Cited by 300Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Atypical mitogen-activated protein kinases: Structure, regulation and functions

Open access
Coulombe, Phillipe, Meloche, Sylvain·2007·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Abstract

Mitogen-activated protein (MAP) kinases are a family of serine/threonine kinases that play a central role in transducing extracellular cues into a variety of intracellular responses ranging from lineage specification to cell division and adaptation. Fourteen MAP kinase genes have been identified in the human genome, which define 7 distinct MAP kinase signaling pathways. MAP kinases can be classified into conventional or atypical enzymes, based on their ability to get phosphorylated and activated by members of the MAP kinase kinase (MAPKK)/MEK family. Conventional MAP kinases comprise ERK1/ERK2, p38s, JNKs, and ERK5, which are all substrates of MAPKKs. Atypical MAP kinases include ERK3/ERK4, NLK and ERK7. Much less is known about the regulation, substrate specificity and physiological functions of atypical MAP kinases.

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Crossref · 10.1016/j.bbamcr.2006.11.001

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86 of 86 references verified0 citation errors · 0 not checkable

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  • NLK is an evolutionary conserved atypical proline-directed serine/threonine MAP kinase.

    “Nemo-like kinase (NLK) is an evolutionary, conserved, atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase [13]”

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Authors
Coulombe, P., & Meloche, S.
Affiliations
Institute for Research in Immunology and Cancer (CA)
Corresponding author
Meloche, Sylvain
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher
Elsevier BV
Published
2007-08
Volume
1773
Issue
8
Pages
1376-1387
ISSN
0167-4889 (ISSN-L)
OpenAlex
W1973460380
Cited by
298
References
87
Citations by year
2026: 6 · 2025: 13 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 28 · 2020: 21 · 2019: 14 · 2018: 18 · 2017: 14 · 2016: 13 · 2015: 12 · 2014: 16 · 2013: 10 · 2012: 13
FWCI
0.69
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Canada Research Chairs
  • National Cancer Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords
mitogen-activated protein kinase, Nemo-like kinase, MAPK signaling, MAP kinase kinase, kinase regulation, substrate specificity, serine/threonine kinase, signal transduction
MeSH terms
Amino Acid Sequence, Animals, Enzyme Activation, Humans, Models, Molecular, Molecular Sequence Data, Substrate Specificity, Sequence Homology, Amino Acid, MAP Kinase Signaling System, Extracellular Signal-Regulated MAP Kinases

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