Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion
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Ablation of the mitochondrial fusion and endoplasmic reticulum (ER)–tethering protein Mfn2 causes ER stress, but whether this is just an epiphenomenon of mitochondrial dysfunction or a contributor to the phenotypes in mitofusin (Mfn)-depleted Drosophila melanogaster is unclear. In this paper, we show that reduction of ER dysfunction ameliorates the functional and developmental defects of flies lacking the single Mfn mitochondrial assembly regulatory factor (Marf). Ubiquitous or neuron- and muscle-specific Marf ablation was lethal, altering mitochondrial and ER morphology and triggering ER stress that was conversely absent in flies lacking the fusion protein optic atrophy 1. Expression of Mfn2 and ER stress reduction in flies lacking Marf corrected ER shape, attenuating the developmental and motor defects. Thus, ER stress is a targetable pathogenetic component of the phenotypes caused by Drosophila Mfn ablation.
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Decreased mitofusin2 and calnexin expression explain why ER stress and UPR are induced by DRP1 inhibition.
“Both the decreased mitofusin2 and calnexin expression explain why ER stress and UPR are induced by DRP1 inhibition36,37.”
From DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass (2019) · cites this paper as [37]
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- Authors
- Debattisti, V., Pendin, D., Ziviani, E., Daga, A., & Scorrano, L.
- Affiliations
- Veneto Institute of Molecular Medicine (IT)
- IRCCS Eugenio Medea (IT)
- University of Geneva (CH)
- University of Padua (IT)
- Corresponding author
- Scorrano, Luca
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2014-01-27
- Volume
- 204
- Issue
- 3
- Pages
- 303-312
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC3912536
- OpenAlex
- W2077906609
- Cited by
- 63
- References
- 44
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 7 · 2018: 11 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 4
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- endoplasmic reticulum stress, mitofusins, mitofusin 2, Marf, mitochondrial fusion, optic atrophy 1, ER morphology, motor defects, developmental defects, Drosophila melanogaster
- MeSH terms
- Animals, Drosophila melanogaster, Genetic Complementation Test, Humans, Locomotion, Membrane Proteins, Mitochondria, Phenylbutyrates, Taurochenodeoxycholic Acid, Drosophila Proteins, RNA Interference, Mice, Endoplasmic Reticulum Stress
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