, D. M., Franklin, V., Williams, D. L., & Lisanti, M. P. (2002) · Biochemistry · doi:10.1021/bi0257078 · Cited by 80 · see citing works
The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis
Meurs, I., Lammers, B., Zhao, Y., Out, R., Hildebrand, R. B., Hoekstra, M., van Berkel, T. J. C., & Eck, M. V. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.11.024 · Cited by 78 · see citing works
ATP‐binding cassette transporters and cholesterol translocation
Li, G., Gu, H., & Zhang, D. (2013) · IUBMB Life · doi:10.1002/iub.1165 · Cited by 78 · see citing works
Self-citation
Caveolin-1 negatively regulates SR-BI mediated selective uptake of high-density lipoprotein-derived cholesteryl ester
Matveev, S., Uittenbogaard, A., van der Westhuyzen, D. R., & Smart, E. J. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2001.02496.x · Cited by 76 · see citing works
Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins
Frank, P. G., Galbiati, F., Volonté, D., Razani, B., Cohen, D. E., Marcel, Y. L., & Lisanti, M. P. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.5.c1204 · Cited by 76 · see citing works
Caveolin-1 does not affect SR-BI-mediated cholesterol efflux or selective uptake of cholesteryl ester in two cell lines
Wang, L., Connelly, M. A., Ostermeyer, A. G., Chen, H.-H., Williams, D. L., & Brown, D. A. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200449-jlr200 · Cited by 59 · see citing works
Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo
Mukhamedova, N., Escher, G., D'Souza, W., Tchoua, U., Grant, A., Krozowski, Z., Bukrinsky, M., & Sviridov, D. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800095-jlr200 · Cited by 53 · see citing works
Characterization of the role of EGF-A of low density lipoprotein receptor in PCSK9 binding
Gu, H.-M., Adijiang, A., Mah, M., & Zhang, D. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m041129 · Cited by 50 · see citing works
Self-citation
Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function
Gu, H., Li, G., Gao, X., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.019 · Cited by 36 · see citing works
Self-citation
Characterization of the Role of a Highly Conserved Sequence in ATP Binding Cassette Transporter G (ABCG) Family in ABCG1 Stability, Oligomerization, and Trafficking
Wang, F., Li, G., Gu, H., et al. (2013) · Biochemistry · doi:10.1021/bi401285j · Cited by 25 · see citing works
Self-citation
Synthetic LXR agonist inhibits the development of atherosclerosis in New Zealand White rabbits
Honzumi, S., Shima, A., Hiroshima, A., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.08.009 · Cited by 24 · see citing works
Apolipoprotein A-I configuration and cell cholesterol efflux activity of discoidal lipoproteins depend on the reconstitution process
Cuellar-Rodríguez, L. A., Prieto, E. D., Cabaleiro, L. V., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.017 · Cited by 17 · see citing works
Identification of an amino acid residue in ATP-binding cassette transport G1 critical for mediating cholesterol efflux
Gao, X., Gu, H., Li, G., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.07.012 · Cited by 15 · see citing works
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Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses
Aho, V., Ollila, H. M., Kronholm, E., Bondia-Pons, I., Soininen, P., Kangas, A. J., Hilvo, M., Seppälä, I., Kettunen, J., Oikonen, M., et al. (2016) · Scientific Reports · doi:10.1038/srep24828 · Cited by 126 · see citing works

Authors: Gu, H.-M., Wang, F.-Q., & Zhang, D.-W.
Affiliations: University of Alberta (CA)
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 2014-06
Volume: 1841
Issue: 6
Pages: 847-858
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/j.bbalip.2014.02.002
OpenAlex: W1997893510
Cited by: 39
References: 55
Citations by year: 2026: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 1
FWCI: 2.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (MOP 93794)
Alberta Heritage Foundation for Medical Research
Canadian Foundation for Innovation
Topics: Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: caveolin-1, ABCG1, ABC transporters, cholesterol efflux, reverse cholesterol transport, macrophages, protein-protein interaction, ABCA1, liver X receptor, flotillin, THP-1 macrophages
MeSH terms: ATP Binding Cassette Transporter, Subfamily G, Member 1, Liver X Receptors, Binding Sites, Biological Transport, Cholesterol, Humans, Membrane Proteins, Protein Binding, ATP-Binding Cassette Transporters, RNA, Small Interfering, Caveolin 1, Orphan Nuclear Receptors

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Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux

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