The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
Open accessAbstract
Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as microbial pathogens, irritants, or toxic cellular components. The primary physical manifestations of inflammation are redness, swelling, heat, pain, and loss of function to the affected area. These processes involve the major cells of the immune system, including monocytes, macrophages, neutrophils, basophils, dendritic cells, mast cells, T-cells, and B-cells. However, examination of a range of inflammatory lesions demonstrates the presence of specific leukocytes in any given lesion. That is, the inflammatory process is regulated in such a way as to ensure that the appropriate leukocytes are recruited. These events are in turn controlled by a host of extracellular molecular regulators, including members of the cytokine and chemokine families that mediate both immune cell recruitment and complex intracellular signalling control mechanisms that characterise inflammation. This review will focus on the role of the main cytokines, chemokines, and their receptors in the pathophysiology of auto-inflammatory disorders, pro-inflammatory disorders, and neurological disorders involving inflammation.
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Functional mapping and annotation of genetic associations with FUMA
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Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
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Combination strategies to maximize the benefits of cancer immunotherapy
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Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis
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Metadata
- Authors
- Turner, M. D., Nedjai, B., Hurst, T., & Pennington, D. J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 1843
- Issue
- 11
- Pages
- 2563-2582
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2118742454
- Cited by
- 2,162
- References
- 32
- FWCI
- 25.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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