Cited by 394Lipid metabolism and biosynthesisSphingolipid Metabolism and SignalingFatty Acid Research and Health

Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism

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Poitelon, Yannick, Kopec, Ashley M., Belin, Sophie·2020·Cells

Abstract

Myelin is critical for the proper function of the nervous system and one of the most complex cell–cell interactions of the body. Myelination allows for the rapid conduction of action potentials along axonal fibers and provides physical and trophic support to neurons. Myelin contains a high content of lipids, and the formation of the myelin sheath requires high levels of fatty acid and lipid synthesis, together with uptake of extracellular fatty acids. Recent studies have further advanced our understanding of the metabolism and functions of myelin fatty acids and lipids. In this review, we present an overview of the basic biology of myelin lipids and recent insights on the regulation of fatty acid metabolism and functions in myelinating cells. In addition, this review may serve to provide a foundation for future research characterizing the role of fatty acids and lipids in myelin biology and metabolic disorders affecting the central and peripheral nervous system.

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Authors
Poitelon, Y., Kopec, A. M., & Belin, S.
Affiliations
Albany Medical College (US)
Corresponding author
Belin, Sophie
Venue
Cells
Publisher
MDPI AG
Published
2020-03-27
Volume
9
Issue
4
Pages
812
ISSN
2073-4409 (ISSN-L)
OpenAlex
W3013269049
Cited by
394
References
173
Citations by year
2026: 71 · 2025: 84 · 2024: 87 · 2023: 68 · 2022: 47 · 2021: 32 · 2020: 4 · 2019: 1
FWCI
3.70
Type
journal article
Language
en
Open access
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institute of Neurological Disorders and Stroke (R01NS110627)
  • Albany Medical College (Start-up grant)
  • AMC - Department of Neuroscience and Experimental Therapeutics (Developmental Fellowship)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
myelin lipids, fatty acid metabolism, myelination, myelinating cells, lipogenesis, myelin sheath, central nervous system, peripheral nervous system
MeSH terms
Animals, Fatty Acids, Humans, Models, Biological, Myelin Sheath, Oxidation-Reduction, Lipid Metabolism

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