Atypical mitogen-activated protein kinases: Structure, regulation and functions
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Mitogen-activated protein (MAP) kinases are a family of serine/threonine kinases that play a central role in transducing extracellular cues into a variety of intracellular responses ranging from lineage specification to cell division and adaptation. Fourteen MAP kinase genes have been identified in the human genome, which define 7 distinct MAP kinase signaling pathways. MAP kinases can be classified into conventional or atypical enzymes, based on their ability to get phosphorylated and activated by members of the MAP kinase kinase (MAPKK)/MEK family. Conventional MAP kinases comprise ERK1/ERK2, p38s, JNKs, and ERK5, which are all substrates of MAPKKs. Atypical MAP kinases include ERK3/ERK4, NLK and ERK7. Much less is known about the regulation, substrate specificity and physiological functions of atypical MAP kinases.
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NLK is an evolutionary conserved atypical proline-directed serine/threonine MAP kinase.
“Nemo-like kinase (NLK) is an evolutionary, conserved, atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase [13]”
From Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies (2020) · cites this paper as [13]
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- Authors
- Coulombe, P., & Meloche, S.
- Affiliations
- Institute for Research in Immunology and Cancer (CA)
- Corresponding author
- Meloche, Sylvain
- ORCID
- Meloche, Sylvain
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 1773
- Issue
- 8
- Pages
- 1376-1387
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W1973460380
- Cited by
- 298
- References
- 87
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 17 · 2023: 19 · 2022: 19 · 2021: 28 · 2020: 21 · 2019: 14 · 2018: 18 · 2017: 14 · 2016: 13 · 2015: 12 · 2014: 16 · 2013: 10 · 2012: 13
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Canada Research Chairs
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- mitogen-activated protein kinase, Nemo-like kinase, MAPK signaling, MAP kinase kinase, kinase regulation, substrate specificity, serine/threonine kinase, signal transduction
- MeSH terms
- Amino Acid Sequence, Animals, Enzyme Activation, Humans, Models, Molecular, Molecular Sequence Data, Substrate Specificity, Sequence Homology, Amino Acid, MAP Kinase Signaling System, Extracellular Signal-Regulated MAP Kinases
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