Cited by 137Sphingolipid Metabolism and SignalingLipid metabolism and biosynthesisLipid Membrane Structure and Behavior

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Lipids in the nervous system: From biochemistry and molecular biology to patho-physiology

Cermenati, Gaia, Mitro, Nico, Audano, Matteo, Melcangi, Roberto C., Crestani, Maurizio, De Fabiani, Emma, Caruso, Donatella·2015·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/j.bbalip.2014.08.011

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Abstract

Lipids in the nervous system accomplish a great number of key functions, from synaptogenesis to impulse conduction, and more. Most of the lipids of the nervous system are localized in myelin sheaths. It has long been known that myelin structure and brain homeostasis rely on specific lipid-protein interactions and on specific cell-to-cell signaling. In more recent years, the growing advances in large-scale technologies and genetically modified animal models have provided valuable insights into the role of lipids in the nervous system. Key findings recently emerged in these areas are here summarized. In addition, we briefly discuss how this new knowledge can open novel approaches for the treatment of diseases associated with alteration of lipid metabolism/homeostasis in the nervous system. This article is part of a Special Issue entitled Linking transcription to physiology in lipidomics.

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβPreprint
Repa, J. J., Liang, G., Ou, J., Bashmakov, Y. K., Lobaccaro, J. A., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L., & Mangelsdorf, D. J. (2000) · Genes & Development · doi:10.1101/gad.844900 · Cited by 1,724
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687
Protein Sensors for Membrane Sterols
Goldstein, J. L., DeBose-Boyd, R. A., & Brown, M. S. (2006) · Cell · doi:10.1016/j.cell.2005.12.022 · Cited by 1,517
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
Rust, S., Rosier, M., Funke, H., Real, J., Amoura, Z., Piette, J.-C., Deleuze, J.-F., Brewer, H. B., Duverger, N., Denèfle, P., et al. (1999) · Nature Genetics · doi:10.1038/11921 · Cited by 1,433
Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360
Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J.-L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3137 · Cited by 1,233
High cholesterol level is essential for myelin membrane growth
Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R.-I., Wehr, M. C., Wieland, F., Ishibashi, S., & Nave, K.-A. (2005) · Nature Neuroscience · doi:10.1038/nn1426 · Cited by 799
Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.
Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., & Weisgraber, K. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47945-8 · Cited by 714
Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I
Lala, D. S. (1992) · Molecular Endocrinology · doi:10.1210/me.6.8.1249 · Cited by 678
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
Lund, E. G., Guileyardo, J. M., & Russell, D. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7238 · Cited by 668
A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s.
Morohashi, K.-I., Honda, S., Inomata, Y., Handa, H., & Omura, T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37129-7 · Cited by 537
Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver
Chakravarthy, M. V., Lodhi, I. J., Yin, L., Malapaka, R. R. V., Xu, H. E., TURK, J. W., & Semenkovich, C. F. (2009) · Journal of End-to-End-testing · doi:10.1016/j.cell.2009.05.036 · Cited by 536
Assembly of CNS Myelin in the Absence of Proteolipid Protein
Klugmann, M., Schwab, M. H., Pühlhofer, A., Schneider, A., Zimmermann, F., Griffiths, I. R., & Nave, K. (1997) · Neuron · doi:10.1016/s0896-6273(01)80046-5 · Cited by 472
Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain
Schönfeld, P., & Reiser, G. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.128 · Cited by 457
Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia
Caron, K. M., Soo, S.-C., Wetsel, W. C., Stocco, D. M., Clark, B. J., & Parker, K. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11540 · Cited by 449
Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells
Hulce, J. J., Cognetta, A. B., Niphakis, M. J., Tully, S. E., & Cravatt, B. F. (2013) · Nature Methods · doi:10.1038/nmeth.2368 · Cited by 429
Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain
Björkhem, I. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01725.x · Cited by 397
Biochemistry of the Developing Nervous System
Glass, B. (1956) · AIBS Bulletin · doi:10.1093/aibsbulletin/6.2.34-e · Cited by 387
Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis
Papadopoulos, V., Amri, H., Boujrad, N., Cascio, C., Culty, M., Garnier, M., Hardwick, M., Li, H., Vidic, B., Brown, A. S., et al. (1997) · Steroids · doi:10.1016/s0039-128x(96)00154-7 · Cited by 386
Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain
Hirsch-Reinshagen, V., Zhou, S., Burgess, B. L., Bernier, L., McIsaac, S. A., Chan, J. Y., Tansley, G. H., Cohn, J. S., Hayden, M. R., & Wellington, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407962200 · Cited by 385
A Transgenic Rat Model of Charcot-Marie-Tooth Disease
Sereda, M. W., Griffiths, I. R., Pühlhofer, A., Helen, S., Rossner, M. J., Zimmermann, F., Magyar, J. P., Schneider, A., Hund, E., Meinck, H.-M., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80128-2 · Cited by 382
Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice
Adlkofer, K., Martini, R., Aguzzi, A., Zielasek, J., Toyka, K. V., & Suter, U. (1995) · Nature Genetics · doi:10.1038/ng1195-274 · Cited by 373
Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport
Sleat, D. E., Wiseman, J. A., El-Banna, M., Price, S. M., Vérot, L., Shen, M. M., Tint, G. S., Vanier, M. T., Walkley, S. U., & Lobel, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308456101 · Cited by 365
Mutations in the ABC 1 gene in familial HDL deficiency with defective cholesterol efflux
Marcil, M., Brooks-Wilson, A. R., Clee, S. M., Roomp, K., Zhang, L., Yu, L., Collins, J. A., van Dam, M., Molhuizen, H. O. F., Loubster, O., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)07026-9 · Cited by 350
Emerging roles of resolvins in the resolution of inflammation and pain
Ji, R., Xu, Z., Strichartz, G. R., & Serhan, C. N. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.08.005 · Cited by 345
Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases
Vance, J. E. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010124 · Cited by 342
Metabolic signaling by lactate in the brain
Barros, L. F. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.002 · Cited by 333
Protein zero (P0)–deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies
Martini, R., Zielasek, J., Toyka, K. V., Giese, K.-P., & Schachner, M. (1995) · Nature Genetics · doi:10.1038/ng1195-281 · Cited by 318
Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models
Chrast, R., Saher, G., Nave, K.-A., & Verheijen, M. H. G. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009761 · Cited by 314
Myelin synthesis in the peripheral nervous system
Garbay, B. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00049-0 · Cited by 308
Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin.
Nave, K., Lai, C., Bloom, F. E., & Milner, R. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5665 · Cited by 302
Central nervous system myelin: structure, synthesis and assembly
Aggarwal, S., Yurlova, L., & Simons, M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.004 · Cited by 301
Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration
Wang, L., Schuster, G. U., Hultenby, K. R., Zhang, Q., Andersson, S., & Gustafsson, J.-Α. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172510899 · Cited by 298
Neural circuitry engaged by prostaglandins during the sickness syndrome
Saper, C. B., Romanovsky, A. A., & Scammell, T. E. (2012) · Nature Neuroscience · doi:10.1038/nn.3159 · Cited by 285
The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator ofN-Methyl-d-Aspartate Receptors
Paul, S. M., Doherty, J., Robichaud, A. J., Belfort, G. M., Chow, B. Y., Hammond, R., Crawford, D. C., Linsenbardt, A. J., Shu, H., Izumi, Y., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2619-13.2013 · Cited by 276
The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain
Keitel, V., Görg, B., Bidmon, H. J., Zemtsova, I., Spomer, L., Zilles, K., & Häussinger, D. (2010) · Glia · doi:10.1002/glia.21049 · Cited by 274
Brain cholesterol turnover required for geranylgeraniol production and learning in mice
Kotti, T. J., Ramirez, D. M. O., Pfeiffer, B. E., Huber, K. M., & Russell, D. W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600316103 · Cited by 270
Human ATP-binding cassette transporter 1 (ABC1): Genomic organization and identification of the genetic defect in the original Tangier disease kindred
Remaley, A. T., Rust, S., Rosier, M., Knapper, C., Naudin, L., Broccardo, C., Peterson, K. M., Koch, C., Reguigne-Arnould, I., Prades, C., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12685 · Cited by 269
Role of mitochondria in steroidogenesis
Papadopoulos, V., & Miller, W. L. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.05.002 · Cited by 261
Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection
Bazan, N. G. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32802b7030 · Cited by 252
Translocator Protein/Peripheral Benzodiazepine Receptor Is Not Required for Steroid Hormone Biosynthesis
Morohaku, K., Pelton, S. H., Daugherty, D. J., Butler, W. R., Deng, W., & Selvaraj, V. (2013) · Endocrinology · doi:10.1210/en.2013-1556 · Cited by 250
Neuroactive steroids: State of the art and new perspectives
Melcangi, R. C., García‐Segura, L. M., & Mensah‐Nyagan, A. G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7403-5 · Cited by 249
Self-citation
Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero
Chirala, S. S., Chang, H., Matzuk, M. M., Abu-Elheiga, L. A., Mao, J., Mahon, K., Finegold, M. J., & Wakil, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931394100 · Cited by 242
Functional Loss of ABCA1 in Mice Causes Severe Placental Malformation, Aberrant Lipid Distribution, and Kidney Glomerulonephritis As Well As High-Density Lipoprotein Cholesterol Deficiency
Christiansen-Weber, T. A., Voland, J. R., Wu, Y., Ngo, K., Roland, B. L., Nguyen, S., Peterson, P. A., & Fung‐Leung, W. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64614-7 · Cited by 236
Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease
Hudry, E., Dam, D. V., Kulik, W., Deyn, P. P. D., Stet, F. S., Ahouansou, O., Benraiss, A., Delacourte, A., Bougneres, P. F., Aubourg, P. R., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.175 · Cited by 214
Estrogen Receptor Protein Interaction with Phosphatidylinositol 3-Kinase Leads to Activation of Phosphorylated Akt and Extracellular Signal-Regulated Kinase 1/2 in the Same Population of Cortical Neurons: A Unified Mechanism of Estrogen Action
Mannella, P., & Brinton, R. D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1443-06.2006 · Cited by 213
On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
Bogdanović, N., Brétillon, L., Lund, E. G., Diczfalusy, U., Lannfelt, L., Winblad, B. G., Russell, D. W., & Björkhem, I. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02277-7 · Cited by 213
Brain fatty acid synthase activates PPARα to maintain energy homeostasis
Chakravarthy, M. V., Zhu, Y., López, M., Yin, L., Wozniak, D. F., Coleman, T., Hu, Z., Wolfgang, M. J., Vidal‐Puig, A., Lane, M. D., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31183 · Cited by 211
Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis
Macedo, A. F., Taylor, F. C., Casas, J. P., Adler, A. J., Prieto‐Merino, D., & Ebrahim, S. B. J. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-51 · Cited by 190
Nutrition and neurodegeneration: epidemiological evidence and challenges for future research
Guyonnet, S., Secher, M., & Vellas, B. J. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12058 · Cited by 186
Fatty acid transport into the brain: Of fatty acid fables and lipid tails
Mitchell, R. W., & Hatch, G. M. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.04.007 · Cited by 180
Generation of Viable Cholesterol-Free Mice
Wechsler, A. S., Brafman, A., Shafir, M., Heverin, M., Gottlieb, H., Damari, G. M., Gozlan-Kelner, S., Spivak, I., Moshkin, O., Fridman, E., et al. (2003) · Science · doi:10.1126/science.1090776 · Cited by 179
Inactivation of liver X receptor β leads to adult-onset motor neuron degeneration in male mice
Andersson, S., Gustafsson, N., Warner, M. N., & Gustafsson, J.-Α. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500634102 · Cited by 173
Prostaglandins as inflammatory messengers across the blood-brain barrier
Engblom, D., Ek, M., Saha, S., Ericsson‐Dahlstrand, A., Jakobsson, P., & Blomqvist, A. G. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-001-0289-z · Cited by 167
Local regulation of fat metabolism in peripheral nerves
Verheijen, M. H. G., Chrast, R., Burrola, P., & Lemke, G. (2003) · Genes & Development · doi:10.1101/gad.1116203 · Cited by 165
Transfer of omega‐3 fatty acids across the blood–brain barrier after dietary supplementation with a docosahexaenoic acid‐rich omega‐3 fatty acid preparation in patients with A lzheimer's disease: the O meg AD study
Freund‐Levi, Y., Vedin, I., Cederholm, T., Basun, H., Irving, G. F., Eriksdotter, M., Hjorth, E., Schultzberg, M., Vessby, B., Wahlund, L., et al. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12166 · Cited by 165
Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith--Lemli--Opitz syndrome
Wassif, C. A. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.6.555 · Cited by 164
On the biogenesis of myelin membranes: Sorting, trafficking and cell polarity
Baron, W., & Hoekstra, D. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.10.085 · Cited by 162
The Estrogen Trinity: Membrane, Cytosolic, and Nuclear Effects
Nadal, Ã., Díaz, M. L., & Valverde, M. A. (2001) · Physiology · doi:10.1152/physiologyonline.2001.16.6.251 · Cited by 159
Sonic hedgehog in the nervous system: functions, modifications and mechanisms
Ho, K. S., & Scott, M. P. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00290-8 · Cited by 155
7-Dehydrocholesterol–dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome
Fitzky, B. U., Moebius, F. F., Asaoka, H., Waage-Baudet, H., Xu, L., Xu, G., Maeda, N., Kluckman, K. D., Hiller, S., Yu, H., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112103 · Cited by 153
P0 Glycoprotein Overexpression Causes Congenital Hypomyelination of Peripheral Nerves
Wrabetz, L. G., Feltri, M. L., Quattrini, A., Imperiale, D., Previtali, S. C., D’Antonio, M., Martini, R., Yin, X., Trapp, B. D., Zhou, L., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.5.1021 · Cited by 152
7-Dehydrocholesterol–dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome
Fitzky, B. U., Moebius, F. F., Asaoka, H., Waage-Baudet, H., Xu, L., Xu, G., Maeda, N., Kluckman, K. D., Hiller, S., Yu, H., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12103 · Cited by 150
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Theofilopoulos, S., Wang, Y., Kitambi, S. S., Sacchetti, P., Sousa, K. M., Bodin, K., Kirk, J. M., Saltó, C., Gustafsson, M., Toledo, E. M., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.1156 · Cited by 139
Cholesterol Regulates the Endoplasmic Reticulum Exit of the Major Membrane Protein P0 Required for Peripheral Myelin Compaction
Saher, G., Quintes, S., Möbius, W., Wehr, M. C., Krämer‐Albers, E., Brügger, B., & Nave, K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0686-09.2009 · Cited by 135
Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function
Karasinska, J. M., Rinninger, F., Lütjohann, D., Ruddle, P., Franciosi, S., Kruit, J. K., Singaraja, R. R., Hirsch-Reinshagen, V., Fan, J., Brunham, L. R., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4741-08.2009 · Cited by 133
A critical role for the cholesterol‐associated proteolipids PLP and M6B in myelination of the central nervous system
Werner, H. B., Krämer‐Albers, E., Strenzke, N., Saher, G., Tenzer, S., Ohno‐Iwashita, Y., de Monasterio‐Schrader, P., Möbius, W., Moser, T., Griffiths, I. R., et al. (2013) · Glia · doi:10.1002/glia.22456 · Cited by 133
Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?
Ogundare, M., Theofilopoulos, S., Lockhart, A., Hall, L. J., Arenas, E., Sjövall, J., Brenton, A. G., Wang, Y., & Griffiths, W. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.086678 · Cited by 127
Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions
Melcangi, R. C., Giatti, S., Calabrese, D., Pesaresi, M., Cermenati, G., Mitro, N., Viviani, B., García‐Segura, L. M., & Caruso, D. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.07.006 · Cited by 127
Self-citation
A novel mouse model of Niemann–Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations
Maue, R. A., Burgess, R. W., Wang, B., Wooley, C. M., Seburn, K. L., Vanier, M. T., Rogers, M. A., Chang, C. C. Y., Chang, T., Harris, B. T., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr505 · Cited by 127
Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation
Hermanson, D. J., Hartley, N. D., Gamble-George, J., Brown, N., Shonesy, B. C., Kingsley, P. J., Colbran, R. J., Reese, J., Marnett, L. J., & Patel, S. (2013) · Nature Neuroscience · doi:10.1038/nn.3480 · Cited by 126
Embryonic Lethality and Defective Neural Tube Closure in Mice Lacking Squalene Synthase
Tozawa, R., Ishibashi, S., Osuga, J.-I., Yagyu, H., Oka, T., Chen, Z., Ohashi, K., Perrey, S., Shionoiri, F., Yahagi, N., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30843 · Cited by 125
SCAP is required for timely and proper myelin membrane synthesis
Verheijen, M. H. G., Camargo, N., Verdier, V., Nadra, K., de Preux Charles, A.-S., Médard, J.-J., Luoma, A., Crowther, M., Inouye, H., Shimano, H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905633106 · Cited by 119
Non-redundant Functions of Cyclooxygenases: Oxygenation of Endocannabinoids
Rouzer, C. A., & Marnett, L. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800005200 · Cited by 118
Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann‐Pick C disease
German, D. C., Quintero, E. M., Liang, C., Ng, B., Punia, S., Xie, C., & Dietschy, J. M. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1149 · Cited by 118
Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats
Pesaresi, M., Maschi, O., Giatti, S., García‐Segura, L. M., Caruso, D., & Melcangi, R. C. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.04.008 · Cited by 114
Self-citation
Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain
Strauss, K. I. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.09.011 · Cited by 105
Peripheral nerves: a target for the action of neuroactive steroids
Melcangi, R. C., Cavarretta, I. T. R., Ballabio, M., Leonelli, E., Schenone, A. E., Azcoitia, Í., García‐Segura, L. M., & Magnaghi, V. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.021 · Cited by 105
Self-citation
Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation
Cermenati, G., Abbiati, F., Cermenati, S., Brioschi, E., Volonterio, A., Cavaletti, G., Sáez, E., Fabiani, E. D., Crestani, M., García‐Segura, L. M., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m021188 · Cited by 104
Self-citation
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Background
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Authors: Cermenati, G., Mitro, N., Audano, M., Melcangi, R. C., Crestani, M., De Fabiani, E., & Caruso, D.
Affiliations: University of Milan (IT)
ORCID: Cermenati, Gaia
Mitro, Nico
Audano, Matteo
Melcangi, Roberto C.
Crestani, Maurizio
Caruso, Donatella
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 2015-01
Volume: 1851
Issue: 1
Pages: 51-60
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/j.bbalip.2014.08.011
OpenAlex: W2007699925
Cited by: 137
References: 111
Citations by year: 2026: 7 · 2025: 18 · 2024: 19 · 2023: 16 · 2022: 18 · 2021: 15 · 2020: 19 · 2019: 10 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 2
FWCI: 0.38
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
PubMed (publishedVersion)
Funders: The Giovanni Armenise-Harvard Foundation Career Development
Fondazione Cariplo (2012-0547, 2008–2511)
European Commission (FP6 LSHM-CT2006-037498-SOUTH, FP7 602757-HUMAN, FP7 Marie Curie PITN-GA-2013-606806-NR-NET)
Italian Ministry of Education, Universities and Research (PRIN 2009-K7R7NA, PRIN 2008-ZTN724)
Research Center for the Characterization and Safety Use of Natural Compounds — “Giovanni Galli”
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords: myelin sheath, protein-lipid interactions, synaptogenesis, impulse conduction, brain homeostasis, cell-to-cell signaling, lipid metabolism, lipidomics, neurodegenerative diseases, transgenic animal models
MeSH terms: Animals, Humans, Nervous System, Lipid Metabolism

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Lipids in the nervous system: From biochemistry and molecular biology to patho-physiology

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