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The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond

Scott, Nicola A., Sharpe, Laura J., Brown, Andrew J.·2021·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2020.158837
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Abstract

MARCHF6 is a large multi-pass E3 ubiquitin ligase embedded in the membranes of the endoplasmic reticulum. It participates in endoplasmic reticulum associated degradation, including autoubiquitination, and many of its identified substrates are involved in sterol and lipid metabolism. Post-translationally, MARCHF6 expression is attuned to cholesterol status, with high cholesterol preventing its degradation and hence boosting MARCHF6 levels. By modulating MARCHF6 activity, cholesterol may regulate other aspects of cell metabolism beyond the known repertoire. Whilst we have learnt much about MARCHF6 in the past decade, there are still many more mysteries to be unravelled to fully understand its regulation, substrates, and role in human health and disease.

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Metadata

Authors
Scott, N. A., Sharpe, L. J., & Brown, A. J.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2021-01
Volume
1866
Issue
1
Pages
158837
ISSN
1388-1981
DOI
10.1016/j.bbalip.2020.158837
Cited by
16
References
8
Language
en
Licence
Funders
  • Australian Research Council
  • NSW Health

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