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Lipids in the nervous system: From biochemistry and molecular biology to patho-physiology
Abstract
Lipids in the nervous system accomplish a great number of key functions, from synaptogenesis to impulse conduction, and more. Most of the lipids of the nervous system are localized in myelin sheaths. It has long been known that myelin structure and brain homeostasis rely on specific lipid-protein interactions and on specific cell-to-cell signaling. In more recent years, the growing advances in large-scale technologies and genetically modified animal models have provided valuable insights into the role of lipids in the nervous system. Key findings recently emerged in these areas are here summarized. In addition, we briefly discuss how this new knowledge can open novel approaches for the treatment of diseases associated with alteration of lipid metabolism/homeostasis in the nervous system. This article is part of a Special Issue entitled Linking transcription to physiology in lipidomics.
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“Out of all the brain lipids, the most abundant are cholesterol, ceramides, glucosyl ceramides, phosphatidylcholine, sphingomyelin, and sulfatides [61, 62].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [62]
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Metadata
- Authors
- Cermenati, G., Mitro, N., Audano, M., Melcangi, R. C., Crestani, M., De Fabiani, E., & Caruso, D.
- Affiliations
- University of Milan (IT)
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 1851
- Issue
- 1
- Pages
- 51-60
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2007699925
- Cited by
- 137
- References
- 111
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 19 · 2023: 16 · 2022: 18 · 2021: 15 · 2020: 19 · 2019: 10 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 2
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The Giovanni Armenise-Harvard Foundation Career Development
- Fondazione Cariplo (2012-0547, 2008–2511)
- European Commission (FP6 LSHM-CT2006-037498-SOUTH, FP7 602757-HUMAN, FP7 Marie Curie PITN-GA-2013-606806-NR-NET)
- Italian Ministry of Education, Universities and Research (PRIN 2009-K7R7NA, PRIN 2008-ZTN724)
- Research Center for the Characterization and Safety Use of Natural Compounds — “Giovanni Galli”
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- myelin sheath, protein-lipid interactions, synaptogenesis, impulse conduction, brain homeostasis, cell-to-cell signaling, lipid metabolism, lipidomics, neurodegenerative diseases, transgenic animal models
- MeSH terms
- Animals, Humans, Nervous System, Lipid Metabolism
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