HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model
Open accessAbstract
Oval cells constitute an interesting hepatic cell population. They contribute to sustain liver regeneration during chronic liver damage, but in doing this they can be target of malignant conversion and become tumor-initiating cells and drive hepatocarcinogenesis. The molecular mechanisms beneath either their pro-regenerative or pro-tumorigenic potential are still poorly understood. In this study, we have investigated the role of the HGF/c-Met pathway in regulation of oval cell migratory and invasive properties. Our results show that HGF induces c-Met-dependent oval cell migration both in normal culture conditions and after in vitro wounding. HGF-triggered migration involves F-actin cytoskeleton reorganization, which is also evidenced by activation of Rac1. Furthermore, HGF causes ZO-1 translocation from cell-cell contact sites to cytoplasm and its concomitant activation by phosphorylation. However, no loss of expression of cell-cell adhesion proteins, including E-cadherin, ZO-1 and Occludin-1, is observed. Additionally, migration does not lead to cell dispersal but to a characteristic organized pattern in rows, in turn associated with Golgi compaction, providing strong evidence of a morphogenic collective migration. Besides migration, HGF increases oval cell invasion through extracellular matrix, a process that requires PI3K activation and is at least partly mediated by expression and activation of metalloproteases. Altogether, our findings provide novel insights into the cellular and molecular mechanisms mediating the essential role of HGF/c-Met signaling during oval cell-mediated mouse liver regeneration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In vitro studies have shown evidence of collective migration of hepatic cell lines.
“in vitro studies have further shown evidence of collective migration of hepatic cell lines”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Suárez-Causado et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091 · see citing works
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151 · see citing works
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90164-8 · Cited by 3,651 · see citing works
Collective cell migration in morphogenesis, regeneration and cancer
Friedl, P., & Gilmour, D. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,668 · see citing works
Scatter factor/hepatocyte growth factor is essential for liver development
Schmidt, C. S., Bladt, F., Gödecke, S., Brinkmann, V., Zschiesche, W., Sharpe, M. J., Gherardi, E., & Birchmeler, C. (1995) · Nature · doi:10.1038/373699a0 · Cited by 1,395 · see citing works
Brew, K., & Nagase, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.01.003 · Cited by 1,384 · see citing works
Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
Stoker, M. G. P., Gherardi, E., Perryman, M., & Gray, J. (1987) · Nature · doi:10.1038/327239a0 · Cited by 1,316 · see citing works
MET signalling: principles and functions in development, organ regeneration and cancer
Trusolino, L., Bertotti, A., & Comoglio, P. M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3012 · Cited by 1,244 · see citing works
Wolf, K., Wu, Y., Liu, Y., Geiger, J., Tam, E. M., Overall, C. M., Stack, M. S., & Friedl, P. (2007) · Nature Cell Biology · doi:10.1038/ncb1616 · Cited by 1,009 · see citing works
Huh, C.-G., Factor, V. M., Sánchez, A., Uchida, K., Conner, E. A., & Thorgeirsson, S. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306068101 · Cited by 750 · see citing works
Self-citationBuilding epithelial architecture: insights from three-dimensional culture models
O'Brien, L. E., Zegers, M. M. P., & Mostov, K. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm859 · Cited by 596 · see citing works
Stem Cells and Liver Regeneration
Duncan, A. W., Dorrell, C., & Grompe, M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.05.044 · Cited by 547 · see citing works
Met provides essential signals for liver regeneration
Borowiak, M., Garratt, A. N., Wüstefeld, T., Strehle, M., Trautwein, C., & Birchmeier, C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403412101 · Cited by 497 · see citing works
Hepatocyte growth factor twenty years on: Much more than a growth factor
Nakamura, T., Sakai, K., Nakamura, T., & Matsumoto, K. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06549.x · Cited by 472 · see citing works
Hepatocyte growth factor induces cell scattering through MAPK/Egr‐1‐mediated upregulation of Snail
Grotegut, S., von Schweinitz, D., Christofori, G., & Lehembre, F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601213 · Cited by 363 · see citing works
p38 and ERK1/2 Coordinate Cellular Migration and Proliferation in Epithelial Wound Healing
Sharma, G.-D., He, J., & Bazan, H. E. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302650200 · Cited by 337 · see citing works
Integrin-dependent actomyosin contraction regulates epithelial cell scattering
de Rooij, J., Kerstens, A., Danuser, G. M., Schwartz, M. A., & Waterman, C. M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506152 · Cited by 324 · see citing works
HGF/SF‐met signaling in the control of branching morphogenesis and invasion
Zhang, Y., & Woude, G. F. V. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10358 · Cited by 309 · see citing works
New concepts in liver regeneration
Riehle, K. J., Dan, Y. Y., Campbell, J. S., & Fausto, N. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06539.x · Cited by 245 · see citing works
Royal, I., & Park, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27780 · Cited by 238 · see citing works
The actin cytoskeleton in normal and pathological cell motility
Lambrechts, A., Troys, M. V., & Ampè, C. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.01.024 · Cited by 228 · see citing works
Kumar, B., Koul, S., Petersen, J., Khandrika, L., Hwa, J. S., Meacham, R. B., Wilson, S., & Koul, H. K. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2918 · Cited by 217 · see citing works
Series Introduction: Invasive growth: from development to metastasis
Comoglio, P. M., & Trusolino, L. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15392 · Cited by 200 · see citing works
Ishikawa, T., Factor, V. M., Marquardt, J. U., Raggi, C., Seo, D., Kitade, M., Conner, E. A., & Thorgeirsson, S. S. (2011) · Hepatology · doi:10.1002/hep.24796 · Cited by 188 · see citing works
Series Introduction: Invasive growth: from development to metastasis
Comoglio, P. M., & Trusolino, L. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215392 · Cited by 176 · see citing works
Epithelial-to-Mesenchymal Transition of Murine Liver Tumor Cells Promotes Invasion†,‡
Ding, W., You, H., Dang, H. T., LeBlanc, F., Galicia, V. A., Lu, S. C.-L., Stiles, B. L., & Rountree, B. C. (2010) · Hepatology · doi:10.1002/hep.23748 · Cited by 154 · see citing works
Pichon, S., Bryckaert, M., & Berrou, E. (2004) · Journal of Cell Science · doi:10.1242/jcs.01110 · Cited by 152 · see citing works
Uttamsingh, S., Bao, X., Nguyen, K. T., Bhanot, M., Gong, J., Chan, J., Liu, F., Chu, T.-Y., & Wang, L. (2007) · Oncogene · doi:10.1038/sj.onc.1210915 · Cited by 146 · see citing works
Schulze‐Bergkamen, H., Brenner, D., Krueger, A., Suess, D., Fas, S. C., Frey, C. R., Dax, A., Zink, D., Büchler, P., Müller, M., et al. (2004) · Hepatology · doi:10.1002/hep.20138 · Cited by 118 · see citing works
Johnson, M., Koukoulis, G. Κ., Matsumoto, K., Nakamura, T., & Iyer, A. (1993) · Hepatology · doi:10.1002/hep.1840170618 · Cited by 115 · see citing works
Kuramitsu, K., Sverdlov, D., Liu, S. B., Csizmadia, E., Burkly, L. C., Schuppan, D., Hanto, D. W., Otterbein, L. E., & Popov, Y. V. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.03.018 · Cited by 107 · see citing works
Li, C., Hu, Y., Sturm, G., Wick, G., & Xu, Q. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.e1 · Cited by 107 · see citing works
Segarra, J., Balenci, L., Drenth, T., Maina, F., & Lamballe, F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508298200 · Cited by 101 · see citing works
Yu, W., O’Brien, L. E., Wang, F., Bourne, H. R., Mostov, K. E., & Zegers, M. M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-06-0350 · Cited by 99 · see citing works
Liver cancer stem cells: implications for a new therapeutic target
Lee, T. K., Castilho, A., Ma, S., & Ng, I. O. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02040.x · Cited by 92 · see citing works
Ito, S., Kimura, K., Haneda, M., Ishida, Y., Sawada, M., & Isobe, K. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2006.11.012 · Cited by 89 · see citing works
Marquardt, J. U., Seo, D., Gómez-Quiroz, L. E., Uchida, K., Gillen, M. C., Kitade, M., Kaposi-Novák, P., Conner, E. A., Factor, V. M., & Thorgeirsson, S. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.012 · Cited by 88 · see citing works
Olle, E. W., Ren, X., McClintock, S. D., Warner, R. L., Deogracias, M. P., Johnson, K. J., & Colletti, L. M. (2006) · Hepatology · doi:10.1002/hep.21314 · Cited by 87 · see citing works
Rosengren, S., Corr, M., & Boyle, D. L. (2010) · Arthritis Research & Therapy · doi:10.1186/ar2981 · Cited by 83 · see citing works
HGF regulates tight junctions in new nontumorigenic gastric epithelial cell line
Hollande, F., Blanc, E. M., Bali, J. P., Whitehead, R. H., Pèlegrin, A., Baldwin, G. S., & Choquet, A. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.5.g910 · Cited by 81 · see citing works
Kadono, Y., Shibahara, K., Namiki, M., Watanabe, Y., Seiki, M., & Sato, H. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9531 · Cited by 80 · see citing works
Monvoisin, A., Bisson, C., Si‐Tayeb, K., Balabaud, C. P., Desmoulière, A., & Rosenbaum, J. (2001) · International Journal of Cancer · doi:10.1002/ijc.1595 · Cited by 77 · see citing works
A PI3K activity‐independent function of p85 regulatory subunit in control of mammalian cytokinesis
García, Z., Silió, V., Marqués, M., Cortés, I., Kumar, A., Hernandez, C., Checa, A. I., Serrano, A., & Carrera, A. C. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601324 · Cited by 70 · see citing works
Kroy, D. C., Schumacher, F., Ramadori, P., Hatting, M., Bergheim, I., Gaßler, N., Boekschoten, M. V., Müller, M. M., Streetz, K. L., & Trautwein, C. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.05.019 · Cited by 70 · see citing works
Matrix Metalloproteinase-13 Promotes Recovery from Experimental Liver Cirrhosis in Rats
Endo, H., Niioka, M., Sugioka, Y., Itoh, J., Kameyama, K., Okazaki, I., Ala‐aho, R., Kähäri, V., & Watanabe, T. (2011) · Pathobiology · doi:10.1159/000328841 · Cited by 68 · see citing works
Michalopoulos, G. K., Bowen, W. C., Nussler, A. K., Becich, M. J., & Howard, T. A. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041560303 · Cited by 67 · see citing works
Signaling networks in hepatic oval cell activation.
Erker, L. R., & Grompe, M. (2008) · Stem Cell Research · doi:10.1016/j.scr.2008.01.002 · Cited by 61 · see citing works
Cell Motility: Golgi Signalling Shapes up to Ship out
Mellor, H. (2004) · Current Biology · doi:10.1016/j.cub.2004.05.038 · Cited by 42 · see citing works
Pollack, A. L., Apodaca, G., & Mostov, K. E. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00377.2003 · Cited by 41 · see citing works
Hecht, M., Heider, U., Kaiser, M., von Metzler, I., Sterz, J., & Sezer, O. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06665.x · Cited by 41 · see citing works
Phaneuf, D., Moscioni, A. D., LeClair, C., Raper, S. E., & Wilson, J. M. (2004) · DNA and Cell Biology · doi:10.1089/dna.2004.23.592 · Cited by 40 · see citing works
Growth factor- and cytokine-driven pathways governing liver stemness and differentiation
Sánchez, A. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i41.5148 · Cited by 40 · see citing works
Self-citationdel Castillo, G., Factor, V. M., Fernández, M., Alvarez, A. M., Fabregat, I., Thorgeirsson, S. S., & Sánchez, A. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070793 · Cited by 34 · see citing works
Self-citationMartínez‐Palacián, A., del Castillo, G., Causado, A. S., García‐Álvaro, M., de la Morena-Frutos, D., Fernández, M., Roncero, C., Fabregat, I., Herrera, B. M., & Sánchez, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053108 · Cited by 31 · see citing works
Self-citationMurakami, K., Sakukawa, R., Ikeda, T., Matsuura, T., HASUMURA, S., Nagamori, S., Yamada, Y., & Saiki, I. (1999) · Neoplasia · doi:10.1038/sj.neo.7900046 · Cited by 29 · see citing works
Sánchez, A., Pagan, R., Alvarez, A. M., Roncero, C., Vilaró, S., Benito, M., & Fabregat, I. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4088 · Cited by 24 · see citing works
Self-citationp38α MAPK can positively or negatively regulate Rac‐1 activity depending on the presence of serum
Zuluaga, S., Gutiérrez-Uzquiza, Á., Bragado, P., Alvarez, A. M., Benito, M., Nebreda, Á. R., & Porrás, A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.06.078 · Cited by 16 · see citing works
Delgado, J.-P., Vanneaux, V., Branger, J., Touboul, T., Sentilhes, L., Goulinet, S., Laïnas, P., Leclerc, P., Uzan, G., Mahieu‐Caputo, D., et al. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.07.007 · Cited by 13 · see citing works
Kamiyama, T., Une, Y., Uchino, J., & Hamada, J. (1998) · International Journal of Oncology · doi:10.3892/ijo.12.3.655 · Cited by 13 · see citing works
Ras‐dependent and Ras‐independent effects of PI3K in Drosophila motor neurons
Johnson, C. B., Lin, C. C.-J., & Stern, M. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00822.x · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells
Kim, Y., Kang, K., Lee, S. B., Seo, D., Yoon, S., Kim, S. J., Jang, K., Jung, Y. K., Lee, K. G., Factor, V. M., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.09.007 · Cited by 167 · see citing works
Partial EMT in head and neck cancer biology: a spectrum instead of a switch
Pal, A., Barrett, T. F., Paolini, R. L., Parikh, A. S., & Puram, S. V. (2021) · Oncogene · doi:10.1038/s41388-021-01868-5 · Cited by 131 · see citing works
New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression
Bhatia, S., Wang, P., Toh, A. K. L., & Thompson, E. W. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00071 · Cited by 94 · see citing works
Lotto, J., Drissler, S., Cullum, R., Wei, W., Setty, M., Bell, E. M., Boutet, S. C., Nowotschin, S., Kuo, Y.-Y., Garg, V., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.012 · Cited by 86 · see citing works
Bhatia, S., Monkman, J. H., Toh, A. K. L., Nagaraj, S. H., & Thompson, E. W. (2017) · Biochemical Journal · doi:10.1042/bcj20160782 · Cited by 73 · see citing works
Mechanosensing in liver regeneration
Song, Z., Gupta, K., Ng, I. C., Xing, J., Yang, Y. A., & Yu, H. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.07.041 · Cited by 63 · see citing works
The hippo pathway: A master regulator of liver metabolism, regeneration, and disease
Nguyen‐Lefebvre, A. T., Selzner, N., Wrana, J. L., & Bhat, M. (2021) · The FASEB Journal · doi:10.1096/fj.202002284rr · Cited by 58 · see citing works
Geleta, B., Park, K. C., Jansson, P. J., Sahni, S., Maleki, S., Xu, Z., Murakami, T., Pajic, M., Apte, M. V., Richardson, D. R., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002279r · Cited by 48 · see citing works
The Role of HGF/MET in Liver Cancer
Gupta, G., Almalki, W. H., Kazmi, I., Thangavelu, L. P., Gupta, P. K., Jha, N. K., Prasher, P., Singh, S. K., & Dua, K. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2021-0128 · Cited by 43 · see citing works
Wang, G., Zhou, X., Guo, Z., Huang, N. J., Li, J., Lv, Y.-F., Han, L., Zheng, W., Xu, D., Chai, D., et al. (2022) · Cancer Biology & Therapy · doi:10.1080/15384047.2022.2035629 · Cited by 38 · see citing works
MicroRNAs and signaling networks involved in epithelial–mesenchymal transition
Shenas, M. H. M., Eghbal‐Fard, S., Mehrisofiani, V., Yazdani, N. A., Farzam, O. R., Marofi, F., & Yousefi, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27489 · Cited by 34 · see citing works
Generation of functional human hepatocytes in vitro: current status and future prospects
Yamaguchi, T., Matsuzaki, J., Katsuda, T., Saito, Y., Saito, H., & Ochiya, T. (2019) · Inflammation and Regeneration · doi:10.1186/s41232-019-0102-4 · Cited by 34 · see citing works
González‐Rodríguez, Á., Valdecantos, M. P., Rada, P., Addante, A., Barahona, I., Rey, E., Pardo, V., Ruíz-Cañas, L., Laiglesia, L. M., Moreno-Aliaga, M. J., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.10.008 · Cited by 33 · see citing works
Self-citationXie, C., Sun, H., Wang, F., Zhao, L., Yin, Y.-R., Fang, Q., Sun, Y., Zhao, W., Zhang, S., Zhao, W., et al. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3974 · Cited by 33 · see citing works
Kwon, Y., & Godwin, A. K. (2016) · Reproductive Sciences · doi:10.1177/1933719116648212 · Cited by 33 · see citing works
Priego, N., Arechederra, M., Sequera, C., Bragado, P., Vázquez‐Carballo, A., Gutiérrez-Uzquiza, Á., Martín-Granado, V., Ventura, J., Kazanietz, M. G., Guerrero, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9911 · Cited by 25 · see citing works
Metabolic networks classification and knowledge discovery by information granulation
Martino, A., Giuliani, A., Todde, V., Bizzarri, M., & Rizzi, A. (2019) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2019.107187 · Cited by 24 · see citing works
Almalé, L., García‐Álvaro, M., Martínez‐Palacián, A., Garcı́a-Bravo, M., Lazcanoiturburu, N., Addante, A., Roncero, C., Sanz‐Ortega, J., Lopez, M. J., Bragado, P., et al. (2019) · Stem Cells · doi:10.1002/stem.3038 · Cited by 23 · see citing works
Self-citationMicroenvironmental control of the ductular reaction: balancing repair and disease progression
Sorrentino, G. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07590-4 · Cited by 23 · see citing works
Ginkgolic acid suppresses the invasion of HepG2 cells via downregulation of HGF/c‑Met signaling
Li, H., Meng, X., Zhang, D., Xu, X., Li, S., & Li, Y. (2018) · Oncology Reports · doi:10.3892/or.2018.6786 · Cited by 22 · see citing works
Liu, Y., Pan, X., Li, S., Yu, Y., Chen, J., Yin, J., & Li, G. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.08.015 · Cited by 18 · see citing works
Revisiting the liver: from development to regeneration - what we ought to know!
López‐Luque, J., & Fabregat, I. (2018) · The International Journal of Developmental Biology · doi:10.1387/ijdb.170264jl · Cited by 17 · see citing works
Self-citationTherapeutic Strategies for Ovarian Cancer in Point of HGF/c-MET Targeting
Kim, H. J. (2022) · Medicina · doi:10.3390/medicina58050649 · Cited by 16 · see citing works
Jia, Y., Dai, G., Wang, J., Gao, X., Zhao, Z., DUAN, Z., Gu, B., YANG, W., WU, J., Ju, Y., et al. (2016) · Oncology Letters · doi:10.3892/ol.2016.4303 · Cited by 16 · see citing works
Cheng, H., Zhou, L., Long, Y., Xiang, J., & Chen, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.644120 · Cited by 13 · see citing works
Oncological transformation in vitro of hepatic progenitor cell lines isolated from adult mice
Olivera-Salazar, R., García‐Arranz, M., Sánchez, A., López, S. O., Vega-Clemente, L., Serrano, L. J., Herrera, B. M., & García‐Olmo, D. (2022) · Scientific Reports · doi:10.1038/s41598-022-06427-w · Cited by 12 · see citing works
Self-citationOgoke, O., Yousef, O., Ott, C., Kalinousky, A. J., Lin, W., Shamul, C., Ross, S., & Parashurama, N. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.621286 · Cited by 10 · see citing works
Addante, A., González‐Corralejo, C., Roncero, C., Lazcanoiturburu, N., García‐Sáez, J., Herrera, B. M., & Sánchez, A. (2022) · Cells · doi:10.3390/cells11030365 · Cited by 11 · see citing works
Self-citation3‐Cl‐ AHPC inhibits pro‐ HGF maturation by inducing matriptase/ HAI ‐1 complex formation
Ye, F., Chen, S., Liu, X., Ye, X., Wang, K., Zeng, Z., Su, Y., Zhang, X., & Zhou, H. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13900 · Cited by 10 · see citing works
Palao, N., Sequera, C., Cuesta, Á. M., Baquero, C., Bragado, P., Gutiérrez-Uzquiza, Á., Sánchez, A., Guerrero, C., & Porrás, A. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.73192 · Cited by 10 · see citing works
Self-citationYe, F., Yuan, Z., Tang, Y. C., Li, J., Liu, X., Sun, X., Chen, S., Ye, X., Zeng, Z., Zhang, X.-K., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114002 · Cited by 9 · see citing works
Yoshimoto, K., Maki, K., ADACHI, T., & Kamei, K. (2023) · Tissue Engineering Part A · doi:10.1089/ten.tea.2023.0148 · Cited by 6 · see citing works
Gabriel, V., Lincoln, A., Zdyrski, C., Ralston, A., Wickham, H., Honold, S. T., Ahmed, B. H., Paukner, K., Feauto, R., Merodio, M. M., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28420 · Cited by 6 · see citing works
Xing, X., Feng, H., & Yuan, Z. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15038550 · Cited by 6 · see citing works
Hou, S.-H., Wang, L., Chong, Y., Li, Y., & Liu, H. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112073 · Cited by 4 · see citing works
Tripura, C., Srinivas, G., Vishwakarma, S. K., Thatipalli, A. R., Jose, J., Jerald, M. K., Khan, A. A., & Pande, G. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i10.1884 · Cited by 4 · see citing works
García‐Sáez, J., Figueroa‐Fuentes, M., González‐Corralejo, C., Roncero, C., Lazcanoiturburu, N., Gutiérrez-Uzquiza, Á., Vaquero, J., Gonzalez‐Sanchez, E., Bhutia, K., Calero‐Pérez, S., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.90645 · Cited by 4 · see citing works
Self-citationA Brief Analysis of Proteomic Profile Changes during Zebrafish Regeneration
Ulhaq, Z. S., & Tse, W. K. F. (2021) · Biomolecules · doi:10.3390/biom12010035 · Cited by 4 · see citing works
Relación entre el factor de crecimiento hepático y el estadio de la cirrosis
Barreto, I. D. J. Y., Contreras, M. N. M., & Causado, A. S. (2017) · Revista Colombiana de Gastroenterología · doi:10.22516/25007440.126 · Cited by 3 · see citing works
Romero-Suárez, D. E., Solana-Tinoco, J. B., Espiñeira, M. C. G., Lambis-Anaya, L., & Causado, A. S. (2024) · Revista de Gastroenterología del Perú · doi:10.47892/rgp.2024.443.1718 · Cited by 3 · see citing works
al., Z. E. (2025) · Egyptian Journal of Aquatic Biology and Fisheries · doi:10.21608/ejabf.2025.426199 · Cited by 2 · see citing works
Treatment of AECHB and Severe Hepatitis (Liver Failure)
Wang, Y., Li, K., Dou, X., Bai, H., Zhao, X., Ma, X., Li, L., Chen, Z., & Huang, Y. (2019) · Springer eBooks · doi:10.1007/978-94-024-1603-9_4 · Cited by 2 · see citing works
Jorge, G. P., Lambis-Anaya, L., Puello-Ramos, W., Solana-Tinoco, J. B., & Causado, A. S. (2021) · Duazary · doi:10.21676/2389783x.4077 · Cited by 2 · see citing works
Mankovska, O. S., Gerashchenko, G. V., Rozenberg, E., Stakhovsky, E. O., Kononenko, O. A., Bondarenko, Y. V., & Kashuba, V. I. (2019) · The Ukrainian Biochemical Journal · doi:10.15407/ubj91.06.015 · Cited by 1 · see citing works
Ogoke, O., Yousef, O., Ott, C., Kalinousky, A. J., Lin, W., Shamul, C., Ross, S., & Parashurama, N. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.27.315580 · Cited by 1 · see citing works
Chen, X., Ma, R., Li, H., Tang, Y., & Yin, D. (2021) · doi:10.21203/rs.3.rs-153940/v1 · Cited by 1 · see citing works
Yoshimoto, K., Maki, K., ADACHI, T., & Kamei, K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.11.544492
González‐Corralejo, C., García‐Sáez, J., Figueroa‐Fuentes, M., Addante, A., Roncero, C., Lazcanoiturburu, N., Pacheco, B., Sanz, J., Gato, C., Fernández‐Calderón, E., et al. (2025) · FEBS Journal · doi:10.1111/febs.70315
Self-citation
- Authors
- Suárez-Causado, A., Caballero-Díaz, D., Bertrán, E., Roncero, C., Addante, A., García-Álvaro, M., Fernández, M., Herrera, B., Porras, A., Fabregat, I., & Sánchez, A.
- Affiliations
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Universidad Complutense de Madrid (ES)
- Corresponding author
- Sánchez, A.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 1853
- Issue
- 10
- Pages
- 2453-2463
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W314299795
- Cited by
- 49
- References
- 60
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 9 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 1
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Library Open Repository (Universidad Complutense Madrid) (submittedVersion, other-oa)
- Funders
- Spanish Ministry of Economy and Competitiveness, MINECO (SAF2009-12477, BFU2012-35538)
- UCM Research Funding (920359)
- People Programme (Marie Curie Actions) (#PITN-GA-2012-316549)
- Alban Programme (SAF2009-12477)
- General Direction of Universities and Research (Community of Madrid) (S2010/BMD-2402)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- HGF/MET signaling, oval cells, liver progenitor cells, cell migration, cell invasion, PI3K signaling, collective migration, F-actin cytoskeleton, Rac1, cell-cell adhesion, matrix metalloproteinases, liver regeneration, hepatocarcinogenesis
- MeSH terms
- Actins, Animals, Cell Movement, Liver, Models, Biological, Neuropeptides, Stem Cells, Cadherins, Hepatocyte Growth Factor, Mice, Knockout, Proto-Oncogene Proteins c-met, Phosphatidylinositol 3-Kinases, rac1 GTP-Binding Protein, Mice, Epithelial-Mesenchymal Transition, Occludin, Zonula Occludens-1 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
