Lipids in the nervous system: From biochemistry and molecular biology to patho-physiology

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβPreprint

Repa, J. J., Liang, G., Ou, J., Bashmakov, Y. K., Lobaccaro, J. A., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L., & Mangelsdorf, D. J. (2000) · Genes & Development · doi:10.1101/gad.844900 · Cited by 1,724

CNS synaptogenesis promoted by glia-derived cholesterol

Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687

Protein Sensors for Membrane Sterols

Goldstein, J. L., DeBose-Boyd, R. A., & Brown, M. S. (2006) · Cell · doi:10.1016/j.cell.2005.12.022 · Cited by 1,517

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

Rust, S., Rosier, M., Funke, H., Real, J., Amoura, Z., Piette, J.-C., Deleuze, J.-F., Brewer, H. B., Duverger, N., Denèfle, P., et al. (1999) · Nature Genetics · doi:10.1038/11921 · Cited by 1,433

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J.-L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3137 · Cited by 1,233

High cholesterol level is essential for myelin membrane growth

Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R.-I., Wehr, M. C., Wieland, F., Ishibashi, S., & Nave, K.-A. (2005) · Nature Neuroscience · doi:10.1038/nn1426 · Cited by 799

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., & Weisgraber, K. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47945-8 · Cited by 714

Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I

Lala, D. S. (1992) · Molecular Endocrinology · doi:10.1210/me.6.8.1249 · Cited by 678

Functionality of bioactive lipids in cognitive function

de Melo, M. F. F. T., de Souza, M. A., Queiroga, R. D. C. R. D. E., & Soares, J. K. B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824043-4.00010-5 · Cited by 3

Phospholipid biogenesis maintains neuronal integrity during aging and axon regeneration

Park, S., Jin, Y., & Chisholm, A. D. (2025) · Genetics · doi:10.1093/genetics/iyaf122 · Cited by 2

Early weaning alters redox status in the hippocampus and hypothalamus of rat pups

RODRIGUES, K. D. S., Klein, C. P., August, P. M., dos Santos, B. G., Hözer, R. M., Maurmann, R. M., Crestani, M. S., Hoppe, J. B., & Matté, C. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10047 · Cited by 2

Astrocyte, Lipid Metabolism in Alzheimer’s Disease and Glioblastoma

(2022) · doi:10.31038/jcrm.2022555 · Cited by 1

An LC-MS/MS Multiplexed Method to Quantify 14 Sphingolipids in Human Cerebrospinal Fluid (CSF)

Paramo, Y. P., Veeramachaneni, R. J., Parkhurst, E., Dufield, D. R., Mathews, W. R., & Anania, V. G. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4462-1_18 · Cited by 1

Identification of differentially co-expressed genes with lipid metabolism in Parkinson’s disease by bioinformatics analysis

Song, J., Wang, X., Dong, L., Hui, S., Huang, Z., Fan, L., Zhu, Y., & Zhao, J. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.06.053 · Cited by 1

The frequency of adding salt to food and incident neuropsychiatric disorders: a large prospective cohort study of 426,832 participants

Yu, H.-H., Chi, H., Gao, P., Zhang, D.-D., Fu, Y., Hu, H., He, X., Zhao, Y.-L., Huang, Y., Feng, J., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119975 · Cited by 1

Increased fatty acid synthesis and disturbed lipid metabolism in Neuro2a cells after repeated cocaine exposure: A preliminary study

Nomura, M., Wen, S., Unuma, K., Funakoshi, T., Aki, T., & Uemura, K. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149438 · Cited by 1

Recent Advances in Understanding and Managing Alzheimer's Disease: from Pathogenesis to Treatment

Cavalcante, R. L. D. C., Samartino, M., Miranda, L. A., Mendes, J. D. S. A., Tanaka, T. D. L., Silva, F., Molina, L. M., Diniz, B. C., Dantas, D. A., Sarges, D. A. F., et al. (2024) · Revista de Gestão Social e Ambiental · doi:10.24857/rgsa.v18n1-176 · Cited by 1

Efficacy and tolerability of a fixed dose combination of cortex phospholipid liposomes and cyanocobalamin for intramuscular use in peripheral neuropathies

Mauro, G. L., Lauricella, L., Vecchio, M. M., Tomasello, S., & Scaturro, D. (2019) · Minerva Medica · doi:10.23736/s0026-4806.19.06068-3 · Cited by 1

Cell lipotypes localization in brain by mass spectrometry imagingPreprint

Martínez‐Gardeazabal, J., Moreno‐Rodríguez, M., Llorente‐Ovejero, A., Román, E. G. D. S., Lombardero, L., de Tena, I. B., Sustacha, J., Matute, C., Manuel, I., Bonifazi, P., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.02.578599 · Cited by 1

Recognizing the Beauty of Myelination through Identifying Sites of Phospholipid, Protein, and RNA Syntheses and Characterizing Their Movements in Myelin InternodesPreprint

Gould, R. M., & Gow, A. (2024) · Preprints.org · doi:10.20944/preprints202405.0549.v1

Prenatal Diagnosis of Disorders of Lipid Metabolism

Humphries, S. E., Mole, S., & WINCHESTER, B. G. (2015) · Wiley eBooks · doi:10.1002/9781118981559.ch20

Lipids, Brain, and Mental Health

Hussain, G., Rasul, A., Anwar, H., Malik, S. A., Sun, T., Razzaq, A., Aziz, N., & Shabbir, A. (2020) · Wiley eBooks · doi:10.1002/047167849x.bio113

Lisofosfolipidoen eta Alzheimer gaixotasunaren arteko erlazioa: etorkizuneko itu farmakologikoaren bila

Manuel, I., Moreno‐Rodríguez, M., Martínez‐Gardeazabal, J., de Tena, I. B., Román, E. G. D. S., Lombardero, L., Llorente‐Ovejero, A., & Rodríguez‐Puertas, R. (2020) · EKAIA Euskal Herriko Unibertsitateko Zientzi eta Teknologi Aldizkaria · doi:10.1387/ekaia.21399

Effect of Heavy Ion 12C6+ Radiation on Lipid Constitution in the Rat Brain

Li, B., Han, C., Liu, Y., Ismail, N., Smith, K. B., Zhang, P., Chen, Z., Dai, R., & Deng, Y. (2020) · Molecules · doi:10.3390/molecules25163762

Improved Reproducibility of Protein Detection in Neuromelanin-containing Human Substantia Nigra Tissue enriched by Laser MicrodissectionPreprint

Kösters, S., Rettel, M., Eggers, B., Riederer, P. F., Gerlach, M., Savitski, M. M., Marcus, K., & May, C. (2020) · doi:10.21203/rs.3.rs-70905/v1

Local Delivery System to Reduce Pain in a Model of Back Surgery

Ngai, J. W.-Y. (2016) · TSpace (University of Toronto)

Roles of Lipids in Health and Disease.

(2021) · doi:10.37512/1400

Prenatal Diagnosis of Disorders of Lipid Metabolism

Davison, J. E., Humphries, S. E., WINCHESTER, B. G., & Mole, S. (2021) · Wiley eBooks · doi:10.1002/9781119676980.ch25

Short-Term and Long-Term Effects of Low and High Fat Diets on Lipid Profile and Acetylcholinesterase Activity in Different Brain Regions of Male Wistar Rats

(2020) · ARC Journal of Neuroscience · doi:10.20431/2456-057x.0501001

Ocena profilu metabolomicznego u pacjentów ze stwardnieniem rozsianym jako wskaźnik rozwoju choroby z uwzględnieniem postaci rzutowo - remisyjnej, pierwotnie postępującej i wtórnie postępującej

Górka, M., Dębiec, M., Białoń, N., Bieczek, D., Suszyńśki, K., & Górka, D. (2023) · Postępy Biochemii · doi:10.18388/pb.2021_492

Advancing age, nutraceuticals, and neuroprotection

Woźniak, L. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95735-9.00001-2

Role of individual structural and functional elements of myelin in Parkinson’s disease

Shulskaya, M. V., Slominsky, P. A., Shadrina, M. I., & Alieva, A. K. (2024) · Журнал высшей нервной деятельности им И П Павлова · doi:10.31857/s0044467724030011

Myelin Genes Whose Expression Is Linked with Parkinson’s Disease

Shulskaya, M. V., Slominsky, P. A., Shadrina, M. I., & Alieva, A. K. (2024) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-024-01733-4

Context-specific interaction of the lipid regulator DIP-2 with phospholipid synthesis in axon regeneration and maintenancePreprint

Park, S., Jin, Y., & Chisholm, A. D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.06.636954

Metabolism of sphingolipids in a rat spinal cord stenosis model

Uranbileg, B., Hoshino, Y., Ezaka, M., Kurano, M., Uchida, K., Yatomi, Y., & Ito, N. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102025

Selected Lipidome Components and Their Association with Perinatal Depression

Ładno, D., Nowak, B., Palka, A., Strzelecki, D., & Gawlik-Kotelnicka, O. (2025) · Nutrients · doi:10.3390/nu17223590

Additional file 1 of Sphingolipid changes in mouse brain and plasma after mild traumatic brain injury at the acute phases

Mondal, K., Mar, N. A. D., Gary, A. A., Grambergs, R. C., Yousuf, M., Tahia, F., Stephenson, B. D., STEPHENSON, D., Chalfant, C. E., Reiner, A. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26739873

Additional file 1 of Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn

Xiong, Q., Sun, H., Wang, Y., Xu, Q., Zhang, Y., Xu, M., Zhao, Z., Li, P., & Wu, C. (2024) · Figshare · doi:10.6084/m9.figshare.25495204

Chemogenetic manipulation of the hippocampus alleviates obesogenic diet-induced memory deficits

Bakoyiannis, I. (2021) · theses.fr (ABES) · doi:10.70675/f5ac23cezc829z4dc0zaf4az467fb1eb75a9

Influence des lipides membranaires sur les interactions protéiques liées aux anomalies endolysosomales dans un modèle neuronal de la maladie d'Alzheimer

Vigier, M. (2022) · theses.fr (ABES) · doi:10.70675/45a1855bz1cb2z4326zb34az61e2ad59f5c2

Disturbed lipid metabolism in microglia after cerebral ischemia-reperfusion

Li, X., Shifeng, C. H. U., Zhang, Z., & Chen, N. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106193

In Vivo Hyperspectral CARS Imaging Reveals Photobiomodulation-Driven Remodeling of Fatty Acid Homeostasis in an AD Mouse Model

Luo, Z., Lin, F., Xu, H., Huang, Z., Weng, X., Liu, L., Chen, Y., & Qu, J. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c01421

Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment

Dhar, M., Vázquez‐Rosa, E., Chaubey, K., Miller, E., Corella, S. G., Chakraborty, S., Tripathi, S. J., Das, T., Liao, X., Alosman, M. A., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2426990123

Dyslipidemia-Induced Mitochondrial Dysfunctions in the Brains Does Not Reach Pathological Levels in the ApoE-Knockout Mice

Hsu, C.-H., Chu, P.-W., Chen, Y.-Y., Ho, M.-H., Liao, E.-C., & Chen, S.-K. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04842-3

Dysregulated phosphatidylglycerol metabolism in dorsal root ganglia contributes to pain hypersensitivity in a mouse model of Fabry disease

Lian, N., Luo, J., Ou, W., Wang, J., Du, J., Tan, Z., Zuo, X., Yin, Y., Zhou, C., Tao, L., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107595

The fat brain

Montesinos, J., Guardia‐Laguarta, C., & Área-Gómez, E. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000634 · Cited by 35

Regulation of synaptic function and lipid metabolism

Zhang, T., Yin, Y., Xia, X., Que, X., Liu, X. Y., Zhao, G., Chen, J., Chen, Q., Xu, Q., Tang, Y., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01412 · Cited by 44

Myelin lipid metabolism and its role in myelination and myelin maintenance

Barnes-Vélez, J. A., Aksoy Yasar, F. B., & Hu, J. (2023) · The Innovation · doi:10.1016/j.xinn.2022.100360 · Cited by 73

Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism

Poitelon, Y., Kopec, A. M., & Belin, S. (2020) · Cells · doi:10.3390/cells9040812 · Cited by 394

A neuroscientist's guide to lipidomics

Piomelli, D., Astarita, G., & Rapaka, R. S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2233 · Cited by 399