Caveolin-1 does not affect SR-BI-mediated cholesterol efflux or selective uptake of cholesteryl ester in two cell lines
Open accessAbstract
Free cholesterol (FC) has been reported to efflux from cells through caveolae, which are 50-100 nm plasma membrane pits. The 22 kDa protein caveolin-1 is concentrated in caveolae and is required for their formation. The HDL scavenger receptor BI (SR-BI), which stimulates both FC efflux and selective uptake of HDL-derived cholesteryl ester (CE), has been reported to be concentrated in caveolae, suggesting that this localization facilitates flux of FC and CE across the membrane. However, we found that overexpression of caveolin-1 in Fischer rat thyroid (FRT) cells, which lack caveolin-1 and caveolae, or HEK 293 cells, which normally express very low levels of caveolin-1, did not affect FC efflux to HDL or liposomes. Transient expression of SR-B1 did not affect this result. Similarly, caveolin-1 expression did not affect selective uptake of CE from labeled HDL particles in FRT or HEK 293 cells transfected with SR-BI. We conclude that basal and SR-BI-stimulated FC efflux to HDL and liposomes and SR-BI-mediated selective uptake of HDL CE are not affected by caveolin-1 expression in HEK 293 or FRT cells.
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Some other studies have not found an effect of CAV1 on cholesterol efflux, and the overall effect of CAV1 on cholesterol efflux is complex.
“Some other studies have not found an effect6263, and the overall effect of CAV1 on cholesterol efflux is complex61.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [62]
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Cell-based screening assay for anti-inflammatory activity of bioactive compounds
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Caveolin-1 and Atherosclerosis: Regulation of LDLs Fate in Endothelial Cells
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Opposite effect of caveolin-1 in the metabolism of high-density and low-density lipoproteins
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Caveolin-1 Variant Is Associated With the Metabolic Syndrome in Kuwaiti Children
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- Authors
- Wang, L., Connelly, M. A., Ostermeyer, A. G., Chen, H.-H., Williams, D. L., & Brown, D. A.
- Affiliations
- Stony Brook University (US)
- Corresponding author
- Brown, Deborah A.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 44
- Issue
- 4
- Pages
- 807-815
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2145629533
- Cited by
- 59
- References
- 56
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 3 · 2020: 1 · 2018: 3 · 2016: 3 · 2014: 3 · 2013: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Heart, Lung, and Blood Institute (HL 58012, R01HL058012)
- National Institute of General Medical Sciences (R01GM047897, GM 47897)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- caveolin-1, scavenger receptor class B type I, cholesteryl ester uptake, HDL cholesterol, caveolae, FRT cells, HEK293 cells, liposomes
- MeSH terms
- Animals, Cell Line, Cholesterol, Cholesterol Esters, Humans, Lipoproteins, HDL, Liposomes, Membrane Proteins, Receptors, Immunologic, Transfection, Receptors, Lipoprotein, CD36 Antigens, Caveolae, Caveolins, Receptors, Scavenger, Scavenger Receptors, Class B, Caveolin 1, Rats
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