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The Sterol-sensing Endoplasmic Reticulum (ER) Membrane Protein TRC8 Hampers ER to Golgi Transport of Sterol Regulatory Element-binding Protein-2 (SREBP-2)/SREBP Cleavage-activated Protein and Reduces SREBP-2 Cleavage
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Effects of GP78 and TRC8 are consistent with previous reports that they target INSIGs and HMG-CoA reductase for degradation.
“These effects of GP78 and TRC8 are consistent with previous reports that they target INSIGs and HMG-CoA reductase for degradation.”
From Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP (2017) · cites this paper as Irisawa et al., 2009
TRC8 reduces stability of SREBP and inhibits SREBP processing in cultured cells.
“TRC8 was reported to reduce the stability of SREBP, and to inhibit SREBP processing in cultured cells (Irisawa et al., 2009; Lee et al., 2010).”
From Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP (2017) · cites this paper as Irisawa et al., 2009
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Mechanisms and regulation of cholesterol homeostasis
Luo, J., Yang, H., & Song, B.-L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0190-7 · Cited by 1,980
Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP
Zhang, L., Rajbhandari, P., Priest, C., Sandhu, J., Wu, X., Temel, R., Castrillo, A., de Aguiar Vallim, T. Q., Sallam, T., & Tontonoz, P. (2017) · eLife · doi:10.7554/elife.28766 · Cited by 69
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation
Xiao, J., Xiong, Y., Yang, L.-T., Wang, J.-Q., Zhou, Z.-M., Dong, L.-W., Shi, X.-J., Zhao, X., Luo, J., & Song, B.-L. (2021) · Protein & Cell · doi:10.1007/s13238-020-00753-3 · Cited by 49
Metadata
- Authors
- Irisawa, M., Inoue, J., Ozawa, N., Mori, K., & Sato, R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 284
- Issue
- 42
- Pages
- 28995-29004
- ISSN
- 0021-9258
- Cited by
- 64
- References
- 0
- Language
- en
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