Cited by 335Antioxidant Activity and Oxidative StressFatty Acid Research and HealthEicosanoids and Hypertension Pharmacology

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The isoprostanes—25 years later

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Milne, Ginger L., Dai, Qi, Roberts, L. Jackson·2015·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/j.bbalip.2014.10.007PMC PMC5404383

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Abstract

Isoprostanes (IsoPs) are prostaglandin-like molecules generated independent of the cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first isoprostane species discovered were isomeric to prostaglandin F2α and were thus termed F2-IsoPs. Since the initial discovery of the F2-IsoPs, IsoPs with differing ring structures have been identified as well as IsoPs from different polyunsaturated fatty acids, including eicosapentaenoic acid and docosahexanenoic acid. The discovery of these molecules in vivo in humans has been a major contribution to the field of lipid oxidation and free radical research over the course of the past 25 years. These molecules have been determined to be both biomarkers and mediators of oxidative stress in numerous disease settings. This review focuses on recent developments in the field with an emphasis on clinical research. Special focus is given to the use of IsoPs as biomarkers in obesity, ischemia-reperfusion injury, the central nervous system, cancer, and genetic disorders. Additionally, attention is paid to diet and lifestyle factors that can affect endogenous levels of IsoPs. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance."

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A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
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Authors: Milne, G. L., Dai, Q., & Roberts, L. J.
Affiliations: Vanderbilt University (US)
Corresponding author: Roberts, L. Jackson
ORCID: Milne, Ginger L.
Dai, Qi
Roberts, L. Jackson
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 2015-04
Volume: 1851
Issue: 4
Pages: 433-445
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/j.bbalip.2014.10.007
PMC: PMC5404383
OpenAlex: W2059867409
Cited by: 335
References: 238
Citations by year: 2026: 20 · 2025: 20 · 2024: 17 · 2023: 26 · 2022: 30 · 2021: 37 · 2020: 39 · 2019: 37 · 2018: 31 · 2017: 31 · 2016: 34 · 2015: 13
FWCI: 2.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: GM15431
ES000267
CA106591
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: isoprostanes, lipid peroxidation, arachidonic acid, free radicals, oxidative stress, biomarkers, F2-isoprostanes, eicosapentaenoic acid, docosahexaenoic acid, obesity, ischemia-reperfusion injury, central nervous system, cancer, genetic disorders, diet and lifestyle, polyunsaturated fatty acids
MeSH terms: Animals, Disease, Humans, Structure-Activity Relationship, Lipid Peroxidation, Molecular Structure, Signal Transduction, Biomarkers, Oxidative Stress, Isoprostanes

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